Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I293_LEIIN

TriTrypDb:

LINF_260021000

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I293

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I293

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.566
CLV_C14_Caspase3-7	383	387	PF00656	0.507
CLV_C14_Caspase3-7	424	428	PF00656	0.423
CLV_C14_Caspase3-7	570	574	PF00656	0.696
CLV_NRD_NRD_1	310	312	PF00675	0.369
CLV_NRD_NRD_1	43	45	PF00675	0.513
CLV_NRD_NRD_1	477	479	PF00675	0.657
CLV_NRD_NRD_1	489	491	PF00675	0.707
CLV_NRD_NRD_1	515	517	PF00675	0.643
CLV_NRD_NRD_1	589	591	PF00675	0.462
CLV_NRD_NRD_1	75	77	PF00675	0.475
CLV_PCSK_FUR_1	486	490	PF00082	0.691
CLV_PCSK_FUR_1	510	514	PF00082	0.579
CLV_PCSK_FUR_1	587	591	PF00082	0.419
CLV_PCSK_KEX2_1	477	479	PF00082	0.658
CLV_PCSK_KEX2_1	488	490	PF00082	0.705
CLV_PCSK_KEX2_1	512	514	PF00082	0.746
CLV_PCSK_KEX2_1	515	517	PF00082	0.625
CLV_PCSK_KEX2_1	589	591	PF00082	0.437
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.737
CLV_PCSK_PC7_1	508	514	PF00082	0.591
CLV_PCSK_SKI1_1	120	124	PF00082	0.559
CLV_PCSK_SKI1_1	193	197	PF00082	0.454
CLV_PCSK_SKI1_1	280	284	PF00082	0.447
CLV_PCSK_SKI1_1	311	315	PF00082	0.463
CLV_PCSK_SKI1_1	459	463	PF00082	0.455
CLV_PCSK_SKI1_1	77	81	PF00082	0.533
CLV_Separin_Metazoa	190	194	PF03568	0.411
DEG_APCC_DBOX_1	119	127	PF00400	0.445
DEG_APCC_DBOX_1	279	287	PF00400	0.449
DEG_APCC_DBOX_1	289	297	PF00400	0.312
DEG_Nend_UBRbox_2	1	3	PF02207	0.468
DEG_SPOP_SBC_1	615	619	PF00917	0.459
DOC_CDC14_PxL_1	610	618	PF14671	0.421
DOC_CYCLIN_RxL_1	187	200	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	230	236	PF00134	0.501
DOC_MAPK_gen_1	137	146	PF00069	0.407
DOC_MAPK_gen_1	442	450	PF00069	0.461
DOC_MAPK_MEF2A_6	280	288	PF00069	0.362
DOC_MAPK_MEF2A_6	322	330	PF00069	0.423
DOC_MAPK_RevD_3	63	77	PF00069	0.462
DOC_PP1_RVXF_1	191	198	PF00149	0.445
DOC_PP1_RVXF_1	74	81	PF00149	0.447
DOC_USP7_MATH_1	174	178	PF00917	0.480
DOC_USP7_MATH_1	214	218	PF00917	0.592
DOC_USP7_MATH_1	252	256	PF00917	0.347
DOC_USP7_MATH_1	267	271	PF00917	0.504
DOC_USP7_MATH_1	350	354	PF00917	0.444
DOC_USP7_MATH_1	377	381	PF00917	0.454
DOC_USP7_MATH_1	392	396	PF00917	0.368
DOC_USP7_MATH_1	52	56	PF00917	0.526
DOC_USP7_MATH_1	574	578	PF00917	0.692
DOC_USP7_MATH_1	643	647	PF00917	0.410
DOC_USP7_MATH_1	94	98	PF00917	0.536
DOC_WW_Pin1_4	265	270	PF00397	0.529
DOC_WW_Pin1_4	34	39	PF00397	0.521
DOC_WW_Pin1_4	449	454	PF00397	0.449
DOC_WW_Pin1_4	533	538	PF00397	0.599
LIG_14-3-3_CanoR_1	109	115	PF00244	0.713
LIG_14-3-3_CanoR_1	120	130	PF00244	0.395
LIG_14-3-3_CanoR_1	137	147	PF00244	0.359
LIG_14-3-3_CanoR_1	379	385	PF00244	0.553
LIG_14-3-3_CanoR_1	393	399	PF00244	0.351
LIG_14-3-3_CanoR_1	410	418	PF00244	0.295
LIG_14-3-3_CanoR_1	44	53	PF00244	0.456
LIG_Actin_WH2_2	295	313	PF00022	0.381
LIG_BRCT_BRCA1_1	230	234	PF00533	0.500
LIG_Clathr_ClatBox_1	550	554	PF01394	0.584
LIG_EH1_1	182	190	PF00400	0.437
LIG_EH1_1	235	243	PF00400	0.381
LIG_eIF4E_1	236	242	PF01652	0.371
LIG_FHA_1	152	158	PF00498	0.434
LIG_FHA_1	220	226	PF00498	0.670
LIG_FHA_1	30	36	PF00498	0.467
LIG_FHA_1	346	352	PF00498	0.349
LIG_FHA_1	536	542	PF00498	0.658
LIG_FHA_1	597	603	PF00498	0.510
LIG_FHA_1	617	623	PF00498	0.375
LIG_FHA_2	110	116	PF00498	0.655
LIG_FHA_2	197	203	PF00498	0.434
LIG_FHA_2	381	387	PF00498	0.543
LIG_FHA_2	392	398	PF00498	0.362
LIG_LIR_Gen_1	199	208	PF02991	0.527
LIG_LIR_Gen_1	249	259	PF02991	0.304
LIG_LIR_Gen_1	303	314	PF02991	0.459
LIG_LIR_Gen_1	421	426	PF02991	0.434
LIG_LIR_Gen_1	452	462	PF02991	0.492
LIG_LIR_LC3C_4	649	652	PF02991	0.394
LIG_LIR_Nem_3	160	165	PF02991	0.409
LIG_LIR_Nem_3	196	201	PF02991	0.479
LIG_LIR_Nem_3	303	309	PF02991	0.460
LIG_LIR_Nem_3	421	425	PF02991	0.440
LIG_LIR_Nem_3	452	458	PF02991	0.481
LIG_LIR_Nem_3	630	634	PF02991	0.371
LIG_NRBOX	295	301	PF00104	0.429
LIG_NRBOX	64	70	PF00104	0.461
LIG_SH2_CRK	162	166	PF00017	0.459
LIG_SH2_CRK	306	310	PF00017	0.458
LIG_SH2_CRK	455	459	PF00017	0.583
LIG_SH2_CRK	528	532	PF00017	0.554
LIG_SH2_SRC	257	260	PF00017	0.318
LIG_SH2_STAP1	248	252	PF00017	0.314
LIG_SH2_STAP1	306	310	PF00017	0.458
LIG_SH2_STAT5	257	260	PF00017	0.487
LIG_SH2_STAT5	265	268	PF00017	0.531
LIG_SH2_STAT5	601	604	PF00017	0.384
LIG_SH2_STAT5	621	624	PF00017	0.224
LIG_SH2_STAT5	631	634	PF00017	0.374
LIG_SH3_3	32	38	PF00018	0.468
LIG_SH3_3	320	326	PF00018	0.352
LIG_SH3_3	466	472	PF00018	0.644
LIG_Sin3_3	648	655	PF02671	0.449
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.469
LIG_SUMO_SIM_anti_2	152	160	PF11976	0.443
LIG_SUMO_SIM_par_1	127	133	PF11976	0.466
LIG_SUMO_SIM_par_1	292	298	PF11976	0.405
LIG_SUMO_SIM_par_1	347	354	PF11976	0.271
