Putative DNA ligase k alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA ligase k alpha - putative

Species:

Leishmania infantum

UniProt:

A4I263_LEIIN

TriTrypDb:

LINF_260018400

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4I263

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I263

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	18
GO:0006259	DNA metabolic process	4	18
GO:0006281	DNA repair	5	18
GO:0006310	DNA recombination	5	18
GO:0006725	cellular aromatic compound metabolic process	3	18
GO:0006807	nitrogen compound metabolic process	2	18
GO:0006950	response to stress	2	18
GO:0006974	DNA damage response	4	18
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	18
GO:0033554	cellular response to stress	3	18
GO:0034641	cellular nitrogen compound metabolic process	3	18
GO:0043170	macromolecule metabolic process	3	18
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18
GO:0044260	obsolete cellular macromolecule metabolic process	3	18
GO:0046483	heterocycle metabolic process	3	18
GO:0050896	response to stimulus	1	18
GO:0051716	cellular response to stimulus	2	18
GO:0071704	organic substance metabolic process	2	18
GO:0090304	nucleic acid metabolic process	4	18
GO:1901360	organic cyclic compound metabolic process	3	18

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0003909	DNA ligase activity	4	18
GO:0003910	DNA ligase (ATP) activity	5	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016874	ligase activity	2	18
GO:0016886	ligase activity, forming phosphoric ester bonds	3	18
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140097	catalytic activity, acting on DNA	3	18
GO:0140640	catalytic activity, acting on a nucleic acid	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.454
CLV_C14_Caspase3-7	453	457	PF00656	0.460
CLV_NRD_NRD_1	152	154	PF00675	0.665
CLV_NRD_NRD_1	443	445	PF00675	0.439
CLV_NRD_NRD_1	473	475	PF00675	0.315
CLV_NRD_NRD_1	7	9	PF00675	0.769
CLV_NRD_NRD_1	91	93	PF00675	0.335
CLV_PCSK_KEX2_1	108	110	PF00082	0.335
CLV_PCSK_KEX2_1	27	29	PF00082	0.582
CLV_PCSK_KEX2_1	443	445	PF00082	0.465
CLV_PCSK_KEX2_1	473	475	PF00082	0.315
CLV_PCSK_KEX2_1	499	501	PF00082	0.693
CLV_PCSK_KEX2_1	7	9	PF00082	0.756
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.367
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.705
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.703
CLV_PCSK_SKI1_1	209	213	PF00082	0.429
CLV_PCSK_SKI1_1	24	28	PF00082	0.697
CLV_PCSK_SKI1_1	252	256	PF00082	0.433
CLV_PCSK_SKI1_1	276	280	PF00082	0.386
CLV_PCSK_SKI1_1	496	500	PF00082	0.652
CLV_PCSK_SKI1_1	555	559	PF00082	0.449
CLV_PCSK_SKI1_1	597	601	PF00082	0.353
DEG_APCC_DBOX_1	208	216	PF00400	0.402
DEG_Nend_UBRbox_1	1	4	PF02207	0.701
DEG_SCF_FBW7_1	574	579	PF00400	0.424
DOC_ANK_TNKS_1	620	627	PF00023	0.505
DOC_CDC14_PxL_1	14	22	PF14671	0.465
DOC_CKS1_1	377	382	PF01111	0.545
DOC_CYCLIN_RxL_1	273	282	PF00134	0.389
DOC_CYCLIN_yClb5_NLxxxL_5	209	215	PF00134	0.495
DOC_MAPK_gen_1	108	114	PF00069	0.352
DOC_MAPK_RevD_3	461	474	PF00069	0.409
DOC_PP1_RVXF_1	250	257	PF00149	0.446
DOC_PP1_RVXF_1	90	97	PF00149	0.316
DOC_SPAK_OSR1_1	571	575	PF12202	0.424
DOC_USP7_MATH_1	139	143	PF00917	0.646
DOC_USP7_MATH_1	502	506	PF00917	0.521
DOC_USP7_MATH_1	75	79	PF00917	0.424
