Guanine nucleotide-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanine nucleotide-binding protein-like protein

Species:

Leishmania infantum

UniProt:

A4I266_LEIIN

TriTrypDb:

LINF_260018700

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I266

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I266

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.689
CLV_C14_Caspase3-7	228	232	PF00656	0.667
CLV_C14_Caspase3-7	323	327	PF00656	0.850
CLV_C14_Caspase3-7	366	370	PF00656	0.593
CLV_C14_Caspase3-7	635	639	PF00656	0.604
CLV_C14_Caspase3-7	761	765	PF00656	0.549
CLV_NRD_NRD_1	114	116	PF00675	0.710
CLV_NRD_NRD_1	145	147	PF00675	0.539
CLV_NRD_NRD_1	18	20	PF00675	0.658
CLV_NRD_NRD_1	219	221	PF00675	0.683
CLV_NRD_NRD_1	430	432	PF00675	0.595
CLV_NRD_NRD_1	450	452	PF00675	0.241
CLV_NRD_NRD_1	524	526	PF00675	0.605
CLV_NRD_NRD_1	528	530	PF00675	0.629
CLV_NRD_NRD_1	595	597	PF00675	0.587
CLV_NRD_NRD_1	616	618	PF00675	0.475
CLV_NRD_NRD_1	673	675	PF00675	0.778
CLV_NRD_NRD_1	70	72	PF00675	0.682
CLV_NRD_NRD_1	74	76	PF00675	0.678
CLV_NRD_NRD_1	83	85	PF00675	0.728
CLV_PCSK_FUR_1	68	72	PF00082	0.684
CLV_PCSK_KEX2_1	114	116	PF00082	0.710
CLV_PCSK_KEX2_1	16	18	PF00082	0.650
CLV_PCSK_KEX2_1	191	193	PF00082	0.836
CLV_PCSK_KEX2_1	20	22	PF00082	0.651
CLV_PCSK_KEX2_1	218	220	PF00082	0.768
CLV_PCSK_KEX2_1	359	361	PF00082	0.469
CLV_PCSK_KEX2_1	450	452	PF00082	0.358
CLV_PCSK_KEX2_1	524	526	PF00082	0.652
CLV_PCSK_KEX2_1	595	597	PF00082	0.587
CLV_PCSK_KEX2_1	616	618	PF00082	0.475
CLV_PCSK_KEX2_1	668	670	PF00082	0.707
CLV_PCSK_KEX2_1	673	675	PF00082	0.735
CLV_PCSK_KEX2_1	70	72	PF00082	0.684
CLV_PCSK_KEX2_1	73	75	PF00082	0.688
CLV_PCSK_KEX2_1	837	839	PF00082	0.478
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.650
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.758
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.651
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.434
CLV_PCSK_PC1ET2_1	668	670	PF00082	0.707
CLV_PCSK_PC1ET2_1	837	839	PF00082	0.478
CLV_PCSK_PC7_1	669	675	PF00082	0.703
CLV_PCSK_PC7_1	70	76	PF00082	0.662
CLV_PCSK_SKI1_1	132	136	PF00082	0.545
CLV_PCSK_SKI1_1	209	213	PF00082	0.627
CLV_PCSK_SKI1_1	454	458	PF00082	0.362
CLV_PCSK_SKI1_1	498	502	PF00082	0.491
CLV_PCSK_SKI1_1	777	781	PF00082	0.285
CLV_PCSK_SKI1_1	838	842	PF00082	0.458
CLV_PCSK_SKI1_1	846	850	PF00082	0.445
CLV_PCSK_SKI1_1	866	870	PF00082	0.326
CLV_PCSK_SKI1_1	898	902	PF00082	0.582
DEG_APCC_DBOX_1	776	784	PF00400	0.286
DEG_APCC_KENBOX_2	76	80	PF00400	0.576
DEG_SCF_FBW7_1	740	747	PF00400	0.546
DEG_SCF_TRCP1_1	692	698	PF00400	0.838
DEG_SPOP_SBC_1	236	240	PF00917	0.661
DEG_SPOP_SBC_1	640	644	PF00917	0.744
DOC_ANK_TNKS_1	555	562	PF00023	0.640
