Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2B4_LEIIN

TriTrypDb:

LINF_260023400

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2B4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.624
CLV_NRD_NRD_1	135	137	PF00675	0.580
CLV_NRD_NRD_1	317	319	PF00675	0.575
CLV_NRD_NRD_1	323	325	PF00675	0.536
CLV_NRD_NRD_1	38	40	PF00675	0.511
CLV_NRD_NRD_1	426	428	PF00675	0.614
CLV_NRD_NRD_1	429	431	PF00675	0.444
CLV_NRD_NRD_1	61	63	PF00675	0.431
CLV_NRD_NRD_1	64	66	PF00675	0.466
CLV_PCSK_FUR_1	132	136	PF00082	0.554
CLV_PCSK_FUR_1	427	431	PF00082	0.513
CLV_PCSK_FUR_1	62	66	PF00082	0.462
CLV_PCSK_KEX2_1	134	136	PF00082	0.577
CLV_PCSK_KEX2_1	317	319	PF00082	0.576
CLV_PCSK_KEX2_1	323	325	PF00082	0.535
CLV_PCSK_KEX2_1	331	333	PF00082	0.478
CLV_PCSK_KEX2_1	38	40	PF00082	0.511
CLV_PCSK_KEX2_1	426	428	PF00082	0.542
CLV_PCSK_KEX2_1	429	431	PF00082	0.449
CLV_PCSK_KEX2_1	61	63	PF00082	0.431
CLV_PCSK_KEX2_1	64	66	PF00082	0.466
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.478
CLV_PCSK_PC7_1	57	63	PF00082	0.460
CLV_PCSK_SKI1_1	218	222	PF00082	0.637
CLV_PCSK_SKI1_1	326	330	PF00082	0.495
DEG_APCC_DBOX_1	150	158	PF00400	0.459
DEG_APCC_DBOX_1	159	167	PF00400	0.507
DEG_SPOP_SBC_1	390	394	PF00917	0.692
DOC_CKS1_1	408	413	PF01111	0.548
DOC_MAPK_gen_1	134	144	PF00069	0.615
DOC_MAPK_gen_1	93	102	PF00069	0.503
DOC_MAPK_MEF2A_6	138	146	PF00069	0.590
DOC_MAPK_RevD_3	24	39	PF00069	0.533
DOC_PP2B_LxvP_1	257	260	PF13499	0.588
DOC_PP2B_LxvP_1	34	37	PF13499	0.553
DOC_PP4_FxxP_1	439	442	PF00568	0.442
DOC_PP4_FxxP_1	75	78	PF00568	0.521
DOC_USP7_MATH_1	158	162	PF00917	0.685
DOC_USP7_MATH_1	169	173	PF00917	0.687
DOC_USP7_MATH_1	252	256	PF00917	0.719
DOC_USP7_MATH_1	28	32	PF00917	0.577
DOC_USP7_MATH_1	344	348	PF00917	0.500
DOC_USP7_MATH_1	364	368	PF00917	0.580
DOC_USP7_MATH_1	388	392	PF00917	0.727
DOC_USP7_MATH_1	404	408	PF00917	0.451
DOC_WW_Pin1_4	194	199	PF00397	0.653
DOC_WW_Pin1_4	210	215	PF00397	0.738
DOC_WW_Pin1_4	220	225	PF00397	0.715
DOC_WW_Pin1_4	232	237	PF00397	0.803
DOC_WW_Pin1_4	260	265	PF00397	0.595
DOC_WW_Pin1_4	279	284	PF00397	0.512
DOC_WW_Pin1_4	379	384	PF00397	0.647
DOC_WW_Pin1_4	407	412	PF00397	0.557
LIG_14-3-3_CanoR_1	135	144	PF00244	0.556
LIG_14-3-3_CanoR_1	200	204	PF00244	0.708
LIG_14-3-3_CanoR_1	246	256	PF00244	0.610
LIG_14-3-3_CanoR_1	98	103	PF00244	0.562
LIG_Actin_WH2_2	150	166	PF00022	0.462
LIG_APCC_ABBA_1	461	466	PF00400	0.487
