LeishMANIAdb
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Glutaredoxin domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glutaredoxin domain-containing protein
Gene product:
Glutaredoxin/Glutathione S-transferase - N-terminal domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4I288_LEIIN
TriTrypDb:
LINF_260020400
Length:
397

Annotations

Annotations by Jardim et al.

Redox homeostasis, glutaredoxin, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 21
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 10
GO:0005739 mitochondrion 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0020023 kinetoplast 2 1

Expansion

Sequence features

A4I288
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I288

Function

Biological processes
Term Name Level Count
GO:0001516 prostaglandin biosynthetic process 8 4
GO:0006082 organic acid metabolic process 3 4
GO:0006629 lipid metabolic process 3 4
GO:0006631 fatty acid metabolic process 4 4
GO:0006633 fatty acid biosynthetic process 5 4
GO:0006636 unsaturated fatty acid biosynthetic process 6 4
GO:0006690 icosanoid metabolic process 6 4
GO:0006692 prostanoid metabolic process 6 4
GO:0006693 prostaglandin metabolic process 7 4
GO:0008152 metabolic process 1 4
GO:0008610 lipid biosynthetic process 4 4
GO:0009058 biosynthetic process 2 4
GO:0009987 cellular process 1 4
GO:0016053 organic acid biosynthetic process 4 4
GO:0019752 carboxylic acid metabolic process 5 4
GO:0032787 monocarboxylic acid metabolic process 6 4
GO:0033559 unsaturated fatty acid metabolic process 5 4
GO:0043436 oxoacid metabolic process 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044249 cellular biosynthetic process 3 4
GO:0044255 cellular lipid metabolic process 3 4
GO:0044281 small molecule metabolic process 2 4
GO:0044283 small molecule biosynthetic process 3 4
GO:0046394 carboxylic acid biosynthetic process 5 4
GO:0046456 icosanoid biosynthetic process 6 4
GO:0046457 prostanoid biosynthetic process 7 4
GO:0071704 organic substance metabolic process 2 4
GO:0072330 monocarboxylic acid biosynthetic process 6 4
GO:1901576 organic substance biosynthetic process 3 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 20
GO:0015035 protein-disulfide reductase activity 3 18
GO:0015036 disulfide oxidoreductase activity 4 18
GO:0016491 oxidoreductase activity 2 18
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 3 18
GO:0097573 obsolete glutathione oxidoreductase activity 4 18
GO:0140096 catalytic activity, acting on a protein 2 18
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor 4 5
GO:0016740 transferase activity 2 13
GO:0016853 isomerase activity 2 11
GO:0016860 intramolecular oxidoreductase activity 3 11
GO:0019153 protein-disulfide reductase (glutathione) activity 4 5
GO:0050220 prostaglandin-E synthase activity 4 11