LIG_SUMO_SIM_par_1	445	452	PF11976	0.420
LIG_SxIP_EBH_1	589	603	PF03271	0.397
LIG_TRAF2_1	200	203	PF00917	0.522
LIG_TYR_ITIM	632	637	PF00017	0.466
MOD_CK1_1	110	116	PF00069	0.509
MOD_CK1_1	121	127	PF00069	0.414
MOD_CK1_1	133	139	PF00069	0.383
MOD_CK1_1	219	225	PF00069	0.530
MOD_CK1_1	228	234	PF00069	0.449
MOD_CK1_1	268	274	PF00069	0.594
MOD_CK1_1	353	359	PF00069	0.392
MOD_CK1_1	380	386	PF00069	0.479
MOD_CK1_1	409	415	PF00069	0.384
MOD_CK1_1	451	457	PF00069	0.565
MOD_CK1_1	557	563	PF00069	0.665
MOD_CK1_1	641	647	PF00069	0.412
MOD_CK2_1	109	115	PF00069	0.625
MOD_CK2_1	150	156	PF00069	0.446
MOD_CK2_1	196	202	PF00069	0.492
MOD_CK2_1	28	34	PF00069	0.591
MOD_CK2_1	391	397	PF00069	0.419
MOD_CK2_1	557	563	PF00069	0.668
MOD_GlcNHglycan	109	112	PF01048	0.522
MOD_GlcNHglycan	132	135	PF01048	0.489
MOD_GlcNHglycan	176	179	PF01048	0.469
MOD_GlcNHglycan	227	230	PF01048	0.486
MOD_GlcNHglycan	378	382	PF01048	0.395
MOD_GlcNHglycan	394	397	PF01048	0.439
MOD_GlcNHglycan	411	414	PF01048	0.292
MOD_GlcNHglycan	427	430	PF01048	0.560
MOD_GlcNHglycan	46	49	PF01048	0.456
MOD_GlcNHglycan	611	614	PF01048	0.392
MOD_GlcNHglycan	640	643	PF01048	0.409
MOD_GlcNHglycan	98	101	PF01048	0.477
MOD_GSK3_1	109	116	PF00069	0.548
MOD_GSK3_1	157	164	PF00069	0.446
MOD_GSK3_1	193	200	PF00069	0.420
MOD_GSK3_1	219	226	PF00069	0.590
MOD_GSK3_1	267	274	PF00069	0.667
MOD_GSK3_1	30	37	PF00069	0.635
MOD_GSK3_1	353	360	PF00069	0.385
MOD_GSK3_1	380	387	PF00069	0.471
MOD_GSK3_1	4	11	PF00069	0.463
MOD_GSK3_1	421	428	PF00069	0.589
MOD_GSK3_1	436	443	PF00069	0.431
MOD_GSK3_1	498	505	PF00069	0.765
MOD_GSK3_1	532	539	PF00069	0.712
MOD_GSK3_1	554	561	PF00069	0.657
MOD_GSK3_1	592	599	PF00069	0.622
MOD_GSK3_1	601	608	PF00069	0.374
MOD_GSK3_1	96	103	PF00069	0.551
MOD_LATS_1	105	111	PF00433	0.493
MOD_N-GLC_1	368	373	PF02516	0.404
MOD_N-GLC_1	498	503	PF02516	0.582
MOD_NEK2_1	101	106	PF00069	0.629
MOD_NEK2_1	28	33	PF00069	0.519
MOD_NEK2_1	284	289	PF00069	0.469
MOD_NEK2_1	295	300	PF00069	0.331
MOD_NEK2_1	345	350	PF00069	0.427
MOD_NEK2_1	384	389	PF00069	0.481
MOD_NEK2_1	4	9	PF00069	0.491
MOD_NEK2_1	448	453	PF00069	0.433
MOD_NEK2_1	46	51	PF00069	0.466
MOD_NEK2_1	605	610	PF00069	0.378
MOD_NEK2_1	616	621	PF00069	0.383
MOD_NEK2_2	252	257	PF00069	0.315
MOD_NEK2_2	340	345	PF00069	0.577
MOD_PIKK_1	121	127	PF00454	0.467
