Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I278_LEIIN

TriTrypDb:

LINF_260019400

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I278

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I278

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	532	536	PF00656	0.571
CLV_C14_Caspase3-7	543	547	PF00656	0.677
CLV_C14_Caspase3-7	679	683	PF00656	0.707
CLV_NRD_NRD_1	134	136	PF00675	0.638
CLV_NRD_NRD_1	17	19	PF00675	0.626
CLV_NRD_NRD_1	483	485	PF00675	0.623
CLV_NRD_NRD_1	586	588	PF00675	0.577
CLV_NRD_NRD_1	691	693	PF00675	0.685
CLV_NRD_NRD_1	751	753	PF00675	0.459
CLV_NRD_NRD_1	92	94	PF00675	0.674
CLV_PCSK_FUR_1	131	135	PF00082	0.660
CLV_PCSK_KEX2_1	131	133	PF00082	0.626
CLV_PCSK_KEX2_1	134	136	PF00082	0.631
CLV_PCSK_KEX2_1	483	485	PF00082	0.623
CLV_PCSK_KEX2_1	691	693	PF00082	0.685
CLV_PCSK_KEX2_1	753	755	PF00082	0.461
CLV_PCSK_KEX2_1	92	94	PF00082	0.668
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.452
CLV_PCSK_SKI1_1	34	38	PF00082	0.453
CLV_PCSK_SKI1_1	361	365	PF00082	0.518
CLV_PCSK_SKI1_1	427	431	PF00082	0.378
CLV_PCSK_SKI1_1	450	454	PF00082	0.468
CLV_PCSK_SKI1_1	473	477	PF00082	0.425
CLV_PCSK_SKI1_1	489	493	PF00082	0.473
CLV_PCSK_SKI1_1	723	727	PF00082	0.419
CLV_PCSK_SKI1_1	736	740	PF00082	0.384
CLV_Separin_Metazoa	724	728	PF03568	0.444
DEG_MDM2_SWIB_1	230	238	PF02201	0.422
DEG_SPOP_SBC_1	347	351	PF00917	0.722
DEG_SPOP_SBC_1	393	397	PF00917	0.672
DOC_CKS1_1	418	423	PF01111	0.498
DOC_CYCLIN_RxL_1	30	38	PF00134	0.466
DOC_CYCLIN_RxL_1	483	496	PF00134	0.465
DOC_MAPK_gen_1	205	215	PF00069	0.420
DOC_MAPK_gen_1	273	282	PF00069	0.699
DOC_MAPK_gen_1	736	744	PF00069	0.448
DOC_MAPK_MEF2A_6	138	146	PF00069	0.629
DOC_MAPK_MEF2A_6	276	284	PF00069	0.645
DOC_MAPK_MEF2A_6	30	39	PF00069	0.624
DOC_MAPK_MEF2A_6	48	57	PF00069	0.304
DOC_MAPK_MEF2A_6	736	744	PF00069	0.500
DOC_PP1_RVXF_1	448	455	PF00149	0.451
DOC_PP2B_LxvP_1	170	173	PF13499	0.737
DOC_PP2B_LxvP_1	310	313	PF13499	0.583
DOC_PP2B_LxvP_1	453	456	PF13499	0.463
DOC_USP7_MATH_1	158	162	PF00917	0.777
DOC_USP7_MATH_1	187	191	PF00917	0.732
DOC_USP7_MATH_1	255	259	PF00917	0.720
DOC_USP7_MATH_1	347	351	PF00917	0.702
DOC_USP7_MATH_1	371	375	PF00917	0.802
DOC_USP7_MATH_1	392	396	PF00917	0.679
DOC_USP7_MATH_1	419	423	PF00917	0.555
DOC_USP7_MATH_1	456	460	PF00917	0.578
DOC_USP7_MATH_1	524	528	PF00917	0.590
DOC_USP7_MATH_1	545	549	PF00917	0.601
DOC_USP7_MATH_1	628	632	PF00917	0.614
DOC_USP7_MATH_1	674	678	PF00917	0.689