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 1
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 1
GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 233 237 PF00656 0.326
CLV_C14_Caspase3-7 279 283 PF00656 0.672
CLV_NRD_NRD_1 153 155 PF00675 0.620
CLV_NRD_NRD_1 309 311 PF00675 0.381
CLV_NRD_NRD_1 335 337 PF00675 0.419
CLV_PCSK_KEX2_1 153 155 PF00082 0.613
CLV_PCSK_KEX2_1 309 311 PF00082 0.408
CLV_PCSK_KEX2_1 335 337 PF00082 0.380
CLV_PCSK_KEX2_1 56 58 PF00082 0.446
CLV_PCSK_PC1ET2_1 56 58 PF00082 0.446
CLV_PCSK_SKI1_1 111 115 PF00082 0.512
CLV_PCSK_SKI1_1 309 313 PF00082 0.375
CLV_PCSK_SKI1_1 56 60 PF00082 0.554
CLV_PCSK_SKI1_1 6 10 PF00082 0.288
CLV_PCSK_SKI1_1 82 86 PF00082 0.619
DEG_Nend_UBRbox_1 1 4 PF02207 0.642
DEG_SPOP_SBC_1 7 11 PF00917 0.236
DOC_CDC14_PxL_1 155 163 PF14671 0.311
DOC_CKS1_1 243 248 PF01111 0.321
DOC_CYCLIN_yCln2_LP_2 118 124 PF00134 0.271
DOC_CYCLIN_yCln2_LP_2 196 202 PF00134 0.352
DOC_MAPK_MEF2A_6 154 163 PF00069 0.290
DOC_MAPK_RevD_3 140 154 PF00069 0.423
DOC_PP1_RVXF_1 109 115 PF00149 0.302
DOC_USP7_MATH_1 105 109 PF00917 0.416
DOC_USP7_MATH_1 178 182 PF00917 0.431
DOC_USP7_MATH_1 209 213 PF00917 0.437
DOC_USP7_MATH_1 35 39 PF00917 0.481
DOC_WW_Pin1_4 242 247 PF00397 0.308
DOC_WW_Pin1_4 344 349 PF00397 0.497
LIG_14-3-3_CanoR_1 101 110 PF00244 0.374
LIG_Actin_WH2_2 45 61 PF00022 0.420
LIG_deltaCOP1_diTrp_1 216 222 PF00928 0.363
LIG_FHA_1 35 41 PF00498 0.403
LIG_FHA_1 357 363 PF00498 0.515
LIG_FHA_1 390 396 PF00498 0.607
LIG_FHA_1 8 14 PF00498 0.322
LIG_FHA_1 83 89 PF00498 0.266
LIG_LIR_Apic_2 240 246 PF02991 0.301
LIG_LIR_Gen_1 134 145 PF02991 0.281
LIG_LIR_Gen_1 240 249 PF02991 0.333
LIG_LIR_Nem_3 134 140 PF02991 0.289
LIG_LIR_Nem_3 236 241 PF02991 0.303
LIG_LIR_Nem_3 247 252 PF02991 0.296
LIG_LIR_Nem_3 315 321 PF02991 0.475
LIG_LIR_Nem_3 48 52 PF02991 0.350
LIG_PDZ_Class_2 392 397 PF00595 0.614
LIG_PTB_Apo_2 228 235 PF02174 0.381
LIG_PTB_Apo_2 248 255 PF02174 0.214
LIG_PTB_Phospho_1 248 254 PF10480 0.230
LIG_SH2_CRK 115 119 PF00017 0.256
LIG_SH2_CRK 241 245 PF00017 0.310
LIG_SH2_CRK 78 82 PF00017 0.294
LIG_SH2_GRB2like 249 252 PF00017 0.334
LIG_SH2_GRB2like 78 81 PF00017 0.287
LIG_SH2_PTP2 137 140 PF00017 0.170
LIG_SH2_PTP2 243 246 PF00017 0.312
LIG_SH2_SRC 137 140 PF00017 0.321
LIG_SH2_STAP1 202 206 PF00017 0.397
LIG_SH2_STAT3 268 271 PF00017 0.579
LIG_SH2_STAT5 103 106 PF00017 0.435
LIG_SH2_STAT5 122 125 PF00017 0.238
LIG_SH2_STAT5 137 140 PF00017 0.271
LIG_SH2_STAT5 162 165 PF00017 0.365
LIG_SH2_STAT5 185 188 PF00017 0.333
LIG_SH2_STAT5 24 27 PF00017 0.428
LIG_SH2_STAT5 241 244 PF00017 0.304
LIG_SH2_STAT5 78 81 PF00017 0.287
LIG_TRAF2_1 320 323 PF00917 0.591
LIG_TRAF2_1 383 386 PF00917 0.461
LIG_TRFH_1 155 159 PF08558 0.307
LIG_TYR_ITIM 113 118 PF00017 0.301
LIG_TYR_ITIM 130 135 PF00017 0.242
