Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I292_LEIIN

TriTrypDb:

LINF_260020800

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I292

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I292

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.467
CLV_C14_Caspase3-7	47	51	PF00656	0.519
CLV_C14_Caspase3-7	561	565	PF00656	0.561
CLV_C14_Caspase3-7	7	11	PF00656	0.588
CLV_NRD_NRD_1	238	240	PF00675	0.395
CLV_NRD_NRD_1	25	27	PF00675	0.490
CLV_NRD_NRD_1	488	490	PF00675	0.478
CLV_NRD_NRD_1	56	58	PF00675	0.452
CLV_NRD_NRD_1	93	95	PF00675	0.523
CLV_PCSK_FUR_1	23	27	PF00082	0.480
CLV_PCSK_FUR_1	91	95	PF00082	0.543
CLV_PCSK_KEX2_1	238	240	PF00082	0.392
CLV_PCSK_KEX2_1	25	27	PF00082	0.512
CLV_PCSK_KEX2_1	488	490	PF00082	0.478
CLV_PCSK_KEX2_1	91	93	PF00082	0.528
CLV_PCSK_PC7_1	87	93	PF00082	0.541
CLV_PCSK_SKI1_1	140	144	PF00082	0.476
CLV_PCSK_SKI1_1	184	188	PF00082	0.637
CLV_PCSK_SKI1_1	382	386	PF00082	0.333
CLV_PCSK_SKI1_1	446	450	PF00082	0.517
CLV_PCSK_SKI1_1	554	558	PF00082	0.461
DEG_APCC_DBOX_1	553	561	PF00400	0.376
DEG_Nend_UBRbox_2	1	3	PF02207	0.649
DEG_SPOP_SBC_1	159	163	PF00917	0.629
DEG_SPOP_SBC_1	252	256	PF00917	0.546
DEG_SPOP_SBC_1	309	313	PF00917	0.347
DOC_AGCK_PIF_1	569	574	PF00069	0.396
DOC_CYCLIN_RxL_1	342	353	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.411
DOC_MAPK_gen_1	57	65	PF00069	0.461
DOC_MAPK_MEF2A_6	257	266	PF00069	0.430
DOC_MAPK_MEF2A_6	57	65	PF00069	0.445
DOC_PP2B_LxvP_1	214	217	PF13499	0.483
DOC_PP4_FxxP_1	46	49	PF00568	0.520
DOC_USP7_MATH_1	112	116	PF00917	0.537
DOC_USP7_MATH_1	260	264	PF00917	0.453
DOC_USP7_MATH_1	380	384	PF00917	0.423
DOC_USP7_MATH_1	523	527	PF00917	0.399
DOC_USP7_MATH_1	556	560	PF00917	0.427
DOC_WW_Pin1_4	449	454	PF00397	0.484
DOC_WW_Pin1_4	547	552	PF00397	0.483
DOC_WW_Pin1_4	572	577	PF00397	0.419
LIG_14-3-3_CanoR_1	169	174	PF00244	0.719
LIG_14-3-3_CanoR_1	190	196	PF00244	0.508
LIG_14-3-3_CanoR_1	319	325	PF00244	0.435
LIG_14-3-3_CanoR_1	398	403	PF00244	0.473
LIG_14-3-3_CanoR_1	45	49	PF00244	0.507
LIG_14-3-3_CanoR_1	541	551	PF00244	0.623
LIG_APCC_ABBA_1	136	141	PF00400	0.447
LIG_Clathr_ClatBox_1	531	535	PF01394	0.397
LIG_FHA_1	116	122	PF00498	0.499
LIG_FHA_1	266	272	PF00498	0.424
LIG_FHA_1	334	340	PF00498	0.399
LIG_FHA_1	431	437	PF00498	0.401
LIG_FHA_1	500	506	PF00498	0.518
LIG_FHA_1	527	533	PF00498	0.485
LIG_FHA_1	544	550	PF00498	0.367
LIG_FHA_2	130	136	PF00498	0.467
LIG_FHA_2	163	169	PF00498	0.527
