Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2B0_LEIIN

TriTrypDb:

LINF_260022900

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.712
CLV_C14_Caspase3-7	158	162	PF00656	0.692
CLV_NRD_NRD_1	210	212	PF00675	0.582
CLV_NRD_NRD_1	316	318	PF00675	0.668
CLV_NRD_NRD_1	373	375	PF00675	0.658
CLV_NRD_NRD_1	76	78	PF00675	0.659
CLV_PCSK_FUR_1	208	212	PF00082	0.583
CLV_PCSK_FUR_1	314	318	PF00082	0.667
CLV_PCSK_FUR_1	92	96	PF00082	0.578
CLV_PCSK_KEX2_1	210	212	PF00082	0.582
CLV_PCSK_KEX2_1	314	316	PF00082	0.726
CLV_PCSK_KEX2_1	373	375	PF00082	0.658
CLV_PCSK_KEX2_1	75	77	PF00082	0.658
CLV_PCSK_KEX2_1	94	96	PF00082	0.513
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.579
CLV_PCSK_PC7_1	311	317	PF00082	0.658
CLV_PCSK_SKI1_1	210	214	PF00082	0.558
DEG_SCF_TRCP1_1	253	258	PF00400	0.611
DEG_SPOP_SBC_1	137	141	PF00917	0.662
DEG_SPOP_SBC_1	298	302	PF00917	0.632
DEG_SPOP_SBC_1	36	40	PF00917	0.618
DOC_CYCLIN_RxL_1	207	217	PF00134	0.568
DOC_CYCLIN_RxL_1	218	226	PF00134	0.478
DOC_PP1_RVXF_1	219	226	PF00149	0.595
DOC_USP7_MATH_1	132	136	PF00917	0.779
DOC_USP7_MATH_1	154	158	PF00917	0.665
DOC_USP7_MATH_1	236	240	PF00917	0.705
DOC_USP7_MATH_1	26	30	PF00917	0.747
DOC_USP7_MATH_1	298	302	PF00917	0.660
DOC_USP7_MATH_1	35	39	PF00917	0.750
DOC_USP7_MATH_1	55	59	PF00917	0.526
DOC_WW_Pin1_4	12	17	PF00397	0.719
DOC_WW_Pin1_4	139	144	PF00397	0.695
DOC_WW_Pin1_4	214	219	PF00397	0.578
DOC_WW_Pin1_4	27	32	PF00397	0.570
DOC_WW_Pin1_4	294	299	PF00397	0.628
DOC_WW_Pin1_4	358	363	PF00397	0.549
LIG_14-3-3_CanoR_1	210	220	PF00244	0.562
LIG_14-3-3_CanoR_1	316	322	PF00244	0.719
LIG_14-3-3_CanoR_1	79	88	PF00244	0.644
LIG_BIR_II_1	1	5	PF00653	0.707
LIG_BIR_III_4	83	87	PF00653	0.636
LIG_Clathr_ClatBox_1	222	226	PF01394	0.555
LIG_CSL_BTD_1	191	194	PF09270	0.599
LIG_FHA_1	118	124	PF00498	0.645
LIG_FHA_1	184	190	PF00498	0.603
LIG_FHA_1	52	58	PF00498	0.697
LIG_FHA_2	103	109	PF00498	0.683
LIG_FHA_2	114	120	PF00498	0.628
LIG_FHA_2	37	43	PF00498	0.680
LIG_LIR_Apic_2	337	343	PF02991	0.613
LIG_LIR_Gen_1	328	338	PF02991	0.627
LIG_LIR_Nem_3	217	223	PF02991	0.569
LIG_LIR_Nem_3	300	306	PF02991	0.616
LIG_LIR_Nem_3	328	334	PF02991	0.632
LIG_PDZ_Class_3	376	381	PF00595	0.646
LIG_Rb_LxCxE_1	174	190	PF01857	0.658
LIG_SH2_CRK	340	344	PF00017	0.580
LIG_SH2_NCK_1	340	344	PF00017	0.580
LIG_SH2_NCK_1	360	364	PF00017	0.452
LIG_SH2_STAT5	331	334	PF00017	0.546
LIG_SH2_STAT5	357	360	PF00017	0.601
LIG_SH3_3	11	17	PF00018	0.580
LIG_SH3_3	230	236	PF00018	0.687
LIG_TRFH_1	340	344	PF08558	0.545
LIG_WW_3	15	19	PF00397	0.583
MOD_CDC14_SPxK_1	15	18	PF00782	0.720
MOD_CDK_SPK_2	27	32	PF00069	0.680
MOD_CDK_SPxK_1	12	18	PF00069	0.720
