LeishMANIAdb
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Proline dehydrogenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proline dehydrogenase
Gene product:
proline oxidase - mitochondrial precursor-like protein
Species:
Leishmania infantum
UniProt:
A4I294_LEIIN
TriTrypDb:
LINF_260021100
Length:
561

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Proline oxidase, mitochondrial-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I294
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I294

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 12
GO:0006520 amino acid metabolic process 3 12
GO:0006560 proline metabolic process 6 12
GO:0006562 proline catabolic process 5 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009056 catabolic process 2 12
GO:0009063 amino acid catabolic process 4 12
GO:0009064 glutamine family amino acid metabolic process 5 12
GO:0009065 glutamine family amino acid catabolic process 6 12
GO:0009987 cellular process 1 12
GO:0016054 organic acid catabolic process 4 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044248 cellular catabolic process 3 12
GO:0044281 small molecule metabolic process 2 12
GO:0044282 small molecule catabolic process 3 12
GO:0046395 carboxylic acid catabolic process 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901565 organonitrogen compound catabolic process 4 12
GO:1901575 organic substance catabolic process 3 12
GO:1901605 alpha-amino acid metabolic process 4 12
GO:1901606 alpha-amino acid catabolic process 5 12
GO:0006536 glutamate metabolic process 6 1
GO:0010133 proline catabolic process to glutamate 6 1
GO:0043648 dicarboxylic acid metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004657 proline dehydrogenase activity 5 12
GO:0016491 oxidoreductase activity 2 12
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3 12
GO:0016649 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor 4 12
GO:0000166 nucleotide binding 3 1
GO:0005488 binding 1 5
GO:0005509 calcium ion binding 5 5
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 5
GO:0043168 anion binding 3 1
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
GO:0050660 flavin adenine dinucleotide binding 4 1
GO:0071949 FAD binding 5 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 390 394 PF00656 0.487
CLV_C14_Caspase3-7 542 546 PF00656 0.553
CLV_MEL_PAP_1 203 209 PF00089 0.284
CLV_MEL_PAP_1 487 493 PF00089 0.287
CLV_NRD_NRD_1 2 4 PF00675 0.581
CLV_NRD_NRD_1 240 242 PF00675 0.542
CLV_NRD_NRD_1 279 281 PF00675 0.259
CLV_NRD_NRD_1 532 534 PF00675 0.201
CLV_NRD_NRD_1 557 559 PF00675 0.354
CLV_PCSK_KEX2_1 2 4 PF00082 0.581
CLV_PCSK_KEX2_1 448 450 PF00082 0.242
CLV_PCSK_KEX2_1 532 534 PF00082 0.201
CLV_PCSK_KEX2_1 556 558 PF00082 0.346
CLV_PCSK_KEX2_1 73 75 PF00082 0.354
CLV_PCSK_PC1ET2_1 448 450 PF00082 0.262
CLV_PCSK_PC1ET2_1 556 558 PF00082 0.466
CLV_PCSK_PC1ET2_1 73 75 PF00082 0.356
CLV_PCSK_SKI1_1 2 6 PF00082 0.601
CLV_PCSK_SKI1_1 220 224 PF00082 0.429
CLV_PCSK_SKI1_1 271 275 PF00082 0.298
CLV_PCSK_SKI1_1 291 295 PF00082 0.263
CLV_PCSK_SKI1_1 448 452 PF00082 0.242
CLV_PCSK_SKI1_1 553 557 PF00082 0.369
DEG_Nend_UBRbox_1 1 4 PF02207 0.621
DOC_CYCLIN_yClb5_NLxxxL_5 500 507 PF00134 0.487
DOC_MAPK_gen_1 241 247 PF00069 0.481
DOC_MAPK_gen_1 460 466 PF00069 0.487
DOC_MAPK_MEF2A_6 500 507 PF00069 0.487
DOC_MAPK_MEF2A_6 51 58 PF00069 0.389
DOC_PP1_RVXF_1 488 494 PF00149 0.487
DOC_PP2B_LxvP_1 503 506 PF13499 0.413
DOC_USP7_MATH_1 205 209 PF00917 0.284
DOC_USP7_MATH_1 315 319 PF00917 0.487
DOC_USP7_MATH_1 65 69 PF00917 0.448
DOC_USP7_UBL2_3 322 326 PF12436 0.487
DOC_USP7_UBL2_3 73 77 PF12436 0.413
DOC_WW_Pin1_4 180 185 PF00397 0.476
DOC_WW_Pin1_4 301 306 PF00397 0.413
DOC_WW_Pin1_4 427 432 PF00397 0.393
LIG_14-3-3_CanoR_1 19 24 PF00244 0.582
LIG_14-3-3_CanoR_1 206 214 PF00244 0.285
LIG_14-3-3_CanoR_1 331 335 PF00244 0.398
LIG_14-3-3_CanoR_1 42 50 PF00244 0.362
LIG_14-3-3_CanoR_1 420 428 PF00244 0.506
LIG_14-3-3_CanoR_1 490 494 PF00244 0.487
LIG_14-3-3_CanoR_1 57 62 PF00244 0.479
LIG_Clathr_ClatBox_1 298 302 PF01394 0.487
LIG_EH1_1 47 55 PF00400 0.451
LIG_eIF4E_1 48 54 PF01652 0.447
LIG_FHA_1 272 278 PF00498 0.499
LIG_FHA_1 293 299 PF00498 0.442
LIG_FHA_1 427 433 PF00498 0.487
LIG_FHA_1 476 482 PF00498 0.442
LIG_FHA_1 502 508 PF00498 0.401
LIG_FHA_1 82 88 PF00498 0.493
LIG_FHA_2 221 227 PF00498 0.495
LIG_FHA_2 384 390 PF00498 0.415
LIG_FHA_2 433 439 PF00498 0.402
LIG_FHA_2 540 546 PF00498 0.580
LIG_LIR_Gen_1 248 256 PF02991 0.390
LIG_LIR_Gen_1 60 71 PF02991 0.407
LIG_LIR_Gen_1 84 93 PF02991 0.372
LIG_LIR_Nem_3 248 252 PF02991 0.388
LIG_LIR_Nem_3 267 273 PF02991 0.479
LIG_LIR_Nem_3 323 328 PF02991 0.380
LIG_LIR_Nem_3 351 357 PF02991 0.411
LIG_LIR_Nem_3 380 384 PF02991 0.400
LIG_LIR_Nem_3 430 436 PF02991 0.413
LIG_LIR_Nem_3 45 50 PF02991 0.313
LIG_LIR_Nem_3 492 496 PF02991 0.464
LIG_LIR_Nem_3 84 88 PF02991 0.345
LIG_LIR_Nem_3 92 97 PF02991 0.321
LIG_Pex14_1 218 222 PF04695 0.322
LIG_Pex14_2 493 497 PF04695 0.487
LIG_Pex14_2 93 97 PF04695 0.382
LIG_SH2_CRK 249 253 PF00017 0.400
LIG_SH2_CRK 428 432 PF00017 0.401
LIG_SH2_CRK 515 519 PF00017 0.416
LIG_SH2_CRK 520 524 PF00017 0.386
LIG_SH2_CRK 85 89 PF00017 0.334
LIG_SH2_NCK_1 443 447 PF00017 0.462
LIG_SH2_STAP1 124 128 PF00017 0.364
LIG_SH2_STAP1 85 89 PF00017 0.399
LIG_SH2_STAT3 415 418 PF00017 0.410
LIG_SH2_STAT5 287 290 PF00017 0.462
LIG_SH2_STAT5 384 387 PF00017 0.401
LIG_SH2_STAT5 415 418 PF00017 0.496
LIG_SH2_STAT5 428 431 PF00017 0.404
LIG_SH2_STAT5 48 51 PF00017 0.418
LIG_SH2_STAT5 517 520 PF00017 0.401
LIG_SH2_STAT5 529 532 PF00017 0.401
LIG_SH2_STAT5 63 66 PF00017 0.340
LIG_SH2_STAT5 96 99 PF00017 0.371
LIG_SH3_1 3 9 PF00018 0.615
LIG_SH3_1 428 434 PF00018 0.362
LIG_SH3_1 516 522 PF00018 0.401
LIG_SH3_2 519 524 PF14604 0.401
LIG_SH3_3 148 154 PF00018 0.521
LIG_SH3_3 27 33 PF00018 0.475
LIG_SH3_3 3 9 PF00018 0.615
LIG_SH3_3 428 434 PF00018 0.360
LIG_SH3_3 516 522 PF00018 0.396
LIG_SH3_4 153 160 PF00018 0.445
LIG_SUMO_SIM_anti_2 472 478 PF11976 0.487
LIG_SUMO_SIM_par_1 297 302 PF11976 0.431
LIG_TRAF2_1 223 226 PF00917 0.421
LIG_TRAF2_1 435 438 PF00917 0.413
LIG_TYR_ITIM 247 252 PF00017 0.409
LIG_TYR_ITIM 518 523 PF00017 0.401
LIG_TYR_ITIM 83 88 PF00017 0.339
LIG_UBA3_1 334 340 PF00899 0.444
LIG_UBA3_1 551 556 PF00899 0.465
LIG_WRC_WIRS_1 451 456 PF05994 0.506
MOD_CDK_SPK_2 180 185 PF00069 0.503
MOD_CK1_1 146 152 PF00069 0.382
MOD_CK1_1 180 186 PF00069 0.488