DOC_MAPK_FxFP_2	171	174	PF00069	0.639
DOC_MAPK_gen_1	428	437	PF00069	0.573
DOC_MAPK_gen_1	539	547	PF00069	0.657
DOC_MAPK_gen_1	595	603	PF00069	0.584
DOC_MAPK_gen_1	836	842	PF00069	0.461
DOC_MAPK_gen_1	843	851	PF00069	0.438
DOC_MAPK_gen_1	885	894	PF00069	0.484
DOC_MAPK_MEF2A_6	428	437	PF00069	0.471
DOC_MAPK_MEF2A_6	885	894	PF00069	0.484
DOC_PP2B_LxvP_1	768	771	PF13499	0.446
DOC_PP4_FxxP_1	171	174	PF00568	0.639
DOC_PP4_FxxP_1	773	776	PF00568	0.481
DOC_PP4_FxxP_1	870	873	PF00568	0.546
DOC_USP7_MATH_1	182	186	PF00917	0.747
DOC_USP7_MATH_1	257	261	PF00917	0.716
DOC_USP7_MATH_1	264	268	PF00917	0.752
DOC_USP7_MATH_1	639	643	PF00917	0.722
DOC_USP7_MATH_1	648	652	PF00917	0.696
DOC_USP7_MATH_1	754	758	PF00917	0.536
DOC_USP7_MATH_1	794	798	PF00917	0.562
DOC_USP7_UBL2_3	16	20	PF12436	0.608
DOC_USP7_UBL2_3	428	432	PF12436	0.496
DOC_USP7_UBL2_3	527	531	PF12436	0.776
DOC_USP7_UBL2_3	664	668	PF12436	0.660
DOC_WW_Pin1_4	296	301	PF00397	0.800
DOC_WW_Pin1_4	641	646	PF00397	0.804
DOC_WW_Pin1_4	706	711	PF00397	0.630
DOC_WW_Pin1_4	740	745	PF00397	0.545
DOC_WW_Pin1_4	762	767	PF00397	0.549
LIG_14-3-3_CanoR_1	114	118	PF00244	0.830
LIG_14-3-3_CanoR_1	146	152	PF00244	0.522
LIG_14-3-3_CanoR_1	157	161	PF00244	0.560
LIG_14-3-3_CanoR_1	360	364	PF00244	0.369
LIG_14-3-3_CanoR_1	502	510	PF00244	0.538
LIG_14-3-3_CanoR_1	544	548	PF00244	0.657
LIG_14-3-3_CanoR_1	623	629	PF00244	0.650
LIG_APCC_ABBA_1	361	366	PF00400	0.579
LIG_APCC_ABBAyCdc20_2	360	366	PF00400	0.584
LIG_BIR_III_2	369	373	PF00653	0.509
LIG_BIR_III_2	638	642	PF00653	0.608
LIG_BIR_III_4	231	235	PF00653	0.761
LIG_BRCT_BRCA1_1	237	241	PF00533	0.618
LIG_Clathr_ClatBox_1	377	381	PF01394	0.522
LIG_deltaCOP1_diTrp_1	169	173	PF00928	0.616
LIG_deltaCOP1_diTrp_1	390	396	PF00928	0.464
LIG_FHA_1	363	369	PF00498	0.577
LIG_FHA_1	396	402	PF00498	0.461
LIG_FHA_1	540	546	PF00498	0.737
LIG_FHA_1	607	613	PF00498	0.494
LIG_FHA_1	629	635	PF00498	0.794
LIG_FHA_1	647	653	PF00498	0.593
LIG_FHA_1	733	739	PF00498	0.546
LIG_FHA_1	750	756	PF00498	0.546
LIG_FHA_1	783	789	PF00498	0.506
LIG_FHA_2	759	765	PF00498	0.546
LIG_GBD_Chelix_1	604	612	PF00786	0.622
LIG_HCF-1_HBM_1	534	537	PF13415	0.620
LIG_LIR_Apic_2	169	174	PF02991	0.623
LIG_LIR_Apic_2	369	374	PF02991	0.514
LIG_LIR_Gen_1	390	399	PF02991	0.460
LIG_LIR_Gen_1	534	545	PF02991	0.607
LIG_LIR_Gen_1	709	718	PF02991	0.524
LIG_LIR_LC3C_4	402	407	PF02991	0.536
LIG_LIR_Nem_3	150	154	PF02991	0.520
LIG_LIR_Nem_3	169	173	PF02991	0.707
LIG_LIR_Nem_3	238	244	PF02991	0.652
LIG_LIR_Nem_3	390	395	PF02991	0.467
LIG_LIR_Nem_3	410	416	PF02991	0.203
LIG_LIR_Nem_3	534	540	PF02991	0.605
LIG_LIR_Nem_3	709	715	PF02991	0.544
LIG_LIR_Nem_3	822	828	PF02991	0.555
LIG_LIR_Nem_3	895	900	PF02991	0.420
