Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I280_LEIIN

TriTrypDb:

LINF_260019600

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4I280

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I280

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.724
CLV_C14_Caspase3-7	94	98	PF00656	0.400
CLV_PCSK_KEX2_1	313	315	PF00082	0.565
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.565
DEG_SPOP_SBC_1	84	88	PF00917	0.328
DOC_PP4_FxxP_1	64	67	PF00568	0.436
DOC_USP7_MATH_1	282	286	PF00917	0.673
DOC_USP7_MATH_1	293	297	PF00917	0.723
DOC_USP7_MATH_1	84	88	PF00917	0.398
DOC_USP7_MATH_1	96	100	PF00917	0.346
DOC_WW_Pin1_4	149	154	PF00397	0.382
DOC_WW_Pin1_4	299	304	PF00397	0.785
DOC_WW_Pin1_4	73	78	PF00397	0.371
LIG_14-3-3_CanoR_1	18	23	PF00244	0.657
LIG_APCC_ABBA_1	278	283	PF00400	0.719
LIG_BRCT_BRCA1_1	103	107	PF00533	0.320
LIG_BRCT_BRCA1_1	24	28	PF00533	0.621
LIG_FHA_1	165	171	PF00498	0.418
LIG_FHA_1	201	207	PF00498	0.373
LIG_FHA_1	84	90	PF00498	0.322
LIG_FHA_2	2	8	PF00498	0.723
LIG_HCF-1_HBM_1	135	138	PF13415	0.406
LIG_LIR_Apic_2	61	67	PF02991	0.454
LIG_LIR_Gen_1	203	212	PF02991	0.388
LIG_LIR_Gen_1	87	98	PF02991	0.349
LIG_LIR_Nem_3	203	207	PF02991	0.388
LIG_LIR_Nem_3	25	31	PF02991	0.538
LIG_LIR_Nem_3	87	93	PF02991	0.340
LIG_Pex14_2	107	111	PF04695	0.325
LIG_PTB_Apo_2	186	193	PF02174	0.507
LIG_PTB_Phospho_1	186	192	PF10480	0.510
LIG_Rb_LxCxE_1	121	135	PF01857	0.389
LIG_SH2_CRK	150	154	PF00017	0.459
LIG_SH2_GRB2like	53	56	PF00017	0.480
LIG_SH2_NCK_1	150	154	PF00017	0.390
LIG_SH2_PTP2	30	33	PF00017	0.399
LIG_SH2_SRC	53	56	PF00017	0.480
LIG_SH2_STAT5	138	141	PF00017	0.358
LIG_SH2_STAT5	192	195	PF00017	0.485
LIG_SH2_STAT5	30	33	PF00017	0.399
LIG_SH2_STAT5	319	322	PF00017	0.700
LIG_SH2_STAT5	53	56	PF00017	0.480
LIG_SH3_1	150	156	PF00018	0.330
LIG_SH3_3	150	156	PF00018	0.355
MOD_CDK_SPK_2	73	78	PF00069	0.375
MOD_CK1_1	10	16	PF00069	0.744
MOD_CK1_1	151	157	PF00069	0.385
MOD_CK1_1	88	94	PF00069	0.356
MOD_CK2_1	121	127	PF00069	0.389
MOD_GlcNHglycan	145	148	PF01048	0.654
MOD_GlcNHglycan	184	187	PF01048	0.672
MOD_GlcNHglycan	289	292	PF01048	0.569
MOD_GlcNHglycan	43	46	PF01048	0.767
MOD_GlcNHglycan	7	10	PF01048	0.459
MOD_GSK3_1	1	8	PF00069	0.775
MOD_GSK3_1	160	167	PF00069	0.433
MOD_GSK3_1	18	25	PF00069	0.577
MOD_GSK3_1	282	289	PF00069	0.699
MOD_GSK3_1	293	300	PF00069	0.705
MOD_GSK3_1	37	44	PF00069	0.365
MOD_GSK3_1	58	65	PF00069	0.446
MOD_GSK3_1	84	91	PF00069	0.360
MOD_N-GLC_1	101	106	PF02516	0.685
MOD_N-GLC_1	119	124	PF02516	0.544
MOD_N-GLC_1	148	153	PF02516	0.554
MOD_N-GLC_1	182	187	PF02516	0.736
MOD_N-GLC_1	188	193	PF02516	0.697
MOD_N-GLC_1	235	240	PF02516	0.510
MOD_N-GLC_1	272	277	PF02516	0.421
MOD_N-GLC_1	286	291	PF02516	0.522
MOD_N-GLC_1	297	302	PF02516	0.435
MOD_N-GLC_1	48	53	PF02516	0.711
MOD_N-GLC_2	110	112	PF02516	0.562
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	101	106	PF00069	0.464
MOD_NEK2_1	118	123	PF00069	0.376
MOD_NEK2_1	175	180	PF00069	0.500
MOD_NEK2_1	227	232	PF00069	0.698
MOD_NEK2_1	39	44	PF00069	0.523
MOD_NEK2_1	72	77	PF00069	0.333
MOD_NEK2_1	85	90	PF00069	0.337
MOD_NEK2_2	48	53	PF00069	0.487
MOD_OFUCOSY	38	43	PF10250	0.399
MOD_PIKK_1	22	28	PF00454	0.641
MOD_PIKK_1	293	299	PF00454	0.747
MOD_PKA_2	306	312	PF00069	0.709
MOD_PKB_1	16	24	PF00069	0.699
MOD_Plk_1	119	125	PF00069	0.386
MOD_Plk_1	159	165	PF00069	0.402
MOD_Plk_1	188	194	PF00069	0.488
MOD_Plk_1	235	241	PF00069	0.709
MOD_Plk_1	48	54	PF00069	0.494
MOD_Plk_1	96	102	PF00069	0.447
MOD_Plk_4	166	172	PF00069	0.420
MOD_Plk_4	188	194	PF00069	0.498
MOD_Plk_4	235	241	PF00069	0.627
MOD_Plk_4	48	54	PF00069	0.482
MOD_Plk_4	85	91	PF00069	0.362
MOD_Plk_4	96	102	PF00069	0.421
MOD_ProDKin_1	149	155	PF00069	0.379
MOD_ProDKin_1	299	305	PF00069	0.784
MOD_ProDKin_1	73	79	PF00069	0.376
TRG_ENDOCYTIC_2	204	207	PF00928	0.334
TRG_ENDOCYTIC_2	281	284	PF00928	0.763
TRG_ENDOCYTIC_2	30	33	PF00928	0.449
TRG_ENDOCYTIC_2	90	93	PF00928	0.395
TRG_ER_diArg_1	15	18	PF00400	0.752
TRG_NES_CRM1_1	269	283	PF08389	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM62	Leptomonas seymouri	30%	100%
A0A3Q8ICZ0	Leishmania donovani	99%	100%
A4HF01	Leishmania braziliensis	55%	100%
E9AYC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q948	Leishmania major	79%	99%