Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2A8_LEIIN

TriTrypDb:

LINF_260022700

Length:

475

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.689
CLV_C14_Caspase3-7	125	129	PF00656	0.609
CLV_C14_Caspase3-7	266	270	PF00656	0.545
CLV_NRD_NRD_1	137	139	PF00675	0.740
CLV_NRD_NRD_1	16	18	PF00675	0.664
CLV_NRD_NRD_1	187	189	PF00675	0.671
CLV_NRD_NRD_1	250	252	PF00675	0.534
CLV_NRD_NRD_1	292	294	PF00675	0.531
CLV_NRD_NRD_1	313	315	PF00675	0.517
CLV_NRD_NRD_1	32	34	PF00675	0.513
CLV_NRD_NRD_1	366	368	PF00675	0.575
CLV_NRD_NRD_1	9	11	PF00675	0.786
CLV_PCSK_FUR_1	187	191	PF00082	0.607
CLV_PCSK_FUR_1	247	251	PF00082	0.628
CLV_PCSK_FUR_1	360	364	PF00082	0.637
CLV_PCSK_KEX2_1	16	18	PF00082	0.664
CLV_PCSK_KEX2_1	187	189	PF00082	0.616
CLV_PCSK_KEX2_1	249	251	PF00082	0.533
CLV_PCSK_KEX2_1	292	294	PF00082	0.516
CLV_PCSK_KEX2_1	32	34	PF00082	0.507
CLV_PCSK_KEX2_1	362	364	PF00082	0.590
CLV_PCSK_KEX2_1	365	367	PF00082	0.572
CLV_PCSK_KEX2_1	454	456	PF00082	0.696
CLV_PCSK_KEX2_1	9	11	PF00082	0.786
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.597
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.633
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.696
CLV_PCSK_PC7_1	288	294	PF00082	0.504
CLV_PCSK_SKI1_1	167	171	PF00082	0.716
CLV_PCSK_SKI1_1	205	209	PF00082	0.635
CLV_PCSK_SKI1_1	293	297	PF00082	0.509
CLV_PCSK_SKI1_1	300	304	PF00082	0.469
CLV_PCSK_SKI1_1	366	370	PF00082	0.561
CLV_PCSK_SKI1_1	427	431	PF00082	0.681
CLV_PCSK_SKI1_1	471	475	PF00082	0.651
DEG_APCC_DBOX_1	299	307	PF00400	0.526
DEG_Nend_Nbox_1	1	3	PF02207	0.728
DOC_CKS1_1	140	145	PF01111	0.682
DOC_CKS1_1	348	353	PF01111	0.644
DOC_CKS1_1	99	104	PF01111	0.568
DOC_CYCLIN_RxL_1	367	380	PF00134	0.638
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.665
DOC_CYCLIN_yCln2_LP_2	466	469	PF00134	0.525
DOC_MAPK_gen_1	298	305	PF00069	0.530
DOC_MAPK_gen_1	365	377	PF00069	0.646
DOC_MAPK_MEF2A_6	268	277	PF00069	0.625
DOC_PP1_RVXF_1	410	416	PF00149	0.606
DOC_PP2B_LxvP_1	100	103	PF13499	0.562
DOC_PP2B_LxvP_1	466	469	PF13499	0.525
DOC_USP7_MATH_1	172	176	PF00917	0.590
DOC_USP7_MATH_1	460	464	PF00917	0.714
DOC_USP7_UBL2_3	471	475	PF12436	0.740
DOC_WW_Pin1_4	133	138	PF00397	0.769
DOC_WW_Pin1_4	139	144	PF00397	0.695
