Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I2A1_LEIIN

TriTrypDb:

LINF_260021800

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I2A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2A1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.617
CLV_NRD_NRD_1	107	109	PF00675	0.478
CLV_NRD_NRD_1	116	118	PF00675	0.498
CLV_NRD_NRD_1	129	131	PF00675	0.472
CLV_NRD_NRD_1	133	135	PF00675	0.364
CLV_NRD_NRD_1	258	260	PF00675	0.608
CLV_NRD_NRD_1	81	83	PF00675	0.565
CLV_NRD_NRD_1	95	97	PF00675	0.437
CLV_PCSK_KEX2_1	107	109	PF00082	0.478
CLV_PCSK_KEX2_1	129	131	PF00082	0.714
CLV_PCSK_KEX2_1	133	135	PF00082	0.703
CLV_PCSK_KEX2_1	258	260	PF00082	0.608
CLV_PCSK_KEX2_1	81	83	PF00082	0.565
CLV_PCSK_KEX2_1	95	97	PF00082	0.437
CLV_PCSK_PC7_1	129	135	PF00082	0.710
CLV_PCSK_SKI1_1	13	17	PF00082	0.524
CLV_PCSK_SKI1_1	18	22	PF00082	0.458
CLV_PCSK_SKI1_1	8	12	PF00082	0.680
CLV_PCSK_SKI1_1	89	93	PF00082	0.616
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DOC_CKS1_1	9	14	PF01111	0.498
DOC_CYCLIN_RxL_1	13	26	PF00134	0.458
DOC_MAPK_gen_1	107	115	PF00069	0.430
DOC_MAPK_gen_1	98	106	PF00069	0.552
DOC_MAPK_MEF2A_6	13	21	PF00069	0.510
DOC_MAPK_MEF2A_6	161	169	PF00069	0.488
DOC_PP1_RVXF_1	16	22	PF00149	0.465
DOC_USP7_MATH_1	213	217	PF00917	0.588
DOC_WW_Pin1_4	215	220	PF00397	0.759
DOC_WW_Pin1_4	8	13	PF00397	0.581
LIG_14-3-3_CanoR_1	133	140	PF00244	0.545
LIG_FHA_1	14	20	PF00498	0.549
LIG_FHA_1	152	158	PF00498	0.477
LIG_FHA_1	162	168	PF00498	0.256
LIG_FHA_1	183	189	PF00498	0.581
LIG_FHA_1	225	231	PF00498	0.728
LIG_LIR_Gen_1	45	53	PF02991	0.485
LIG_LIR_Nem_3	201	206	PF02991	0.532
LIG_LIR_Nem_3	242	248	PF02991	0.614
LIG_LIR_Nem_3	45	50	PF02991	0.673
LIG_NRP_CendR_1	258	261	PF00754	0.742
LIG_Pex14_1	199	203	PF04695	0.436
LIG_REV1ctd_RIR_1	103	112	PF16727	0.473
LIG_RPA_C_Fungi	105	117	PF08784	0.567
LIG_SH2_CRK	65	69	PF00017	0.494
LIG_SH2_NCK_1	120	124	PF00017	0.677
LIG_SH2_STAP1	203	207	PF00017	0.432
LIG_SH2_STAT5	206	209	PF00017	0.477
LIG_SH2_STAT5	30	33	PF00017	0.381
LIG_SH3_3	216	222	PF00018	0.731
LIG_SH3_3	6	12	PF00018	0.661
LIG_SUMO_SIM_par_1	39	46	PF11976	0.445
LIG_WRC_WIRS_1	31	36	PF05994	0.364
MOD_CDK_SPK_2	8	13	PF00069	0.499
MOD_CK1_1	241	247	PF00069	0.643
MOD_CK1_1	42	48	PF00069	0.483
MOD_GlcNHglycan	135	138	PF01048	0.645
MOD_GlcNHglycan	140	143	PF01048	0.506
MOD_GlcNHglycan	224	227	PF01048	0.726
MOD_GlcNHglycan	23	26	PF01048	0.432
MOD_GlcNHglycan	68	71	PF01048	0.491
MOD_GSK3_1	195	202	PF00069	0.512
MOD_GSK3_1	213	220	PF00069	0.579
MOD_GSK3_1	237	244	PF00069	0.665
MOD_GSK3_1	29	36	PF00069	0.452
MOD_GSK3_1	39	46	PF00069	0.672
MOD_GSK3_1	85	92	PF00069	0.439
MOD_NEK2_1	106	111	PF00069	0.329
MOD_NEK2_1	20	25	PF00069	0.533
MOD_NEK2_1	66	71	PF00069	0.611
MOD_NEK2_1	90	95	PF00069	0.552
MOD_NEK2_2	3	8	PF00069	0.508
MOD_PKA_1	133	139	PF00069	0.655
MOD_PKA_2	106	112	PF00069	0.414
MOD_PKA_2	133	139	PF00069	0.583
MOD_PKA_2	3	9	PF00069	0.527
MOD_Plk_4	182	188	PF00069	0.569
MOD_Plk_4	23	29	PF00069	0.412
MOD_ProDKin_1	215	221	PF00069	0.760
MOD_ProDKin_1	8	14	PF00069	0.582
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.486
TRG_ENDOCYTIC_2	245	248	PF00928	0.597
TRG_ENDOCYTIC_2	65	68	PF00928	0.506
TRG_ER_diArg_1	106	108	PF00400	0.369
TRG_ER_diArg_1	258	261	PF00400	0.652
TRG_ER_diArg_1	95	98	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I008	Leptomonas seymouri	37%	100%
A0A3S7WZY2	Leishmania donovani	99%	100%
E9AYE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q927	Leishmania major	89%	100%