LIG_FHA_2	265	271	PF00498	0.441
LIG_FHA_2	37	43	PF00498	0.613
LIG_FHA_2	401	407	PF00498	0.313
LIG_FHA_2	45	51	PF00498	0.468
LIG_LIR_Apic_2	171	176	PF02991	0.588
LIG_LIR_Apic_2	43	49	PF02991	0.524
LIG_LIR_Gen_1	179	189	PF02991	0.541
LIG_LIR_Gen_1	207	217	PF02991	0.482
LIG_LIR_Gen_1	67	75	PF02991	0.457
LIG_LIR_Nem_3	133	139	PF02991	0.425
LIG_LIR_Nem_3	207	212	PF02991	0.467
LIG_LIR_Nem_3	383	388	PF02991	0.465
LIG_LIR_Nem_3	567	572	PF02991	0.361
LIG_LIR_Nem_3	573	577	PF02991	0.385
LIG_LIR_Nem_3	60	65	PF02991	0.455
LIG_LIR_Nem_3	67	72	PF02991	0.399
LIG_PDZ_Class_2	581	586	PF00595	0.406
LIG_Pex14_1	244	248	PF04695	0.380
LIG_Pex14_1	324	328	PF04695	0.470
LIG_Pex14_2	187	191	PF04695	0.579
LIG_Pex14_2	385	389	PF04695	0.472
LIG_REV1ctd_RIR_1	134	143	PF16727	0.465
LIG_SH2_CRK	471	475	PF00017	0.391
LIG_SH2_GRB2like	248	251	PF00017	0.429
LIG_SH2_PTP2	317	320	PF00017	0.339
LIG_SH2_PTP2	62	65	PF00017	0.504
LIG_SH2_PTP2	69	72	PF00017	0.406
LIG_SH2_SRC	226	229	PF00017	0.455
LIG_SH2_SRC	248	251	PF00017	0.418
LIG_SH2_SRC	69	72	PF00017	0.475
LIG_SH2_STAP1	226	230	PF00017	0.402
LIG_SH2_STAP1	248	252	PF00017	0.494
LIG_SH2_STAP1	578	582	PF00017	0.537
LIG_SH2_STAT3	464	467	PF00017	0.400
LIG_SH2_STAT3	577	580	PF00017	0.458
LIG_SH2_STAT5	245	248	PF00017	0.452
LIG_SH2_STAT5	281	284	PF00017	0.383
LIG_SH2_STAT5	317	320	PF00017	0.372
LIG_SH2_STAT5	322	325	PF00017	0.366
LIG_SH2_STAT5	572	575	PF00017	0.392
LIG_SH2_STAT5	62	65	PF00017	0.485
LIG_SH2_STAT5	69	72	PF00017	0.368
LIG_SH3_3	151	157	PF00018	0.646
LIG_SH3_3	361	367	PF00018	0.577
LIG_SH3_3	416	422	PF00018	0.597
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.430
LIG_SUMO_SIM_par_1	267	273	PF11976	0.442
LIG_SUMO_SIM_par_1	306	313	PF11976	0.425
LIG_SUMO_SIM_par_1	520	526	PF11976	0.393
LIG_TRAF2_1	165	168	PF00917	0.529
LIG_TYR_ITIM	469	474	PF00017	0.425
LIG_WRC_WIRS_1	399	404	PF05994	0.456
LIG_WRC_WIRS_1	571	576	PF05994	0.403
MOD_CDK_SPK_2	449	454	PF00069	0.484
MOD_CDK_SPxxK_3	547	554	PF00069	0.472
MOD_CK1_1	115	121	PF00069	0.691
MOD_CK1_1	129	135	PF00069	0.514
MOD_CK1_1	251	257	PF00069	0.669
MOD_CK1_1	350	356	PF00069	0.416
MOD_CK1_1	36	42	PF00069	0.558
MOD_CK1_1	4	10	PF00069	0.556
MOD_CK1_1	458	464	PF00069	0.481
MOD_CK1_1	525	531	PF00069	0.423
MOD_CK2_1	162	168	PF00069	0.528
MOD_CK2_1	36	42	PF00069	0.568
MOD_GlcNHglycan	114	117	PF01048	0.557
MOD_GlcNHglycan	249	253	PF01048	0.476
MOD_GlcNHglycan	35	38	PF01048	0.522
MOD_GlcNHglycan	369	372	PF01048	0.545
MOD_GlcNHglycan	509	512	PF01048	0.497
MOD_GSK3_1	1	8	PF00069	0.609
MOD_GSK3_1	122	129	PF00069	0.430
MOD_GSK3_1	158	165	PF00069	0.672
MOD_GSK3_1	248	255	PF00069	0.511
MOD_GSK3_1	260	267	PF00069	0.335
MOD_GSK3_1	32	39	PF00069	0.632
MOD_GSK3_1	367	374	PF00069	0.631
MOD_GSK3_1	398	405	PF00069	0.456
MOD_GSK3_1	40	47	PF00069	0.539
MOD_GSK3_1	455	462	PF00069	0.433
MOD_GSK3_1	496	503	PF00069	0.487
MOD_GSK3_1	507	514	PF00069	0.521
MOD_GSK3_1	522	529	PF00069	0.305
MOD_GSK3_1	543	550	PF00069	0.482
MOD_N-GLC_1	371	376	PF02516	0.452
MOD_N-GLC_1	430	435	PF02516	0.372
MOD_N-GLC_1	449	454	PF02516	0.419
MOD_NEK2_1	1	6	PF00069	0.679
MOD_NEK2_1	158	163	PF00069	0.627
MOD_NEK2_1	177	182	PF00069	0.565
MOD_NEK2_1	308	313	PF00069	0.390
MOD_NEK2_1	320	325	PF00069	0.412
MOD_NEK2_1	347	352	PF00069	0.407
MOD_NEK2_1	44	49	PF00069	0.423
MOD_NEK2_1	500	505	PF00069	0.501
MOD_NEK2_1	522	527	PF00069	0.396
MOD_NEK2_1	542	547	PF00069	0.291
MOD_NEK2_2	333	338	PF00069	0.391
MOD_NEK2_2	380	385	PF00069	0.391
MOD_PIKK_1	543	549	PF00454	0.473
MOD_PK_1	338	344	PF00069	0.454
MOD_PK_1	57	63	PF00069	0.376
MOD_PKA_1	57	63	PF00069	0.376
MOD_PKA_2	104	110	PF00069	0.436
MOD_PKA_2	126	132	PF00069	0.401
MOD_PKA_2	168	174	PF00069	0.604
MOD_PKA_2	191	197	PF00069	0.510
MOD_PKA_2	32	38	PF00069	0.699
MOD_PKA_2	44	50	PF00069	0.446
MOD_PKB_1	396	404	PF00069	0.588
MOD_Plk_1	226	232	PF00069	0.361
MOD_Plk_1	371	377	PF00069	0.478
MOD_Plk_1	405	411	PF00069	0.375
MOD_Plk_1	458	464	PF00069	0.407
MOD_Plk_2-3	50	56	PF00069	0.550
MOD_Plk_4	338	344	PF00069	0.541
MOD_Plk_4	459	465	PF00069	0.384
MOD_Plk_4	496	502	PF00069	0.461
MOD_Plk_4	57	63	PF00069	0.438
MOD_ProDKin_1	449	455	PF00069	0.475
MOD_ProDKin_1	547	553	PF00069	0.474
MOD_ProDKin_1	572	578	PF00069	0.419
MOD_SUMO_for_1	337	340	PF00179	0.452
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.528
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.460
TRG_ENDOCYTIC_2	317	320	PF00928	0.339
TRG_ENDOCYTIC_2	471	474	PF00928	0.405
TRG_ENDOCYTIC_2	62	65	PF00928	0.480
TRG_ENDOCYTIC_2	69	72	PF00928	0.411
TRG_ER_diArg_1	396	399	PF00400	0.581
TRG_ER_diArg_1	487	489	PF00400	0.479
TRG_ER_diArg_1	90	93	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II93	Leptomonas seymouri	43%	100%
A0A3S7WZW7	Leishmania donovani	99%	100%
A4HF13	Leishmania braziliensis	80%	100%
C9ZRP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9AYD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q936	Leishmania major	94%	100%