Putative aldo/keto reductase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldo/keto reductase - putative

Species:

Leishmania infantum

UniProt:

A4I250_LEIIN

TriTrypDb:

LINF_260017100

Length:

565

Annotations

Annotations by Jardim et al.

Oxidoreductase, aldo/keto reductase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I250

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I250

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	7	1
GO:0004033	aldo-keto reductase (NADP) activity	5	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	6	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.525
CLV_NRD_NRD_1	252	254	PF00675	0.369
CLV_NRD_NRD_1	36	38	PF00675	0.562
CLV_NRD_NRD_1	406	408	PF00675	0.471
CLV_NRD_NRD_1	55	57	PF00675	0.692
CLV_PCSK_KEX2_1	405	407	PF00082	0.473
CLV_PCSK_KEX2_1	55	57	PF00082	0.509
CLV_PCSK_SKI1_1	191	195	PF00082	0.330
CLV_PCSK_SKI1_1	312	316	PF00082	0.419
CLV_PCSK_SKI1_1	529	533	PF00082	0.538
CLV_PCSK_SKI1_1	96	100	PF00082	0.608
DEG_APCC_DBOX_1	223	231	PF00400	0.619
DOC_CYCLIN_RxL_1	526	535	PF00134	0.576
DOC_MAPK_gen_1	112	121	PF00069	0.495
DOC_MAPK_gen_1	37	44	PF00069	0.496
DOC_MAPK_gen_1	405	412	PF00069	0.492
DOC_MAPK_gen_1	541	549	PF00069	0.523
DOC_MAPK_MEF2A_6	224	233	PF00069	0.546
DOC_MAPK_MEF2A_6	37	44	PF00069	0.476
DOC_MAPK_MEF2A_6	77	86	PF00069	0.448
DOC_PP2B_LxvP_1	381	384	PF13499	0.605
DOC_PP2B_LxvP_1	64	67	PF13499	0.515
DOC_PP4_FxxP_1	132	135	PF00568	0.475
DOC_PP4_FxxP_1	169	172	PF00568	0.451
DOC_PP4_MxPP_1	80	83	PF00568	0.496
DOC_USP7_MATH_1	14	18	PF00917	0.506
DOC_USP7_MATH_1	148	152	PF00917	0.612
DOC_USP7_MATH_1	185	189	PF00917	0.563
DOC_USP7_MATH_1	234	238	PF00917	0.619
DOC_USP7_MATH_1	339	343	PF00917	0.768
DOC_USP7_MATH_1	366	370	PF00917	0.728
DOC_USP7_MATH_1	374	378	PF00917	0.636
DOC_USP7_MATH_1	58	62	PF00917	0.562
DOC_USP7_UBL2_3	232	236	PF12436	0.546
DOC_WW_Pin1_4	114	119	PF00397	0.493
DOC_WW_Pin1_4	362	367	PF00397	0.725
DOC_WW_Pin1_4	379	384	PF00397	0.343
DOC_WW_Pin1_4	413	418	PF00397	0.454
DOC_WW_Pin1_4	453	458	PF00397	0.787
LIG_14-3-3_CanoR_1	108	114	PF00244	0.685
LIG_14-3-3_CanoR_1	149	154	PF00244	0.527
LIG_14-3-3_CanoR_1	18	24	PF00244	0.507
LIG_14-3-3_CanoR_1	49	55	PF00244	0.508
LIG_14-3-3_CanoR_1	529	539	PF00244	0.461
LIG_14-3-3_CanoR_1	59	67	PF00244	0.467
LIG_14-3-3_CanoR_1	69	78	PF00244	0.492
LIG_14-3-3_CanoR_1	96	106	PF00244	0.557
LIG_Actin_WH2_2	81	98	PF00022	0.493
LIG_BIR_III_4	277	281	PF00653	0.546
LIG_BRCT_BRCA1_1	116	120	PF00533	0.492
LIG_BRCT_BRCA1_1	165	169	PF00533	0.584
LIG_eIF4E_1	207	213	PF01652	0.543
LIG_eIF4E_1	259	265	PF01652	0.539
LIG_FHA_1	153	159	PF00498	0.596
LIG_FHA_1	176	182	PF00498	0.546
LIG_Integrin_RGD_1	182	184	PF01839	0.346
LIG_LIR_Apic_2	166	172	PF02991	0.561
LIG_LIR_Gen_1	226	235	PF02991	0.506
LIG_LIR_Gen_1	26	35	PF02991	0.492
LIG_LIR_Gen_1	499	508	PF02991	0.437
LIG_LIR_Nem_3	100	106	PF02991	0.494
LIG_LIR_Nem_3	226	231	PF02991	0.549
LIG_LIR_Nem_3	26	30	PF02991	0.493
LIG_LIR_Nem_3	499	504	PF02991	0.475
LIG_MYND_1	93	97	PF01753	0.483
LIG_PCNA_PIPBox_1	536	545	PF02747	0.584
LIG_Pex14_2	132	136	PF04695	0.477
LIG_SH2_CRK	303	307	PF00017	0.598
LIG_SH2_CRK	415	419	PF00017	0.485
LIG_SH2_CRK	478	482	PF00017	0.437
LIG_SH2_CRK	9	13	PF00017	0.523
LIG_SH2_STAP1	109	113	PF00017	0.488
LIG_SH2_STAP1	259	263	PF00017	0.520
LIG_SH2_STAP1	560	564	PF00017	0.434