DOC_USP7_MATH_1	78	82	PF00917	0.786
DOC_USP7_UBL2_3	30	34	PF12436	0.554
DOC_WW_Pin1_4	161	166	PF00397	0.679
DOC_WW_Pin1_4	342	347	PF00397	0.637
DOC_WW_Pin1_4	407	412	PF00397	0.613
DOC_WW_Pin1_4	417	422	PF00397	0.536
DOC_WW_Pin1_4	473	478	PF00397	0.552
DOC_WW_Pin1_4	587	592	PF00397	0.643
DOC_WW_Pin1_4	610	615	PF00397	0.483
DOC_WW_Pin1_4	626	631	PF00397	0.516
DOC_WW_Pin1_4	672	677	PF00397	0.786
DOC_WW_Pin1_4	68	73	PF00397	0.722
DOC_WW_Pin1_4	92	97	PF00397	0.826
LIG_14-3-3_CanoR_1	103	112	PF00244	0.793
LIG_14-3-3_CanoR_1	223	227	PF00244	0.414
LIG_14-3-3_CanoR_1	359	366	PF00244	0.629
LIG_14-3-3_CanoR_1	427	432	PF00244	0.377
LIG_14-3-3_CanoR_1	52	56	PF00244	0.613
LIG_14-3-3_CanoR_1	587	591	PF00244	0.554
LIG_14-3-3_CanoR_1	727	731	PF00244	0.520
LIG_BIR_III_2	474	478	PF00653	0.487
LIG_BIR_III_2	673	677	PF00653	0.673
LIG_BIR_III_4	115	119	PF00653	0.672
LIG_BIR_III_4	157	161	PF00653	0.707
LIG_BIR_III_4	533	537	PF00653	0.630
LIG_BRCT_BRCA1_1	271	275	PF00533	0.692
LIG_BRCT_BRCA1_1	427	431	PF00533	0.378
LIG_Clathr_ClatBox_1	298	302	PF01394	0.530
LIG_Clathr_ClatBox_1	705	709	PF01394	0.634
LIG_CSL_BTD_1	453	456	PF09270	0.463
LIG_deltaCOP1_diTrp_1	463	470	PF00928	0.429
LIG_EVH1_2	740	744	PF00568	0.543
LIG_FHA_1	279	285	PF00498	0.588
LIG_FHA_1	336	342	PF00498	0.582
LIG_FHA_1	394	400	PF00498	0.759
LIG_FHA_1	412	418	PF00498	0.511
LIG_FHA_1	428	434	PF00498	0.288
LIG_FHA_1	436	442	PF00498	0.404
LIG_FHA_1	494	500	PF00498	0.732
LIG_FHA_1	52	58	PF00498	0.490
LIG_FHA_1	587	593	PF00498	0.518
LIG_FHA_1	667	673	PF00498	0.671
LIG_FHA_2	120	126	PF00498	0.647
LIG_FHA_2	474	480	PF00498	0.431
LIG_FHA_2	530	536	PF00498	0.621
LIG_FHA_2	677	683	PF00498	0.710
LIG_FXI_DFP_1	47	51	PF00024	0.417
LIG_LIR_Apic_2	161	165	PF02991	0.717
LIG_LIR_Apic_2	535	540	PF02991	0.647
LIG_LIR_Gen_1	231	239	PF02991	0.435
LIG_LIR_Gen_1	428	437	PF02991	0.372
LIG_LIR_LC3C_4	235	239	PF02991	0.460
LIG_LIR_Nem_3	231	237	PF02991	0.423
LIG_LIR_Nem_3	613	618	PF02991	0.431
LIG_LIR_Nem_3	68	73	PF02991	0.720
LIG_LIR_Nem_3	743	747	PF02991	0.571
LIG_LIR_Nem_3	95	100	PF02991	0.629
LIG_MYND_1	169	173	PF01753	0.692
LIG_Pex14_1	466	470	PF04695	0.416
LIG_Pex14_2	226	230	PF04695	0.390
LIG_SH2_CRK	70	74	PF00017	0.682
LIG_SH2_NCK_1	618	622	PF00017	0.522
LIG_SH2_NCK_1	70	74	PF00017	0.632
LIG_SH2_STAP1	593	597	PF00017	0.404
LIG_SH2_STAP1	618	622	PF00017	0.522
LIG_SH2_STAT3	766	769	PF00017	0.539
LIG_SH2_STAT5	110	113	PF00017	0.648