LIG_WRC_WIRS_1 329 334 PF05994 0.537
MOD_CK1_1 11 17 PF00069 0.463
MOD_CK1_1 194 200 PF00069 0.324
MOD_CK1_1 263 269 PF00069 0.392
MOD_CK1_1 295 301 PF00069 0.645
MOD_CK1_1 305 311 PF00069 0.627
MOD_CK1_1 38 44 PF00069 0.480
MOD_CK1_1 89 95 PF00069 0.507
MOD_CK2_1 42 48 PF00069 0.314
MOD_GlcNHglycan 10 13 PF01048 0.377
MOD_GlcNHglycan 145 148 PF01048 0.534
MOD_GlcNHglycan 170 173 PF01048 0.642
MOD_GlcNHglycan 188 191 PF01048 0.546
MOD_GlcNHglycan 196 199 PF01048 0.548
MOD_GlcNHglycan 211 214 PF01048 0.594
MOD_GlcNHglycan 258 261 PF01048 0.334
MOD_GlcNHglycan 43 47 PF01048 0.531
MOD_GSK3_1 101 108 PF00069 0.308
MOD_GSK3_1 223 230 PF00069 0.293
MOD_GSK3_1 256 263 PF00069 0.386
MOD_GSK3_1 283 290 PF00069 0.666
MOD_GSK3_1 34 41 PF00069 0.485
MOD_GSK3_1 7 14 PF00069 0.413
MOD_GSK3_1 82 89 PF00069 0.451
MOD_N-GLC_1 230 235 PF02516 0.508
MOD_NEK2_1 227 232 PF00069 0.290
MOD_NEK2_1 312 317 PF00069 0.565
MOD_PIKK_1 191 197 PF00454 0.317
MOD_PIKK_1 83 89 PF00454 0.438
MOD_PKA_2 76 82 PF00069 0.378
MOD_Plk_1 230 236 PF00069 0.290
MOD_Plk_4 239 245 PF00069 0.332
MOD_Plk_4 260 266 PF00069 0.386
MOD_Plk_4 328 334 PF00069 0.534
MOD_Plk_4 391 397 PF00069 0.528
MOD_ProDKin_1 242 248 PF00069 0.310
MOD_ProDKin_1 344 350 PF00069 0.492
MOD_SUMO_for_1 124 127 PF00179 0.271
MOD_SUMO_for_1 276 279 PF00179 0.606
MOD_SUMO_rev_2 106 113 PF00179 0.390
TRG_DiLeu_BaEn_2 327 333 PF01217 0.510
TRG_DiLeu_BaLyEn_6 113 118 PF01217 0.290
TRG_DiLeu_BaLyEn_6 270 275 PF01217 0.494
TRG_ENDOCYTIC_2 115 118 PF00928 0.257
TRG_ENDOCYTIC_2 132 135 PF00928 0.279
TRG_ENDOCYTIC_2 137 140 PF00928 0.277
TRG_ENDOCYTIC_2 241 244 PF00928 0.302
TRG_ENDOCYTIC_2 249 252 PF00928 0.335
TRG_ENDOCYTIC_2 78 81 PF00928 0.417
TRG_ER_diArg_1 153 155 PF00400 0.420
TRG_ER_diArg_1 335 337 PF00400 0.579
TRG_Pf-PMV_PEXEL_1 56 60 PF00026 0.645
TRG_Pf-PMV_PEXEL_1 82 87 PF00026 0.482

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HS46 Leptomonas seymouri 25% 100%
A0A0N1ILY8 Leptomonas seymouri 60% 100%
A0A0S4IXT4 Bodo saltans 23% 100%
A0A0S4JV60 Bodo saltans 31% 100%
A0A1X0NND6 Trypanosomatidae 29% 100%
A0A1X0NTT0 Trypanosomatidae 40% 100%
A0A3S7WT83 Leishmania donovani 27% 100%
A0A3S7WZV5 Leishmania donovani 99% 100%
A0A422MZ79 Trypanosoma rangeli 42% 100%
A0A422N3R5 Trypanosoma rangeli 25% 100%
A4H7W8 Leishmania braziliensis 27% 100%
A4HF09 Leishmania braziliensis 84% 100%
A4HW95 Leishmania infantum 25% 81%
C9ZRQ5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZSR6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 23% 100%
E9APZ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AYD3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q940 Leishmania major 92% 100%
Q4QFI5 Leishmania major 25% 81%
V5AYZ4 Trypanosoma cruzi 41% 100%
V5DC17 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS