ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2A6_LEIIN

TriTrypDb:

LINF_260022500

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2A6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	565	569	PF00656	0.791
CLV_C14_Caspase3-7	594	598	PF00656	0.484
CLV_NRD_NRD_1	12	14	PF00675	0.596
CLV_NRD_NRD_1	434	436	PF00675	0.453
CLV_NRD_NRD_1	531	533	PF00675	0.475
CLV_NRD_NRD_1	632	634	PF00675	0.633
CLV_PCSK_KEX2_1	12	14	PF00082	0.586
CLV_PCSK_KEX2_1	434	436	PF00082	0.501
CLV_PCSK_KEX2_1	531	533	PF00082	0.475
CLV_PCSK_KEX2_1	631	633	PF00082	0.637
CLV_PCSK_SKI1_1	12	16	PF00082	0.591
CLV_PCSK_SKI1_1	2	6	PF00082	0.673
CLV_PCSK_SKI1_1	504	508	PF00082	0.562
CLV_Separin_Metazoa	620	624	PF03568	0.631
DEG_Nend_UBRbox_1	1	4	PF02207	0.645
DOC_CDC14_PxL_1	397	405	PF14671	0.589
DOC_CKS1_1	289	294	PF01111	0.742
DOC_CKS1_1	582	587	PF01111	0.676
DOC_CYCLIN_RxL_1	9	19	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	582	588	PF00134	0.680
DOC_MAPK_gen_1	459	468	PF00069	0.588
DOC_MAPK_gen_1	611	621	PF00069	0.633
DOC_MAPK_gen_1	631	639	PF00069	0.645
DOC_MAPK_gen_1	649	659	PF00069	0.645
DOC_MAPK_MEF2A_6	140	147	PF00069	0.722
DOC_MAPK_MEF2A_6	652	661	PF00069	0.637
DOC_PP1_SILK_1	500	505	PF00149	0.557
DOC_PP2B_LxvP_1	312	315	PF13499	0.790
DOC_PP4_FxxP_1	14	17	PF00568	0.566
DOC_PP4_FxxP_1	233	236	PF00568	0.651
DOC_PP4_FxxP_1	59	62	PF00568	0.825
DOC_USP7_MATH_1	119	123	PF00917	0.764
DOC_USP7_MATH_1	318	322	PF00917	0.767
DOC_USP7_MATH_1	34	38	PF00917	0.554
DOC_USP7_MATH_1	488	492	PF00917	0.660
DOC_USP7_MATH_1	562	566	PF00917	0.634
DOC_USP7_MATH_2	337	343	PF00917	0.488
DOC_WW_Pin1_4	196	201	PF00397	0.758
DOC_WW_Pin1_4	223	228	PF00397	0.650
DOC_WW_Pin1_4	278	283	PF00397	0.692
DOC_WW_Pin1_4	288	293	PF00397	0.567
DOC_WW_Pin1_4	310	315	PF00397	0.790
DOC_WW_Pin1_4	386	391	PF00397	0.701
DOC_WW_Pin1_4	576	581	PF00397	0.782
DOC_WW_Pin1_4	597	602	PF00397	0.592
LIG_14-3-3_CanoR_1	234	240	PF00244	0.752
LIG_14-3-3_CanoR_1	277	282	PF00244	0.691
LIG_14-3-3_CanoR_1	330	337	PF00244	0.533
LIG_14-3-3_CanoR_1	402	410	PF00244	0.546
LIG_14-3-3_CanoR_1	434	438	PF00244	0.582
LIG_14-3-3_CanoR_1	459	464	PF00244	0.605
LIG_14-3-3_CanoR_1	536	542	PF00244	0.591
LIG_BIR_III_4	523	527	PF00653	0.620
LIG_CSL_BTD_1	582	585	PF09270	0.685