LIG_SH2_STAT5	424	427	PF00017	0.388
LIG_SH2_STAT5	581	584	PF00017	0.458
LIG_SH3_1	93	99	PF00018	0.668
LIG_SH3_2	633	638	PF14604	0.597
LIG_SH3_3	170	176	PF00018	0.675
LIG_SH3_3	323	329	PF00018	0.603
LIG_SH3_3	338	344	PF00018	0.687
LIG_SH3_3	627	633	PF00018	0.618
LIG_SH3_3	651	657	PF00018	0.648
LIG_SH3_3	687	693	PF00018	0.715
LIG_SH3_3	93	99	PF00018	0.677
LIG_SH3_4	84	91	PF00018	0.684
LIG_SUMO_SIM_anti_2	211	218	PF11976	0.401
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.426
LIG_SUMO_SIM_anti_2	729	734	PF11976	0.436
LIG_SUMO_SIM_par_1	211	218	PF11976	0.401
LIG_SUMO_SIM_par_1	278	283	PF11976	0.699
LIG_SUMO_SIM_par_1	294	303	PF11976	0.379
LIG_SUMO_SIM_par_1	328	334	PF11976	0.546
LIG_SUMO_SIM_par_1	668	673	PF11976	0.647
LIG_SUMO_SIM_par_1	692	698	PF11976	0.607
LIG_SUMO_SIM_par_1	704	709	PF11976	0.580
LIG_TRAF2_1	317	320	PF00917	0.574
MOD_CDK_SPxK_1	417	423	PF00069	0.514
MOD_CK1_1	161	167	PF00069	0.787
MOD_CK1_1	229	235	PF00069	0.534
MOD_CK1_1	3	9	PF00069	0.626
MOD_CK1_1	331	337	PF00069	0.597
MOD_CK1_1	350	356	PF00069	0.675
MOD_CK1_1	395	401	PF00069	0.638
MOD_CK1_1	410	416	PF00069	0.562
MOD_CK1_1	502	508	PF00069	0.609
MOD_CK1_1	520	526	PF00069	0.693
MOD_CK1_1	652	658	PF00069	0.721
MOD_CK1_1	677	683	PF00069	0.708
MOD_CK1_1	71	77	PF00069	0.764
MOD_CK2_1	119	125	PF00069	0.640
MOD_CK2_1	3	9	PF00069	0.673
MOD_CK2_1	71	77	PF00069	0.715
MOD_CMANNOS	454	457	PF00535	0.462
MOD_GlcNHglycan	139	142	PF01048	0.804
MOD_GlcNHglycan	147	151	PF01048	0.505
MOD_GlcNHglycan	189	192	PF01048	0.696
MOD_GlcNHglycan	2	5	PF01048	0.597
MOD_GlcNHglycan	231	234	PF01048	0.601
MOD_GlcNHglycan	257	260	PF01048	0.726
MOD_GlcNHglycan	294	297	PF01048	0.431
MOD_GlcNHglycan	305	308	PF01048	0.646
MOD_GlcNHglycan	333	336	PF01048	0.618
MOD_GlcNHglycan	350	353	PF01048	0.716
MOD_GlcNHglycan	390	393	PF01048	0.768
MOD_GlcNHglycan	427	430	PF01048	0.381
MOD_GlcNHglycan	496	499	PF01048	0.619
MOD_GlcNHglycan	501	504	PF01048	0.596
MOD_GlcNHglycan	542	545	PF01048	0.587
MOD_GlcNHglycan	546	550	PF01048	0.588
MOD_GSK3_1	101	108	PF00069	0.693
MOD_GSK3_1	119	126	PF00069	0.589
MOD_GSK3_1	161	168	PF00069	0.667
MOD_GSK3_1	222	229	PF00069	0.504
MOD_GSK3_1	331	338	PF00069	0.673
MOD_GSK3_1	342	349	PF00069	0.635
MOD_GSK3_1	371	378	PF00069	0.722
MOD_GSK3_1	388	395	PF00069	0.720
MOD_GSK3_1	407	414	PF00069	0.713
MOD_GSK3_1	487	494	PF00069	0.519
MOD_GSK3_1	520	527	PF00069	0.667
MOD_GSK3_1	582	589	PF00069	0.510
MOD_GSK3_1	634	641	PF00069	0.730
MOD_GSK3_1	668	675	PF00069	0.790
MOD_GSK3_1	678	685	PF00069	0.682
MOD_GSK3_1	88	95	PF00069	0.620
MOD_N-GLC_1	492	497	PF02516	0.492
MOD_N-GLC_1	552	557	PF02516	0.539
MOD_N-GLC_1	682	687	PF02516	0.644
MOD_N-GLC_2	290	292	PF02516	0.388
MOD_N-GLC_2	554	556	PF02516	0.623
MOD_NEK2_1	491	496	PF00069	0.532
MOD_NEK2_1	56	61	PF00069	0.594
MOD_NEK2_1	746	751	PF00069	0.499
MOD_NEK2_2	51	56	PF00069	0.578
MOD_NEK2_2	597	602	PF00069	0.396
MOD_NEK2_2	697	702	PF00069	0.555
MOD_NMyristoyl	1	7	PF02799	0.599
MOD_PIKK_1	103	109	PF00454	0.681
MOD_PIKK_1	260	266	PF00454	0.654
MOD_PIKK_1	380	386	PF00454	0.675
MOD_PIKK_1	435	441	PF00454	0.400
MOD_PIKK_1	712	718	PF00454	0.370
MOD_PKA_2	222	228	PF00069	0.409
MOD_PKA_2	388	394	PF00069	0.752
MOD_PKA_2	51	57	PF00069	0.603
MOD_PKA_2	517	523	PF00069	0.702
MOD_PKA_2	586	592	PF00069	0.554
MOD_PKA_2	726	732	PF00069	0.461
MOD_PKB_1	103	111	PF00069	0.618
MOD_PKB_1	359	367	PF00069	0.517
MOD_Plk_1	644	650	PF00069	0.609
MOD_Plk_1	697	703	PF00069	0.555
MOD_Plk_2-3	668	674	PF00069	0.647
MOD_Plk_4	322	328	PF00069	0.562
MOD_Plk_4	51	57	PF00069	0.594
MOD_Plk_4	604	610	PF00069	0.566
MOD_Plk_4	638	644	PF00069	0.651
MOD_Plk_4	649	655	PF00069	0.770
MOD_ProDKin_1	161	167	PF00069	0.680
MOD_ProDKin_1	342	348	PF00069	0.636
MOD_ProDKin_1	407	413	PF00069	0.609
MOD_ProDKin_1	417	423	PF00069	0.524
MOD_ProDKin_1	473	479	PF00069	0.546
MOD_ProDKin_1	587	593	PF00069	0.636
MOD_ProDKin_1	610	616	PF00069	0.484
MOD_ProDKin_1	626	632	PF00069	0.527
MOD_ProDKin_1	672	678	PF00069	0.785
MOD_ProDKin_1	68	74	PF00069	0.725
MOD_ProDKin_1	92	98	PF00069	0.825
MOD_SUMO_rev_2	583	590	PF00179	0.501
TRG_DiLeu_BaEn_1	211	216	PF01217	0.345
TRG_DiLeu_BaEn_1	649	654	PF01217	0.626
TRG_DiLeu_BaEn_3	756	762	PF01217	0.377
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.692
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.559
TRG_ENDOCYTIC_2	70	73	PF00928	0.678
TRG_ER_diArg_1	102	105	PF00400	0.681
TRG_ER_diArg_1	131	134	PF00400	0.622
TRG_ER_diArg_1	690	692	PF00400	0.683
TRG_ER_diArg_1	751	754	PF00400	0.511
TRG_ER_diLys_1	778	782	PF00400	0.624
TRG_NLS_MonoExtN_4	15	22	PF00514	0.622
TRG_NLS_MonoExtN_4	270	277	PF00514	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P8	Leptomonas seymouri	41%	99%
A0A3Q8IFV9	Leishmania donovani	100%	100%
A4HEZ9	Leishmania braziliensis	63%	99%
E9AYC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q950	Leishmania major	89%	100%