Conserved oligomeric Golgi complex subunit 7

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I282_LEIIN

TriTrypDb:

LINF_260019800

Length:

1019

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	9
GO:0016020	membrane	2	9
GO:0017119	Golgi transport complex	3	9
GO:0031090	organelle membrane	3	9
GO:0032991	protein-containing complex	1	9
GO:0098588	bounding membrane of organelle	4	9
GO:0099023	vesicle tethering complex	2	9
GO:0110165	cellular anatomical entity	1	9

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I282

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I282

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006886	intracellular protein transport	4	9
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0033036	macromolecule localization	2	9
GO:0045184	establishment of protein localization	3	9
GO:0046907	intracellular transport	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051641	cellular localization	2	9
GO:0051649	establishment of localization in cell	3	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1000	1004	PF00656	0.480
CLV_C14_Caspase3-7	31	35	PF00656	0.522
CLV_C14_Caspase3-7	869	873	PF00656	0.514
CLV_NRD_NRD_1	115	117	PF00675	0.565
CLV_NRD_NRD_1	212	214	PF00675	0.423
CLV_NRD_NRD_1	408	410	PF00675	0.379
CLV_NRD_NRD_1	431	433	PF00675	0.418
CLV_NRD_NRD_1	710	712	PF00675	0.433
CLV_NRD_NRD_1	855	857	PF00675	0.467
CLV_PCSK_FUR_1	210	214	PF00082	0.322
CLV_PCSK_KEX2_1	212	214	PF00082	0.438
CLV_PCSK_KEX2_1	408	410	PF00082	0.379
CLV_PCSK_KEX2_1	431	433	PF00082	0.418
CLV_PCSK_KEX2_1	67	69	PF00082	0.460
CLV_PCSK_KEX2_1	709	711	PF00082	0.420
CLV_PCSK_KEX2_1	855	857	PF00082	0.467
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.460
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.385
CLV_PCSK_SKI1_1	302	306	PF00082	0.432
CLV_PCSK_SKI1_1	348	352	PF00082	0.438
CLV_PCSK_SKI1_1	421	425	PF00082	0.486
CLV_PCSK_SKI1_1	592	596	PF00082	0.458
CLV_PCSK_SKI1_1	768	772	PF00082	0.426
CLV_PCSK_SKI1_1	776	780	PF00082	0.459
CLV_PCSK_SKI1_1	958	962	PF00082	0.321
CLV_Separin_Metazoa	405	409	PF03568	0.430
DEG_APCC_DBOX_1	297	305	PF00400	0.380
DEG_APCC_DBOX_1	775	783	PF00400	0.388
DEG_APCC_DBOX_1	957	965	PF00400	0.417
DEG_Nend_UBRbox_2	1	3	PF02207	0.541
DEG_SCF_FBW7_1	690	697	PF00400	0.454
DEG_SPOP_SBC_1	110	114	PF00917	0.514
DEG_SPOP_SBC_1	439	443	PF00917	0.451
