Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2A7_LEIIN

TriTrypDb:

LINF_260022600

Length:

516

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	380	384	PF00656	0.391
CLV_NRD_NRD_1	145	147	PF00675	0.502
CLV_NRD_NRD_1	247	249	PF00675	0.470
CLV_NRD_NRD_1	419	421	PF00675	0.473
CLV_NRD_NRD_1	487	489	PF00675	0.455
CLV_NRD_NRD_1	68	70	PF00675	0.606
CLV_PCSK_KEX2_1	145	147	PF00082	0.490
CLV_PCSK_KEX2_1	247	249	PF00082	0.368
CLV_PCSK_KEX2_1	419	421	PF00082	0.394
CLV_PCSK_KEX2_1	68	70	PF00082	0.516
CLV_PCSK_PC7_1	243	249	PF00082	0.386
CLV_PCSK_SKI1_1	247	251	PF00082	0.469
CLV_PCSK_SKI1_1	254	258	PF00082	0.382
CLV_PCSK_SKI1_1	298	302	PF00082	0.320
CLV_PCSK_SKI1_1	389	393	PF00082	0.528
CLV_PCSK_SKI1_1	420	424	PF00082	0.404
CLV_PCSK_SKI1_1	58	62	PF00082	0.540
DEG_APCC_DBOX_1	26	34	PF00400	0.537
DEG_APCC_DBOX_1	419	427	PF00400	0.374
DEG_APCC_DBOX_1	505	513	PF00400	0.491
DEG_SPOP_SBC_1	335	339	PF00917	0.524
DEG_SPOP_SBC_1	78	82	PF00917	0.593
DOC_ANK_TNKS_1	392	399	PF00023	0.461
DOC_MAPK_DCC_7	127	136	PF00069	0.440
DOC_MAPK_DCC_7	180	190	PF00069	0.377
DOC_MAPK_gen_1	127	136	PF00069	0.387
DOC_MAPK_gen_1	251	261	PF00069	0.350
DOC_MAPK_MEF2A_6	127	136	PF00069	0.412
DOC_MAPK_MEF2A_6	254	263	PF00069	0.480
DOC_MAPK_RevD_3	132	146	PF00069	0.478
DOC_PP4_FxxP_1	13	16	PF00568	0.483
DOC_PP4_FxxP_1	165	168	PF00568	0.456
DOC_USP7_MATH_1	112	116	PF00917	0.755
DOC_USP7_MATH_1	125	129	PF00917	0.309
DOC_USP7_MATH_1	335	339	PF00917	0.644
DOC_USP7_MATH_1	341	345	PF00917	0.700
DOC_USP7_MATH_1	396	400	PF00917	0.593
DOC_USP7_MATH_1	430	434	PF00917	0.311
DOC_USP7_MATH_1	439	443	PF00917	0.400
DOC_USP7_MATH_1	6	10	PF00917	0.484
DOC_WW_Pin1_4	101	106	PF00397	0.485
DOC_WW_Pin1_4	339	344	PF00397	0.628
DOC_WW_Pin1_4	403	408	PF00397	0.626
DOC_WW_Pin1_4	79	84	PF00397	0.652
DOC_WW_Pin1_4	88	93	PF00397	0.762
LIG_14-3-3_CanoR_1	119	126	PF00244	0.559
LIG_14-3-3_CanoR_1	27	31	PF00244	0.565
LIG_14-3-3_CanoR_1	318	326	PF00244	0.546
LIG_14-3-3_CanoR_1	480	485	PF00244	0.372
LIG_14-3-3_CanoR_1	506	510	PF00244	0.474
LIG_Actin_WH2_2	283	300	PF00022	0.458
LIG_APCC_ABBA_1	375	380	PF00400	0.416
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BIR_III_2	443	447	PF00653	0.432
LIG_BIR_III_4	155	159	PF00653	0.486
LIG_BRCT_BRCA1_1	470	474	PF00533	0.359
LIG_deltaCOP1_diTrp_1	280	287	PF00928	0.521
LIG_FHA_1	137	143	PF00498	0.445
LIG_FHA_1	244	250	PF00498	0.474
LIG_FHA_1	277	283	PF00498	0.489
LIG_FHA_1	85	91	PF00498	0.752
LIG_FHA_2	27	33	PF00498	0.596
LIG_FHA_2	453	459	PF00498	0.463
LIG_LIR_Apic_2	163	168	PF02991	0.424
LIG_LIR_Gen_1	361	371	PF02991	0.415
LIG_LIR_Nem_3	172	177	PF02991	0.483
LIG_LIR_Nem_3	361	366	PF02991	0.382
LIG_MYND_3	509	513	PF01753	0.498
LIG_NRBOX	199	205	PF00104	0.357
LIG_NRBOX	494	500	PF00104	0.412
LIG_PCNA_yPIPBox_3	197	209	PF02747	0.402
LIG_Pex14_1	283	287	PF04695	0.489
LIG_Pex14_2	363	367	PF04695	0.456
LIG_RPA_C_Fungi	141	153	PF08784	0.452
LIG_SH2_CRK	74	78	PF00017	0.609
LIG_SH2_NCK_1	460	464	PF00017	0.478
LIG_SH2_NCK_1	74	78	PF00017	0.592
