Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I274_LEIIN

TriTrypDb:

LINF_260023900

Length:

548

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 2 (POMP2) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	9
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4I274

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I274

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.587
CLV_MEL_PAP_1	257	263	PF00089	0.579
CLV_NRD_NRD_1	158	160	PF00675	0.766
CLV_NRD_NRD_1	339	341	PF00675	0.613
CLV_NRD_NRD_1	391	393	PF00675	0.537
CLV_PCSK_KEX2_1	325	327	PF00082	0.572
CLV_PCSK_KEX2_1	374	376	PF00082	0.671
CLV_PCSK_KEX2_1	393	395	PF00082	0.409
CLV_PCSK_KEX2_1	504	506	PF00082	0.784
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.573
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.678
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.426
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.784
CLV_PCSK_SKI1_1	152	156	PF00082	0.727
CLV_PCSK_SKI1_1	209	213	PF00082	0.688
CLV_PCSK_SKI1_1	223	227	PF00082	0.550
CLV_PCSK_SKI1_1	341	345	PF00082	0.610
CLV_PCSK_SKI1_1	366	370	PF00082	0.520
DEG_APCC_DBOX_1	393	401	PF00400	0.318
DOC_CKS1_1	32	37	PF01111	0.543
DOC_CKS1_1	491	496	PF01111	0.460
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.459
DOC_MAPK_DCC_7	247	257	PF00069	0.352
DOC_MAPK_gen_1	159	166	PF00069	0.569
DOC_MAPK_gen_1	337	346	PF00069	0.339
DOC_MAPK_JIP1_4	160	166	PF00069	0.566
DOC_MAPK_MEF2A_6	249	257	PF00069	0.352
DOC_MAPK_RevD_3	530	546	PF00069	0.419
DOC_PP2B_LxvP_1	275	278	PF13499	0.419
DOC_PP2B_LxvP_1	4	7	PF13499	0.590
DOC_PP2B_PxIxI_1	252	258	PF00149	0.356
DOC_PP4_FxxP_1	240	243	PF00568	0.333
DOC_SPAK_OSR1_1	427	431	PF12202	0.293
DOC_USP7_MATH_1	102	106	PF00917	0.580
DOC_USP7_MATH_1	150	154	PF00917	0.488
DOC_USP7_MATH_1	17	21	PF00917	0.611
DOC_USP7_MATH_1	22	26	PF00917	0.610
DOC_USP7_MATH_1	309	313	PF00917	0.388
DOC_USP7_MATH_1	36	40	PF00917	0.595
DOC_USP7_MATH_1	456	460	PF00917	0.368
DOC_USP7_MATH_1	513	517	PF00917	0.561
DOC_USP7_MATH_1	533	537	PF00917	0.483
DOC_USP7_UBL2_3	205	209	PF12436	0.511
DOC_WW_Pin1_4	132	137	PF00397	0.552
DOC_WW_Pin1_4	138	143	PF00397	0.478
DOC_WW_Pin1_4	235	240	PF00397	0.357
DOC_WW_Pin1_4	27	32	PF00397	0.556
DOC_WW_Pin1_4	490	495	PF00397	0.459
DOC_WW_Pin1_4	523	528	PF00397	0.233
LIG_14-3-3_CanoR_1	159	165	PF00244	0.566
LIG_14-3-3_CanoR_1	483	491	PF00244	0.555
LIG_14-3-3_CanoR_1	505	510	PF00244	0.551
LIG_Actin_WH2_2	361	376	PF00022	0.418
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.432
LIG_FHA_1	161	167	PF00498	0.533
LIG_FHA_1	367	373	PF00498	0.323
LIG_FHA_1	382	388	PF00498	0.326
LIG_FHA_1	524	530	PF00498	0.346
LIG_FHA_1	536	542	PF00498	0.346
LIG_FHA_2	57	63	PF00498	0.497
LIG_GBD_Chelix_1	364	372	PF00786	0.598
LIG_LIR_Apic_2	238	243	PF02991	0.334
LIG_LIR_Gen_1	302	311	PF02991	0.315
LIG_LIR_Gen_1	402	411	PF02991	0.321
LIG_LIR_Gen_1	449	458	PF02991	0.445
LIG_LIR_Gen_1	520	530	PF02991	0.381
LIG_LIR_Nem_3	302	306	PF02991	0.305
LIG_LIR_Nem_3	323	327	PF02991	0.417
LIG_LIR_Nem_3	396	401	PF02991	0.326
LIG_LIR_Nem_3	402	407	PF02991	0.296
LIG_LIR_Nem_3	449	455	PF02991	0.394
LIG_LIR_Nem_3	520	525	PF02991	0.512
LIG_LIR_Nem_3	75	81	PF02991	0.386
LIG_Pex14_1	74	78	PF04695	0.384
LIG_Pex14_2	299	303	PF04695	0.312
LIG_Pex14_2	404	408	PF04695	0.307
LIG_Rb_pABgroove_1	395	403	PF01858	0.313