LIG_SH2_STAT3	560	563	PF00017	0.514
LIG_SH2_STAT5	109	112	PF00017	0.604
LIG_SH2_STAT5	303	306	PF00017	0.619
LIG_SH2_STAT5	403	406	PF00017	0.479
LIG_SH2_STAT5	438	441	PF00017	0.452
LIG_SH2_STAT5	478	481	PF00017	0.435
LIG_SH2_STAT5	500	503	PF00017	0.471
LIG_SH2_STAT5	87	90	PF00017	0.687
LIG_SH3_3	445	451	PF00018	0.725
LIG_SH3_3	64	70	PF00018	0.652
LIG_SH3_3	76	82	PF00018	0.485
LIG_SH3_3	91	97	PF00018	0.482
LIG_TYR_ITIM	301	306	PF00017	0.619
LIG_UBA3_1	248	254	PF00899	0.530
LIG_UBA3_1	291	300	PF00899	0.619
MOD_CDK_SPxxK_3	413	420	PF00069	0.486
MOD_CK1_1	17	23	PF00069	0.504
MOD_CK1_1	237	243	PF00069	0.486
MOD_CK1_1	358	364	PF00069	0.776
MOD_CK1_1	365	371	PF00069	0.717
MOD_CK1_1	375	381	PF00069	0.501
MOD_CK1_1	440	446	PF00069	0.656
MOD_CK1_1	521	527	PF00069	0.696
MOD_CK1_1	72	78	PF00069	0.675
MOD_CK2_1	325	331	PF00069	0.752
MOD_CK2_1	364	370	PF00069	0.768
MOD_GlcNHglycan	187	190	PF01048	0.363
MOD_GlcNHglycan	219	222	PF01048	0.346
MOD_GlcNHglycan	277	281	PF01048	0.337
MOD_GlcNHglycan	361	364	PF01048	0.783
MOD_GlcNHglycan	374	377	PF01048	0.549
MOD_GlcNHglycan	523	526	PF01048	0.738
MOD_GlcNHglycan	60	63	PF01048	0.518
MOD_GlcNHglycan	74	77	PF01048	0.473
MOD_GlcNHglycan	88	91	PF01048	0.441
MOD_GlcNHglycan	99	102	PF01048	0.480
MOD_GSK3_1	10	17	PF00069	0.514
MOD_GSK3_1	148	155	PF00069	0.672
MOD_GSK3_1	19	26	PF00069	0.464
MOD_GSK3_1	355	362	PF00069	0.766
MOD_GSK3_1	375	382	PF00069	0.439
MOD_GSK3_1	40	47	PF00069	0.677
MOD_GSK3_1	477	484	PF00069	0.562
MOD_GSK3_1	520	527	PF00069	0.653
MOD_GSK3_1	65	72	PF00069	0.620
MOD_LATS_1	435	441	PF00433	0.507
MOD_N-GLC_1	358	363	PF02516	0.588
MOD_N-GLC_1	440	445	PF02516	0.664
MOD_NEK2_1	119	124	PF00069	0.487
MOD_NEK2_1	137	142	PF00069	0.581
MOD_NEK2_1	153	158	PF00069	0.661
MOD_NEK2_1	200	205	PF00069	0.546
MOD_NEK2_1	481	486	PF00069	0.444
MOD_NEK2_1	71	76	PF00069	0.651
MOD_NEK2_1	86	91	PF00069	0.442
MOD_NEK2_2	339	344	PF00069	0.618
MOD_PIKK_1	518	524	PF00454	0.663
MOD_PIKK_1	559	565	PF00454	0.618
MOD_PIKK_1	69	75	PF00454	0.536
MOD_PKA_1	149	155	PF00069	0.526
MOD_PKA_2	10	16	PF00069	0.516
MOD_PKA_2	107	113	PF00069	0.490
MOD_PKA_2	148	154	PF00069	0.524
MOD_PKA_2	17	23	PF00069	0.477
MOD_PKA_2	58	64	PF00069	0.517
MOD_PKB_1	147	155	PF00069	0.525
MOD_Plk_4	19	25	PF00069	0.502
MOD_Plk_4	477	483	PF00069	0.435
MOD_ProDKin_1	114	120	PF00069	0.493
MOD_ProDKin_1	362	368	PF00069	0.723
MOD_ProDKin_1	379	385	PF00069	0.332
MOD_ProDKin_1	413	419	PF00069	0.453
MOD_ProDKin_1	453	459	PF00069	0.782
MOD_SUMO_for_1	343	346	PF00179	0.583
TRG_DiLeu_BaEn_1	466	471	PF01217	0.462
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.546
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.518
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.513
TRG_ENDOCYTIC_2	198	201	PF00928	0.546
TRG_ENDOCYTIC_2	27	30	PF00928	0.444
TRG_ENDOCYTIC_2	303	306	PF00928	0.598
TRG_ENDOCYTIC_2	415	418	PF00928	0.487
TRG_ENDOCYTIC_2	478	481	PF00928	0.419
TRG_ENDOCYTIC_2	9	12	PF00928	0.525
TRG_ER_diArg_1	405	407	PF00400	0.473
TRG_ER_diArg_1	54	56	PF00400	0.508
TRG_NES_CRM1_1	246	261	PF08389	0.563
TRG_NLS_MonoExtC_3	252	258	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R8	Leptomonas seymouri	58%	100%
A0A3S7WZZ0	Leishmania donovani	99%	100%
A4HEX6	Leishmania braziliensis	77%	100%
E9AYA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q973	Leishmania major	92%	100%