LIG_deltaCOP1_diTrp_1	419	427	PF00928	0.582
LIG_FHA_1	413	419	PF00498	0.566
LIG_FHA_1	537	543	PF00498	0.578
LIG_FHA_1	565	571	PF00498	0.646
LIG_FHA_1	598	604	PF00498	0.586
LIG_FHA_2	103	109	PF00498	0.696
LIG_FHA_2	150	156	PF00498	0.687
LIG_FHA_2	582	588	PF00498	0.680
LIG_LIR_Apic_2	238	242	PF02991	0.597
LIG_LIR_Apic_2	58	62	PF02991	0.823
LIG_LIR_Gen_1	152	160	PF02991	0.587
LIG_LIR_Gen_1	187	196	PF02991	0.590
LIG_LIR_Gen_1	452	463	PF02991	0.582
LIG_LIR_Gen_1	587	597	PF02991	0.632
LIG_LIR_Nem_3	146	150	PF02991	0.540
LIG_LIR_Nem_3	152	157	PF02991	0.543
LIG_LIR_Nem_3	187	193	PF02991	0.580
LIG_LIR_Nem_3	393	397	PF02991	0.669
LIG_LIR_Nem_3	452	458	PF02991	0.568
LIG_LIR_Nem_3	587	593	PF02991	0.642
LIG_MAD2	9	17	PF02301	0.572
LIG_NRBOX	368	374	PF00104	0.571
LIG_NRP_CendR_1	669	670	PF00754	0.723
LIG_Pex14_1	219	223	PF04695	0.629
LIG_Pex14_2	274	278	PF04695	0.650
LIG_Rb_LxCxE_1	170	187	PF01857	0.703
LIG_SH2_CRK	239	243	PF00017	0.623
LIG_SH2_CRK	248	252	PF00017	0.508
LIG_SH2_NCK_1	328	332	PF00017	0.711
LIG_SH2_STAT5	133	136	PF00017	0.595
LIG_SH2_STAT5	248	251	PF00017	0.635
LIG_SH2_STAT5	262	265	PF00017	0.628
LIG_SH2_STAT5	352	355	PF00017	0.556
LIG_SH2_STAT5	365	368	PF00017	0.349
LIG_SH2_STAT5	399	402	PF00017	0.594
LIG_SH2_STAT5	656	659	PF00017	0.640
LIG_SH3_1	239	245	PF00018	0.590
LIG_SH3_3	239	245	PF00018	0.717
LIG_SH3_3	294	300	PF00018	0.756
LIG_SH3_3	308	314	PF00018	0.568
LIG_SH3_3	384	390	PF00018	0.664
LIG_SH3_3	582	588	PF00018	0.629
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.555
LIG_SUMO_SIM_anti_2	617	623	PF11976	0.618
LIG_SUMO_SIM_par_1	293	299	PF11976	0.729
LIG_SUMO_SIM_par_1	556	561	PF11976	0.617
LIG_TRAF2_1	296	299	PF00917	0.643
LIG_TRAF2_1	428	431	PF00917	0.588
LIG_TRAF2_1	643	646	PF00917	0.644
LIG_UBA3_1	180	184	PF00899	0.686
LIG_UBA3_1	653	658	PF00899	0.621
LIG_WRC_WIRS_1	56	61	PF05994	0.695
MOD_CK1_1	112	118	PF00069	0.771
MOD_CK1_1	122	128	PF00069	0.680
MOD_CK1_1	310	316	PF00069	0.790
MOD_CK1_1	486	492	PF00069	0.676
MOD_CK1_1	576	582	PF00069	0.644
MOD_CK1_1	648	654	PF00069	0.646
MOD_CK1_1	83	89	PF00069	0.810
MOD_CK2_1	143	149	PF00069	0.712
MOD_CK2_1	23	29	PF00069	0.705
MOD_CK2_1	318	324	PF00069	0.773
MOD_CK2_1	635	641	PF00069	0.645