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.527
LIG_CaM_IQ_9	85	100	PF13499	0.455
LIG_CtBP_PxDLS_1	307	311	PF00389	0.496
LIG_FHA_1	124	130	PF00498	0.591
LIG_FHA_1	137	143	PF00498	0.511
LIG_FHA_1	21	27	PF00498	0.662
LIG_FHA_1	260	266	PF00498	0.701
LIG_FHA_1	343	349	PF00498	0.492
LIG_FHA_1	408	414	PF00498	0.539
LIG_FHA_1	6	12	PF00498	0.629
LIG_FHA_2	145	151	PF00498	0.463
LIG_FHA_2	286	292	PF00498	0.653
LIG_FHA_2	44	50	PF00498	0.476
LIG_Integrin_isoDGR_2	241	243	PF01839	0.592
LIG_LIR_Apic_2	72	78	PF02991	0.531
LIG_LIR_Gen_1	446	451	PF02991	0.426
LIG_LIR_Nem_3	446	450	PF02991	0.413
LIG_MAD2	474	482	PF02301	0.502
LIG_MYND_1	33	37	PF01753	0.531
LIG_RPA_C_Fungi	312	324	PF08784	0.555
LIG_SH2_CRK	219	223	PF00017	0.568
LIG_SH2_CRK	401	405	PF00017	0.585
LIG_SH2_CRK	447	451	PF00017	0.422
LIG_SH2_NCK_1	219	223	PF00017	0.568
LIG_SH2_PTP2	99	102	PF00017	0.538
LIG_SH2_STAP1	170	174	PF00017	0.684
LIG_SH2_STAP1	447	451	PF00017	0.422
LIG_SH2_STAT3	86	89	PF00017	0.508
LIG_SH2_STAT5	153	156	PF00017	0.428
LIG_SH2_STAT5	443	446	PF00017	0.594
LIG_SH2_STAT5	447	450	PF00017	0.523
LIG_SH2_STAT5	67	70	PF00017	0.417
LIG_SH2_STAT5	99	102	PF00017	0.538
LIG_SH3_1	27	33	PF00018	0.535
LIG_SH3_2	211	216	PF14604	0.653
LIG_SH3_3	208	214	PF00018	0.795
LIG_SH3_3	27	33	PF00018	0.535
LIG_SH3_3	8	14	PF00018	0.793
LIG_SUMO_SIM_anti_2	418	424	PF11976	0.490
LIG_SUMO_SIM_par_1	139	148	PF11976	0.543
LIG_TRAF2_1	482	485	PF00917	0.579
MOD_CDC14_SPxK_1	197	200	PF00782	0.659
MOD_CDC14_SPxK_1	213	216	PF00782	0.677
MOD_CDK_SPK_2	220	225	PF00069	0.567
MOD_CDK_SPK_2	279	284	PF00069	0.626
MOD_CDK_SPxK_1	194	200	PF00069	0.654
MOD_CDK_SPxK_1	210	216	PF00069	0.533
MOD_CDK_SPxxK_3	236	243	PF00069	0.604
MOD_CDK_SPxxK_3	260	267	PF00069	0.565
MOD_CK1_1	101	107	PF00069	0.593
MOD_CK1_1	137	143	PF00069	0.684
MOD_CK1_1	16	22	PF00069	0.602
MOD_CK1_1	172	178	PF00069	0.583
MOD_CK1_1	186	192	PF00069	0.804
MOD_CK1_1	194	200	PF00069	0.613
MOD_CK1_1	247	253	PF00069	0.622
MOD_CK1_1	285	291	PF00069	0.737
MOD_CK1_1	391	397	PF00069	0.690
MOD_CK1_1	407	413	PF00069	0.430
MOD_CK2_1	125	131	PF00069	0.807
MOD_CK2_1	144	150	PF00069	0.453
MOD_CK2_1	285	291	PF00069	0.645
MOD_GlcNHglycan	104	107	PF01048	0.565
MOD_GlcNHglycan	15	18	PF01048	0.584
MOD_GlcNHglycan	159	163	PF01048	0.682
MOD_GlcNHglycan	173	177	PF01048	0.619
MOD_GlcNHglycan	252	255	PF01048	0.689
MOD_GlcNHglycan	279	282	PF01048	0.798
MOD_GlcNHglycan	319	322	PF01048	0.560
