DUF4460 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4460) - putative

Species:

Leishmania infantum

UniProt:

A4I272_LEIIN

TriTrypDb:

LINF_260024100

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I272

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I272

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.454
CLV_C14_Caspase3-7	245	249	PF00656	0.517
CLV_C14_Caspase3-7	96	100	PF00656	0.538
CLV_NRD_NRD_1	177	179	PF00675	0.367
CLV_NRD_NRD_1	199	201	PF00675	0.518
CLV_NRD_NRD_1	208	210	PF00675	0.512
CLV_NRD_NRD_1	428	430	PF00675	0.384
CLV_NRD_NRD_1	507	509	PF00675	0.532
CLV_NRD_NRD_1	547	549	PF00675	0.522
CLV_NRD_NRD_1	579	581	PF00675	0.740
CLV_NRD_NRD_1	64	66	PF00675	0.481
CLV_NRD_NRD_1	699	701	PF00675	0.576
CLV_PCSK_FUR_1	206	210	PF00082	0.581
CLV_PCSK_KEX2_1	109	111	PF00082	0.649
CLV_PCSK_KEX2_1	177	179	PF00082	0.381
CLV_PCSK_KEX2_1	199	201	PF00082	0.510
CLV_PCSK_KEX2_1	206	208	PF00082	0.506
CLV_PCSK_KEX2_1	507	509	PF00082	0.462
CLV_PCSK_KEX2_1	547	549	PF00082	0.517
CLV_PCSK_KEX2_1	579	581	PF00082	0.740
CLV_PCSK_KEX2_1	64	66	PF00082	0.506
CLV_PCSK_KEX2_1	699	701	PF00082	0.576
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.695
CLV_PCSK_PC7_1	173	179	PF00082	0.358
CLV_PCSK_SKI1_1	173	177	PF00082	0.337
CLV_PCSK_SKI1_1	200	204	PF00082	0.612
CLV_PCSK_SKI1_1	221	225	PF00082	0.393
CLV_PCSK_SKI1_1	3	7	PF00082	0.277
CLV_PCSK_SKI1_1	375	379	PF00082	0.358
CLV_PCSK_SKI1_1	393	397	PF00082	0.443
CLV_PCSK_SKI1_1	43	47	PF00082	0.303
CLV_PCSK_SKI1_1	436	440	PF00082	0.387
CLV_PCSK_SKI1_1	476	480	PF00082	0.333
CLV_PCSK_SKI1_1	530	534	PF00082	0.572
CLV_PCSK_SKI1_1	537	541	PF00082	0.572
CLV_PCSK_SKI1_1	580	584	PF00082	0.551
CLV_PCSK_SKI1_1	684	688	PF00082	0.462
CLV_PCSK_SKI1_1	727	731	PF00082	0.631
DEG_APCC_DBOX_1	270	278	PF00400	0.390
DEG_APCC_DBOX_1	414	422	PF00400	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.360
DOC_CDC14_PxL_1	237	245	PF14671	0.450
DOC_CYCLIN_RxL_1	575	585	PF00134	0.548
DOC_CYCLIN_RxL_1	678	689	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.583
DOC_MAPK_MEF2A_6	397	406	PF00069	0.479
DOC_PP1_RVXF_1	469	475	PF00149	0.337
DOC_PP2B_LxvP_1	303	306	PF13499	0.358
DOC_PP2B_LxvP_1	50	53	PF13499	0.385
DOC_PP2B_LxvP_1	510	513	PF13499	0.430
DOC_PP4_FxxP_1	148	151	PF00568	0.404
DOC_USP7_MATH_1	102	106	PF00917	0.598
DOC_USP7_MATH_1	119	123	PF00917	0.701
DOC_USP7_MATH_1	156	160	PF00917	0.566
DOC_USP7_MATH_1	54	58	PF00917	0.455
DOC_USP7_MATH_1	79	83	PF00917	0.713
DOC_USP7_MATH_1	88	92	PF00917	0.758
DOC_USP7_UBL2_3	217	221	PF12436	0.617
DOC_USP7_UBL2_3	533	537	PF12436	0.563
DOC_WW_Pin1_4	130	135	PF00397	0.636
DOC_WW_Pin1_4	256	261	PF00397	0.372
DOC_WW_Pin1_4	495	500	PF00397	0.428
DOC_WW_Pin1_4	603	608	PF00397	0.521
LIG_14-3-3_CanoR_1	271	275	PF00244	0.515
LIG_14-3-3_CanoR_1	409	417	PF00244	0.378
LIG_14-3-3_CanoR_1	429	435	PF00244	0.241
LIG_14-3-3_CanoR_1	542	549	PF00244	0.592
