Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine rich repeat - putative

Species:

Leishmania infantum

UniProt:

A4I251_LEIIN

TriTrypDb:

LINF_260017200

Length:

668

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4I251

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I251

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0036158	outer dynein arm assembly	7	10
GO:0036159	inner dynein arm assembly	7	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0044877	protein-containing complex binding	2	10
GO:0070840	dynein complex binding	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.590
CLV_C14_Caspase3-7	525	529	PF00656	0.711
CLV_C14_Caspase3-7	552	556	PF00656	0.740
CLV_C14_Caspase3-7	593	597	PF00656	0.647
CLV_C14_Caspase3-7	600	604	PF00656	0.663
CLV_NRD_NRD_1	266	268	PF00675	0.565
CLV_NRD_NRD_1	338	340	PF00675	0.614
CLV_NRD_NRD_1	430	432	PF00675	0.360
CLV_NRD_NRD_1	454	456	PF00675	0.359
CLV_NRD_NRD_1	491	493	PF00675	0.444
CLV_PCSK_FUR_1	437	441	PF00082	0.439
CLV_PCSK_KEX2_1	266	268	PF00082	0.709
CLV_PCSK_KEX2_1	296	298	PF00082	0.500
CLV_PCSK_KEX2_1	338	340	PF00082	0.614
CLV_PCSK_KEX2_1	432	434	PF00082	0.481
CLV_PCSK_KEX2_1	439	441	PF00082	0.432
CLV_PCSK_KEX2_1	454	456	PF00082	0.274
CLV_PCSK_KEX2_1	491	493	PF00082	0.433
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.519
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.474
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.506
CLV_PCSK_SKI1_1	173	177	PF00082	0.374
CLV_PCSK_SKI1_1	432	436	PF00082	0.443
CLV_PCSK_SKI1_1	439	443	PF00082	0.415
CLV_PCSK_SKI1_1	447	451	PF00082	0.367
CLV_PCSK_SKI1_1	455	459	PF00082	0.309
DEG_COP1_1	655	667	PF00400	0.536
DEG_ODPH_VHL_1	72	85	PF01847	0.388
DEG_SIAH_1	106	114	PF03145	0.502
DEG_SPOP_SBC_1	554	558	PF00917	0.593
DEG_SPOP_SBC_1	624	628	PF00917	0.579
DOC_CDC14_PxL_1	407	415	PF14671	0.386
DOC_CYCLIN_RxL_1	433	446	PF00134	0.450
DOC_MAPK_gen_1	201	210	PF00069	0.484
DOC_MAPK_gen_1	296	303	PF00069	0.422
DOC_MAPK_gen_1	338	345	PF00069	0.616
DOC_MAPK_gen_1	409	418	PF00069	0.361
DOC_MAPK_gen_1	437	444	PF00069	0.463
DOC_PP1_RVXF_1	82	88	PF00149	0.339
DOC_USP7_MATH_1	113	117	PF00917	0.522
DOC_USP7_MATH_1	175	179	PF00917	0.477
DOC_USP7_MATH_1	246	250	PF00917	0.703
DOC_USP7_MATH_1	25	29	PF00917	0.690
DOC_USP7_MATH_1	358	362	PF00917	0.422
DOC_USP7_MATH_1	535	539	PF00917	0.739
DOC_USP7_MATH_1	554	558	PF00917	0.666
DOC_USP7_MATH_1	599	603	PF00917	0.620
DOC_USP7_MATH_1	624	628	PF00917	0.691
DOC_USP7_MATH_1	645	649	PF00917	0.806
DOC_WW_Pin1_4	148	153	PF00397	0.693
DOC_WW_Pin1_4	239	244	PF00397	0.640
DOC_WW_Pin1_4	317	322	PF00397	0.490
LIG_14-3-3_CanoR_1	267	275	PF00244	0.715
LIG_14-3-3_CanoR_1	305	315	PF00244	0.419
LIG_14-3-3_CanoR_1	338	344	PF00244	0.795
LIG_14-3-3_CanoR_1	356	365	PF00244	0.319
LIG_14-3-3_CanoR_1	412	417	PF00244	0.398
LIG_14-3-3_CanoR_1	454	462	PF00244	0.452
LIG_14-3-3_CanoR_1	548	554	PF00244	0.723
LIG_14-3-3_CanoR_1	623	630	PF00244	0.783
LIG_14-3-3_CanoR_1	635	643	PF00244	0.574
LIG_Actin_WH2_2	403	419	PF00022	0.355
LIG_AP2alpha_2	112	114	PF02296	0.609
LIG_APCC_ABBA_1	77	82	PF00400	0.402
LIG_APCC_ABBAyCdc20_2	439	445	PF00400	0.442
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	210	214	PF00533	0.425
LIG_BRCT_BRCA1_2	210	216	PF00533	0.317
LIG_Clathr_ClatBox_1	404	408	PF01394	0.346
LIG_Clathr_ClatBox_1	441	445	PF01394	0.348
LIG_eIF4E_1	187	193	PF01652	0.420
LIG_FHA_1	205	211	PF00498	0.299
LIG_FHA_1	307	313	PF00498	0.468
LIG_FHA_1	38	44	PF00498	0.382
LIG_FHA_1	7	13	PF00498	0.736
LIG_FHA_2	520	526	PF00498	0.596
LIG_FHA_2	557	563	PF00498	0.626
LIG_FHA_2	73	79	PF00498	0.503
LIG_LIR_Gen_1	174	183	PF02991	0.343
LIG_LIR_Gen_1	200	210	PF02991	0.412
LIG_LIR_Gen_1	311	321	PF02991	0.423
LIG_LIR_Gen_1	78	88	PF02991	0.346
LIG_LIR_Nem_3	174	179	PF02991	0.361
LIG_LIR_Nem_3	200	205	PF02991	0.427
LIG_LIR_Nem_3	311	316	PF02991	0.412
LIG_LIR_Nem_3	488	493	PF02991	0.498
LIG_LIR_Nem_3	75	80	PF02991	0.399
LIG_LYPXL_S_1	179	183	PF13949	0.342
LIG_LYPXL_yS_3	180	183	PF13949	0.344
LIG_PDZ_Class_1	663	668	PF00595	0.503
LIG_PTB_Apo_2	187	194	PF02174	0.483
LIG_PTB_Apo_2	63	70	PF02174	0.445
LIG_PTB_Phospho_1	63	69	PF10480	0.440
LIG_REV1ctd_RIR_1	212	219	PF16727	0.322
LIG_SH2_CRK	102	106	PF00017	0.569
LIG_SH2_CRK	384	388	PF00017	0.393
LIG_SH2_CRK	53	57	PF00017	0.370
LIG_SH2_CRK	69	73	PF00017	0.357
LIG_SH2_GRB2like	510	513	PF00017	0.491
LIG_SH2_NCK_1	69	73	PF00017	0.433
LIG_SH2_SRC	510	513	PF00017	0.539
LIG_SH2_STAP1	225	229	PF00017	0.544
LIG_SH2_STAP1	69	73	PF00017	0.437
LIG_SH2_STAT5	102	105	PF00017	0.551
LIG_SH2_STAT5	187	190	PF00017	0.422
LIG_SH2_STAT5	510	513	PF00017	0.622
LIG_SH2_STAT5	63	66	PF00017	0.361
LIG_SH2_STAT5	80	83	PF00017	0.350
LIG_SH3_3	102	108	PF00018	0.550
LIG_SH3_3	126	132	PF00018	0.722
LIG_SH3_3	286	292	PF00018	0.542
LIG_SH3_3	345	351	PF00018	0.706
LIG_SH3_5	506	510	PF00018	0.621
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.579
LIG_SUMO_SIM_anti_2	386	391	PF11976	0.441
LIG_SUMO_SIM_anti_2	401	408	PF11976	0.251
LIG_SUMO_SIM_par_1	287	294	PF11976	0.430
LIG_SUMO_SIM_par_1	388	393	PF11976	0.331
LIG_SUMO_SIM_par_1	401	408	PF11976	0.408
LIG_TRAF2_1	474	477	PF00917	0.581
LIG_TYR_ITIM	382	387	PF00017	0.387
MOD_CK1_1	151	157	PF00069	0.701
MOD_CK1_1	23	29	PF00069	0.626
MOD_CK1_1	242	248	PF00069	0.595
MOD_CK1_1	249	255	PF00069	0.488
MOD_CK1_1	361	367	PF00069	0.328
MOD_CK1_1	539	545	PF00069	0.728
MOD_CK1_1	556	562	PF00069	0.670
MOD_CK1_1	648	654	PF00069	0.534
MOD_CK2_1	113	119	PF00069	0.424
MOD_CK2_1	197	203	PF00069	0.563
MOD_CK2_1	535	541	PF00069	0.653
MOD_CK2_1	556	562	PF00069	0.651
MOD_CK2_1	609	615	PF00069	0.766
MOD_CK2_1	72	78	PF00069	0.397
MOD_GlcNHglycan	210	213	PF01048	0.417
MOD_GlcNHglycan	226	229	PF01048	0.338
MOD_GlcNHglycan	244	247	PF01048	0.628
MOD_GlcNHglycan	248	251	PF01048	0.651
MOD_GlcNHglycan	27	30	PF01048	0.646
MOD_GlcNHglycan	275	278	PF01048	0.640
MOD_GlcNHglycan	418	421	PF01048	0.358
MOD_GlcNHglycan	574	577	PF01048	0.770
MOD_GlcNHglycan	580	583	PF01048	0.735
MOD_GlcNHglycan	665	668	PF01048	0.563
MOD_GSK3_1	1	8	PF00069	0.703
MOD_GSK3_1	11	18	PF00069	0.638
MOD_GSK3_1	175	182	PF00069	0.372
MOD_GSK3_1	20	27	PF00069	0.605
MOD_GSK3_1	204	211	PF00069	0.328
MOD_GSK3_1	238	245	PF00069	0.768
MOD_GSK3_1	249	256	PF00069	0.630
MOD_GSK3_1	273	280	PF00069	0.664
MOD_GSK3_1	30	37	PF00069	0.502
MOD_GSK3_1	357	364	PF00069	0.357
MOD_GSK3_1	412	419	PF00069	0.372
MOD_GSK3_1	519	526	PF00069	0.554
MOD_GSK3_1	535	542	PF00069	0.780
MOD_GSK3_1	549	556	PF00069	0.653
MOD_GSK3_1	574	581	PF00069	0.601
MOD_GSK3_1	68	75	PF00069	0.520
MOD_LATS_1	336	342	PF00433	0.551
MOD_LATS_1	546	552	PF00433	0.610
MOD_N-GLC_1	20	25	PF02516	0.753
MOD_N-GLC_1	208	213	PF02516	0.336
MOD_N-GLC_1	31	36	PF02516	0.583
MOD_N-GLC_1	590	595	PF02516	0.781
MOD_NEK2_1	192	197	PF00069	0.523
MOD_NEK2_1	24	29	PF00069	0.659
MOD_NEK2_1	253	258	PF00069	0.561
MOD_NEK2_1	390	395	PF00069	0.321
MOD_NEK2_1	416	421	PF00069	0.352
MOD_NEK2_1	423	428	PF00069	0.383
MOD_NEK2_1	590	595	PF00069	0.521
MOD_NEK2_1	609	614	PF00069	0.664
MOD_NEK2_2	175	180	PF00069	0.450
MOD_NEK2_2	358	363	PF00069	0.422
MOD_PIKK_1	100	106	PF00454	0.505
MOD_PIKK_1	609	615	PF00454	0.663
MOD_PIKK_1	625	631	PF00454	0.498
MOD_PKA_1	338	344	PF00069	0.621
MOD_PKA_2	306	312	PF00069	0.426
MOD_PKA_2	338	344	PF00069	0.711
MOD_PKA_2	536	542	PF00069	0.741
MOD_PKA_2	6	12	PF00069	0.572
MOD_PKB_1	431	439	PF00069	0.480
MOD_Plk_1	158	164	PF00069	0.575
MOD_Plk_1	197	203	PF00069	0.443
MOD_Plk_1	20	26	PF00069	0.736
MOD_Plk_4	12	18	PF00069	0.594
MOD_Plk_4	175	181	PF00069	0.341
MOD_Plk_4	249	255	PF00069	0.484
MOD_Plk_4	91	97	PF00069	0.384
MOD_ProDKin_1	148	154	PF00069	0.691
MOD_ProDKin_1	239	245	PF00069	0.641
MOD_ProDKin_1	317	323	PF00069	0.497
MOD_SUMO_rev_2	612	619	PF00179	0.610
MOD_SUMO_rev_2	78	86	PF00179	0.352
TRG_DiLeu_BaEn_1	401	406	PF01217	0.339
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.523
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.552
TRG_ENDOCYTIC_2	102	105	PF00928	0.551
TRG_ENDOCYTIC_2	180	183	PF00928	0.344
TRG_ENDOCYTIC_2	384	387	PF00928	0.391
TRG_ENDOCYTIC_2	69	72	PF00928	0.426
TRG_ENDOCYTIC_2	80	83	PF00928	0.293
TRG_ER_diArg_1	338	340	PF00400	0.608
TRG_ER_diArg_1	430	433	PF00400	0.478
TRG_ER_diArg_1	454	456	PF00400	0.359
TRG_ER_diArg_1	490	492	PF00400	0.453
TRG_NLS_MonoExtN_4	428	435	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	440	445	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C5	Leptomonas seymouri	53%	100%
A0A0S4JQS0	Bodo saltans	37%	100%
A0A3Q8IFU8	Leishmania donovani	99%	100%
A0A422N6Q2	Trypanosoma rangeli	41%	100%
A4HEX7	Leishmania braziliensis	71%	98%
C9ZRV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AYA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q972	Leishmania major	90%	100%
V5DQX0	Trypanosoma cruzi	39%	90%