LeishMANIAdb
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Heat shock protein 70-related protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Heat shock protein 70-related protein
Gene product:
heat shock 70-related protein 1 - mitochondrial precursor - putative
Species:
Leishmania infantum
UniProt:
A4I253_LEIIN
TriTrypDb:
LINF_260017400
Length:
641

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Annotations by Jardim et al.

Chaperone/Protein Folding, Heat shock 70-related HSP70.4

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 4
Pissara et al. yes yes: 14
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 2
GO:0043226 organelle 2 15
GO:0110165 cellular anatomical entity 1 15
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Phosphorylation

Promastigote/Amastigote: 631

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I253
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I253

Function

Biological processes
TermNameLevelCount
GO:0006457 protein folding 2 2
GO:0006458 'de novo' protein folding 3 2
GO:0006950 response to stress 2 2
GO:0006986 response to unfolded protein 4 2
GO:0009987 cellular process 1 2
GO:0010033 response to organic substance 3 2
GO:0033554 cellular response to stress 3 2
GO:0034620 cellular response to unfolded protein 5 2
GO:0035966 response to topologically incorrect protein 3 2
GO:0035967 cellular response to topologically incorrect protein 4 2
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 15
GO:0003824 catalytic activity 1 2
GO:0005488 binding 1 15
GO:0005515 protein binding 2 2
GO:0005524 ATP binding 5 15
GO:0016462 pyrophosphatase activity 5 2
GO:0016787 hydrolase activity 2 2
GO:0016817 hydrolase activity, acting on acid anhydrides 3 2
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 2
GO:0016887 ATP hydrolysis activity 7 2
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 138 142 PF00656 0.179
CLV_C14_Caspase3-7 387 391 PF00656 0.325
CLV_C14_Caspase3-7 95 99 PF00656 0.287
CLV_NRD_NRD_1 186 188 PF00675 0.325
CLV_NRD_NRD_1 262 264 PF00675 0.276
CLV_NRD_NRD_1 497 499 PF00675 0.325
CLV_NRD_NRD_1 75 77 PF00675 0.295
CLV_PCSK_FUR_1 270 274 PF00082 0.262
CLV_PCSK_KEX2_1 262 264 PF00082 0.276
CLV_PCSK_KEX2_1 272 274 PF00082 0.278
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0D1CD96 Ustilago maydis (strain 521 / FGSC 9021) 52% 97%
A0A0N0P290 Leptomonas seymouri 66% 97%
A0A0N1I1E4 Leptomonas seymouri 55% 97%
A0A0N1I1R3 Leptomonas seymouri 84% 96%
A0A0N1I3L9 Leptomonas seymouri 47% 97%
A0A0N1PEK8 Leptomonas seymouri 29% 69%
A0A0S4IPK6 Bodo saltans 55% 97%
A0A0S4IUD0 Bodo saltans 66% 97%
A0A0S4IUZ2 Bodo saltans 24% 73%
A0A0S4J8H0 Bodo saltans 45% 95%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS