LeishMANIAdb
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Sphingolipid 4-desaturase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sphingolipid 4-desaturase
Gene product:
sphingolipid delta 4 desaturase - putative
Species:
Leishmania infantum
UniProt:
A4I2A2_LEIIN
TriTrypDb:
LINF_260022100 *
Length:
361

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, dihydroceramide desaturase fatty acid desaturase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16

Expansion

Sequence features

A4I2A2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2A2

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 16
GO:0006643 membrane lipid metabolic process 4 14
GO:0006665 sphingolipid metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 16
GO:0008610 lipid biosynthetic process 4 14
GO:0009058 biosynthetic process 2 14
GO:0009987 cellular process 1 14
GO:0030148 sphingolipid biosynthetic process 5 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 16
GO:0044249 cellular biosynthetic process 3 14
GO:0044255 cellular lipid metabolic process 3 14
GO:0046467 membrane lipid biosynthetic process 4 14
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 14
GO:1901566 organonitrogen compound biosynthetic process 4 14
GO:1901576 organic substance biosynthetic process 3 14
GO:0006672 ceramide metabolic process 4 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0043603 amide metabolic process 3 2
GO:0043604 amide biosynthetic process 4 2
GO:0044271 cellular nitrogen compound biosynthetic process 4 2
GO:0046513 ceramide biosynthetic process 5 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 14
GO:0016491 oxidoreductase activity 2 14
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 14
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 4 14
GO:0042284 sphingolipid delta-4 desaturase activity 5 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.279
CLV_PCSK_SKI1_1 158 162 PF00082 0.264
CLV_PCSK_SKI1_1 177 181 PF00082 0.221
CLV_PCSK_SKI1_1 24 28 PF00082 0.150
CLV_PCSK_SKI1_1 354 358 PF00082 0.363
DEG_Nend_Nbox_1 1 3 PF02207 0.531
DOC_CKS1_1 47 52 PF01111 0.299
DOC_CKS1_1 98 103 PF01111 0.474
DOC_CYCLIN_yCln2_LP_2 113 119 PF00134 0.281
DOC_CYCLIN_yCln2_LP_2 47 53 PF00134 0.345
DOC_MAPK_gen_1 177 186 PF00069 0.446
DOC_MAPK_MEF2A_6 45 54 PF00069 0.266
DOC_MAPK_MEF2A_6 63 72 PF00069 0.301
DOC_PP1_RVXF_1 130 137 PF00149 0.263
DOC_PP1_RVXF_1 175 182 PF00149 0.445
DOC_PP1_RVXF_1 352 359 PF00149 0.532
DOC_PP2B_LxvP_1 113 116 PF13499 0.281
DOC_PP4_FxxP_1 98 101 PF00568 0.486
DOC_USP7_MATH_1 305 309 PF00917 0.537
DOC_WW_Pin1_4 46 51 PF00397 0.299
DOC_WW_Pin1_4 97 102 PF00397 0.474
LIG_14-3-3_CanoR_1 150 156 PF00244 0.254
LIG_14-3-3_CanoR_1 290 295 PF00244 0.538
LIG_Actin_WH2_2 159 174 PF00022 0.402
LIG_AP2alpha_2 41 43 PF02296 0.446
LIG_BRCT_BRCA1_1 229 233 PF00533 0.470
LIG_FHA_1 161 167 PF00498 0.264
LIG_FHA_1 47 53 PF00498 0.271
LIG_FHA_1 67 73 PF00498 0.306
LIG_FHA_1 91 97 PF00498 0.426
LIG_FHA_2 143 149 PF00498 0.232
LIG_FHA_2 295 301 PF00498 0.436
LIG_FXI_DFP_1 263 267 PF00024 0.211
LIG_KLC1_Yacidic_2 283 287 PF13176 0.548
LIG_LIR_Apic_2 243 249 PF02991 0.421
LIG_LIR_Gen_1 100 111 PF02991 0.426
LIG_LIR_Gen_1 163 171 PF02991 0.264
LIG_LIR_Gen_1 178 189 PF02991 0.469
LIG_LIR_Gen_1 297 307 PF02991 0.562
LIG_LIR_Gen_1 49 58 PF02991 0.291
LIG_LIR_Gen_1 84 92 PF02991 0.317
LIG_LIR_Nem_3 100 106 PF02991 0.438
LIG_LIR_Nem_3 163 167 PF02991 0.257
LIG_LIR_Nem_3 178 184 PF02991 0.421
LIG_LIR_Nem_3 219 224 PF02991 0.330
LIG_LIR_Nem_3 242 247 PF02991 0.418
LIG_LIR_Nem_3 265 269 PF02991 0.419
LIG_LIR_Nem_3 283 288 PF02991 0.440
LIG_LIR_Nem_3 297 302 PF02991 0.475
LIG_LIR_Nem_3 41 46 PF02991 0.450
LIG_LIR_Nem_3 49 54 PF02991 0.266
LIG_LIR_Nem_3 64 70 PF02991 0.181
LIG_LIR_Nem_3 84 89 PF02991 0.434
LIG_NRBOX 208 214 PF00104 0.392
LIG_Pex14_1 206 210 PF04695 0.269
LIG_Pex14_1 255 259 PF04695 0.465
LIG_Pex14_2 160 164 PF04695 0.260
LIG_Pex14_2 202 206 PF04695 0.359
LIG_PTB_Apo_2 101 108 PF02174 0.446
LIG_PTB_Apo_2 253 260 PF02174 0.518
LIG_PTB_Phospho_1 101 107 PF10480 0.463
LIG_PTB_Phospho_1 253 259 PF10480 0.518
LIG_SH2_CRK 247 251 PF00017 0.411
LIG_SH2_PTP2 285 288 PF00017 0.549
LIG_SH2_STAP1 107 111 PF00017 0.291
LIG_SH2_STAP1 119 123 PF00017 0.257
LIG_SH2_STAT3 189 192 PF00017 0.308
LIG_SH2_STAT5 133 136 PF00017 0.225
LIG_SH2_STAT5 151 154 PF00017 0.221
LIG_SH2_STAT5 17 20 PF00017 0.371
LIG_SH2_STAT5 189 192 PF00017 0.291
LIG_SH2_STAT5 201 204 PF00017 0.242
LIG_SH2_STAT5 210 213 PF00017 0.254
LIG_SH2_STAT5 285 288 PF00017 0.546
LIG_SH2_STAT5 46 49 PF00017 0.335
LIG_SH2_STAT5 57 60 PF00017 0.278
LIG_SH2_STAT5 75 78 PF00017 0.113
LIG_SH3_3 112 118 PF00018 0.280
LIG_SH3_3 264 270 PF00018 0.421
LIG_SUMO_SIM_anti_2 69 74 PF11976 0.341
LIG_TRFH_1 169 173 PF08558 0.311
LIG_TRFH_1 301 305 PF08558 0.547
LIG_TYR_ITIM 208 213 PF00017 0.324
LIG_WRC_WIRS_1 161 166 PF05994 0.264
LIG_WRC_WIRS_1 213 218 PF05994 0.392
MOD_CK1_1 308 314 PF00069 0.534
MOD_CK2_1 10 16 PF00069 0.369
MOD_CK2_1 142 148 PF00069 0.232
MOD_CMANNOS 203 206 PF00535 0.341
MOD_CMANNOS 252 255 PF00535 0.254
MOD_GlcNHglycan 318 321 PF01048 0.366
MOD_GlcNHglycan 4 7 PF01048 0.213
MOD_GSK3_1 138 145 PF00069 0.248
MOD_GSK3_1 171 178 PF00069 0.518
MOD_GSK3_1 212 219 PF00069 0.330
MOD_GSK3_1 290 297 PF00069 0.442
MOD_GSK3_1 77 84 PF00069 0.271
MOD_N-GLC_1 305 310 PF02516 0.334
MOD_NEK2_1 122 127 PF00069 0.275
MOD_NEK2_1 160 165 PF00069 0.300
MOD_NEK2_1 2 7 PF00069 0.421
MOD_NEK2_1 212 217 PF00069 0.281
MOD_NEK2_1 233 238 PF00069 0.500
MOD_NEK2_1 288 293 PF00069 0.557
MOD_PKA_2 171 177 PF00069 0.446
MOD_PKA_2 316 322 PF00069 0.505
MOD_Plk_1 305 311 PF00069 0.488
MOD_Plk_4 171 177 PF00069 0.465
MOD_Plk_4 212 218 PF00069 0.300
MOD_Plk_4 294 300 PF00069 0.449
MOD_Plk_4 66 72 PF00069 0.247
MOD_ProDKin_1 46 52 PF00069 0.299
MOD_ProDKin_1 97 103 PF00069 0.474
MOD_SUMO_for_1 179 182 PF00179 0.518
TRG_DiLeu_BaLyEn_6 204 209 PF01217 0.324
TRG_ENDOCYTIC_2 103 106 PF00928 0.465
TRG_ENDOCYTIC_2 107 110 PF00928 0.321
TRG_ENDOCYTIC_2 119 122 PF00928 0.286
TRG_ENDOCYTIC_2 210 213 PF00928 0.347
TRG_ENDOCYTIC_2 247 250 PF00928 0.412
TRG_ENDOCYTIC_2 285 288 PF00928 0.443
TRG_Pf-PMV_PEXEL_1 132 137 PF00026 0.463

