LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I2A9_LEIIN
TriTrypDb:
LINF_260022800
Length:
106

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2A9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2A9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 74 78 PF00656 0.572
CLV_C14_Caspase3-7 86 90 PF00656 0.683
CLV_PCSK_KEX2_1 100 102 PF00082 0.623
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.623
CLV_PCSK_SKI1_1 21 25 PF00082 0.453
DEG_Nend_UBRbox_3 1 3 PF02207 0.523
DOC_MAPK_MEF2A_6 35 43 PF00069 0.314
DOC_USP7_MATH_1 31 35 PF00917 0.501
DOC_USP7_MATH_1 76 80 PF00917 0.688
DOC_USP7_MATH_1 96 100 PF00917 0.500
DOC_WW_Pin1_4 89 94 PF00397 0.599
LIG_14-3-3_CanoR_1 101 106 PF00244 0.562
LIG_FHA_1 100 106 PF00498 0.513
LIG_FHA_2 72 78 PF00498 0.610
LIG_FHA_2 84 90 PF00498 0.525
LIG_SH2_STAT5 14 17 PF00017 0.480
LIG_SH2_STAT5 40 43 PF00017 0.310
LIG_SUMO_SIM_anti_2 53 59 PF11976 0.560
LIG_TRAF2_1 64 67 PF00917 0.614
MOD_CK1_1 53 59 PF00069 0.588
MOD_CK1_1 79 85 PF00069 0.571
MOD_CK1_1 91 97 PF00069 0.523
MOD_CK1_1 99 105 PF00069 0.455
MOD_CK2_1 100 106 PF00069 0.513
MOD_CK2_1 61 67 PF00069 0.604
MOD_GSK3_1 79 86 PF00069 0.609
MOD_GSK3_1 91 98 PF00069 0.537
MOD_NEK2_1 88 93 PF00069 0.504
MOD_PKA_1 100 106 PF00069 0.564
MOD_PKA_2 100 106 PF00069 0.616
MOD_ProDKin_1 89 95 PF00069 0.598
TRG_ENDOCYTIC_2 4 7 PF00928 0.462
TRG_ENDOCYTIC_2 40 43 PF00928 0.504
TRG_Pf-PMV_PEXEL_1 21 25 PF00026 0.433

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZH4 Leptomonas seymouri 43% 77%
A0A3Q8IH46 Leishmania donovani 98% 100%
A4HD52 Leishmania braziliensis 61% 100%
E9AYF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 80% 100%
Q4Q916 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS