Methylated-DNA--protein-cysteine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-O-methylguanine DNA methyltransferase - DNA binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4I2B3_LEIIN

TriTrypDb:

LINF_260023300

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I2B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2B3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006259	DNA metabolic process	4	9
GO:0006281	DNA repair	5	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0006950	response to stress	2	9
GO:0006974	DNA damage response	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0032259	methylation	2	9
GO:0033554	cellular response to stress	3	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0050896	response to stimulus	1	9
GO:0051716	cellular response to stimulus	2	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	6	9
GO:0008168	methyltransferase activity	4	9
GO:0008172	S-methyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016741	transferase activity, transferring one-carbon groups	3	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.502
CLV_NRD_NRD_1	83	85	PF00675	0.401
CLV_NRD_NRD_1	9	11	PF00675	0.625
CLV_PCSK_KEX2_1	110	112	PF00082	0.389
CLV_PCSK_KEX2_1	83	85	PF00082	0.401
CLV_PCSK_KEX2_1	9	11	PF00082	0.629
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.389
CLV_PCSK_SKI1_1	134	138	PF00082	0.462
CLV_PCSK_SKI1_1	158	162	PF00082	0.434
DEG_SPOP_SBC_1	235	239	PF00917	0.498
DEG_SPOP_SBC_1	29	33	PF00917	0.574
DOC_ANK_TNKS_1	82	89	PF00023	0.335
DOC_CKS1_1	60	65	PF01111	0.415
DOC_CYCLIN_RxL_1	199	209	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.323
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.449
DOC_MAPK_gen_1	107	116	PF00069	0.392
DOC_MAPK_MEF2A_6	158	165	PF00069	0.355
DOC_PP2B_LxvP_1	161	164	PF13499	0.327
DOC_PP2B_LxvP_1	204	207	PF13499	0.449
DOC_SPAK_OSR1_1	250	254	PF12202	0.461
DOC_USP7_MATH_1	46	50	PF00917	0.592
DOC_USP7_MATH_2	22	28	PF00917	0.510
DOC_USP7_UBL2_3	19	23	PF12436	0.597
DOC_WW_Pin1_4	109	114	PF00397	0.344
DOC_WW_Pin1_4	59	64	PF00397	0.437
LIG_14-3-3_CanoR_1	111	117	PF00244	0.411
LIG_14-3-3_CanoR_1	134	139	PF00244	0.439
LIG_14-3-3_CanoR_1	182	186	PF00244	0.481
LIG_14-3-3_CanoR_1	234	242	PF00244	0.537
LIG_14-3-3_CanoR_1	83	87	PF00244	0.349
LIG_APCC_ABBA_1	67	72	PF00400	0.388
LIG_BIR_III_4	72	76	PF00653	0.419
LIG_FHA_1	237	243	PF00498	0.498
LIG_FHA_1	263	269	PF00498	0.387
LIG_LIR_Gen_1	177	186	PF02991	0.494
LIG_LIR_Nem_3	177	181	PF02991	0.544
LIG_LIR_Nem_3	190	196	PF02991	0.478
LIG_NRBOX	155	161	PF00104	0.350
LIG_NRP_CendR_1	283	284	PF00754	0.641
LIG_SH2_CRK	193	197	PF00017	0.506
LIG_SH2_GRB2like	142	145	PF00017	0.428
LIG_SH2_SRC	70	73	PF00017	0.402
LIG_SH2_STAT5	142	145	PF00017	0.385
LIG_SH2_STAT5	56	59	PF00017	0.399
LIG_SH2_STAT5	70	73	PF00017	0.373
LIG_SH3_1	23	29	PF00018	0.566
LIG_SH3_3	225	231	PF00018	0.505
LIG_SH3_3	23	29	PF00018	0.723
LIG_SH3_3	57	63	PF00018	0.389
LIG_TYR_ITIM	191	196	PF00017	0.498
MOD_CK1_1	187	193	PF00069	0.498
MOD_CK1_1	238	244	PF00069	0.494
MOD_CK1_1	49	55	PF00069	0.400
MOD_GlcNHglycan	127	130	PF01048	0.398
MOD_GlcNHglycan	170	173	PF01048	0.495
MOD_GlcNHglycan	186	189	PF01048	0.277
MOD_GlcNHglycan	208	211	PF01048	0.279
MOD_GlcNHglycan	32	35	PF01048	0.602
MOD_GlcNHglycan	43	46	PF01048	0.597
MOD_GlcNHglycan	48	51	PF01048	0.669
MOD_GlcNHglycan	84	87	PF01048	0.484
MOD_GSK3_1	177	184	PF00069	0.521
MOD_GSK3_1	234	241	PF00069	0.487
MOD_GSK3_1	24	31	PF00069	0.605
MOD_GSK3_1	272	279	PF00069	0.553
MOD_NEK2_1	174	179	PF00069	0.538
MOD_NEK2_1	181	186	PF00069	0.540
MOD_NEK2_1	236	241	PF00069	0.540
MOD_PKA_2	181	187	PF00069	0.498
MOD_PKA_2	82	88	PF00069	0.333
MOD_Plk_1	272	278	PF00069	0.518
MOD_Plk_4	134	140	PF00069	0.398
MOD_ProDKin_1	109	115	PF00069	0.345
MOD_ProDKin_1	59	65	PF00069	0.440
TRG_DiLeu_BaEn_1	155	160	PF01217	0.353
TRG_DiLeu_LyEn_5	155	160	PF01217	0.353
TRG_ENDOCYTIC_2	193	196	PF00928	0.481
TRG_ER_diArg_1	82	84	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Q0	Leptomonas seymouri	55%	100%
A0A3Q8IFY3	Leishmania donovani	99%	100%
A0A3R7ML39	Trypanosoma rangeli	33%	100%
A4HF26	Leishmania braziliensis	80%	100%
E9AYG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q912	Leishmania major	89%	99%
V5AV65	Trypanosoma cruzi	30%	100%