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P225 Leptomonas seymouri 84% 100%
A0A0S4IWE2 Bodo saltans 51% 100%
A0A0S4IZS1 Bodo saltans 49% 100%
A0A1X0NG21 Trypanosomatidae 69% 100%
A0A1X0P7H0 Trypanosomatidae 69% 100%
A0A3S5H7G4 Leishmania donovani 99% 100%
A0A3S7WZX6 Leishmania donovani 99% 100%
A4HD58 Leishmania braziliensis 84% 100%
C4R613 Komagataella phaffii (strain GS115 / ATCC 20864) 40% 100%
C9ZQX1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E8NHH2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9AYE9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
G5EC63 Caenorhabditis elegans 40% 100%
O09005 Mus musculus 41% 100%
O15121 Homo sapiens 43% 100%
O44186 Caenorhabditis elegans 40% 100%
O59715 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 100%
Q0II71 Bos taurus 43% 100%
Q3ZBY7 Bos taurus 42% 100%
Q4Q923 Leishmania major 96% 100%
Q4Q925 Leishmania major 98% 100%
Q564G3 Rattus norvegicus 41% 100%
Q5AJX2 Candida albicans (strain SC5314 / ATCC MYA-2876) 44% 98%
Q5F3C1 Gallus gallus 40% 100%
Q5RE51 Pongo abelii 42% 100%
Q5XIF5 Rattus norvegicus 42% 100%
Q68FB8 Xenopus tropicalis 42% 100%
Q6H5U3 Oryza sativa subsp. japonica 44% 100%
Q6QHC5 Homo sapiens 43% 100%
Q6UQ04 Microtus fortis 41% 100%
Q8R2F2 Mus musculus 41% 100%
Q94515 Drosophila melanogaster 43% 100%
Q9ZPH4 Arabidopsis thaliana 42% 100%
V5DBA3 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS