Uncharacterized protein

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I265_LEIIN

TriTrypDb:

LINF_260018600

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I265

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I265

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.513
CLV_C14_Caspase3-7	322	326	PF00656	0.431
CLV_C14_Caspase3-7	494	498	PF00656	0.315
CLV_C14_Caspase3-7	539	543	PF00656	0.742
CLV_NRD_NRD_1	31	33	PF00675	0.498
CLV_NRD_NRD_1	328	330	PF00675	0.438
CLV_NRD_NRD_1	354	356	PF00675	0.402
CLV_NRD_NRD_1	407	409	PF00675	0.345
CLV_NRD_NRD_1	421	423	PF00675	0.280
CLV_NRD_NRD_1	67	69	PF00675	0.710
CLV_NRD_NRD_1	7	9	PF00675	0.654
CLV_PCSK_KEX2_1	31	33	PF00082	0.513
CLV_PCSK_KEX2_1	328	330	PF00082	0.521
CLV_PCSK_KEX2_1	354	356	PF00082	0.402
CLV_PCSK_KEX2_1	421	423	PF00082	0.324
CLV_PCSK_KEX2_1	564	566	PF00082	0.518
CLV_PCSK_KEX2_1	67	69	PF00082	0.711
CLV_PCSK_KEX2_1	7	9	PF00082	0.654
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.514
CLV_PCSK_PC7_1	3	9	PF00082	0.530
CLV_PCSK_PC7_1	63	69	PF00082	0.519
CLV_PCSK_SKI1_1	421	425	PF00082	0.404
CLV_PCSK_SKI1_1	564	568	PF00082	0.377
DEG_APCC_DBOX_1	420	428	PF00400	0.398
DEG_APCC_DBOX_1	467	475	PF00400	0.374
DEG_APCC_DBOX_1	596	604	PF00400	0.337
DEG_Nend_Nbox_1	1	3	PF02207	0.568
DEG_SPOP_SBC_1	141	145	PF00917	0.575
DOC_CYCLIN_RxL_1	419	428	PF00134	0.402
DOC_MAPK_gen_1	192	201	PF00069	0.504
DOC_MAPK_MEF2A_6	246	254	PF00069	0.503
DOC_PP4_FxxP_1	366	369	PF00568	0.431
DOC_USP7_MATH_1	140	144	PF00917	0.648
DOC_USP7_MATH_1	152	156	PF00917	0.442
DOC_USP7_MATH_1	176	180	PF00917	0.538
DOC_USP7_MATH_1	183	187	PF00917	0.510
DOC_USP7_MATH_1	283	287	PF00917	0.664
DOC_USP7_MATH_1	479	483	PF00917	0.353
DOC_USP7_MATH_1	505	509	PF00917	0.486
DOC_USP7_MATH_1	546	550	PF00917	0.671
DOC_USP7_UBL2_3	122	126	PF12436	0.463
DOC_USP7_UBL2_3	519	523	PF12436	0.389
DOC_WW_Pin1_4	179	184	PF00397	0.688
DOC_WW_Pin1_4	279	284	PF00397	0.537
LIG_14-3-3_CanoR_1	210	218	PF00244	0.350
LIG_14-3-3_CanoR_1	222	228	PF00244	0.282
LIG_14-3-3_CanoR_1	246	254	PF00244	0.429
LIG_14-3-3_CanoR_1	31	39	PF00244	0.561
LIG_14-3-3_CanoR_1	328	332	PF00244	0.487
LIG_14-3-3_CanoR_1	354	361	PF00244	0.399
LIG_14-3-3_CanoR_1	387	393	PF00244	0.440
LIG_14-3-3_CanoR_1	449	454	PF00244	0.402
LIG_14-3-3_CanoR_1	468	472	PF00244	0.429
LIG_14-3-3_CanoR_1	53	62	PF00244	0.540
LIG_14-3-3_CanoR_1	599	604	PF00244	0.344
LIG_14-3-3_CanoR_1	84	89	PF00244	0.614
LIG_Actin_WH2_2	407	423	PF00022	0.509
LIG_Actin_WH2_2	424	439	PF00022	0.311
LIG_Actin_WH2_2	507	525	PF00022	0.367