LIG_SH2_CRK	327	331	PF00017	0.321
LIG_SH2_GRB2like	147	150	PF00017	0.529
LIG_SH2_NCK_1	327	331	PF00017	0.327
LIG_SH2_SRC	147	150	PF00017	0.529
LIG_SH2_SRC	53	56	PF00017	0.498
LIG_SH2_STAP1	147	151	PF00017	0.540
LIG_SH2_STAP1	301	305	PF00017	0.382
LIG_SH2_STAP1	360	364	PF00017	0.370
LIG_SH2_STAP1	401	405	PF00017	0.387
LIG_SH2_STAT5	331	334	PF00017	0.301
LIG_SH2_STAT5	53	56	PF00017	0.467
LIG_SH3_3	10	16	PF00018	0.577
LIG_SUMO_SIM_anti_2	538	543	PF11976	0.451
LIG_SUMO_SIM_par_1	442	449	PF11976	0.441
LIG_TYR_ITIM	329	334	PF00017	0.345
MOD_CK1_1	168	174	PF00069	0.518
MOD_CK1_1	39	45	PF00069	0.544
MOD_CK1_1	423	429	PF00069	0.359
MOD_CK1_1	56	62	PF00069	0.501
MOD_CK2_1	22	28	PF00069	0.607
MOD_CK2_1	351	357	PF00069	0.434
MOD_CK2_1	383	389	PF00069	0.431
MOD_GlcNHglycan	105	108	PF01048	0.768
MOD_GlcNHglycan	109	112	PF01048	0.768
MOD_GlcNHglycan	152	155	PF01048	0.698
MOD_GlcNHglycan	19	22	PF01048	0.750
MOD_GlcNHglycan	24	27	PF01048	0.747
MOD_GlcNHglycan	263	266	PF01048	0.653
MOD_GlcNHglycan	311	314	PF01048	0.518
MOD_GlcNHglycan	38	41	PF01048	0.719
MOD_GlcNHglycan	422	425	PF01048	0.577
MOD_GlcNHglycan	469	472	PF01048	0.734
MOD_GlcNHglycan	515	518	PF01048	0.730
MOD_GlcNHglycan	535	538	PF01048	0.150
MOD_GSK3_1	103	110	PF00069	0.557
MOD_GSK3_1	128	135	PF00069	0.542
MOD_GSK3_1	189	196	PF00069	0.549
MOD_GSK3_1	27	34	PF00069	0.545
MOD_GSK3_1	403	410	PF00069	0.387
MOD_GSK3_1	416	423	PF00069	0.367
MOD_GSK3_1	49	56	PF00069	0.514
MOD_GSK3_1	513	520	PF00069	0.536
MOD_LATS_1	207	213	PF00433	0.544
MOD_NEK2_1	126	131	PF00069	0.532
MOD_NEK2_1	195	200	PF00069	0.552
MOD_NEK2_1	233	238	PF00069	0.373
MOD_NEK2_1	261	266	PF00069	0.443
MOD_NEK2_1	381	386	PF00069	0.415
MOD_NEK2_1	521	526	PF00069	0.437
MOD_NEK2_1	82	87	PF00069	0.482
MOD_NEK2_2	403	408	PF00069	0.358
MOD_PIKK_1	218	224	PF00454	0.478
MOD_PIKK_1	483	489	PF00454	0.509
MOD_PKA_1	159	165	PF00069	0.529
MOD_PKA_1	209	215	PF00069	0.465
MOD_PKA_1	504	510	PF00069	0.580
MOD_PKA_2	504	510	PF00069	0.580
MOD_Plk_1	189	195	PF00069	0.543
MOD_Plk_1	456	462	PF00069	0.446
MOD_Plk_2-3	383	389	PF00069	0.434
MOD_Plk_4	383	389	PF00069	0.355
MOD_Plk_4	403	409	PF00069	0.181
MOD_Plk_4	49	55	PF00069	0.484
MOD_Plk_4	517	523	PF00069	0.511
MOD_ProDKin_1	132	138	PF00069	0.552
MOD_ProDKin_1	235	241	PF00069	0.350
MOD_ProDKin_1	27	33	PF00069	0.555
MOD_ProDKin_1	490	496	PF00069	0.460
MOD_ProDKin_1	523	529	PF00069	0.233
MOD_SUMO_rev_2	73	81	PF00179	0.445
TRG_DiLeu_BaEn_1	77	82	PF01217	0.455
TRG_ENDOCYTIC_2	331	334	PF00928	0.348
TRG_ENDOCYTIC_2	401	404	PF00928	0.336
TRG_ER_diArg_1	283	286	PF00400	0.368
TRG_ER_diArg_1	391	394	PF00400	0.347
TRG_ER_diLys_1	545	548	PF00400	0.709
TRG_NES_CRM1_1	295	308	PF08389	0.388
TRG_NES_CRM1_1	377	389	PF08389	0.398
TRG_NES_CRM1_1	453	464	PF08389	0.471
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.755
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.717
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG5	Leptomonas seymouri	64%	96%
A0A0S4IT25	Bodo saltans	45%	80%
A0A1X0P7G8	Trypanosomatidae	45%	88%
A0A3Q8IDW3	Leishmania donovani	100%	100%
A0A422NQN2	Trypanosoma rangeli	47%	91%
A4HF31	Leishmania braziliensis	88%	100%
C9ZX99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	90%
E9AYG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
Q4Q906	Leishmania major	96%	100%