Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeat/Leucine Rich Repeat - putative

Species:

Leishmania infantum

UniProt:

A4I2A0_LEIIN

TriTrypDb:

LINF_260021700

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I2A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I2A0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.415
CLV_NRD_NRD_1	139	141	PF00675	0.472
CLV_NRD_NRD_1	168	170	PF00675	0.400
CLV_NRD_NRD_1	226	228	PF00675	0.394
CLV_NRD_NRD_1	434	436	PF00675	0.488
CLV_NRD_NRD_1	53	55	PF00675	0.501
CLV_NRD_NRD_1	629	631	PF00675	0.438
CLV_PCSK_FUR_1	224	228	PF00082	0.400
CLV_PCSK_KEX2_1	139	141	PF00082	0.583
CLV_PCSK_KEX2_1	167	169	PF00082	0.529
CLV_PCSK_KEX2_1	226	228	PF00082	0.394
CLV_PCSK_KEX2_1	434	436	PF00082	0.458
CLV_PCSK_KEX2_1	454	456	PF00082	0.402
CLV_PCSK_KEX2_1	473	475	PF00082	0.334
CLV_PCSK_KEX2_1	53	55	PF00082	0.501
CLV_PCSK_KEX2_1	629	631	PF00082	0.402
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.435
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.334
CLV_PCSK_SKI1_1	127	131	PF00082	0.523
CLV_PCSK_SKI1_1	217	221	PF00082	0.338
CLV_PCSK_SKI1_1	24	28	PF00082	0.418
CLV_PCSK_SKI1_1	372	376	PF00082	0.415
CLV_PCSK_SKI1_1	435	439	PF00082	0.481
CLV_PCSK_SKI1_1	448	452	PF00082	0.505
CLV_PCSK_SKI1_1	622	626	PF00082	0.470
CLV_PCSK_SKI1_1	657	661	PF00082	0.494
CLV_PCSK_SKI1_1	670	674	PF00082	0.388
CLV_PCSK_SKI1_1	99	103	PF00082	0.565
DEG_APCC_DBOX_1	126	134	PF00400	0.563
DEG_Nend_UBRbox_4	1	3	PF02207	0.438
DEG_SPOP_SBC_1	185	189	PF00917	0.359
DEG_SPOP_SBC_1	482	486	PF00917	0.305
DOC_CYCLIN_RxL_1	94	104	PF00134	0.539
DOC_MAPK_DCC_7	586	595	PF00069	0.462
DOC_MAPK_DCC_7	632	641	PF00069	0.321
DOC_MAPK_gen_1	256	265	PF00069	0.487
DOC_MAPK_gen_1	370	379	PF00069	0.383
DOC_MAPK_gen_1	453	462	PF00069	0.347
DOC_MAPK_MEF2A_6	24	31	PF00069	0.414
DOC_MAPK_MEF2A_6	370	379	PF00069	0.293
DOC_MAPK_MEF2A_6	586	595	PF00069	0.417
DOC_MAPK_MEF2A_6	632	641	PF00069	0.587
DOC_MAPK_NFAT4_5	24	32	PF00069	0.412
DOC_MAPK_NFAT4_5	372	380	PF00069	0.283
DOC_MAPK_RevD_3	154	169	PF00069	0.434
DOC_PP1_RVXF_1	224	231	PF00149	0.403
DOC_PP1_RVXF_1	602	609	PF00149	0.447
DOC_PP4_FxxP_1	25	28	PF00568	0.475
DOC_PP4_FxxP_1	30	33	PF00568	0.481
DOC_USP7_MATH_1	337	341	PF00917	0.400
DOC_USP7_MATH_1	482	486	PF00917	0.377
DOC_USP7_MATH_1	568	572	PF00917	0.402
DOC_USP7_MATH_1	614	618	PF00917	0.429
DOC_USP7_MATH_1	64	68	PF00917	0.510
DOC_USP7_MATH_1	678	682	PF00917	0.521
DOC_USP7_UBL2_3	552	556	PF12436	0.613
DOC_WW_Pin1_4	150	155	PF00397	0.551
DOC_WW_Pin1_4	29	34	PF00397	0.404
DOC_WW_Pin1_4	57	62	PF00397	0.503
DOC_WW_Pin1_4	8	13	PF00397	0.463
LIG_14-3-3_CanoR_1	256	261	PF00244	0.475
LIG_14-3-3_CanoR_1	313	319	PF00244	0.354
LIG_14-3-3_CanoR_1	320	325	PF00244	0.373
LIG_14-3-3_CanoR_1	398	406	PF00244	0.406
LIG_14-3-3_CanoR_1	434	438	PF00244	0.444
LIG_14-3-3_CanoR_1	448	457	PF00244	0.382
LIG_14-3-3_CanoR_1	570	575	PF00244	0.369
LIG_14-3-3_CanoR_1	622	628	PF00244	0.548
LIG_14-3-3_CanoR_1	670	677	PF00244	0.460
LIG_Actin_WH2_2	642	659	PF00022	0.512
LIG_BRCT_BRCA1_1	122	126	PF00533	0.578
LIG_BRCT_BRCA1_1	383	387	PF00533	0.400
LIG_BRCT_BRCA1_1	393	397	PF00533	0.379
LIG_BRCT_BRCA1_1	560	564	PF00533	0.459
LIG_CtBP_PxDLS_1	537	541	PF00389	0.424
LIG_eIF4E_1	21	27	PF01652	0.438
LIG_FHA_1	101	107	PF00498	0.491
LIG_FHA_1	151	157	PF00498	0.522
LIG_FHA_1	428	434	PF00498	0.472
LIG_FHA_1	482	488	PF00498	0.343
LIG_FHA_1	658	664	PF00498	0.430
LIG_FHA_2	203	209	PF00498	0.478
LIG_FHA_2	410	416	PF00498	0.449
LIG_GBD_Chelix_1	242	250	PF00786	0.335
LIG_HP1_1	591	595	PF01393	0.378
LIG_IRF3_LxIS_1	341	347	PF10401	0.360
LIG_LIR_Gen_1	257	266	PF02991	0.401
LIG_LIR_Gen_1	274	282	PF02991	0.223
LIG_LIR_Gen_1	284	293	PF02991	0.305
LIG_LIR_Gen_1	326	336	PF02991	0.447
LIG_LIR_Gen_1	348	357	PF02991	0.390
LIG_LIR_Gen_1	376	387	PF02991	0.382
LIG_LIR_Gen_1	559	569	PF02991	0.535
LIG_LIR_Gen_1	602	613	PF02991	0.403
LIG_LIR_LC3C_4	196	199	PF02991	0.448
LIG_LIR_Nem_3	211	216	PF02991	0.367
LIG_LIR_Nem_3	257	263	PF02991	0.492
LIG_LIR_Nem_3	274	278	PF02991	0.300
LIG_LIR_Nem_3	284	288	PF02991	0.397
LIG_LIR_Nem_3	32	37	PF02991	0.395
LIG_LIR_Nem_3	326	331	PF02991	0.473
LIG_LIR_Nem_3	348	354	PF02991	0.436
LIG_LIR_Nem_3	376	382	PF02991	0.379
LIG_LIR_Nem_3	384	390	PF02991	0.305
LIG_LIR_Nem_3	559	565	PF02991	0.551
LIG_LIR_Nem_3	602	608	PF02991	0.371
LIG_LIR_Nem_3	650	656	PF02991	0.546
LIG_LIR_Nem_3	96	101	PF02991	0.409
LIG_MAD2	35	43	PF02301	0.400
LIG_NRBOX	215	221	PF00104	0.462
LIG_Pex14_2	30	34	PF04695	0.408
LIG_PTB_Apo_2	466	473	PF02174	0.299
LIG_REV1ctd_RIR_1	469	478	PF16727	0.357
LIG_SH2_CRK	213	217	PF00017	0.419
LIG_SH2_CRK	285	289	PF00017	0.453
LIG_SH2_SRC	576	579	PF00017	0.403
LIG_SH2_STAP1	285	289	PF00017	0.385
LIG_SH2_STAT3	248	251	PF00017	0.410
LIG_SH2_STAT5	248	251	PF00017	0.552
LIG_SH2_STAT5	307	310	PF00017	0.383
LIG_SH2_STAT5	576	579	PF00017	0.403
LIG_SH3_3	125	131	PF00018	0.560
LIG_SH3_3	138	144	PF00018	0.585
LIG_SH3_3	151	157	PF00018	0.548
LIG_SH3_3	49	55	PF00018	0.487
LIG_SH3_3	585	591	PF00018	0.470
LIG_SH3_3	646	652	PF00018	0.415
LIG_SH3_3	9	15	PF00018	0.460
LIG_SUMO_SIM_anti_2	338	343	PF11976	0.356
LIG_SUMO_SIM_par_1	591	597	PF11976	0.336
MOD_CDC14_SPxK_1	32	35	PF00782	0.398
MOD_CDK_SPxK_1	29	35	PF00069	0.403
MOD_CK1_1	120	126	PF00069	0.443
MOD_CK1_1	254	260	PF00069	0.577
MOD_CK1_1	274	280	PF00069	0.318
MOD_CK1_1	436	442	PF00069	0.401
MOD_CK1_1	516	522	PF00069	0.447
MOD_CK1_1	60	66	PF00069	0.722
MOD_CK1_1	609	615	PF00069	0.374
MOD_CK1_1	67	73	PF00069	0.581
MOD_CK1_1	8	14	PF00069	0.536
MOD_CK2_1	256	262	PF00069	0.396
MOD_CK2_1	409	415	PF00069	0.462
MOD_CK2_1	527	533	PF00069	0.452
MOD_CK2_1	645	651	PF00069	0.503
MOD_Cter_Amidation	165	168	PF01082	0.431
MOD_GlcNHglycan	122	125	PF01048	0.482
MOD_GlcNHglycan	147	150	PF01048	0.462
MOD_GlcNHglycan	309	312	PF01048	0.494
MOD_GlcNHglycan	489	492	PF01048	0.438
MOD_GlcNHglycan	529	532	PF01048	0.489
MOD_GlcNHglycan	572	575	PF01048	0.469
MOD_GlcNHglycan	581	585	PF01048	0.397
MOD_GlcNHglycan	615	619	PF01048	0.409
MOD_GlcNHglycan	62	65	PF01048	0.511
MOD_GlcNHglycan	66	69	PF01048	0.507
MOD_GSK3_1	145	152	PF00069	0.494
MOD_GSK3_1	250	257	PF00069	0.451
MOD_GSK3_1	277	284	PF00069	0.347
MOD_GSK3_1	315	322	PF00069	0.482
MOD_GSK3_1	429	436	PF00069	0.464
MOD_GSK3_1	483	490	PF00069	0.468
MOD_GSK3_1	576	583	PF00069	0.456
MOD_GSK3_1	60	67	PF00069	0.508
MOD_GSK3_1	657	664	PF00069	0.553
MOD_GSK3_1	81	88	PF00069	0.468
MOD_N-GLC_1	251	256	PF02516	0.399
MOD_N-GLC_1	344	349	PF02516	0.414
MOD_N-GLC_1	516	521	PF02516	0.374
MOD_N-GLC_1	552	557	PF02516	0.554
MOD_N-GLC_1	606	611	PF02516	0.450
MOD_NEK2_1	184	189	PF00069	0.474
MOD_NEK2_1	220	225	PF00069	0.433
MOD_NEK2_1	250	255	PF00069	0.397
MOD_NEK2_1	3	8	PF00069	0.540
MOD_NEK2_1	319	324	PF00069	0.449
MOD_NEK2_1	344	349	PF00069	0.363
MOD_NEK2_1	360	365	PF00069	0.333
MOD_NEK2_1	375	380	PF00069	0.362
MOD_NEK2_1	381	386	PF00069	0.376
MOD_NEK2_1	427	432	PF00069	0.405
MOD_NEK2_1	48	53	PF00069	0.470
MOD_NEK2_1	487	492	PF00069	0.386
MOD_NEK2_1	513	518	PF00069	0.307
MOD_NEK2_1	543	548	PF00069	0.403
MOD_NEK2_1	580	585	PF00069	0.381
MOD_NEK2_1	608	613	PF00069	0.334
MOD_NEK2_2	599	604	PF00069	0.457
MOD_OFUCOSY	183	190	PF10250	0.360
MOD_PIKK_1	662	668	PF00454	0.506
MOD_PKA_2	312	318	PF00069	0.373
MOD_PKA_2	319	325	PF00069	0.406
MOD_PKA_2	433	439	PF00069	0.452
MOD_PKB_1	167	175	PF00069	0.510
MOD_PKB_1	256	264	PF00069	0.405
MOD_PKB_1	620	628	PF00069	0.463
MOD_Plk_1	251	257	PF00069	0.409
MOD_Plk_1	375	381	PF00069	0.432
MOD_Plk_1	416	422	PF00069	0.538
MOD_Plk_1	516	522	PF00069	0.379
MOD_Plk_1	609	615	PF00069	0.475
MOD_Plk_4	337	343	PF00069	0.368
MOD_Plk_4	483	489	PF00069	0.364
MOD_Plk_4	558	564	PF00069	0.490
MOD_Plk_4	623	629	PF00069	0.414
MOD_ProDKin_1	150	156	PF00069	0.546
MOD_ProDKin_1	29	35	PF00069	0.409
MOD_ProDKin_1	57	63	PF00069	0.505
MOD_ProDKin_1	8	14	PF00069	0.464
MOD_SUMO_for_1	93	96	PF00179	0.452
TRG_DiLeu_BaEn_1	245	250	PF01217	0.450
TRG_DiLeu_BaLyEn_6	585	590	PF01217	0.370
TRG_DiLeu_BaLyEn_6	667	672	PF01217	0.413
TRG_ENDOCYTIC_2	213	216	PF00928	0.356
TRG_ENDOCYTIC_2	285	288	PF00928	0.431
TRG_ENDOCYTIC_2	425	428	PF00928	0.462
TRG_ER_diArg_1	138	140	PF00400	0.562
TRG_ER_diArg_1	167	169	PF00400	0.523
TRG_ER_diArg_1	224	227	PF00400	0.543
TRG_ER_diArg_1	255	258	PF00400	0.429
TRG_ER_diArg_1	369	372	PF00400	0.438
TRG_ER_diArg_1	433	435	PF00400	0.457
TRG_ER_diArg_1	52	54	PF00400	0.497
TRG_ER_diArg_1	620	623	PF00400	0.432
TRG_ER_diArg_1	628	630	PF00400	0.413
TRG_Pf-PMV_PEXEL_1	670	674	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P389	Leptomonas seymouri	68%	100%
A0A1X0NSQ4	Trypanosomatidae	32%	100%
A0A3Q8IPA0	Leishmania donovani	100%	100%
A0A422N1Z7	Trypanosoma rangeli	34%	100%
A4HF21	Leishmania braziliensis	92%	100%
C9ZRP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AYE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q928	Leishmania major	95%	100%
V5B197	Trypanosoma cruzi	33%	100%