MOD_GlcNHglycan	115	118	PF01048	0.574
MOD_GlcNHglycan	227	230	PF01048	0.655
MOD_GlcNHglycan	253	256	PF01048	0.492
MOD_GlcNHglycan	271	274	PF01048	0.631
MOD_GlcNHglycan	301	304	PF01048	0.726
MOD_GlcNHglycan	316	319	PF01048	0.780
MOD_GlcNHglycan	37	40	PF01048	0.764
MOD_GlcNHglycan	85	88	PF01048	0.665
MOD_GSK3_1	109	116	PF00069	0.787
MOD_GSK3_1	119	126	PF00069	0.719
MOD_GSK3_1	310	317	PF00069	0.790
MOD_GSK3_1	386	393	PF00069	0.704
MOD_GSK3_1	449	456	PF00069	0.516
MOD_GSK3_1	558	565	PF00069	0.545
MOD_GSK3_1	572	579	PF00069	0.653
MOD_GSK3_1	593	600	PF00069	0.476
MOD_NEK2_1	102	107	PF00069	0.801
MOD_NEK2_1	189	194	PF00069	0.709
MOD_NEK2_1	23	28	PF00069	0.414
MOD_NEK2_1	412	417	PF00069	0.566
MOD_NEK2_1	451	456	PF00069	0.503
MOD_NEK2_1	457	462	PF00069	0.571
MOD_NEK2_1	483	488	PF00069	0.710
MOD_NEK2_1	5	10	PF00069	0.698
MOD_NEK2_1	558	563	PF00069	0.675
MOD_NEK2_1	572	577	PF00069	0.588
MOD_NEK2_1	607	612	PF00069	0.678
MOD_PIKK_1	149	155	PF00454	0.686
MOD_PIKK_1	486	492	PF00454	0.676
MOD_PIKK_1	664	670	PF00454	0.679
MOD_PK_1	123	129	PF00069	0.800
MOD_PK_1	80	86	PF00069	0.681
MOD_PKA_2	401	407	PF00069	0.558
MOD_PKA_2	433	439	PF00069	0.587
MOD_PKA_2	648	654	PF00069	0.509
MOD_Plk_1	80	86	PF00069	0.809
MOD_Plk_4	23	29	PF00069	0.705
MOD_Plk_4	246	252	PF00069	0.630
MOD_Plk_4	374	380	PF00069	0.573
MOD_Plk_4	488	494	PF00069	0.644
MOD_Plk_4	537	543	PF00069	0.578
MOD_Plk_4	586	592	PF00069	0.647
MOD_Plk_4	635	641	PF00069	0.659
MOD_ProDKin_1	196	202	PF00069	0.757
MOD_ProDKin_1	223	229	PF00069	0.649
MOD_ProDKin_1	278	284	PF00069	0.700
MOD_ProDKin_1	288	294	PF00069	0.569
MOD_ProDKin_1	310	316	PF00069	0.790
MOD_ProDKin_1	386	392	PF00069	0.709
MOD_ProDKin_1	576	582	PF00069	0.772
MOD_ProDKin_1	597	603	PF00069	0.591
MOD_SUMO_for_1	183	186	PF00179	0.693
MOD_SUMO_rev_2	70	78	PF00179	0.674
MOD_SUMO_rev_2	86	96	PF00179	0.799
TRG_DiLeu_BaEn_4	498	504	PF01217	0.446
TRG_ENDOCYTIC_2	133	136	PF00928	0.595
TRG_ENDOCYTIC_2	248	251	PF00928	0.635
TRG_ENDOCYTIC_2	656	659	PF00928	0.640
TRG_ER_diArg_1	11	13	PF00400	0.569
TRG_ER_diArg_1	458	461	PF00400	0.593
TRG_ER_diArg_1	530	532	PF00400	0.472
TRG_ER_diArg_1	630	633	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDV3	Leishmania donovani	99%	100%
Q4Q919	Leishmania major	90%	100%