MOD_GlcNHglycan	490	493	PF01048	0.594
MOD_GSK3_1	13	20	PF00069	0.758
MOD_GSK3_1	134	141	PF00069	0.724
MOD_GSK3_1	183	190	PF00069	0.594
MOD_GSK3_1	220	227	PF00069	0.636
MOD_GSK3_1	232	239	PF00069	0.709
MOD_GSK3_1	244	251	PF00069	0.517
MOD_GSK3_1	445	452	PF00069	0.544
MOD_GSK3_1	98	105	PF00069	0.590
MOD_LATS_1	315	321	PF00433	0.636
MOD_N-GLC_1	260	265	PF02516	0.585
MOD_NEK2_1	185	190	PF00069	0.664
MOD_NEK2_1	245	250	PF00069	0.695
MOD_NEK2_1	85	90	PF00069	0.510
MOD_NEK2_2	344	349	PF00069	0.494
MOD_PIKK_1	245	251	PF00454	0.615
MOD_PIKK_1	402	408	PF00454	0.583
MOD_PIKK_1	449	455	PF00454	0.447
MOD_PIKK_1	85	91	PF00454	0.575
MOD_PK_1	138	144	PF00069	0.571
MOD_PK_1	98	104	PF00069	0.586
MOD_PKA_1	134	140	PF00069	0.536
MOD_PKA_1	317	323	PF00069	0.566
MOD_PKA_2	134	140	PF00069	0.561
MOD_PKA_2	199	205	PF00069	0.738
MOD_PKA_2	245	251	PF00069	0.619
MOD_PKA_2	317	323	PF00069	0.581
MOD_PKB_1	132	140	PF00069	0.549
MOD_PKB_1	96	104	PF00069	0.627
MOD_Plk_1	374	380	PF00069	0.545
MOD_Plk_1	445	451	PF00069	0.480
MOD_Plk_4	252	258	PF00069	0.598
MOD_Plk_4	404	410	PF00069	0.532
MOD_Plk_4	416	422	PF00069	0.545
MOD_ProDKin_1	194	200	PF00069	0.654
MOD_ProDKin_1	210	216	PF00069	0.742
MOD_ProDKin_1	220	226	PF00069	0.717
MOD_ProDKin_1	232	238	PF00069	0.800
MOD_ProDKin_1	260	266	PF00069	0.596
MOD_ProDKin_1	279	285	PF00069	0.512
MOD_ProDKin_1	379	385	PF00069	0.645
MOD_ProDKin_1	407	413	PF00069	0.551
MOD_SUMO_for_1	283	286	PF00179	0.609
MOD_SUMO_rev_2	490	497	PF00179	0.608
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.628
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.587
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.532
TRG_ENDOCYTIC_2	399	402	PF00928	0.686
TRG_ENDOCYTIC_2	447	450	PF00928	0.462
TRG_ENDOCYTIC_2	67	70	PF00928	0.417
TRG_ENDOCYTIC_2	99	102	PF00928	0.587
TRG_ER_diArg_1	133	136	PF00400	0.584
TRG_ER_diArg_1	216	219	PF00400	0.667
TRG_ER_diArg_1	37	39	PF00400	0.527
TRG_ER_diArg_1	425	427	PF00400	0.556
TRG_ER_diArg_1	428	430	PF00400	0.431
TRG_ER_diArg_1	472	475	PF00400	0.540
TRG_ER_diArg_1	60	62	PF00400	0.425
TRG_ER_diArg_1	64	66	PF00400	0.465
TRG_ER_diArg_1	96	99	PF00400	0.662
TRG_NLS_Bipartite_1	317	335	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B6	Leptomonas seymouri	36%	86%
A0A3Q8ID10	Leishmania donovani	98%	100%
A4HF27	Leishmania braziliensis	65%	100%
E9AYG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q911	Leishmania major	87%	100%