LIG_14-3-3_CanoR_1	555	563	PF00244	0.592
LIG_14-3-3_CanoR_1	603	607	PF00244	0.550
LIG_14-3-3_CanoR_1	627	635	PF00244	0.577
LIG_APCC_ABBA_1	11	16	PF00400	0.274
LIG_BRCT_BRCA1_1	56	60	PF00533	0.448
LIG_BRCT_BRCA1_1	697	701	PF00533	0.573
LIG_deltaCOP1_diTrp_1	116	124	PF00928	0.635
LIG_deltaCOP1_diTrp_1	489	495	PF00928	0.402
LIG_FHA_1	139	145	PF00498	0.459
LIG_FHA_1	298	304	PF00498	0.349
LIG_FHA_1	385	391	PF00498	0.359
LIG_FHA_1	409	415	PF00498	0.510
LIG_FHA_1	492	498	PF00498	0.341
LIG_FHA_1	556	562	PF00498	0.414
LIG_FHA_1	659	665	PF00498	0.580
LIG_FHA_1	668	674	PF00498	0.561
LIG_FHA_2	220	226	PF00498	0.531
LIG_FHA_2	240	246	PF00498	0.235
LIG_FHA_2	335	341	PF00498	0.434
LIG_FHA_2	346	352	PF00498	0.394
LIG_FHA_2	408	414	PF00498	0.366
LIG_FHA_2	612	618	PF00498	0.637
LIG_FHA_2	637	643	PF00498	0.569
LIG_LIR_Apic_2	146	151	PF02991	0.386
LIG_LIR_Apic_2	648	654	PF02991	0.551
LIG_LIR_Gen_1	280	289	PF02991	0.395
LIG_LIR_Gen_1	308	317	PF02991	0.470
LIG_LIR_Gen_1	489	497	PF02991	0.386
LIG_LIR_Gen_1	702	710	PF02991	0.526
LIG_LIR_Nem_3	308	312	PF02991	0.433
LIG_LIR_Nem_3	489	493	PF02991	0.380
LIG_LIR_Nem_3	57	63	PF02991	0.459
LIG_MYND_3	240	244	PF01753	0.446
LIG_NRBOX	171	177	PF00104	0.333
LIG_NRBOX	34	40	PF00104	0.274
LIG_Pex14_1	41	45	PF04695	0.274
LIG_Pex14_1	647	651	PF04695	0.498
LIG_REV1ctd_RIR_1	7	14	PF16727	0.274
LIG_SH2_SRC	651	654	PF00017	0.542
LIG_SH2_STAP1	468	472	PF00017	0.345
LIG_SH2_STAT3	655	658	PF00017	0.570
LIG_SH2_STAT5	524	527	PF00017	0.377
LIG_SH2_STAT5	655	658	PF00017	0.589
LIG_SH3_3	583	589	PF00018	0.655
LIG_SH3_3	622	628	PF00018	0.563
LIG_SUMO_SIM_par_1	138	147	PF11976	0.584
LIG_SUMO_SIM_par_1	283	291	PF11976	0.364
LIG_SUMO_SIM_par_1	400	405	PF11976	0.406
LIG_SUMO_SIM_par_1	621	626	PF11976	0.594
LIG_TRAF2_1	242	245	PF00917	0.428
LIG_TRAF2_1	410	413	PF00917	0.390
LIG_TRAF2_1	550	553	PF00917	0.561
LIG_TRFH_1	495	499	PF08558	0.337
MOD_CDK_SPxxK_3	130	137	PF00069	0.524
MOD_CK1_1	239	245	PF00069	0.478
MOD_CK1_1	407	413	PF00069	0.458
MOD_CK1_1	566	572	PF00069	0.455
MOD_CK2_1	143	149	PF00069	0.392
MOD_CK2_1	181	187	PF00069	0.407
MOD_CK2_1	239	245	PF00069	0.383
MOD_CK2_1	270	276	PF00069	0.508
MOD_CK2_1	334	340	PF00069	0.405
MOD_CK2_1	345	351	PF00069	0.393
MOD_CK2_1	357	363	PF00069	0.407
MOD_CK2_1	407	413	PF00069	0.376
MOD_CK2_1	528	534	PF00069	0.557
MOD_CK2_1	547	553	PF00069	0.564
MOD_CK2_1	611	617	PF00069	0.631
MOD_CK2_1	634	640	PF00069	0.509
MOD_CK2_1	88	94	PF00069	0.820
MOD_Cter_Amidation	694	697	PF01082	0.490
MOD_GlcNHglycan	120	124	PF01048	0.743
MOD_GlcNHglycan	125	129	PF01048	0.738
MOD_GlcNHglycan	217	220	PF01048	0.682
MOD_GlcNHglycan	263	266	PF01048	0.339
MOD_GlcNHglycan	530	533	PF01048	0.489
MOD_GlcNHglycan	543	546	PF01048	0.418
MOD_GlcNHglycan	81	84	PF01048	0.659
MOD_GlcNHglycan	90	93	PF01048	0.713
MOD_GSK3_1	181	188	PF00069	0.434
MOD_GSK3_1	215	222	PF00069	0.547
MOD_GSK3_1	225	232	PF00069	0.320