LIG_LYPXL_yS_3	413	416	PF13949	0.432
LIG_MAD2	736	744	PF02301	0.546
LIG_MLH1_MIPbox_1	238	242	PF16413	0.679
LIG_NRBOX	52	58	PF00104	0.576
LIG_Pex14_2	167	171	PF04695	0.573
LIG_Pex14_2	897	901	PF04695	0.464
LIG_SH2_CRK	151	155	PF00017	0.563
LIG_SH2_NCK_1	871	875	PF00017	0.463
LIG_SH2_SRC	151	154	PF00017	0.530
LIG_SH2_SRC	712	715	PF00017	0.498
LIG_SH2_SRC	804	807	PF00017	0.456
LIG_SH2_SRC	871	874	PF00017	0.549
LIG_SH2_STAP1	364	368	PF00017	0.539
LIG_SH2_STAP1	385	389	PF00017	0.466
LIG_SH2_STAT3	811	814	PF00017	0.524
LIG_SH2_STAT5	352	355	PF00017	0.608
LIG_SH2_STAT5	364	367	PF00017	0.425
LIG_SH2_STAT5	425	428	PF00017	0.401
LIG_SH2_STAT5	459	462	PF00017	0.454
LIG_SH2_STAT5	712	715	PF00017	0.498
LIG_SH2_STAT5	800	803	PF00017	0.459
LIG_SH2_STAT5	804	807	PF00017	0.451
LIG_SH3_3	243	249	PF00018	0.503
LIG_SH3_3	464	470	PF00018	0.542
LIG_SH3_3	704	710	PF00018	0.628
LIG_SH3_3	715	721	PF00018	0.530
LIG_SH3_3	760	766	PF00018	0.546
LIG_SH3_3	772	778	PF00018	0.481
LIG_SH3_3	893	899	PF00018	0.493
LIG_Sin3_3	855	862	PF02671	0.545
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.746
LIG_SUMO_SIM_anti_2	402	410	PF11976	0.432
LIG_SUMO_SIM_anti_2	600	605	PF11976	0.535
LIG_SUMO_SIM_anti_2	757	765	PF11976	0.533
LIG_SUMO_SIM_par_1	397	403	PF11976	0.464
LIG_SUMO_SIM_par_1	404	410	PF11976	0.427
LIG_SUMO_SIM_par_1	735	741	PF11976	0.546
LIG_TYR_ITIM	149	154	PF00017	0.539
LIG_UBA3_1	422	428	PF00899	0.453
LIG_UBA3_1	728	736	PF00899	0.546
LIG_WRC_WIRS_1	501	506	PF05994	0.510
MOD_CK1_1	116	122	PF00069	0.510
MOD_CK1_1	175	181	PF00069	0.655
MOD_CK1_1	185	191	PF00069	0.669
MOD_CK1_1	237	243	PF00069	0.538
MOD_CK1_1	362	368	PF00069	0.363
MOD_CK1_1	695	701	PF00069	0.765
MOD_CK1_1	98	104	PF00069	0.782
MOD_CK2_1	102	108	PF00069	0.813
MOD_CK2_1	315	321	PF00069	0.763
MOD_CK2_1	380	386	PF00069	0.485
MOD_CK2_1	823	829	PF00069	0.474
MOD_Cter_Amidation	5	8	PF01082	0.663
MOD_Cter_Amidation	68	71	PF01082	0.688
MOD_GlcNHglycan	115	118	PF01048	0.688
MOD_GlcNHglycan	123	126	PF01048	0.558
MOD_GlcNHglycan	138	141	PF01048	0.454
MOD_GlcNHglycan	175	178	PF01048	0.718
MOD_GlcNHglycan	184	187	PF01048	0.649
MOD_GlcNHglycan	227	230	PF01048	0.625
MOD_GlcNHglycan	258	262	PF01048	0.707
MOD_GlcNHglycan	281	284	PF01048	0.648
MOD_GlcNHglycan	296	299	PF01048	0.867
MOD_GlcNHglycan	321	325	PF01048	0.779
MOD_GlcNHglycan	332	335	PF01048	0.674
MOD_GlcNHglycan	4	7	PF01048	0.682
MOD_GlcNHglycan	493	496	PF01048	0.662
MOD_GlcNHglycan	65	68	PF01048	0.562
MOD_GlcNHglycan	691	695	PF01048	0.743
MOD_GlcNHglycan	740	743	PF01048	0.330
MOD_GlcNHglycan	880	883	PF01048	0.476
MOD_GlcNHglycan	92	98	PF01048	0.809
MOD_GSK3_1	113	120	PF00069	0.530
MOD_GSK3_1	156	163	PF00069	0.570
MOD_GSK3_1	169	176	PF00069	0.620
MOD_GSK3_1	275	282	PF00069	0.790
MOD_GSK3_1	320	327	PF00069	0.828
MOD_GSK3_1	330	337	PF00069	0.690
MOD_GSK3_1	395	402	PF00069	0.572
MOD_GSK3_1	539	546	PF00069	0.673
MOD_GSK3_1	732	739	PF00069	0.513
MOD_GSK3_1	740	747	PF00069	0.519
MOD_GSK3_1	754	761	PF00069	0.546
MOD_GSK3_1	95	102	PF00069	0.858
MOD_NEK2_1	113	118	PF00069	0.732
MOD_NEK2_1	225	230	PF00069	0.656
MOD_NEK2_1	380	385	PF00069	0.500
MOD_NEK2_1	611	616	PF00069	0.598
MOD_NEK2_1	63	68	PF00069	0.542
MOD_NEK2_1	684	689	PF00069	0.635
MOD_NEK2_1	878	883	PF00069	0.485
MOD_NEK2_1	892	897	PF00069	0.468
MOD_NEK2_2	130	135	PF00069	0.557
MOD_NEK2_2	445	450	PF00069	0.441
MOD_PIKK_1	275	281	PF00454	0.832
MOD_PK_1	736	742	PF00069	0.546
MOD_PKA_1	359	365	PF00069	0.373
MOD_PKA_2	113	119	PF00069	0.832
MOD_PKA_2	156	162	PF00069	0.574
MOD_PKA_2	314	320	PF00069	0.770
MOD_PKA_2	359	365	PF00069	0.373
MOD_PKA_2	543	549	PF00069	0.671
MOD_PKA_2	622	628	PF00069	0.594
MOD_PKA_2	69	75	PF00069	0.580
MOD_PKA_2	732	738	PF00069	0.546
MOD_Plk_1	264	270	PF00069	0.751
MOD_Plk_1	380	386	PF00069	0.515
MOD_Plk_2-3	381	387	PF00069	0.510
MOD_Plk_2-3	564	570	PF00069	0.677
MOD_Plk_2-3	758	764	PF00069	0.530
MOD_Plk_4	117	123	PF00069	0.795
MOD_Plk_4	237	243	PF00069	0.582
MOD_Plk_4	264	270	PF00069	0.677
MOD_Plk_4	421	427	PF00069	0.448
MOD_Plk_4	52	58	PF00069	0.440
MOD_Plk_4	708	714	PF00069	0.561
MOD_Plk_4	724	730	PF00069	0.546
MOD_Plk_4	758	764	PF00069	0.546
MOD_Plk_4	892	898	PF00069	0.406
MOD_ProDKin_1	296	302	PF00069	0.797
MOD_ProDKin_1	641	647	PF00069	0.804
MOD_ProDKin_1	706	712	PF00069	0.614
MOD_ProDKin_1	740	746	PF00069	0.545
MOD_ProDKin_1	762	768	PF00069	0.549
MOD_SUMO_rev_2	355	361	PF00179	0.443
MOD_SUMO_rev_2	471	481	PF00179	0.583
TRG_DiLeu_BaEn_1	208	213	PF01217	0.632
TRG_DiLeu_BaEn_1	758	763	PF01217	0.530
TRG_DiLeu_BaEn_4	568	574	PF01217	0.699
TRG_DiLeu_BaLyEn_6	775	780	PF01217	0.291
TRG_ENDOCYTIC_2	151	154	PF00928	0.552
TRG_ENDOCYTIC_2	413	416	PF00928	0.401
TRG_ENDOCYTIC_2	537	540	PF00928	0.612
TRG_ENDOCYTIC_2	598	601	PF00928	0.571
TRG_ENDOCYTIC_2	712	715	PF00928	0.498
TRG_ENDOCYTIC_2	804	807	PF00928	0.456
TRG_ER_diArg_1	113	115	PF00400	0.753
TRG_ER_diArg_1	218	220	PF00400	0.768
TRG_ER_diArg_1	449	451	PF00400	0.364
TRG_ER_diArg_1	616	618	PF00400	0.478
TRG_ER_diArg_1	68	71	PF00400	0.676
TRG_ER_diArg_1	73	75	PF00400	0.685
TRG_ER_diArg_1	887	890	PF00400	0.440
TRG_NLS_MonoExtC_3	15	20	PF00514	0.606
TRG_NLS_MonoExtC_3	528	534	PF00514	0.661
TRG_NLS_MonoExtN_4	527	533	PF00514	0.770

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA6	Leptomonas seymouri	59%	100%
A0A3S7WZV4	Leishmania donovani	99%	100%
A4HEZ2	Leishmania braziliensis	76%	99%
E9AYB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q957	Leishmania major	92%	99%