Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I261_LEIIN

TriTrypDb:

LINF_260018200

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4I261

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I261

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.433
CLV_NRD_NRD_1	209	211	PF00675	0.406
CLV_PCSK_FUR_1	207	211	PF00082	0.425
CLV_PCSK_KEX2_1	193	195	PF00082	0.448
CLV_PCSK_KEX2_1	204	206	PF00082	0.421
CLV_PCSK_KEX2_1	209	211	PF00082	0.419
CLV_PCSK_KEX2_1	268	270	PF00082	0.577
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.421
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.614
CLV_PCSK_PC7_1	189	195	PF00082	0.452
CLV_PCSK_PC7_1	205	211	PF00082	0.424
CLV_PCSK_SKI1_1	121	125	PF00082	0.627
CLV_PCSK_SKI1_1	201	205	PF00082	0.436
CLV_PCSK_SKI1_1	37	41	PF00082	0.653
DEG_APCC_DBOX_1	120	128	PF00400	0.652
DEG_APCC_DBOX_1	209	217	PF00400	0.407
DEG_Nend_UBRbox_1	1	4	PF02207	0.567
DOC_MAPK_JIP1_4	121	127	PF00069	0.651
DOC_PP4_FxxP_1	87	90	PF00568	0.643
DOC_USP7_MATH_1	138	142	PF00917	0.704
DOC_USP7_MATH_1	149	153	PF00917	0.629
DOC_USP7_MATH_1	184	188	PF00917	0.449
DOC_USP7_MATH_1	255	259	PF00917	0.512
DOC_USP7_MATH_1	47	51	PF00917	0.649
DOC_USP7_MATH_1	82	86	PF00917	0.726
DOC_USP7_MATH_1	90	94	PF00917	0.495
DOC_USP7_UBL2_3	171	175	PF12436	0.544
DOC_USP7_UBL2_3	264	268	PF12436	0.622
DOC_WW_Pin1_4	22	27	PF00397	0.652
DOC_WW_Pin1_4	40	45	PF00397	0.653
LIG_14-3-3_CanoR_1	111	120	PF00244	0.553
LIG_14-3-3_CanoR_1	9	18	PF00244	0.686
LIG_Actin_WH2_2	218	236	PF00022	0.429
LIG_Clathr_ClatBox_1	124	128	PF01394	0.649
LIG_FHA_1	34	40	PF00498	0.644
LIG_FHA_1	41	47	PF00498	0.579
LIG_FHA_2	112	118	PF00498	0.601
LIG_FHA_2	26	32	PF00498	0.662
LIG_FHA_2	84	90	PF00498	0.644
LIG_LIR_Apic_2	85	90	PF02991	0.634
LIG_LIR_Gen_1	62	72	PF02991	0.567
LIG_LIR_Nem_3	155	160	PF02991	0.647
LIG_LIR_Nem_3	62	67	PF02991	0.580
LIG_PDZ_Class_2	273	278	PF00595	0.506
LIG_Pex14_1	168	172	PF04695	0.433
LIG_PTB_Apo_2	215	222	PF02174	0.431
LIG_SH2_CRK	173	177	PF00017	0.430
LIG_SH2_STAT5	27	30	PF00017	0.662
LIG_SH3_3	66	72	PF00018	0.592
LIG_SUMO_SIM_par_1	122	130	PF11976	0.653
LIG_UBA3_1	229	237	PF00899	0.445
LIG_WRC_WIRS_1	105	110	PF05994	0.564
MOD_CDK_SPK_2	40	45	PF00069	0.653
MOD_CDK_SPxxK_3	22	29	PF00069	0.664
MOD_CK1_1	141	147	PF00069	0.704
MOD_CK1_1	152	158	PF00069	0.473
MOD_CK1_1	235	241	PF00069	0.462
MOD_CK1_1	50	56	PF00069	0.645
MOD_Cter_Amidation	266	269	PF01082	0.588
MOD_GlcNHglycan	11	14	PF01048	0.587
MOD_GlcNHglycan	143	146	PF01048	0.652
MOD_GlcNHglycan	151	154	PF01048	0.630
MOD_GlcNHglycan	253	256	PF01048	0.443
MOD_GlcNHglycan	258	261	PF01048	0.531
MOD_GlcNHglycan	3	6	PF01048	0.670
MOD_GlcNHglycan	31	36	PF01048	0.411
MOD_GlcNHglycan	92	95	PF01048	0.692
MOD_GSK3_1	18	25	PF00069	0.546
MOD_GSK3_1	247	254	PF00069	0.472
MOD_GSK3_1	256	263	PF00069	0.536
MOD_GSK3_1	267	274	PF00069	0.493
MOD_GSK3_1	90	97	PF00069	0.654
MOD_N-GLC_1	138	143	PF02516	0.684
MOD_N-GLC_1	40	45	PF02516	0.731
MOD_N-GLC_1	50	55	PF02516	0.489
MOD_N-GLC_1	82	87	PF02516	0.686
MOD_N-GLC_2	101	103	PF02516	0.587
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	127	132	PF00069	0.637
MOD_NEK2_1	233	238	PF00069	0.460
MOD_NEK2_1	246	251	PF00069	0.453
MOD_PIKK_1	127	133	PF00454	0.641
MOD_PIKK_1	247	253	PF00454	0.542
MOD_PKA_2	256	262	PF00069	0.537
MOD_PKA_2	59	65	PF00069	0.504
MOD_PKB_1	109	117	PF00069	0.568
MOD_PKB_1	269	277	PF00069	0.518
MOD_Plk_1	116	122	PF00069	0.594
MOD_Plk_1	138	144	PF00069	0.623
MOD_Plk_1	50	56	PF00069	0.629
MOD_Plk_4	72	78	PF00069	0.594
MOD_Plk_4	83	89	PF00069	0.551
MOD_ProDKin_1	22	28	PF00069	0.650
MOD_ProDKin_1	40	46	PF00069	0.655
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.641
TRG_ENDOCYTIC_2	157	160	PF00928	0.626
TRG_ENDOCYTIC_2	173	176	PF00928	0.313
TRG_ER_diArg_1	108	111	PF00400	0.546
TRG_ER_diArg_1	193	195	PF00400	0.448
TRG_ER_diArg_1	208	210	PF00400	0.422
TRG_ER_diArg_1	269	272	PF00400	0.537
TRG_ER_diLys_1	273	278	PF00400	0.506
TRG_NLS_Bipartite_1	193	208	PF00514	0.432
TRG_NLS_MonoExtC_3	267	272	PF00514	0.648
TRG_NLS_MonoExtN_4	201	208	PF00514	0.438
TRG_NLS_MonoExtN_4	266	272	PF00514	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC03	Leptomonas seymouri	66%	100%
A0A1X0NS69	Trypanosomatidae	62%	100%
A0A3R7ND13	Trypanosoma rangeli	62%	100%
A0A3S7WZU2	Leishmania donovani	100%	100%
A4HEY7	Leishmania braziliensis	77%	100%
C9ZRT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AYB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q962	Leishmania major	92%	100%
V5BIT0	Trypanosoma cruzi	63%	91%