MOD_PIKK_1	216	222	PF00454	0.549
MOD_PIKK_1	516	522	PF00454	0.547
MOD_PIKK_1	543	549	PF00454	0.666
MOD_PIKK_1	57	63	PF00454	0.483
MOD_PIKK_1	596	602	PF00454	0.404
MOD_PK_1	477	483	PF00069	0.628
MOD_PKA_1	44	50	PF00069	0.483
MOD_PKA_1	477	483	PF00069	0.598
MOD_PKA_2	392	398	PF00069	0.478
MOD_PKA_2	409	415	PF00069	0.287
MOD_PKA_2	477	483	PF00069	0.598
MOD_PKB_1	107	115	PF00069	0.503
MOD_PKB_1	506	514	PF00069	0.671
MOD_Plk_1	118	124	PF00069	0.482
MOD_Plk_1	151	157	PF00069	0.385
MOD_Plk_1	193	199	PF00069	0.368
MOD_Plk_1	340	346	PF00069	0.449
MOD_Plk_1	367	373	PF00069	0.496
MOD_Plk_1	377	383	PF00069	0.561
MOD_Plk_1	543	549	PF00069	0.562
MOD_Plk_1	583	589	PF00069	0.461
MOD_Plk_2-3	558	564	PF00069	0.785
MOD_Plk_4	193	199	PF00069	0.389
MOD_Plk_4	252	258	PF00069	0.437
MOD_Plk_4	284	290	PF00069	0.400
MOD_Plk_4	295	301	PF00069	0.315
MOD_Plk_4	340	346	PF00069	0.425
MOD_Plk_4	368	374	PF00069	0.368
MOD_Plk_4	4	10	PF00069	0.498
MOD_Plk_4	421	427	PF00069	0.485
MOD_Plk_4	605	611	PF00069	0.387
MOD_ProDKin_1	265	271	PF00069	0.539
MOD_ProDKin_1	34	40	PF00069	0.513
MOD_ProDKin_1	449	455	PF00069	0.445
MOD_ProDKin_1	533	539	PF00069	0.601
MOD_SUMO_for_1	656	659	PF00179	0.410
TRG_DiLeu_BaEn_1	279	284	PF01217	0.432
TRG_DiLeu_BaEn_2	117	123	PF01217	0.460
TRG_DiLeu_BaEn_2	340	346	PF01217	0.411
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.408
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.457
TRG_ENDOCYTIC_2	162	165	PF00928	0.393
TRG_ENDOCYTIC_2	201	204	PF00928	0.632
TRG_ENDOCYTIC_2	248	251	PF00928	0.443
TRG_ENDOCYTIC_2	306	309	PF00928	0.517
TRG_ENDOCYTIC_2	455	458	PF00928	0.569
TRG_ENDOCYTIC_2	528	531	PF00928	0.555
TRG_ENDOCYTIC_2	634	637	PF00928	0.474
TRG_ER_diArg_1	444	447	PF00400	0.459
TRG_ER_diArg_1	485	488	PF00400	0.802
TRG_ER_diArg_1	489	492	PF00400	0.700
TRG_ER_diArg_1	513	516	PF00400	0.647
TRG_ER_diArg_1	588	590	PF00400	0.416
TRG_NES_CRM1_1	181	194	PF08389	0.393
TRG_NLS_MonoCore_2	511	516	PF00514	0.589
TRG_NLS_MonoExtC_3	511	516	PF00514	0.589
TRG_NLS_MonoExtN_4	510	516	PF00514	0.772

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I134	Leptomonas seymouri	41%	100%
A0A3S7WZX2	Leishmania donovani	100%	100%
A4HF15	Leishmania braziliensis	76%	100%
E9AYD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q934	Leishmania major	93%	100%