DEG_SPOP_SBC_1	457	461	PF00917	0.583
DOC_ANK_TNKS_1	461	468	PF00023	0.565
DOC_CKS1_1	576	581	PF01111	0.545
DOC_CKS1_1	691	696	PF01111	0.467
DOC_CYCLIN_RxL_1	114	123	PF00134	0.548
DOC_CYCLIN_RxL_1	418	428	PF00134	0.371
DOC_MAPK_DCC_7	709	717	PF00069	0.325
DOC_MAPK_gen_1	154	162	PF00069	0.391
DOC_MAPK_gen_1	902	910	PF00069	0.401
DOC_MAPK_MEF2A_6	902	910	PF00069	0.377
DOC_PP1_RVXF_1	419	426	PF00149	0.365
DOC_PP2B_LxvP_1	24	27	PF13499	0.599
DOC_PP4_FxxP_1	576	579	PF00568	0.551
DOC_USP7_MATH_1	17	21	PF00917	0.569
DOC_USP7_MATH_1	203	207	PF00917	0.460
DOC_USP7_MATH_1	250	254	PF00917	0.708
DOC_USP7_MATH_1	33	37	PF00917	0.614
DOC_USP7_MATH_1	384	388	PF00917	0.458
DOC_USP7_MATH_1	39	43	PF00917	0.585
DOC_USP7_MATH_1	417	421	PF00917	0.383
DOC_USP7_MATH_1	439	443	PF00917	0.608
DOC_USP7_MATH_1	448	452	PF00917	0.673
DOC_USP7_MATH_1	466	470	PF00917	0.689
DOC_USP7_MATH_1	5	9	PF00917	0.663
DOC_USP7_MATH_1	520	524	PF00917	0.290
DOC_USP7_MATH_1	577	581	PF00917	0.455
DOC_USP7_MATH_1	637	641	PF00917	0.499
DOC_USP7_MATH_1	692	696	PF00917	0.493
DOC_USP7_MATH_1	719	723	PF00917	0.391
DOC_USP7_MATH_1	784	788	PF00917	0.364
DOC_USP7_MATH_1	794	798	PF00917	0.646
DOC_USP7_MATH_1	823	827	PF00917	0.525
DOC_USP7_MATH_1	891	895	PF00917	0.260
DOC_USP7_MATH_1	912	916	PF00917	0.565
DOC_USP7_MATH_1	931	935	PF00917	0.530
DOC_USP7_MATH_1	97	101	PF00917	0.672
DOC_WW_Pin1_4	467	472	PF00397	0.579
DOC_WW_Pin1_4	474	479	PF00397	0.498
DOC_WW_Pin1_4	575	580	PF00397	0.551
DOC_WW_Pin1_4	690	695	PF00397	0.453
DOC_WW_Pin1_4	802	807	PF00397	0.577
DOC_WW_Pin1_4	82	87	PF00397	0.523
DOC_WW_Pin1_4	9	14	PF00397	0.651
DOC_WW_Pin1_4	93	98	PF00397	0.528
LIG_14-3-3_CanoR_1	132	140	PF00244	0.374
LIG_14-3-3_CanoR_1	154	162	PF00244	0.425
LIG_14-3-3_CanoR_1	201	208	PF00244	0.509
LIG_14-3-3_CanoR_1	348	354	PF00244	0.435
LIG_14-3-3_CanoR_1	383	393	PF00244	0.551
LIG_14-3-3_CanoR_1	431	435	PF00244	0.479
LIG_14-3-3_CanoR_1	47	52	PF00244	0.452
LIG_14-3-3_CanoR_1	674	683	PF00244	0.395
LIG_14-3-3_CanoR_1	68	78	PF00244	0.470
LIG_14-3-3_CanoR_1	718	724	PF00244	0.360
LIG_14-3-3_CanoR_1	735	743	PF00244	0.379
LIG_14-3-3_CanoR_1	890	900	PF00244	0.252
LIG_14-3-3_CanoR_1	930	939	PF00244	0.506
LIG_Actin_WH2_2	286	304	PF00022	0.426
LIG_Actin_WH2_2	874	892	PF00022	0.299
LIG_APCC_ABBAyCdc20_2	116	122	PF00400	0.503
LIG_BRCT_BRCA1_1	572	576	PF00533	0.558
LIG_CaM_NSCaTE_8	791	798	PF13499	0.358