DOC_WW_Pin1_4	347	352	PF00397	0.548
DOC_WW_Pin1_4	98	103	PF00397	0.756
LIG_14-3-3_CanoR_1	138	143	PF00244	0.718
LIG_14-3-3_CanoR_1	167	177	PF00244	0.690
LIG_14-3-3_CanoR_1	187	197	PF00244	0.349
LIG_14-3-3_CanoR_1	232	241	PF00244	0.640
LIG_14-3-3_CanoR_1	300	306	PF00244	0.525
LIG_14-3-3_CanoR_1	367	377	PF00244	0.644
LIG_14-3-3_CanoR_1	52	58	PF00244	0.712
LIG_14-3-3_CanoR_1	79	88	PF00244	0.692
LIG_Actin_RPEL_3	356	375	PF02755	0.577
LIG_APCC_ABBA_1	148	153	PF00400	0.553
LIG_APCC_ABBA_1	375	380	PF00400	0.627
LIG_BRCT_BRCA1_1	320	324	PF00533	0.617
LIG_BRCT_BRCA1_1	41	45	PF00533	0.731
LIG_CaM_IQ_9	219	234	PF13499	0.560
LIG_FHA_1	118	124	PF00498	0.710
LIG_FHA_1	285	291	PF00498	0.614
LIG_FHA_1	302	308	PF00498	0.444
LIG_FHA_1	369	375	PF00498	0.646
LIG_FHA_1	391	397	PF00498	0.641
LIG_FHA_1	426	432	PF00498	0.485
LIG_FHA_1	68	74	PF00498	0.772
LIG_FHA_2	105	111	PF00498	0.705
LIG_FHA_2	168	174	PF00498	0.689
LIG_LIR_Gen_1	304	313	PF02991	0.602
LIG_LIR_Nem_3	304	308	PF02991	0.605
LIG_PCNA_yPIPBox_3	336	348	PF02747	0.433
LIG_Pex14_2	324	328	PF04695	0.625
LIG_SH2_PTP2	422	425	PF00017	0.599
LIG_SH2_SRC	126	129	PF00017	0.733
LIG_SH2_STAT3	243	246	PF00017	0.544
LIG_SH2_STAT3	256	259	PF00017	0.364
LIG_SH2_STAT5	185	188	PF00017	0.683
LIG_SH2_STAT5	243	246	PF00017	0.544
LIG_SH2_STAT5	422	425	PF00017	0.439
LIG_SH3_1	430	436	PF00018	0.701
LIG_SH3_2	134	139	PF14604	0.737
LIG_SH3_2	4	9	PF14604	0.627
LIG_SH3_3	1	7	PF00018	0.632
LIG_SH3_3	131	137	PF00018	0.793
LIG_SH3_3	156	162	PF00018	0.585
LIG_SH3_3	430	436	PF00018	0.701
LIG_SH3_3	55	61	PF00018	0.787
LIG_SH3_3	70	76	PF00018	0.517
LIG_SH3_3	91	97	PF00018	0.789
LIG_UBA3_1	466	475	PF00899	0.526
MOD_CDC14_SPxK_1	136	139	PF00782	0.740
MOD_CDK_SPK_2	133	138	PF00069	0.737
MOD_CDK_SPxK_1	133	139	PF00069	0.739
MOD_CK1_1	19	25	PF00069	0.775
MOD_CK1_1	28	34	PF00069	0.626
MOD_CK1_1	35	41	PF00069	0.504
MOD_CK1_1	46	52	PF00069	0.479
MOD_CK1_1	71	77	PF00069	0.660
MOD_CK2_1	167	173	PF00069	0.705
MOD_CK2_1	283	289	PF00069	0.560
MOD_GlcNHglycan	113	116	PF01048	0.633
MOD_GlcNHglycan	163	166	PF01048	0.650
MOD_GlcNHglycan	170	173	PF01048	0.642
MOD_GlcNHglycan	234	237	PF01048	0.656
MOD_GlcNHglycan	320	323	PF01048	0.615
MOD_GlcNHglycan	40	44	PF01048	0.684
MOD_GlcNHglycan	456	459	PF01048	0.608
