Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I262_LEIIN

TriTrypDb:

LINF_260018300

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I262

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I262

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	372	374	PF00675	0.569
CLV_PCSK_KEX2_1	372	374	PF00082	0.569
CLV_PCSK_SKI1_1	174	178	PF00082	0.525
CLV_PCSK_SKI1_1	203	207	PF00082	0.490
CLV_PCSK_SKI1_1	304	308	PF00082	0.482
DEG_APCC_DBOX_1	202	210	PF00400	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DOC_CKS1_1	131	136	PF01111	0.562
DOC_CKS1_1	179	184	PF01111	0.607
DOC_CKS1_1	226	231	PF01111	0.551
DOC_MAPK_gen_1	200	210	PF00069	0.416
DOC_MAPK_gen_1	372	381	PF00069	0.621
DOC_MAPK_MEF2A_6	203	210	PF00069	0.413
DOC_MAPK_NFAT4_5	203	211	PF00069	0.418
DOC_PP4_FxxP_1	179	182	PF00568	0.619
DOC_USP7_MATH_1	140	144	PF00917	0.585
DOC_USP7_MATH_1	284	288	PF00917	0.730
DOC_USP7_MATH_1	328	332	PF00917	0.676
DOC_USP7_MATH_1	392	396	PF00917	0.571
DOC_USP7_MATH_1	49	53	PF00917	0.550
DOC_USP7_MATH_1	83	87	PF00917	0.471
DOC_USP7_MATH_1	96	100	PF00917	0.506
DOC_WW_Pin1_4	107	112	PF00397	0.620
DOC_WW_Pin1_4	130	135	PF00397	0.546
DOC_WW_Pin1_4	178	183	PF00397	0.601
DOC_WW_Pin1_4	222	227	PF00397	0.680
DOC_WW_Pin1_4	321	326	PF00397	0.666
DOC_WW_Pin1_4	360	365	PF00397	0.606
DOC_WW_Pin1_4	45	50	PF00397	0.691
LIG_14-3-3_CanoR_1	174	183	PF00244	0.560
LIG_14-3-3_CanoR_1	9	15	PF00244	0.528
LIG_Actin_WH2_2	57	72	PF00022	0.578
LIG_BIR_III_2	62	66	PF00653	0.548
LIG_BRCT_BRCA1_1	35	39	PF00533	0.460
LIG_BRCT_BRCA1_1	361	365	PF00533	0.660
LIG_CSL_BTD_1	30	33	PF09270	0.558
LIG_FHA_1	179	185	PF00498	0.611
LIG_FHA_1	197	203	PF00498	0.538
LIG_FHA_1	226	232	PF00498	0.548
LIG_FHA_2	108	114	PF00498	0.556
LIG_FHA_2	233	239	PF00498	0.581
LIG_FHA_2	255	261	PF00498	0.643
LIG_FHA_2	288	294	PF00498	0.621
LIG_FHA_2	57	63	PF00498	0.593
LIG_LIR_Apic_2	148	154	PF02991	0.626
LIG_LIR_Apic_2	177	182	PF02991	0.611
LIG_LIR_Gen_1	36	44	PF02991	0.569
LIG_LIR_Gen_1	59	69	PF02991	0.521
LIG_LIR_Nem_3	36	42	PF02991	0.490
LIG_LIR_Nem_3	362	368	PF02991	0.626
LIG_LIR_Nem_3	59	64	PF02991	0.539
LIG_MLH1_MIPbox_1	35	39	PF16413	0.460
LIG_NRBOX	114	120	PF00104	0.580
LIG_NRBOX	205	211	PF00104	0.494
LIG_Pex14_1	35	39	PF04695	0.481
LIG_Pex14_2	213	217	PF04695	0.541
LIG_SH2_CRK	211	215	PF00017	0.447
LIG_SH2_STAT5	175	178	PF00017	0.510
LIG_SH3_1	223	229	PF00018	0.637
LIG_SH3_3	131	137	PF00018	0.517
LIG_SH3_3	181	187	PF00018	0.646
LIG_SH3_3	223	229	PF00018	0.637
LIG_SH3_3	358	364	PF00018	0.575
LIG_SH3_3	61	67	PF00018	0.548
LIG_SH3_3	89	95	PF00018	0.534
LIG_SUMO_SIM_par_1	206	212	PF11976	0.421
LIG_SUMO_SIM_par_1	230	235	PF11976	0.499
LIG_SUMO_SIM_par_1	78	86	PF11976	0.562
LIG_TRAF2_1	235	238	PF00917	0.586
LIG_TYR_ITIM	209	214	PF00017	0.431
LIG_WRC_WIRS_1	210	215	PF05994	0.513
LIG_WW_3	220	224	PF00397	0.599
MOD_CDK_SPK_2	130	135	PF00069	0.497
MOD_CDK_SPK_2	45	50	PF00069	0.527
MOD_CK1_1	185	191	PF00069	0.618
MOD_CK1_1	212	218	PF00069	0.470
MOD_CK1_1	225	231	PF00069	0.605
MOD_CK1_1	261	267	PF00069	0.766
MOD_CK1_1	287	293	PF00069	0.742
MOD_CK1_1	317	323	PF00069	0.632
MOD_CK2_1	107	113	PF00069	0.565
MOD_CK2_1	232	238	PF00069	0.522
MOD_CK2_1	254	260	PF00069	0.576
MOD_CK2_1	287	293	PF00069	0.633
MOD_GlcNHglycan	10	13	PF01048	0.506
MOD_GlcNHglycan	122	125	PF01048	0.611
MOD_GlcNHglycan	157	160	PF01048	0.679
MOD_GlcNHglycan	254	257	PF01048	0.494
MOD_GlcNHglycan	27	30	PF01048	0.542
MOD_GlcNHglycan	271	274	PF01048	0.750
MOD_GlcNHglycan	318	322	PF01048	0.713
MOD_GlcNHglycan	330	333	PF01048	0.507
MOD_GlcNHglycan	35	38	PF01048	0.448
MOD_GlcNHglycan	356	359	PF01048	0.610
MOD_GlcNHglycan	394	397	PF01048	0.650
MOD_GlcNHglycan	406	409	PF01048	0.595
MOD_GlcNHglycan	85	88	PF01048	0.624
MOD_GSK3_1	105	112	PF00069	0.534
MOD_GSK3_1	114	121	PF00069	0.535
MOD_GSK3_1	126	133	PF00069	0.477
MOD_GSK3_1	174	181	PF00069	0.530
MOD_GSK3_1	182	189	PF00069	0.564
MOD_GSK3_1	209	216	PF00069	0.446
MOD_GSK3_1	252	259	PF00069	0.605
MOD_GSK3_1	284	291	PF00069	0.730
MOD_GSK3_1	317	324	PF00069	0.817
MOD_GSK3_1	45	52	PF00069	0.604
MOD_N-GLC_1	252	257	PF02516	0.558
MOD_N-GLC_1	269	274	PF02516	0.506
MOD_NEK2_1	118	123	PF00069	0.486
MOD_NEK2_1	126	131	PF00069	0.494
MOD_NEK2_1	19	24	PF00069	0.648
MOD_NEK2_1	195	200	PF00069	0.468
MOD_NEK2_1	209	214	PF00069	0.494
MOD_NEK2_1	252	257	PF00069	0.473
MOD_NEK2_1	68	73	PF00069	0.582
MOD_PK_1	135	141	PF00069	0.628
MOD_PKA_2	328	334	PF00069	0.598
MOD_PKA_2	392	398	PF00069	0.690
MOD_PKA_2	49	55	PF00069	0.565
MOD_PKA_2	8	14	PF00069	0.529
MOD_Plk_1	105	111	PF00069	0.519
MOD_Plk_1	77	83	PF00069	0.442
MOD_Plk_4	114	120	PF00069	0.542
MOD_Plk_4	126	132	PF00069	0.469
MOD_Plk_4	209	215	PF00069	0.537
MOD_Plk_4	258	264	PF00069	0.614
MOD_Plk_4	77	83	PF00069	0.453
MOD_Plk_4	96	102	PF00069	0.466
MOD_ProDKin_1	107	113	PF00069	0.619
MOD_ProDKin_1	130	136	PF00069	0.552
MOD_ProDKin_1	178	184	PF00069	0.605
MOD_ProDKin_1	222	228	PF00069	0.680
MOD_ProDKin_1	321	327	PF00069	0.667
MOD_ProDKin_1	360	366	PF00069	0.609
MOD_ProDKin_1	45	51	PF00069	0.693
TRG_DiLeu_BaEn_4	376	382	PF01217	0.531
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.526
TRG_ENDOCYTIC_2	211	214	PF00928	0.438
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H2	Leptomonas seymouri	30%	95%
A0A3S7WZZ6	Leishmania donovani	99%	82%
A4HEY8	Leishmania braziliensis	64%	100%
E9AYB2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q961	Leishmania major	89%	100%