MOD_GSK3_1	235	242	PF00069	0.271
MOD_GSK3_1	266	273	PF00069	0.465
MOD_GSK3_1	297	304	PF00069	0.427
MOD_GSK3_1	404	411	PF00069	0.403
MOD_GSK3_1	491	498	PF00069	0.413
MOD_GSK3_1	54	61	PF00069	0.422
MOD_GSK3_1	627	634	PF00069	0.601
MOD_GSK3_1	667	674	PF00069	0.534
MOD_GSK3_1	75	82	PF00069	0.644
MOD_GSK3_1	83	90	PF00069	0.619
MOD_N-GLC_1	384	389	PF02516	0.376
MOD_N-GLC_2	464	466	PF02516	0.445
MOD_NEK2_1	124	129	PF00069	0.784
MOD_NEK2_1	143	148	PF00069	0.254
MOD_NEK2_1	233	238	PF00069	0.451
MOD_NEK2_1	254	259	PF00069	0.441
MOD_NEK2_1	261	266	PF00069	0.426
MOD_NEK2_1	270	275	PF00069	0.462
MOD_NEK2_1	355	360	PF00069	0.232
MOD_NEK2_1	438	443	PF00069	0.342
MOD_NEK2_1	541	546	PF00069	0.425
MOD_NEK2_1	667	672	PF00069	0.513
MOD_NEK2_1	690	695	PF00069	0.567
MOD_NEK2_2	102	107	PF00069	0.607
MOD_NEK2_2	266	271	PF00069	0.359
MOD_PIKK_1	136	142	PF00454	0.578
MOD_PK_1	430	436	PF00069	0.376
MOD_PKA_1	547	553	PF00069	0.578
MOD_PKA_2	136	142	PF00069	0.469
MOD_PKA_2	270	276	PF00069	0.510
MOD_PKA_2	408	414	PF00069	0.355
MOD_PKA_2	541	547	PF00069	0.593
MOD_PKA_2	602	608	PF00069	0.533
MOD_PKA_2	671	677	PF00069	0.641
MOD_PKA_2	83	89	PF00069	0.772
MOD_Plk_1	164	170	PF00069	0.480
MOD_Plk_1	307	313	PF00069	0.510
MOD_Plk_1	384	390	PF00069	0.348
MOD_Plk_1	404	410	PF00069	0.488
MOD_Plk_1	439	445	PF00069	0.344
MOD_Plk_1	464	470	PF00069	0.377
MOD_Plk_1	491	497	PF00069	0.327
MOD_Plk_2-3	187	193	PF00069	0.434
MOD_Plk_2-3	621	627	PF00069	0.576
MOD_Plk_4	102	108	PF00069	0.720
MOD_Plk_4	138	144	PF00069	0.468
MOD_Plk_4	219	225	PF00069	0.413
MOD_Plk_4	439	445	PF00069	0.344
MOD_ProDKin_1	130	136	PF00069	0.632
MOD_ProDKin_1	256	262	PF00069	0.366
MOD_ProDKin_1	495	501	PF00069	0.435
MOD_ProDKin_1	603	609	PF00069	0.522
MOD_SUMO_for_1	645	648	PF00179	0.501
TRG_DiLeu_BaEn_1	338	343	PF01217	0.468
TRG_DiLeu_BaEn_1	492	497	PF01217	0.463
TRG_DiLeu_BaEn_1	536	541	PF01217	0.542
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.497
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.463
TRG_ENDOCYTIC_2	63	66	PF00928	0.525
TRG_ENDOCYTIC_2	703	706	PF00928	0.540
TRG_ER_diArg_1	176	178	PF00400	0.378
TRG_ER_diArg_1	205	208	PF00400	0.557
TRG_ER_diArg_1	546	548	PF00400	0.555
TRG_ER_diArg_1	63	65	PF00400	0.517
TRG_ER_diArg_1	699	701	PF00400	0.567
TRG_NES_CRM1_1	180	194	PF08389	0.485
TRG_NES_CRM1_1	340	354	PF08389	0.332
TRG_NES_CRM1_1	416	428	PF08389	0.478
TRG_NLS_Bipartite_1	684	700	PF00514	0.495
TRG_NLS_MonoExtC_3	695	700	PF00514	0.521
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB5	Leptomonas seymouri	77%	100%
A0A0S4IT81	Bodo saltans	50%	100%
A0A1X0P7G1	Trypanosomatidae	58%	100%
A0A3R7MTD0	Trypanosoma rangeli	58%	100%
A0A3S7WZZ9	Leishmania donovani	99%	100%
A4HF33	Leishmania braziliensis	87%	99%
C9ZX97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AYG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q904	Leishmania major	97%	100%
V5DB85	Trypanosoma cruzi	58%	100%