LIG_APCC_ABBA_1	550	555	PF00400	0.445
LIG_BIR_III_2	175	179	PF00653	0.579
LIG_BIR_III_4	542	546	PF00653	0.441
LIG_BRCT_BRCA1_1	296	300	PF00533	0.396
LIG_BRCT_MDC1_1	601	605	PF00533	0.369
LIG_CaM_IQ_9	39	55	PF13499	0.483
LIG_DLG_GKlike_1	449	457	PF00625	0.259
LIG_FHA_1	158	164	PF00498	0.553
LIG_FHA_1	224	230	PF00498	0.289
LIG_FHA_1	287	293	PF00498	0.473
LIG_FHA_1	296	302	PF00498	0.384
LIG_FHA_1	31	37	PF00498	0.447
LIG_FHA_1	436	442	PF00498	0.368
LIG_FHA_1	457	463	PF00498	0.525
LIG_FHA_2	134	140	PF00498	0.524
LIG_FHA_2	231	237	PF00498	0.338
LIG_FHA_2	328	334	PF00498	0.406
LIG_FHA_2	389	395	PF00498	0.401
LIG_FHA_2	468	474	PF00498	0.541
LIG_GBD_Chelix_1	510	518	PF00786	0.351
LIG_LIR_Gen_1	197	206	PF02991	0.447
LIG_LIR_Gen_1	410	419	PF02991	0.337
LIG_LIR_Gen_1	512	522	PF02991	0.298
LIG_LIR_Nem_3	197	201	PF02991	0.469
LIG_LIR_Nem_3	410	414	PF02991	0.343
LIG_LIR_Nem_3	512	518	PF02991	0.330
LIG_LYPXL_SIV_4	119	127	PF13949	0.346
LIG_NRBOX	513	519	PF00104	0.355
LIG_NRBOX	599	605	PF00104	0.368
LIG_Pex14_1	2	6	PF04695	0.532
LIG_SH2_STAT5	111	114	PF00017	0.342
LIG_SH2_STAT5	120	123	PF00017	0.279
LIG_SH2_STAT5	227	230	PF00017	0.293
LIG_SH2_STAT5	365	368	PF00017	0.393
LIG_SH2_STAT5	384	387	PF00017	0.269
LIG_SH2_STAT5	484	487	PF00017	0.371
LIG_SH2_STAT5	88	91	PF00017	0.414
LIG_SH3_3	585	591	PF00018	0.504
LIG_SUMO_SIM_par_1	422	428	PF11976	0.279
LIG_TRAF2_1	330	333	PF00917	0.469
LIG_UBA3_1	251	260	PF00899	0.486
LIG_UBA3_1	514	523	PF00899	0.358
LIG_WRC_WIRS_1	450	455	PF05994	0.254
MOD_CK1_1	157	163	PF00069	0.673
MOD_CK1_1	179	185	PF00069	0.680
MOD_CK1_1	214	220	PF00069	0.354
MOD_CK1_1	273	279	PF00069	0.560
MOD_CK1_1	286	292	PF00069	0.410
MOD_CK1_1	294	300	PF00069	0.345
MOD_CK1_1	388	394	PF00069	0.472
MOD_CK1_1	45	51	PF00069	0.681
MOD_CK1_1	530	536	PF00069	0.597
MOD_CK1_1	57	63	PF00069	0.601
MOD_CK1_1	87	93	PF00069	0.401
MOD_CK2_1	152	158	PF00069	0.665
MOD_CK2_1	327	333	PF00069	0.485
MOD_CK2_1	354	360	PF00069	0.408
MOD_CK2_1	467	473	PF00069	0.526
MOD_GlcNHglycan	117	120	PF01048	0.392
MOD_GlcNHglycan	144	147	PF01048	0.630
MOD_GlcNHglycan	185	188	PF01048	0.693
MOD_GlcNHglycan	213	216	PF01048	0.351
MOD_GlcNHglycan	279	282	PF01048	0.585
MOD_GlcNHglycan	285	288	PF01048	0.528
MOD_GlcNHglycan	293	296	PF01048	0.329
MOD_GlcNHglycan	502	506	PF01048	0.477
MOD_GlcNHglycan	507	510	PF01048	0.375
MOD_GlcNHglycan	57	60	PF01048	0.573
MOD_GlcNHglycan	74	77	PF01048	0.548
MOD_GlcNHglycan	80	83	PF01048	0.554
MOD_GSK3_1	140	147	PF00069	0.620
MOD_GSK3_1	179	186	PF00069	0.679
MOD_GSK3_1	273	280	PF00069	0.611
MOD_GSK3_1	291	298	PF00069	0.325