DOC_USP7_MATH_1	9	13	PF00917	0.710
DOC_USP7_UBL2_3	122	126	PF12436	0.537
DOC_USP7_UBL2_3	217	221	PF12436	0.396
DOC_USP7_UBL2_3	306	310	PF12436	0.475
DOC_USP7_UBL2_3	340	344	PF12436	0.668
DOC_USP7_UBL2_3	591	595	PF12436	0.480
DOC_WW_Pin1_4	147	152	PF00397	0.719
DOC_WW_Pin1_4	232	237	PF00397	0.341
DOC_WW_Pin1_4	309	314	PF00397	0.726
DOC_WW_Pin1_4	376	381	PF00397	0.445
DOC_WW_Pin1_4	562	567	PF00397	0.361
DOC_WW_Pin1_4	572	577	PF00397	0.313
LIG_14-3-3_CanoR_1	177	183	PF00244	0.605
LIG_14-3-3_CanoR_1	421	431	PF00244	0.362
LIG_14-3-3_CanoR_1	527	532	PF00244	0.437
LIG_14-3-3_CanoR_1	571	575	PF00244	0.371
LIG_14-3-3_CanoR_1	585	591	PF00244	0.229
LIG_Actin_WH2_2	427	445	PF00022	0.498
LIG_BRCT_BRCA1_1	398	402	PF00533	0.546
LIG_FHA_1	206	212	PF00498	0.459
LIG_FHA_1	249	255	PF00498	0.506
LIG_FHA_1	282	288	PF00498	0.407
LIG_FHA_1	29	35	PF00498	0.664
LIG_FHA_1	315	321	PF00498	0.577
LIG_FHA_1	366	372	PF00498	0.493
LIG_FHA_1	377	383	PF00498	0.310
LIG_FHA_1	493	499	PF00498	0.702
LIG_FHA_2	260	266	PF00498	0.370
LIG_FHA_2	577	583	PF00498	0.316
LIG_LIR_Apic_2	374	380	PF02991	0.570
LIG_LIR_Gen_1	199	207	PF02991	0.487
LIG_LIR_Gen_1	539	548	PF02991	0.404
LIG_LIR_Gen_1	560	566	PF02991	0.424
LIG_LIR_Gen_1	600	611	PF02991	0.322
LIG_LIR_Nem_3	199	205	PF02991	0.500
LIG_LIR_Nem_3	413	419	PF02991	0.360
LIG_LIR_Nem_3	435	440	PF02991	0.544
LIG_LIR_Nem_3	539	545	PF02991	0.393
LIG_LIR_Nem_3	551	557	PF02991	0.320
LIG_LIR_Nem_3	560	564	PF02991	0.324
LIG_LIR_Nem_3	589	593	PF02991	0.364
LIG_LIR_Nem_3	600	606	PF02991	0.325
LIG_LYPXL_yS_3	17	20	PF13949	0.466
LIG_NRBOX	418	424	PF00104	0.472
LIG_PDZ_Class_3	625	630	PF00595	0.495
LIG_PDZ_Wminus1_1	628	630	PF00595	0.516
LIG_Pex14_1	590	594	PF04695	0.424
LIG_Pex14_2	557	561	PF04695	0.305
LIG_REV1ctd_RIR_1	254	263	PF16727	0.399
LIG_SH2_CRK	330	334	PF00017	0.478
LIG_SH2_CRK	437	441	PF00017	0.482
LIG_SH2_PTP2	542	545	PF00017	0.427
LIG_SH2_SRC	542	545	PF00017	0.357
LIG_SH2_SRC	603	606	PF00017	0.305
LIG_SH2_STAP1	398	402	PF00017	0.406
LIG_SH2_STAP1	448	452	PF00017	0.429
LIG_SH2_STAT5	202	205	PF00017	0.515
LIG_SH2_STAT5	277	280	PF00017	0.300
LIG_SH2_STAT5	542	545	PF00017	0.367
LIG_SH3_1	310	316	PF00018	0.548
LIG_SH3_2	148	153	PF14604	0.552
LIG_SH3_3	12	18	PF00018	0.514
LIG_SH3_3	145	151	PF00018	0.776
LIG_SH3_3	310	316	PF00018	0.548
LIG_SH3_3	609	615	PF00018	0.323
LIG_SUMO_SIM_par_1	282	288	PF11976	0.371
LIG_TYR_ITIM	15	20	PF00017	0.683
LIG_TYR_ITIM	414	419	PF00017	0.459
LIG_TYR_ITIM	465	470	PF00017	0.471
LIG_TYR_ITIM	601	606	PF00017	0.338
LIG_UBA3_1	20	27	PF00899	0.522
LIG_UBA3_1	211	217	PF00899	0.448
LIG_WRC_WIRS_1	558	563	PF05994	0.424
MOD_CDC14_SPxK_1	150	153	PF00782	0.550
MOD_CDK_SPK_2	232	237	PF00069	0.352
MOD_CDK_SPxK_1	147	153	PF00069	0.553
MOD_CDK_SPxK_1	562	568	PF00069	0.446
MOD_CDK_SPxxK_3	147	154	PF00069	0.552
MOD_CDK_SPxxK_3	562	569	PF00069	0.397
MOD_CK1_1	138	144	PF00069	0.702
MOD_CK1_1	158	164	PF00069	0.736
MOD_CK1_1	504	510	PF00069	0.647
MOD_CK1_1	589	595	PF00069	0.462
MOD_CK2_1	158	164	PF00069	0.577
MOD_CK2_1	259	265	PF00069	0.383
MOD_CK2_1	58	64	PF00069	0.498
MOD_CMANNOS	587	590	PF00535	0.424
MOD_Cter_Amidation	338	341	PF01082	0.391
MOD_GlcNHglycan	11	14	PF01048	0.667
MOD_GlcNHglycan	137	140	PF01048	0.634
MOD_GlcNHglycan	157	160	PF01048	0.672
MOD_GlcNHglycan	259	262	PF01048	0.421
MOD_GlcNHglycan	368	371	PF01048	0.378
MOD_GlcNHglycan	39	42	PF01048	0.708
MOD_GlcNHglycan	407	410	PF01048	0.433
MOD_GlcNHglycan	424	427	PF01048	0.369
MOD_GlcNHglycan	492	495	PF01048	0.624
MOD_GlcNHglycan	504	507	PF01048	0.584
MOD_GlcNHglycan	52	55	PF01048	0.677
MOD_GlcNHglycan	549	553	PF01048	0.381
MOD_GSK3_1	131	138	PF00069	0.663
MOD_GSK3_1	139	146	PF00069	0.629
MOD_GSK3_1	177	184	PF00069	0.591
MOD_GSK3_1	255	262	PF00069	0.373
MOD_GSK3_1	300	307	PF00069	0.518
MOD_GSK3_1	366	373	PF00069	0.409
MOD_GSK3_1	444	451	PF00069	0.375
MOD_GSK3_1	50	57	PF00069	0.712
MOD_GSK3_1	572	579	PF00069	0.286
MOD_N-GLC_1	178	183	PF02516	0.510
MOD_N-GLC_1	292	297	PF02516	0.436
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	193	198	PF00069	0.616
MOD_NEK2_1	255	260	PF00069	0.360
MOD_NEK2_1	422	427	PF00069	0.376
MOD_NEK2_1	557	562	PF00069	0.458
MOD_NEK2_1	586	591	PF00069	0.305
MOD_NEK2_2	131	136	PF00069	0.493
MOD_PIKK_1	432	438	PF00454	0.302
MOD_PKA_2	371	377	PF00069	0.401
MOD_PKA_2	405	411	PF00069	0.482
MOD_PKA_2	526	532	PF00069	0.430
MOD_PKA_2	570	576	PF00069	0.375
MOD_PKB_1	175	183	PF00069	0.551
MOD_Plk_1	178	184	PF00069	0.618
MOD_Plk_1	292	298	PF00069	0.436
MOD_Plk_4	1	7	PF00069	0.663
MOD_Plk_4	16	22	PF00069	0.613
MOD_Plk_4	259	265	PF00069	0.387
MOD_Plk_4	281	287	PF00069	0.385
MOD_Plk_4	357	363	PF00069	0.598
MOD_Plk_4	527	533	PF00069	0.450
MOD_Plk_4	557	563	PF00069	0.416
MOD_Plk_4	589	595	PF00069	0.434
MOD_ProDKin_1	147	153	PF00069	0.719
MOD_ProDKin_1	232	238	PF00069	0.340
MOD_ProDKin_1	309	315	PF00069	0.728
MOD_ProDKin_1	376	382	PF00069	0.437
MOD_ProDKin_1	562	568	PF00069	0.361
MOD_ProDKin_1	572	578	PF00069	0.313
MOD_SUMO_for_1	121	124	PF00179	0.269
TRG_DiLeu_BaEn_1	207	212	PF01217	0.465
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.465
TRG_ENDOCYTIC_2	17	20	PF00928	0.466
TRG_ENDOCYTIC_2	202	205	PF00928	0.497
TRG_ENDOCYTIC_2	330	333	PF00928	0.474
TRG_ENDOCYTIC_2	391	394	PF00928	0.342
TRG_ENDOCYTIC_2	416	419	PF00928	0.350
TRG_ENDOCYTIC_2	437	440	PF00928	0.505
TRG_ENDOCYTIC_2	467	470	PF00928	0.319
TRG_ENDOCYTIC_2	534	537	PF00928	0.395
TRG_ENDOCYTIC_2	542	545	PF00928	0.358
TRG_ENDOCYTIC_2	603	606	PF00928	0.323
TRG_ER_diArg_1	172	175	PF00400	0.668
TRG_ER_diArg_1	21	24	PF00400	0.554
TRG_ER_diArg_1	442	444	PF00400	0.473
TRG_ER_diArg_1	472	474	PF00400	0.293
TRG_ER_diArg_1	6	8	PF00400	0.772
TRG_NLS_Bipartite_1	136	157	PF00514	0.558
TRG_NLS_MonoExtC_3	339	344	PF00514	0.444
TRG_NLS_MonoExtC_3	495	500	PF00514	0.683
TRG_NLS_MonoExtN_4	151	157	PF00514	0.717
TRG_NLS_MonoExtN_4	340	345	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ3	Leptomonas seymouri	59%	97%
A0A0S4KIC5	Bodo saltans	29%	100%
A0A0S4KP75	Bodo saltans	27%	100%
A0A1X0NS61	Trypanosomatidae	43%	100%
A0A1X0NSF5	Trypanosomatidae	26%	100%
A0A3Q8IDN6	Leishmania donovani	26%	100%
A0A3Q8IDV4	Leishmania donovani	100%	100%
A0A3S5IR98	Trypanosoma rangeli	43%	100%
A4HEY9	Leishmania braziliensis	81%	100%
A4HEZ0	Leishmania braziliensis	25%	100%
A4I264	Leishmania infantum	26%	100%
C9ZRT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AYB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q959	Leishmania major	25%	76%
Q4Q960	Leishmania major	94%	100%
V5AUB9	Trypanosoma cruzi	26%	100%