LIG_FHA_1	1	7	PF00498	0.597
LIG_FHA_1	102	108	PF00498	0.573
LIG_FHA_1	157	163	PF00498	0.449
LIG_FHA_1	171	177	PF00498	0.476
LIG_FHA_1	576	582	PF00498	0.543
LIG_FHA_1	651	657	PF00498	0.398
LIG_FHA_1	727	733	PF00498	0.441
LIG_FHA_1	773	779	PF00498	0.406
LIG_FHA_1	949	955	PF00498	0.380
LIG_FHA_2	156	162	PF00498	0.373
LIG_FHA_2	29	35	PF00498	0.523
LIG_FHA_2	303	309	PF00498	0.457
LIG_FHA_2	431	437	PF00498	0.560
LIG_FHA_2	534	540	PF00498	0.444
LIG_FHA_2	580	586	PF00498	0.650
LIG_FHA_2	641	647	PF00498	0.613
LIG_FHA_2	729	735	PF00498	0.470
LIG_FHA_2	950	956	PF00498	0.414
LIG_FHA_2	998	1004	PF00498	0.539
LIG_GBD_Chelix_1	335	343	PF00786	0.388
LIG_LIR_Apic_2	573	579	PF02991	0.552
LIG_LIR_Nem_3	320	325	PF02991	0.453
LIG_LIR_Nem_3	749	755	PF02991	0.322
LIG_MAD2	904	912	PF02301	0.409
LIG_NRBOX	124	130	PF00104	0.478
LIG_NRBOX	73	79	PF00104	0.375
LIG_PCNA_PIPBox_1	698	707	PF02747	0.333
LIG_PCNA_yPIPBox_3	67	78	PF02747	0.437
LIG_PCNA_yPIPBox_3	698	711	PF02747	0.450
LIG_PCNA_yPIPBox_3	713	727	PF02747	0.363
LIG_Pex14_2	602	606	PF04695	0.391
LIG_RPA_C_Fungi	390	402	PF08784	0.445
LIG_SH2_CRK	785	789	PF00017	0.430
LIG_SH2_NCK_1	518	522	PF00017	0.331
LIG_SH2_SRC	325	328	PF00017	0.408
LIG_SH2_SRC	518	521	PF00017	0.270
LIG_SH2_SRC	704	707	PF00017	0.321
LIG_SH2_STAP1	615	619	PF00017	0.391
LIG_SH2_STAP1	943	947	PF00017	0.431
LIG_SH2_STAT3	315	318	PF00017	0.445
LIG_SH2_STAT3	366	369	PF00017	0.423
LIG_SH2_STAT5	194	197	PF00017	0.385
LIG_SH2_STAT5	214	217	PF00017	0.250
LIG_SH2_STAT5	230	233	PF00017	0.435
LIG_SH2_STAT5	325	328	PF00017	0.443
LIG_SH2_STAT5	704	707	PF00017	0.429
LIG_SH2_STAT5	785	788	PF00017	0.531
LIG_SH2_STAT5	818	821	PF00017	0.540
LIG_SH2_STAT5	956	959	PF00017	0.327
LIG_SH3_3	150	156	PF00018	0.381
LIG_SH3_3	16	22	PF00018	0.670
LIG_SH3_3	179	185	PF00018	0.480
LIG_SH3_3	616	622	PF00018	0.404
LIG_SH3_3	662	668	PF00018	0.421
LIG_SH3_3	748	754	PF00018	0.369
LIG_SUMO_SIM_anti_2	508	514	PF11976	0.389
LIG_SUMO_SIM_par_1	838	845	PF11976	0.361
LIG_TRAF2_1	329	332	PF00917	0.415
LIG_TRAF2_1	433	436	PF00917	0.439
LIG_TRAF2_1	453	456	PF00917	0.566
LIG_TRAF2_1	659	662	PF00917	0.405
LIG_TYR_ITIM	702	707	PF00017	0.324
LIG_UBA3_1	701	709	PF00899	0.423
LIG_WRC_WIRS_1	897	902	PF05994	0.366
MOD_CK1_1	100	106	PF00069	0.702
MOD_CK1_1	109	115	PF00069	0.489
MOD_CK1_1	224	230	PF00069	0.289
MOD_CK1_1	25	31	PF00069	0.599
MOD_CK1_1	274	280	PF00069	0.682