MOD_CDK_SPxxK_3	214	221	PF00069	0.519
MOD_CK1_1	139	145	PF00069	0.728
MOD_CK1_1	2	8	PF00069	0.649
MOD_CK1_1	297	303	PF00069	0.609
MOD_CK1_1	330	336	PF00069	0.636
MOD_CK1_1	361	367	PF00069	0.527
MOD_CK1_1	82	88	PF00069	0.682
MOD_CK1_1	93	99	PF00069	0.640
MOD_CK2_1	113	119	PF00069	0.724
MOD_CK2_1	132	138	PF00069	0.612
MOD_CK2_1	141	147	PF00069	0.602
MOD_CK2_1	236	242	PF00069	0.660
MOD_CK2_1	284	290	PF00069	0.558
MOD_CK2_1	317	323	PF00069	0.716
MOD_CK2_1	36	42	PF00069	0.673
MOD_GlcNHglycan	1	4	PF01048	0.710
MOD_GlcNHglycan	108	112	PF01048	0.693
MOD_GlcNHglycan	124	127	PF01048	0.565
MOD_GlcNHglycan	134	137	PF01048	0.675
MOD_GlcNHglycan	169	172	PF01048	0.621
MOD_GlcNHglycan	238	241	PF01048	0.667
MOD_GlcNHglycan	253	256	PF01048	0.579
MOD_GlcNHglycan	345	348	PF01048	0.581
MOD_GlcNHglycan	363	366	PF01048	0.467
MOD_GlcNHglycan	374	377	PF01048	0.551
MOD_GlcNHglycan	39	42	PF01048	0.544
MOD_GlcNHglycan	83	87	PF01048	0.712
MOD_GSK3_1	1	8	PF00069	0.643
MOD_GSK3_1	100	107	PF00069	0.604
MOD_GSK3_1	109	116	PF00069	0.516
MOD_GSK3_1	117	124	PF00069	0.586
MOD_GSK3_1	132	139	PF00069	0.643
MOD_GSK3_1	163	170	PF00069	0.698
MOD_GSK3_1	174	181	PF00069	0.597
MOD_GSK3_1	183	190	PF00069	0.434
MOD_GSK3_1	192	199	PF00069	0.414
MOD_GSK3_1	251	258	PF00069	0.637
MOD_GSK3_1	294	301	PF00069	0.628
MOD_GSK3_1	51	58	PF00069	0.593
MOD_GSK3_1	90	97	PF00069	0.713
MOD_N-GLC_1	163	168	PF02516	0.688
MOD_NEK2_1	1	6	PF00069	0.707
MOD_NEK2_1	257	262	PF00069	0.615
MOD_NEK2_1	299	304	PF00069	0.637
MOD_PIKK_1	117	123	PF00454	0.645
MOD_PIKK_1	192	198	PF00454	0.607
MOD_PK_1	100	106	PF00069	0.572
MOD_PKA_1	94	100	PF00069	0.576
MOD_PKA_2	372	378	PF00069	0.651
MOD_PKA_2	94	100	PF00069	0.663
MOD_PKB_1	315	323	PF00069	0.665
MOD_PKB_1	77	85	PF00069	0.664
MOD_Plk_1	163	169	PF00069	0.637
MOD_Plk_1	338	344	PF00069	0.600
MOD_Plk_2-3	102	108	PF00069	0.586
MOD_Plk_4	141	147	PF00069	0.650
MOD_Plk_4	187	193	PF00069	0.576
MOD_ProDKin_1	12	18	PF00069	0.720
MOD_ProDKin_1	139	145	PF00069	0.697
MOD_ProDKin_1	214	220	PF00069	0.575
MOD_ProDKin_1	27	33	PF00069	0.570
MOD_ProDKin_1	294	300	PF00069	0.623
MOD_ProDKin_1	358	364	PF00069	0.547
MOD_SUMO_rev_2	58	67	PF00179	0.568
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.569
TRG_ENDOCYTIC_2	219	222	PF00928	0.586
TRG_ENDOCYTIC_2	306	309	PF00928	0.633
TRG_ENDOCYTIC_2	331	334	PF00928	0.608
TRG_ER_diArg_1	210	212	PF00400	0.582
TRG_ER_diArg_1	313	316	PF00400	0.656
TRG_ER_diArg_1	75	77	PF00400	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICW3	Leishmania donovani	99%	100%
E9AIQ9	Leishmania braziliensis	65%	100%
E9AYF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q915	Leishmania major	88%	100%