MOD_GlcNHglycan	462	465	PF01048	0.608
MOD_GlcNHglycan	48	51	PF01048	0.692
MOD_GlcNHglycan	70	73	PF01048	0.695
MOD_GSK3_1	128	135	PF00069	0.646
MOD_GSK3_1	168	175	PF00069	0.687
MOD_GSK3_1	18	25	PF00069	0.765
MOD_GSK3_1	279	286	PF00069	0.553
MOD_GSK3_1	28	35	PF00069	0.610
MOD_GSK3_1	39	46	PF00069	0.569
MOD_GSK3_1	390	397	PF00069	0.542
MOD_GSK3_1	421	428	PF00069	0.539
MOD_GSK3_1	67	74	PF00069	0.677
MOD_GSK3_1	86	93	PF00069	0.529
MOD_N-GLC_1	19	24	PF02516	0.697
MOD_NEK2_1	104	109	PF00069	0.761
MOD_NEK2_1	111	116	PF00069	0.725
MOD_NEK2_1	152	157	PF00069	0.675
MOD_NEK2_1	324	329	PF00069	0.627
MOD_NEK2_1	44	49	PF00069	0.704
MOD_NEK2_2	394	399	PF00069	0.524
MOD_PIKK_1	19	25	PF00454	0.560
MOD_PIKK_1	2	8	PF00454	0.699
MOD_PKA_1	138	144	PF00069	0.715
MOD_PKA_1	16	22	PF00069	0.774
MOD_PKA_1	188	194	PF00069	0.560
MOD_PKA_1	32	38	PF00069	0.507
MOD_PKA_1	454	460	PF00069	0.559
MOD_PKA_2	16	22	PF00069	0.543
MOD_PKA_2	2	8	PF00069	0.765
MOD_PKA_2	226	232	PF00069	0.524
MOD_PKA_2	32	38	PF00069	0.507
MOD_PKA_2	454	460	PF00069	0.559
MOD_PKB_1	230	238	PF00069	0.665
MOD_Plk_1	172	178	PF00069	0.621
MOD_Plk_1	39	45	PF00069	0.647
MOD_Plk_1	425	431	PF00069	0.673
MOD_Plk_4	301	307	PF00069	0.600
MOD_Plk_4	324	330	PF00069	0.415
MOD_Plk_4	394	400	PF00069	0.469
MOD_ProDKin_1	133	139	PF00069	0.771
MOD_ProDKin_1	347	353	PF00069	0.546
MOD_ProDKin_1	98	104	PF00069	0.758
MOD_SUMO_rev_2	192	197	PF00179	0.601
MOD_SUMO_rev_2	331	337	PF00179	0.634
MOD_SUMO_rev_2	443	449	PF00179	0.663
TRG_DiLeu_BaEn_1	193	198	PF01217	0.645
TRG_DiLeu_BaEn_1	203	208	PF01217	0.436
TRG_DiLeu_BaEn_1	312	317	PF01217	0.532
TRG_DiLeu_BaEn_1	340	345	PF01217	0.612
TRG_ENDOCYTIC_2	422	425	PF00928	0.439
TRG_ER_diArg_1	15	17	PF00400	0.668
TRG_ER_diArg_1	187	190	PF00400	0.611
TRG_ER_diArg_1	247	250	PF00400	0.522
TRG_ER_diArg_1	271	274	PF00400	0.552
TRG_ER_diArg_1	32	34	PF00400	0.485
TRG_ER_diArg_1	365	367	PF00400	0.644
TRG_ER_diArg_1	410	413	PF00400	0.615
TRG_ER_diArg_1	8	10	PF00400	0.785
TRG_ER_diLys_1	471	475	PF00400	0.740
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC93	Leishmania donovani	100%	100%
A4HD53	Leishmania braziliensis	72%	100%
E9AYF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q917	Leishmania major	92%	100%
V5DB99	Trypanosoma cruzi	30%	100%