MOD_CK1_1	442	448	PF00069	0.600
MOD_CK1_1	469	475	PF00069	0.678
MOD_CK1_1	483	489	PF00069	0.509
MOD_CK1_1	553	559	PF00069	0.517
MOD_CK1_1	570	576	PF00069	0.558
MOD_CK1_1	640	646	PF00069	0.584
MOD_CK1_1	651	657	PF00069	0.451
MOD_CK1_1	697	703	PF00069	0.381
MOD_CK1_1	728	734	PF00069	0.428
MOD_CK1_1	801	807	PF00069	0.597
MOD_CK1_1	933	939	PF00069	0.477
MOD_CK1_1	968	974	PF00069	0.439
MOD_CK2_1	155	161	PF00069	0.373
MOD_CK2_1	307	313	PF00069	0.405
MOD_CK2_1	430	436	PF00069	0.432
MOD_CK2_1	640	646	PF00069	0.552
MOD_CK2_1	728	734	PF00069	0.440
MOD_CK2_1	931	937	PF00069	0.454
MOD_GlcNHglycan	108	111	PF01048	0.548
MOD_GlcNHglycan	139	143	PF01048	0.400
MOD_GlcNHglycan	14	17	PF01048	0.531
MOD_GlcNHglycan	243	246	PF01048	0.710
MOD_GlcNHglycan	259	263	PF01048	0.638
MOD_GlcNHglycan	273	276	PF01048	0.578
MOD_GlcNHglycan	387	390	PF01048	0.547
MOD_GlcNHglycan	444	447	PF01048	0.663
MOD_GlcNHglycan	450	453	PF01048	0.694
MOD_GlcNHglycan	471	474	PF01048	0.663
MOD_GlcNHglycan	489	492	PF01048	0.631
MOD_GlcNHglycan	544	547	PF01048	0.424
MOD_GlcNHglycan	552	555	PF01048	0.380
MOD_GlcNHglycan	570	573	PF01048	0.457
MOD_GlcNHglycan	635	638	PF01048	0.456
MOD_GlcNHglycan	738	741	PF01048	0.447
MOD_GlcNHglycan	796	799	PF01048	0.517
MOD_GlcNHglycan	826	829	PF01048	0.471
MOD_GlcNHglycan	847	850	PF01048	0.439
MOD_GlcNHglycan	862	865	PF01048	0.508
MOD_GlcNHglycan	933	936	PF01048	0.541
MOD_GlcNHglycan	961	964	PF01048	0.438
MOD_GSK3_1	106	113	PF00069	0.464
MOD_GSK3_1	134	141	PF00069	0.408
MOD_GSK3_1	156	163	PF00069	0.431
MOD_GSK3_1	235	242	PF00069	0.663
MOD_GSK3_1	34	41	PF00069	0.601
MOD_GSK3_1	344	351	PF00069	0.451
MOD_GSK3_1	417	424	PF00069	0.447
MOD_GSK3_1	438	445	PF00069	0.550
MOD_GSK3_1	456	463	PF00069	0.682
MOD_GSK3_1	483	490	PF00069	0.516
MOD_GSK3_1	5	12	PF00069	0.717
MOD_GSK3_1	552	559	PF00069	0.519
MOD_GSK3_1	567	574	PF00069	0.603
MOD_GSK3_1	575	582	PF00069	0.702
MOD_GSK3_1	629	636	PF00069	0.488
MOD_GSK3_1	650	657	PF00069	0.524
MOD_GSK3_1	669	676	PF00069	0.442
MOD_GSK3_1	690	697	PF00069	0.468
MOD_GSK3_1	742	749	PF00069	0.359
MOD_GSK3_1	794	801	PF00069	0.542
MOD_GSK3_1	891	898	PF00069	0.326
MOD_GSK3_1	912	919	PF00069	0.670
MOD_GSK3_1	925	932	PF00069	0.579
MOD_GSK3_1	93	100	PF00069	0.705
MOD_LATS_1	130	136	PF00433	0.487
MOD_LATS_1	733	739	PF00433	0.354
MOD_N-GLC_1	201	206	PF02516	0.288
MOD_N-GLC_1	239	244	PF02516	0.564
MOD_N-GLC_1	245	250	PF02516	0.556
