Heat shock protein 70-related protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock 70-related protein 1 - mitochondrial precursor - putative

Species:

Leishmania infantum

UniProt:

A4I253_LEIIN

TriTrypDb:

LINF_260017400

Length:

641

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Annotations by Jardim et al.

Chaperone/Protein Folding, Heat shock 70-related HSP70.4

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	15
GO:0110165	cellular anatomical entity	1	15

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Phosphorylation

Promastigote/Amastigote: 631

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I253

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I253

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0006458	'de novo' protein folding	3	2
GO:0006950	response to stress	2	2
GO:0006986	response to unfolded protein	4	2
GO:0009987	cellular process	1	2
GO:0010033	response to organic substance	3	2
GO:0033554	cellular response to stress	3	2
GO:0034620	cellular response to unfolded protein	5	2
GO:0035966	response to topologically incorrect protein	3	2
GO:0035967	cellular response to topologically incorrect protein	4	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	15
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	15
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.179
CLV_C14_Caspase3-7	387	391	PF00656	0.325
CLV_C14_Caspase3-7	95	99	PF00656	0.287
CLV_NRD_NRD_1	186	188	PF00675	0.325
CLV_NRD_NRD_1	262	264	PF00675	0.276
CLV_NRD_NRD_1	497	499	PF00675	0.325
CLV_NRD_NRD_1	75	77	PF00675	0.295
CLV_PCSK_FUR_1	270	274	PF00082	0.262
CLV_PCSK_KEX2_1	262	264	PF00082	0.276
CLV_PCSK_KEX2_1	272	274	PF00082	0.278

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0D1CD96	Ustilago maydis (strain 521 / FGSC 9021)	52%	97%
A0A0N0P290	Leptomonas seymouri	66%	97%
A0A0N1I1E4	Leptomonas seymouri	55%	97%
A0A0N1I1R3	Leptomonas seymouri	84%	96%
A0A0N1I3L9	Leptomonas seymouri	47%	97%
A0A0N1PEK8	Leptomonas seymouri	29%	69%
A0A0S4IPK6	Bodo saltans	55%	97%
A0A0S4IUD0	Bodo saltans	66%	97%
A0A0S4IUZ2	Bodo saltans	24%	73%
A0A0S4J8H0	Bodo saltans	45%	95%

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