MOD_GSK3_1	30	37	PF00069	0.476
MOD_GSK3_1	38	45	PF00069	0.461
MOD_GSK3_1	497	504	PF00069	0.491
MOD_GSK3_1	53	60	PF00069	0.627
MOD_GSK3_1	575	582	PF00069	0.342
MOD_GSK3_1	586	593	PF00069	0.465
MOD_GSK3_1	595	602	PF00069	0.315
MOD_N-GLC_1	115	120	PF02516	0.470
MOD_N-GLC_1	163	168	PF02516	0.527
MOD_N-GLC_1	270	275	PF02516	0.494
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	127	132	PF00069	0.453
MOD_NEK2_1	230	235	PF00069	0.332
MOD_NEK2_1	327	332	PF00069	0.389
MOD_NEK2_1	385	390	PF00069	0.409
MOD_NEK2_1	39	44	PF00069	0.594
MOD_NEK2_1	501	506	PF00069	0.560
MOD_NEK2_1	517	522	PF00069	0.265
MOD_NEK2_1	524	529	PF00069	0.465
MOD_NEK2_1	54	59	PF00069	0.566
MOD_NEK2_1	579	584	PF00069	0.270
MOD_NEK2_2	546	551	PF00069	0.459
MOD_PIKK_1	163	169	PF00454	0.546
MOD_PIKK_1	187	193	PF00454	0.591
MOD_PIKK_1	39	45	PF00454	0.468
MOD_PIKK_1	479	485	PF00454	0.485
MOD_PIKK_1	527	533	PF00454	0.510
MOD_PIKK_1	590	596	PF00454	0.415
MOD_PIKK_1	99	105	PF00454	0.322
MOD_PK_1	246	252	PF00069	0.337
MOD_PKA_1	354	360	PF00069	0.384
MOD_PKA_2	245	251	PF00069	0.473
MOD_PKA_2	30	36	PF00069	0.468
MOD_PKA_2	327	333	PF00069	0.371
MOD_PKA_2	354	360	PF00069	0.384
MOD_PKA_2	467	473	PF00069	0.381
MOD_PKB_1	597	605	PF00069	0.347
MOD_Plk_1	115	121	PF00069	0.348
MOD_Plk_1	152	158	PF00069	0.652
MOD_Plk_1	546	552	PF00069	0.482
MOD_Plk_2-3	497	503	PF00069	0.522
MOD_Plk_4	230	236	PF00069	0.350
MOD_Plk_4	246	252	PF00069	0.377
MOD_Plk_4	449	455	PF00069	0.410
MOD_Plk_4	579	585	PF00069	0.424
MOD_Plk_4	599	605	PF00069	0.343
MOD_Plk_4	84	90	PF00069	0.532
MOD_ProDKin_1	179	185	PF00069	0.690
MOD_ProDKin_1	279	285	PF00069	0.533
MOD_SUMO_rev_2	549	559	PF00179	0.586
TRG_DiLeu_BaEn_1	473	478	PF01217	0.397
TRG_DiLeu_BaEn_4	319	325	PF01217	0.416
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.523
TRG_ENDOCYTIC_2	227	230	PF00928	0.293
TRG_ER_diArg_1	220	223	PF00400	0.371
TRG_ER_diArg_1	327	329	PF00400	0.499
TRG_ER_diArg_1	353	355	PF00400	0.429
TRG_ER_diArg_1	420	422	PF00400	0.313
TRG_ER_diArg_1	597	600	PF00400	0.342
TRG_ER_diArg_1	6	8	PF00400	0.561
TRG_ER_diArg_1	66	68	PF00400	0.701
TRG_NES_CRM1_1	341	352	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P9	Leptomonas seymouri	65%	100%
A0A0S4KJS0	Bodo saltans	33%	100%
A0A1X0NTU8	Trypanosomatidae	43%	100%
A0A3Q8IDS9	Leishmania donovani	100%	100%
A4HEZ1	Leishmania braziliensis	79%	100%
C9ZRT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AYB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4Q958	Leishmania major	94%	100%
V5B9R8	Trypanosoma cruzi	43%	100%