Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif (a.k.a. RRM - RBD - or RNP domain)/RNA recognition motif. (a.k.a. RRM - RBD - or RNP domain) - putative

Species:

Leishmania infantum

UniProt:

A4I287_LEIIN

TriTrypDb:

LINF_260020300

Length:

221

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4I287

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I287

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	121	125	PF00082	0.322
CLV_PCSK_SKI1_1	169	173	PF00082	0.293
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DEG_SCF_TRCP1_1	40	45	PF00400	0.574
DOC_CYCLIN_RxL_1	118	125	PF00134	0.493
DOC_MAPK_gen_1	142	151	PF00069	0.493
DOC_WW_Pin1_4	181	186	PF00397	0.485
LIG_14-3-3_CanoR_1	121	130	PF00244	0.504
LIG_FHA_1	202	208	PF00498	0.447
LIG_FHA_2	151	157	PF00498	0.549
LIG_LIR_Nem_3	125	130	PF02991	0.544
LIG_PAM2_1	6	18	PF00658	0.616
LIG_SH2_CRK	168	172	PF00017	0.493
LIG_SH3_3	11	17	PF00018	0.617
LIG_SH3_3	200	206	PF00018	0.540
LIG_TRAF2_1	153	156	PF00917	0.493
MOD_CK1_1	140	146	PF00069	0.477
MOD_CK1_1	201	207	PF00069	0.462
MOD_CK1_1	38	44	PF00069	0.614
MOD_CK1_1	65	71	PF00069	0.569
MOD_CK2_1	150	156	PF00069	0.529
MOD_CK2_1	191	197	PF00069	0.447
MOD_GlcNHglycan	124	127	PF01048	0.328
MOD_GlcNHglycan	193	196	PF01048	0.449
MOD_GlcNHglycan	40	43	PF01048	0.578
MOD_GlcNHglycan	64	67	PF01048	0.571
MOD_GlcNHglycan	8	11	PF01048	0.643
MOD_GSK3_1	156	163	PF00069	0.492
MOD_GSK3_1	181	188	PF00069	0.509
MOD_GSK3_1	31	38	PF00069	0.659
MOD_LATS_1	29	35	PF00433	0.620
MOD_N-GLC_1	140	145	PF02516	0.303
MOD_N-GLC_1	185	190	PF02516	0.444
MOD_N-GLC_1	6	11	PF02516	0.611
MOD_N-GLC_1	62	67	PF02516	0.575
MOD_NEK2_1	99	104	PF00069	0.472
MOD_NEK2_2	160	165	PF00069	0.529
MOD_PIKK_1	212	218	PF00454	0.460
MOD_PIKK_1	35	41	PF00454	0.736
MOD_PKB_1	167	175	PF00069	0.493
MOD_Plk_4	65	71	PF00069	0.569
MOD_ProDKin_1	181	187	PF00069	0.483
TRG_ENDOCYTIC_2	127	130	PF00928	0.550
TRG_ENDOCYTIC_2	168	171	PF00928	0.500
TRG_ENDOCYTIC_2	79	82	PF00928	0.612
TRG_ER_diArg_1	55	58	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I044	Leptomonas seymouri	71%	96%
A0A3Q8IC83	Leishmania donovani	100%	100%
A4HF08	Leishmania braziliensis	86%	100%
E9AYD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4Q442	Leishmania major	37%	100%
Q4Q6X2	Leishmania major	32%	100%
Q4Q941	Leishmania major	95%	99%