MOD_CK1_1 489 495 PF00069 0.464
MOD_CK1_1 539 545 PF00069 0.548
MOD_CK1_1 81 87 PF00069 0.448
MOD_CK2_1 220 226 PF00069 0.493
MOD_CK2_1 315 321 PF00069 0.408
MOD_CK2_1 383 389 PF00069 0.415
MOD_CK2_1 432 438 PF00069 0.394
MOD_CK2_1 477 483 PF00069 0.462
MOD_Cter_Amidation 530 533 PF01082 0.201
MOD_GlcNHglycan 140 143 PF01048 0.595
MOD_GlcNHglycan 207 210 PF01048 0.291
MOD_GlcNHglycan 317 320 PF01048 0.306
MOD_GlcNHglycan 44 47 PF01048 0.444
MOD_GSK3_1 14 21 PF00069 0.585
MOD_GSK3_1 145 152 PF00069 0.325
MOD_GSK3_1 210 217 PF00069 0.365
MOD_GSK3_1 220 227 PF00069 0.395
MOD_GSK3_1 259 266 PF00069 0.412
MOD_GSK3_1 330 337 PF00069 0.515
MOD_GSK3_1 362 369 PF00069 0.504
MOD_GSK3_1 432 439 PF00069 0.403
MOD_GSK3_1 535 542 PF00069 0.431
MOD_N-GLC_1 501 506 PF02516 0.242
MOD_N-GLC_1 536 541 PF02516 0.226
MOD_N-GLC_1 545 550 PF02516 0.393
MOD_N-GLC_2 440 442 PF02516 0.262
MOD_NEK2_1 106 111 PF00069 0.367
MOD_NEK2_1 14 19 PF00069 0.588
MOD_NEK2_1 177 182 PF00069 0.351
MOD_NEK2_1 210 215 PF00069 0.409
MOD_NEK2_1 334 339 PF00069 0.506
MOD_NEK2_1 366 371 PF00069 0.506
MOD_NEK2_1 465 470 PF00069 0.401
MOD_NEK2_1 83 88 PF00069 0.431
MOD_NEK2_2 350 355 PF00069 0.413
MOD_PK_1 19 25 PF00069 0.597
MOD_PK_1 57 63 PF00069 0.498
MOD_PKA_2 106 112 PF00069 0.471
MOD_PKA_2 18 24 PF00069 0.664
MOD_PKA_2 205 211 PF00069 0.284
MOD_PKA_2 330 336 PF00069 0.398
MOD_PKA_2 419 425 PF00069 0.426
MOD_PKA_2 489 495 PF00069 0.481
MOD_Plk_1 143 149 PF00069 0.362
MOD_Plk_1 224 230 PF00069 0.480
MOD_Plk_1 350 356 PF00069 0.401
MOD_Plk_1 36 42 PF00069 0.361
MOD_Plk_1 501 507 PF00069 0.433
MOD_Plk_1 535 541 PF00069 0.413
MOD_Plk_1 545 551 PF00069 0.365
MOD_Plk_4 146 152 PF00069 0.385
MOD_Plk_4 172 178 PF00069 0.435
MOD_Plk_4 330 336 PF00069 0.398
MOD_Plk_4 350 356 PF00069 0.393
MOD_Plk_4 477 483 PF00069 0.478
MOD_Plk_4 536 542 PF00069 0.421
MOD_Plk_4 545 551 PF00069 0.386
MOD_Plk_4 83 89 PF00069 0.318
MOD_ProDKin_1 180 186 PF00069 0.488
MOD_ProDKin_1 301 307 PF00069 0.413
MOD_ProDKin_1 427 433 PF00069 0.393
MOD_SUMO_for_1 228 231 PF00179 0.458
TRG_DiLeu_BaEn_4 225 231 PF01217 0.505
TRG_ENDOCYTIC_2 249 252 PF00928 0.398
TRG_ENDOCYTIC_2 290 293 PF00928 0.435
TRG_ENDOCYTIC_2 515 518 PF00928 0.416
TRG_ENDOCYTIC_2 520 523 PF00928 0.386
TRG_ENDOCYTIC_2 63 66 PF00928 0.409
TRG_ENDOCYTIC_2 85 88 PF00928 0.343
TRG_ENDOCYTIC_2 94 97 PF00928 0.309
TRG_ER_diArg_1 1 3 PF00400 0.588
TRG_ER_diArg_1 397 400 PF00400 0.487
TRG_ER_diArg_1 41 44 PF00400 0.448
TRG_NLS_MonoExtN_4 553 560 PF00514 0.465
TRG_Pf-PMV_PEXEL_1 345 349 PF00026 0.213

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUG0 Leptomonas seymouri 79% 99%
A0A0S4JS18 Bodo saltans 38% 99%
A0A1X0NS42 Trypanosomatidae 56% 100%
A0A3Q8IFX0 Leishmania donovani 100% 100%
A0A3R7N3G7 Trypanosoma rangeli 55% 100%
A4HF16 Leishmania braziliensis 92% 100%
C9ZRP3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 100%
E9AYE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O43272 Homo sapiens 30% 94%
O45228 Caenorhabditis elegans 30% 91%
Q04499 Drosophila melanogaster 30% 82%
Q148G5 Bos taurus 29% 95%
Q4Q933 Leishmania major 98% 100%
Q9WU79 Mus musculus 30% 94%
V5B5Q5 Trypanosoma cruzi 54% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS