Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I257_LEIIN

TriTrypDb:

LINF_260017800

Length:

1034

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I257

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I257

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.714
CLV_C14_Caspase3-7	209	213	PF00656	0.730
CLV_C14_Caspase3-7	257	261	PF00656	0.657
CLV_C14_Caspase3-7	434	438	PF00656	0.729
CLV_NRD_NRD_1	166	168	PF00675	0.706
CLV_NRD_NRD_1	287	289	PF00675	0.759
CLV_NRD_NRD_1	880	882	PF00675	0.776
CLV_NRD_NRD_1	927	929	PF00675	0.614
CLV_NRD_NRD_1	990	992	PF00675	0.810
CLV_PCSK_FUR_1	924	928	PF00082	0.611
CLV_PCSK_KEX2_1	13	15	PF00082	0.801
CLV_PCSK_KEX2_1	158	160	PF00082	0.649
CLV_PCSK_KEX2_1	287	289	PF00082	0.724
CLV_PCSK_KEX2_1	880	882	PF00082	0.776
CLV_PCSK_KEX2_1	926	928	PF00082	0.622
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.801
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.649
CLV_PCSK_SKI1_1	104	108	PF00082	0.734
CLV_PCSK_SKI1_1	14	18	PF00082	0.724
CLV_PCSK_SKI1_1	170	174	PF00082	0.613
CLV_PCSK_SKI1_1	356	360	PF00082	0.506
CLV_PCSK_SKI1_1	362	366	PF00082	0.452
CLV_PCSK_SKI1_1	399	403	PF00082	0.697
CLV_PCSK_SKI1_1	66	70	PF00082	0.571
CLV_PCSK_SKI1_1	927	931	PF00082	0.616
CLV_PCSK_SKI1_1	981	985	PF00082	0.786
CLV_PCSK_SKI1_1	991	995	PF00082	0.676
DEG_APCC_DBOX_1	563	571	PF00400	0.754
DEG_APCC_DBOX_1	625	633	PF00400	0.607
DEG_COP1_1	888	897	PF00400	0.657
DEG_SCF_FBW7_1	327	332	PF00400	0.717
DEG_SCF_FBW7_1	89	96	PF00400	0.817
DEG_SCF_FBW7_2	1018	1025	PF00400	0.730
DEG_SPOP_SBC_1	277	281	PF00917	0.775
DEG_SPOP_SBC_1	710	714	PF00917	0.734
DEG_SPOP_SBC_1	886	890	PF00917	0.783
DOC_CKS1_1	1019	1024	PF01111	0.681
DOC_CKS1_1	330	335	PF01111	0.673
DOC_CKS1_1	639	644	PF01111	0.612
DOC_CKS1_1	90	95	PF01111	0.678
DOC_CYCLIN_yCln2_LP_2	993	999	PF00134	0.593
DOC_MAPK_FxFP_2	1000	1003	PF00069	0.606
DOC_MAPK_gen_1	243	251	PF00069	0.699
DOC_MAPK_gen_1	462	471	PF00069	0.678
DOC_MAPK_gen_1	664	672	PF00069	0.580
DOC_MAPK_MEF2A_6	465	473	PF00069	0.757
DOC_MAPK_MEF2A_6	664	672	PF00069	0.580
DOC_PP1_RVXF_1	360	366	PF00149	0.508
DOC_PP2B_LxvP_1	348	351	PF13499	0.507
DOC_PP2B_LxvP_1	672	675	PF13499	0.701
DOC_PP4_FxxP_1	1000	1003	PF00568	0.645
DOC_USP7_MATH_1	1003	1007	PF00917	0.556
DOC_USP7_MATH_1	106	110	PF00917	0.787
DOC_USP7_MATH_1	196	200	PF00917	0.726
DOC_USP7_MATH_1	220	224	PF00917	0.698
DOC_USP7_MATH_1	273	277	PF00917	0.764
DOC_USP7_MATH_1	278	282	PF00917	0.660
DOC_USP7_MATH_1	293	297	PF00917	0.550
DOC_USP7_MATH_1	34	38	PF00917	0.822
DOC_USP7_MATH_1	395	399	PF00917	0.657
DOC_USP7_MATH_1	467	471	PF00917	0.697
DOC_USP7_MATH_1	512	516	PF00917	0.721
DOC_USP7_MATH_1	618	622	PF00917	0.576
DOC_USP7_MATH_1	683	687	PF00917	0.664
DOC_USP7_MATH_1	697	701	PF00917	0.737
DOC_USP7_MATH_1	70	74	PF00917	0.785
DOC_USP7_MATH_1	710	714	PF00917	0.665
DOC_USP7_MATH_1	738	742	PF00917	0.765
DOC_USP7_MATH_1	75	79	PF00917	0.756
DOC_USP7_MATH_1	770	774	PF00917	0.659
DOC_USP7_MATH_1	844	848	PF00917	0.660
DOC_USP7_MATH_1	856	860	PF00917	0.601
DOC_USP7_MATH_1	887	891	PF00917	0.754
DOC_USP7_MATH_1	950	954	PF00917	0.794
DOC_USP7_MATH_1	967	971	PF00917	0.619
DOC_USP7_MATH_1	97	101	PF00917	0.745
DOC_USP7_MATH_1	987	991	PF00917	0.511
DOC_USP7_MATH_2	117	123	PF00917	0.721
DOC_WW_Pin1_4	1018	1023	PF00397	0.767
DOC_WW_Pin1_4	14	19	PF00397	0.763
DOC_WW_Pin1_4	190	195	PF00397	0.796
DOC_WW_Pin1_4	2	7	PF00397	0.789
DOC_WW_Pin1_4	325	330	PF00397	0.606
DOC_WW_Pin1_4	423	428	PF00397	0.811
DOC_WW_Pin1_4	638	643	PF00397	0.794
DOC_WW_Pin1_4	646	651	PF00397	0.718
DOC_WW_Pin1_4	71	76	PF00397	0.719
DOC_WW_Pin1_4	733	738	PF00397	0.752
DOC_WW_Pin1_4	746	751	PF00397	0.597
DOC_WW_Pin1_4	89	94	PF00397	0.814
DOC_WW_Pin1_4	992	997	PF00397	0.797
LIG_14-3-3_CanoR_1	161	171	PF00244	0.759
LIG_14-3-3_CanoR_1	232	240	PF00244	0.737
LIG_14-3-3_CanoR_1	387	391	PF00244	0.597
LIG_14-3-3_CanoR_1	444	449	PF00244	0.754
LIG_14-3-3_CanoR_1	462	472	PF00244	0.485
LIG_14-3-3_CanoR_1	548	553	PF00244	0.588
LIG_14-3-3_CanoR_1	626	630	PF00244	0.596
LIG_14-3-3_CanoR_1	854	864	PF00244	0.656
LIG_14-3-3_CanoR_1	932	937	PF00244	0.743
LIG_14-3-3_CanoR_1	986	993	PF00244	0.822
LIG_APCC_ABBA_1	355	360	PF00400	0.516
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_BRCT_BRCA1_1	740	744	PF00533	0.733
LIG_DLG_GKlike_1	444	451	PF00625	0.678
LIG_FHA_1	110	116	PF00498	0.762
LIG_FHA_1	236	242	PF00498	0.710
LIG_FHA_1	367	373	PF00498	0.500
LIG_FHA_1	374	380	PF00498	0.550
LIG_FHA_1	464	470	PF00498	0.685
LIG_FHA_1	508	514	PF00498	0.777
LIG_FHA_1	548	554	PF00498	0.665
LIG_FHA_1	889	895	PF00498	0.821
LIG_FHA_1	913	919	PF00498	0.708
LIG_FHA_1	932	938	PF00498	0.686
LIG_FHA_1	954	960	PF00498	0.851
LIG_FHA_2	199	205	PF00498	0.754
LIG_FHA_2	207	213	PF00498	0.703
LIG_FHA_2	366	372	PF00498	0.494
LIG_FHA_2	432	438	PF00498	0.737
LIG_FHA_2	77	83	PF00498	0.790
LIG_FHA_2	810	816	PF00498	0.740
LIG_FHA_2	960	966	PF00498	0.849
LIG_FHA_2	974	980	PF00498	0.612
LIG_KLC1_Yacidic_2	247	252	PF13176	0.596
LIG_LIR_Apic_2	247	253	PF02991	0.596
LIG_LIR_Apic_2	506	512	PF02991	0.739
LIG_LIR_Gen_1	316	327	PF02991	0.559
LIG_LIR_Gen_1	380	391	PF02991	0.510
LIG_LIR_Gen_1	398	407	PF02991	0.558
LIG_LIR_Gen_1	446	455	PF02991	0.759
LIG_LIR_Gen_1	51	59	PF02991	0.564
LIG_LIR_Nem_3	297	303	PF02991	0.624
LIG_LIR_Nem_3	316	322	PF02991	0.558
LIG_LIR_Nem_3	380	386	PF02991	0.509
LIG_LIR_Nem_3	398	403	PF02991	0.535
LIG_LIR_Nem_3	446	451	PF02991	0.754
LIG_LIR_Nem_3	51	55	PF02991	0.628
LIG_Pex14_2	871	875	PF04695	0.617
LIG_PTB_Apo_2	786	793	PF02174	0.556
LIG_PTB_Phospho_1	786	792	PF10480	0.558
LIG_REV1ctd_RIR_1	927	936	PF16727	0.683
LIG_RPA_C_Fungi	843	855	PF08784	0.605
LIG_SH2_CRK	375	379	PF00017	0.499
LIG_SH2_CRK	400	404	PF00017	0.604
LIG_SH2_CRK	509	513	PF00017	0.599
LIG_SH2_CRK	831	835	PF00017	0.589
LIG_SH2_GRB2like	375	378	PF00017	0.532
LIG_SH2_PTP2	250	253	PF00017	0.595
LIG_SH2_SRC	250	253	PF00017	0.595
LIG_SH2_STAP1	315	319	PF00017	0.664
LIG_SH2_STAP1	400	404	PF00017	0.706
LIG_SH2_STAP1	480	484	PF00017	0.571
LIG_SH2_STAP1	623	627	PF00017	0.609
LIG_SH2_STAP1	852	856	PF00017	0.614
LIG_SH2_STAT3	840	843	PF00017	0.654
LIG_SH2_STAT3	852	855	PF00017	0.558
LIG_SH2_STAT5	250	253	PF00017	0.595
LIG_SH2_STAT5	300	303	PF00017	0.672
LIG_SH2_STAT5	347	350	PF00017	0.321
LIG_SH2_STAT5	375	378	PF00017	0.557
LIG_SH2_STAT5	501	504	PF00017	0.670
LIG_SH2_STAT5	509	512	PF00017	0.634
LIG_SH2_STAT5	573	576	PF00017	0.705
LIG_SH2_STAT5	688	691	PF00017	0.782
LIG_SH2_STAT5	792	795	PF00017	0.533
LIG_SH2_STAT5	840	843	PF00017	0.543
LIG_SH2_STAT5	852	855	PF00017	0.551
LIG_SH3_3	111	117	PF00018	0.712
LIG_SH3_3	466	472	PF00018	0.740
LIG_SH3_3	482	488	PF00018	0.567
LIG_SH3_3	499	505	PF00018	0.399
LIG_SH3_3	571	577	PF00018	0.716
LIG_SH3_3	644	650	PF00018	0.826
LIG_SH3_3	993	999	PF00018	0.656
LIG_SUMO_SIM_anti_2	483	488	PF11976	0.547
LIG_SUMO_SIM_anti_2	832	839	PF11976	0.684
LIG_SUMO_SIM_par_1	474	479	PF11976	0.540
LIG_SUMO_SIM_par_1	800	808	PF11976	0.672
LIG_TRAF2_1	489	492	PF00917	0.626
LIG_TRAF2_1	812	815	PF00917	0.645
LIG_TRAF2_1	9	12	PF00917	0.627
LIG_TRFH_1	347	351	PF08558	0.326
LIG_WRC_WIRS_1	143	148	PF05994	0.634
LIG_WRC_WIRS_1	269	274	PF05994	0.593
LIG_WRC_WIRS_1	445	450	PF05994	0.790
LIG_WRC_WIRS_1	49	54	PF05994	0.641
MOD_CK1_1	109	115	PF00069	0.766
MOD_CK1_1	126	132	PF00069	0.838
MOD_CK1_1	145	151	PF00069	0.625
MOD_CK1_1	163	169	PF00069	0.667
MOD_CK1_1	2	8	PF00069	0.750
MOD_CK1_1	271	277	PF00069	0.720
MOD_CK1_1	279	285	PF00069	0.595
MOD_CK1_1	426	432	PF00069	0.739
MOD_CK1_1	447	453	PF00069	0.708
MOD_CK1_1	520	526	PF00069	0.724
MOD_CK1_1	585	591	PF00069	0.817
MOD_CK1_1	599	605	PF00069	0.606
MOD_CK1_1	648	654	PF00069	0.688
MOD_CK1_1	705	711	PF00069	0.713
MOD_CK1_1	73	79	PF00069	0.828
MOD_CK1_1	731	737	PF00069	0.800
MOD_CK1_1	749	755	PF00069	0.734
MOD_CK1_1	762	768	PF00069	0.612
MOD_CK1_1	803	809	PF00069	0.585
MOD_CK1_1	832	838	PF00069	0.578
MOD_CK1_1	858	864	PF00069	0.669
MOD_CK1_1	953	959	PF00069	0.773
MOD_CK1_1	970	976	PF00069	0.590
MOD_CK1_1	982	988	PF00069	0.633
MOD_CK2_1	198	204	PF00069	0.805
MOD_CK2_1	241	247	PF00069	0.699
MOD_CK2_1	365	371	PF00069	0.492
MOD_CK2_1	500	506	PF00069	0.581
MOD_CK2_1	76	82	PF00069	0.797
MOD_CK2_1	805	811	PF00069	0.610
MOD_CK2_1	844	850	PF00069	0.699
MOD_CK2_1	973	979	PF00069	0.709
MOD_Cter_Amidation	285	288	PF01082	0.705
MOD_Cter_Amidation	924	927	PF01082	0.625
MOD_DYRK1A_RPxSP_1	14	18	PF00069	0.724
MOD_GlcNHglycan	108	111	PF01048	0.746
MOD_GlcNHglycan	14	17	PF01048	0.787
MOD_GlcNHglycan	198	201	PF01048	0.798
MOD_GlcNHglycan	275	278	PF01048	0.745
MOD_GlcNHglycan	281	284	PF01048	0.758
MOD_GlcNHglycan	392	395	PF01048	0.539
MOD_GlcNHglycan	428	431	PF01048	0.769
MOD_GlcNHglycan	502	505	PF01048	0.690
MOD_GlcNHglycan	514	517	PF01048	0.617
MOD_GlcNHglycan	520	523	PF01048	0.763
MOD_GlcNHglycan	601	604	PF01048	0.736
MOD_GlcNHglycan	650	653	PF01048	0.756
MOD_GlcNHglycan	699	702	PF01048	0.824
MOD_GlcNHglycan	704	707	PF01048	0.746
MOD_GlcNHglycan	722	725	PF01048	0.690
MOD_GlcNHglycan	738	741	PF01048	0.777
MOD_GlcNHglycan	752	755	PF01048	0.685
MOD_GlcNHglycan	773	776	PF01048	0.649
MOD_GlcNHglycan	807	810	PF01048	0.636
MOD_GlcNHglycan	860	863	PF01048	0.687
MOD_GlcNHglycan	865	868	PF01048	0.655
MOD_GlcNHglycan	902	905	PF01048	0.772
MOD_GlcNHglycan	945	948	PF01048	0.812
MOD_GlcNHglycan	952	955	PF01048	0.750
MOD_GlcNHglycan	964	970	PF01048	0.598
MOD_GSK3_1	119	126	PF00069	0.678
MOD_GSK3_1	142	149	PF00069	0.738
MOD_GSK3_1	170	177	PF00069	0.621
MOD_GSK3_1	231	238	PF00069	0.717
MOD_GSK3_1	268	275	PF00069	0.662
MOD_GSK3_1	325	332	PF00069	0.607
MOD_GSK3_1	386	393	PF00069	0.656
MOD_GSK3_1	422	429	PF00069	0.732
MOD_GSK3_1	443	450	PF00069	0.705
MOD_GSK3_1	463	470	PF00069	0.467
MOD_GSK3_1	512	519	PF00069	0.746
MOD_GSK3_1	520	527	PF00069	0.682
MOD_GSK3_1	538	545	PF00069	0.767
MOD_GSK3_1	618	625	PF00069	0.604
MOD_GSK3_1	641	648	PF00069	0.686
MOD_GSK3_1	697	704	PF00069	0.709
MOD_GSK3_1	705	712	PF00069	0.732
MOD_GSK3_1	71	78	PF00069	0.714
MOD_GSK3_1	745	752	PF00069	0.735
MOD_GSK3_1	754	761	PF00069	0.778
MOD_GSK3_1	762	769	PF00069	0.601
MOD_GSK3_1	800	807	PF00069	0.580
MOD_GSK3_1	863	870	PF00069	0.764
MOD_GSK3_1	89	96	PF00069	0.695
MOD_GSK3_1	893	900	PF00069	0.664
MOD_GSK3_1	902	909	PF00069	0.583
MOD_GSK3_1	932	939	PF00069	0.789
MOD_GSK3_1	973	980	PF00069	0.760
MOD_GSK3_1	998	1005	PF00069	0.821
MOD_N-GLC_1	720	725	PF02516	0.732
MOD_N-GLC_1	920	925	PF02516	0.754
MOD_N-GLC_1	93	98	PF02516	0.645
MOD_N-GLC_2	818	820	PF02516	0.770
MOD_NEK2_1	146	151	PF00069	0.646
MOD_NEK2_1	222	227	PF00069	0.857
MOD_NEK2_1	272	277	PF00069	0.706
MOD_NEK2_1	365	370	PF00069	0.490
MOD_NEK2_1	386	391	PF00069	0.588
MOD_NEK2_1	443	448	PF00069	0.804
MOD_NEK2_1	50	55	PF00069	0.633
MOD_NEK2_1	518	523	PF00069	0.821
MOD_NEK2_1	538	543	PF00069	0.443
MOD_NEK2_1	696	701	PF00069	0.807
MOD_NEK2_1	717	722	PF00069	0.578
MOD_NEK2_1	805	810	PF00069	0.612
MOD_NEK2_1	936	941	PF00069	0.779
MOD_PIKK_1	225	231	PF00454	0.844
MOD_PIKK_1	34	40	PF00454	0.820
MOD_PIKK_1	555	561	PF00454	0.625
MOD_PIKK_1	73	79	PF00454	0.761
MOD_PKA_1	287	293	PF00069	0.714
MOD_PKA_2	160	166	PF00069	0.758
MOD_PKA_2	231	237	PF00069	0.842
MOD_PKA_2	287	293	PF00069	0.790
MOD_PKA_2	386	392	PF00069	0.599
MOD_PKA_2	443	449	PF00069	0.755
MOD_PKA_2	461	467	PF00069	0.512
MOD_PKA_2	507	513	PF00069	0.758
MOD_PKA_2	547	553	PF00069	0.596
MOD_PKA_2	585	591	PF00069	0.803
MOD_PKA_2	625	631	PF00069	0.601
MOD_PKA_2	701	707	PF00069	0.652
MOD_PKA_2	809	815	PF00069	0.747
MOD_PKA_2	829	835	PF00069	0.366
MOD_PKA_2	931	937	PF00069	0.674
MOD_PKA_2	973	979	PF00069	0.725
MOD_PKA_2	985	991	PF00069	0.753
MOD_Plk_1	315	321	PF00069	0.654
MOD_Plk_1	381	387	PF00069	0.668
MOD_Plk_2-3	119	125	PF00069	0.842
MOD_Plk_4	142	148	PF00069	0.610
MOD_Plk_4	315	321	PF00069	0.513
MOD_Plk_4	548	554	PF00069	0.694
MOD_Plk_4	612	618	PF00069	0.617
MOD_Plk_4	832	838	PF00069	0.679
MOD_Plk_4	867	873	PF00069	0.753
MOD_Plk_4	932	938	PF00069	0.788
MOD_ProDKin_1	1018	1024	PF00069	0.765
MOD_ProDKin_1	14	20	PF00069	0.765
MOD_ProDKin_1	190	196	PF00069	0.796
MOD_ProDKin_1	2	8	PF00069	0.789
MOD_ProDKin_1	325	331	PF00069	0.599
MOD_ProDKin_1	423	429	PF00069	0.816
MOD_ProDKin_1	638	644	PF00069	0.794
MOD_ProDKin_1	646	652	PF00069	0.714
MOD_ProDKin_1	71	77	PF00069	0.724
MOD_ProDKin_1	733	739	PF00069	0.752
MOD_ProDKin_1	746	752	PF00069	0.596
MOD_ProDKin_1	89	95	PF00069	0.814
MOD_ProDKin_1	992	998	PF00069	0.796
MOD_SUMO_rev_2	169	178	PF00179	0.618
MOD_SUMO_rev_2	491	496	PF00179	0.705
MOD_SUMO_rev_2	5	15	PF00179	0.720
MOD_SUMO_rev_2	811	819	PF00179	0.640
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.762
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.522
TRG_DiLeu_BaLyEn_6	579	584	PF01217	0.674
TRG_ENDOCYTIC_2	300	303	PF00928	0.613
TRG_ENDOCYTIC_2	347	350	PF00928	0.321
TRG_ENDOCYTIC_2	400	403	PF00928	0.584
TRG_ENDOCYTIC_2	831	834	PF00928	0.550
TRG_ER_diArg_1	924	927	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.819
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.818
TRG_Pf-PMV_PEXEL_1	582	587	PF00026	0.800

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIE5	Leptomonas seymouri	40%	84%
A0A3S7WZV6	Leishmania donovani	100%	94%
A4HEY3	Leishmania braziliensis	74%	100%
E9AYA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q966	Leishmania major	92%	100%