LIG_SH2_PTP2	133	136	PF00017	0.471
LIG_SH2_STAP1	19	23	PF00017	0.543
LIG_SH2_STAT5	133	136	PF00017	0.389
LIG_SH2_STAT5	189	192	PF00017	0.395
LIG_SH2_STAT5	440	443	PF00017	0.532
LIG_SH2_STAT5	482	485	PF00017	0.378
LIG_SH3_1	89	95	PF00018	0.628
LIG_SH3_3	187	193	PF00018	0.468
LIG_SH3_3	89	95	PF00018	0.650
LIG_SUMO_SIM_par_1	354	359	PF11976	0.401
LIG_SUMO_SIM_par_1	50	57	PF11976	0.435
LIG_TRAF2_1	95	98	PF00917	0.700
LIG_TYR_ITIM	131	136	PF00017	0.364
MOD_CK1_1	115	121	PF00069	0.713
MOD_CK1_1	235	241	PF00069	0.580
MOD_CK1_1	406	412	PF00069	0.694
MOD_CK1_1	433	439	PF00069	0.385
MOD_CK1_1	452	458	PF00069	0.386
MOD_CK2_1	101	107	PF00069	0.578
MOD_CK2_1	268	274	PF00069	0.396
MOD_CK2_1	334	340	PF00069	0.566
MOD_CK2_1	452	458	PF00069	0.477
MOD_CK2_1	79	85	PF00069	0.682
MOD_GlcNHglycan	115	118	PF01048	0.642
MOD_GlcNHglycan	127	130	PF01048	0.482
MOD_GlcNHglycan	21	24	PF01048	0.466
MOD_GlcNHglycan	223	226	PF01048	0.568
MOD_GlcNHglycan	233	237	PF01048	0.520
MOD_GlcNHglycan	35	38	PF01048	0.443
MOD_GlcNHglycan	397	401	PF01048	0.619
MOD_GlcNHglycan	484	487	PF01048	0.556
MOD_GlcNHglycan	8	11	PF01048	0.461
MOD_GSK3_1	101	108	PF00069	0.815
MOD_GSK3_1	115	122	PF00069	0.455
MOD_GSK3_1	264	271	PF00069	0.435
MOD_GSK3_1	335	342	PF00069	0.596
MOD_GSK3_1	398	405	PF00069	0.587
MOD_GSK3_1	444	451	PF00069	0.557
MOD_GSK3_1	73	80	PF00069	0.602
MOD_GSK3_1	84	91	PF00069	0.773
MOD_N-GLC_1	47	52	PF02516	0.360
MOD_N-GLC_2	351	353	PF02516	0.403
MOD_NEK2_1	241	246	PF00069	0.497
MOD_NEK2_1	268	273	PF00069	0.460
MOD_NEK2_1	42	47	PF00069	0.482
MOD_NEK2_1	449	454	PF00069	0.440
MOD_NEK2_1	474	479	PF00069	0.399
MOD_NEK2_2	84	89	PF00069	0.613
MOD_OFUCOSY	353	360	PF10250	0.396
MOD_PIKK_1	216	222	PF00454	0.381
MOD_PIKK_1	99	105	PF00454	0.618
MOD_PK_1	73	79	PF00069	0.501
MOD_PKA_2	118	124	PF00069	0.592
MOD_PKA_2	170	176	PF00069	0.489
MOD_PKA_2	221	227	PF00069	0.424
MOD_PKA_2	26	32	PF00069	0.568
MOD_PKA_2	505	511	PF00069	0.447
MOD_Plk_1	84	90	PF00069	0.642
MOD_Plk_4	474	480	PF00069	0.462
MOD_ProDKin_1	101	107	PF00069	0.485
MOD_ProDKin_1	339	345	PF00069	0.617
MOD_ProDKin_1	403	409	PF00069	0.626
MOD_ProDKin_1	79	85	PF00069	0.660
MOD_ProDKin_1	88	94	PF00069	0.763
MOD_SUMO_for_1	461	464	PF00179	0.482
MOD_SUMO_rev_2	383	391	PF00179	0.375
MOD_SUMO_rev_2	485	490	PF00179	0.481
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.525
TRG_ENDOCYTIC_2	133	136	PF00928	0.360
TRG_ENDOCYTIC_2	201	204	PF00928	0.365
TRG_ENDOCYTIC_2	74	77	PF00928	0.602
TRG_ER_diArg_1	144	146	PF00400	0.493
TRG_ER_diArg_1	247	249	PF00400	0.380
TRG_ER_diArg_1	418	420	PF00400	0.385
TRG_NES_CRM1_1	292	305	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU4	Leptomonas seymouri	55%	99%
A0A1X0P8W2	Trypanosomatidae	34%	100%
A0A3S7X019	Leishmania donovani	99%	100%
A0A422N4R1	Trypanosoma rangeli	30%	100%
A4HD54	Leishmania braziliensis	81%	100%
C9ZXD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AYF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q918	Leishmania major	94%	100%
V5BF90	Trypanosoma cruzi	34%	100%