MOD_N-GLC_1	271	276	PF02516	0.600
MOD_N-GLC_1	772	777	PF02516	0.271
MOD_N-GLC_1	997	1002	PF02516	0.354
MOD_NEK2_1	147	152	PF00069	0.495
MOD_NEK2_1	160	165	PF00069	0.370
MOD_NEK2_1	349	354	PF00069	0.428
MOD_NEK2_1	425	430	PF00069	0.383
MOD_PIKK_1	134	140	PF00454	0.423
MOD_PIKK_1	369	375	PF00454	0.360
MOD_PIKK_1	694	700	PF00454	0.487
MOD_PIKK_1	816	822	PF00454	0.597
MOD_PIKK_1	916	922	PF00454	0.586
MOD_PIKK_1	925	931	PF00454	0.519
MOD_PKA_2	156	162	PF00069	0.482
MOD_PKA_2	234	240	PF00069	0.527
MOD_PKA_2	344	350	PF00069	0.419
MOD_PKA_2	430	436	PF00069	0.475
MOD_PKA_2	673	679	PF00069	0.410
MOD_PKA_2	929	935	PF00069	0.545
MOD_Plk_1	160	166	PF00069	0.433
MOD_Plk_1	302	308	PF00069	0.432
MOD_Plk_1	421	427	PF00069	0.331
MOD_Plk_1	648	654	PF00069	0.492
MOD_Plk_1	965	971	PF00069	0.444
MOD_Plk_1	997	1003	PF00069	0.368
MOD_Plk_4	148	154	PF00069	0.480
MOD_Plk_4	349	355	PF00069	0.517
MOD_Plk_4	421	427	PF00069	0.331
MOD_Plk_4	47	53	PF00069	0.451
MOD_Plk_4	651	657	PF00069	0.467
MOD_Plk_4	697	703	PF00069	0.353
MOD_Plk_4	766	772	PF00069	0.359
MOD_Plk_4	896	902	PF00069	0.415
MOD_ProDKin_1	467	473	PF00069	0.576
MOD_ProDKin_1	474	480	PF00069	0.498
MOD_ProDKin_1	575	581	PF00069	0.549
MOD_ProDKin_1	690	696	PF00069	0.445
MOD_ProDKin_1	802	808	PF00069	0.577
MOD_ProDKin_1	82	88	PF00069	0.521
MOD_ProDKin_1	9	15	PF00069	0.654
MOD_ProDKin_1	93	99	PF00069	0.523
MOD_SUMO_for_1	755	758	PF00179	0.408
MOD_SUMO_rev_2	204	208	PF00179	0.472
MOD_SUMO_rev_2	299	304	PF00179	0.410
TRG_DiLeu_BaEn_3	760	766	PF01217	0.286
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.424
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.320
TRG_ENDOCYTIC_2	518	521	PF00928	0.368
TRG_ENDOCYTIC_2	704	707	PF00928	0.321
TRG_ENDOCYTIC_2	785	788	PF00928	0.418
TRG_ER_diArg_1	210	213	PF00400	0.328
TRG_ER_diArg_1	407	409	PF00400	0.360
TRG_ER_diArg_1	430	432	PF00400	0.413
TRG_ER_diArg_1	710	713	PF00400	0.442
TRG_NLS_MonoExtC_3	708	713	PF00514	0.375
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	878	882	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B9	Leptomonas seymouri	53%	100%
A0A3Q8IP82	Leishmania donovani	99%	100%
A0A422NIU2	Trypanosoma rangeli	26%	100%
A4HF03	Leishmania braziliensis	75%	100%
C9ZRR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AYC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q946	Leishmania major	91%	100%