Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I247_LEIIN

TriTrypDb:

LINF_260016800

Length:

683

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I247

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I247

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.667
CLV_NRD_NRD_1	143	145	PF00675	0.686
CLV_NRD_NRD_1	195	197	PF00675	0.648
CLV_NRD_NRD_1	432	434	PF00675	0.636
CLV_NRD_NRD_1	596	598	PF00675	0.616
CLV_PCSK_KEX2_1	130	132	PF00082	0.744
CLV_PCSK_KEX2_1	142	144	PF00082	0.604
CLV_PCSK_KEX2_1	432	434	PF00082	0.621
CLV_PCSK_KEX2_1	595	597	PF00082	0.653
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.685
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.594
CLV_PCSK_SKI1_1	171	175	PF00082	0.570
CLV_PCSK_SKI1_1	376	380	PF00082	0.397
CLV_PCSK_SKI1_1	597	601	PF00082	0.516
DEG_SCF_FBW7_2	40	45	PF00400	0.603
DEG_SPOP_SBC_1	198	202	PF00917	0.618
DEG_SPOP_SBC_1	246	250	PF00917	0.594
DEG_SPOP_SBC_1	90	94	PF00917	0.601
DEG_SPOP_SBC_1	96	100	PF00917	0.514
DOC_ANK_TNKS_1	464	471	PF00023	0.672
DOC_MAPK_FxFP_2	230	233	PF00069	0.429
DOC_MAPK_HePTP_8	522	534	PF00069	0.499
DOC_MAPK_MEF2A_6	296	303	PF00069	0.493
DOC_MAPK_MEF2A_6	525	534	PF00069	0.502
DOC_MAPK_MEF2A_6	77	84	PF00069	0.478
DOC_MAPK_NFAT4_5	77	85	PF00069	0.443
DOC_PP1_RVXF_1	71	77	PF00149	0.531
DOC_PP2B_LxvP_1	652	655	PF13499	0.618
DOC_PP2B_PxIxI_1	343	349	PF00149	0.534
DOC_PP4_FxxP_1	230	233	PF00568	0.429
DOC_PP4_FxxP_1	466	469	PF00568	0.602
DOC_SPAK_OSR1_1	465	469	PF12202	0.611
DOC_USP7_MATH_1	12	16	PF00917	0.745
DOC_USP7_MATH_1	162	166	PF00917	0.619
DOC_USP7_MATH_1	173	177	PF00917	0.740
DOC_USP7_MATH_1	192	196	PF00917	0.566
DOC_USP7_MATH_1	245	249	PF00917	0.672
DOC_USP7_MATH_1	260	264	PF00917	0.540
DOC_USP7_MATH_1	334	338	PF00917	0.791
DOC_USP7_MATH_1	380	384	PF00917	0.433
DOC_USP7_MATH_1	399	403	PF00917	0.552
DOC_USP7_MATH_1	409	413	PF00917	0.663
DOC_USP7_MATH_1	469	473	PF00917	0.629
DOC_USP7_MATH_1	575	579	PF00917	0.760
DOC_USP7_MATH_1	89	93	PF00917	0.589
DOC_USP7_MATH_1	96	100	PF00917	0.501
DOC_WW_Pin1_4	136	141	PF00397	0.686
DOC_WW_Pin1_4	326	331	PF00397	0.573
DOC_WW_Pin1_4	38	43	PF00397	0.614
DOC_WW_Pin1_4	8	13	PF00397	0.632
DOC_WW_Pin1_4	92	97	PF00397	0.595
LIG_14-3-3_CanoR_1	113	118	PF00244	0.425
LIG_14-3-3_CanoR_1	196	204	PF00244	0.671
LIG_14-3-3_CanoR_1	319	327	PF00244	0.454
LIG_14-3-3_CanoR_1	345	353	PF00244	0.495
LIG_14-3-3_CanoR_1	597	606	PF00244	0.387
LIG_BIR_II_1	1	5	PF00653	0.689
LIG_BRCT_BRCA1_1	209	213	PF00533	0.677
LIG_BRCT_BRCA1_1	53	57	PF00533	0.565
LIG_BRCT_BRCA1_1	607	611	PF00533	0.497
LIG_CaM_NSCaTE_8	148	155	PF13499	0.574
LIG_FHA_1	248	254	PF00498	0.585
LIG_FHA_1	321	327	PF00498	0.458
LIG_FHA_1	426	432	PF00498	0.644
LIG_FHA_1	495	501	PF00498	0.455
LIG_FHA_2	333	339	PF00498	0.713
LIG_GBD_Chelix_1	549	557	PF00786	0.453
LIG_LIR_Apic_2	134	140	PF02991	0.725
LIG_LIR_Gen_1	35	43	PF02991	0.637
LIG_LIR_Gen_1	542	553	PF02991	0.515
LIG_LIR_Gen_1	659	667	PF02991	0.618
LIG_LIR_Nem_3	35	40	PF02991	0.629
LIG_LIR_Nem_3	367	372	PF02991	0.434
LIG_LIR_Nem_3	542	548	PF02991	0.491
LIG_LIR_Nem_3	659	665	PF02991	0.641
LIG_LYPXL_S_1	226	230	PF13949	0.523
LIG_MYND_1	224	228	PF01753	0.481
LIG_NRBOX	552	558	PF00104	0.432
LIG_PALB2_WD40_1	144	152	PF16756	0.588
LIG_Pex14_2	57	61	PF04695	0.569
LIG_PTB_Apo_2	626	633	PF02174	0.535
LIG_SH2_CRK	137	141	PF00017	0.710
LIG_SH2_CRK	372	376	PF00017	0.385
LIG_SH2_CRK	545	549	PF00017	0.507
LIG_SH2_NCK_1	396	400	PF00017	0.675
LIG_SH2_NCK_1	88	92	PF00017	0.527
LIG_SH2_SRC	372	375	PF00017	0.433
LIG_SH2_SRC	533	536	PF00017	0.434
LIG_SH2_STAP1	115	119	PF00017	0.567
LIG_SH2_STAP1	545	549	PF00017	0.444
LIG_SH2_STAT3	256	259	PF00017	0.649
LIG_SH2_STAT5	151	154	PF00017	0.641
LIG_SH2_STAT5	238	241	PF00017	0.501
LIG_SH2_STAT5	533	536	PF00017	0.434
LIG_SH2_STAT5	664	667	PF00017	0.652
LIG_SH3_3	209	215	PF00018	0.590
LIG_SH3_3	383	389	PF00018	0.457
LIG_SH3_3	555	561	PF00018	0.441
LIG_SH3_3	571	577	PF00018	0.706
LIG_SH3_3	628	634	PF00018	0.544
LIG_SUMO_SIM_anti_2	484	491	PF11976	0.429
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.384
LIG_SUMO_SIM_par_1	97	106	PF11976	0.530
LIG_TRAF2_1	16	19	PF00917	0.690
LIG_TRAF2_1	283	286	PF00917	0.733
LIG_TRAF2_1	577	580	PF00917	0.699
LIG_TYR_ITIM	543	548	PF00017	0.490
MOD_CDC14_SPxK_1	139	142	PF00782	0.706
MOD_CDK_SPxK_1	136	142	PF00069	0.715
MOD_CDK_SPxxK_3	136	143	PF00069	0.715
MOD_CK1_1	200	206	PF00069	0.682
MOD_CK1_1	208	214	PF00069	0.643
MOD_CK1_1	337	343	PF00069	0.635
MOD_CK1_1	402	408	PF00069	0.580
MOD_CK1_1	523	529	PF00069	0.473
MOD_CK1_1	92	98	PF00069	0.649
MOD_CK2_1	12	18	PF00069	0.696
MOD_CK2_1	278	284	PF00069	0.671
MOD_CK2_1	332	338	PF00069	0.728
MOD_CK2_1	523	529	PF00069	0.436
MOD_CK2_1	97	103	PF00069	0.556
MOD_GlcNHglycan	1	4	PF01048	0.696
MOD_GlcNHglycan	15	18	PF01048	0.556
MOD_GlcNHglycan	165	168	PF01048	0.666
MOD_GlcNHglycan	207	210	PF01048	0.620
MOD_GlcNHglycan	279	283	PF01048	0.733
MOD_GlcNHglycan	366	369	PF01048	0.517
MOD_GlcNHglycan	399	402	PF01048	0.602
MOD_GlcNHglycan	404	407	PF01048	0.632
MOD_GlcNHglycan	415	418	PF01048	0.447
MOD_GlcNHglycan	448	451	PF01048	0.721
MOD_GlcNHglycan	471	474	PF01048	0.634
MOD_GlcNHglycan	561	564	PF01048	0.463
MOD_GlcNHglycan	622	625	PF01048	0.616
MOD_GSK3_1	122	129	PF00069	0.671
MOD_GSK3_1	163	170	PF00069	0.646
MOD_GSK3_1	199	206	PF00069	0.737
MOD_GSK3_1	232	239	PF00069	0.523
MOD_GSK3_1	333	340	PF00069	0.669
MOD_GSK3_1	388	395	PF00069	0.621
MOD_GSK3_1	405	412	PF00069	0.592
MOD_GSK3_1	514	521	PF00069	0.336
MOD_GSK3_1	8	15	PF00069	0.629
MOD_GSK3_1	90	97	PF00069	0.577
MOD_N-GLC_1	13	18	PF02516	0.733
MOD_N-GLC_1	272	277	PF02516	0.605
MOD_NEK2_1	204	209	PF00069	0.726
MOD_NEK2_1	317	322	PF00069	0.384
MOD_OFUCOSY	377	384	PF10250	0.494
MOD_PIKK_1	425	431	PF00454	0.669
MOD_PIKK_1	598	604	PF00454	0.386
MOD_PK_1	113	119	PF00069	0.408
MOD_PK_1	520	526	PF00069	0.516
MOD_PKA_2	575	581	PF00069	0.706
MOD_Plk_1	337	343	PF00069	0.658
MOD_Plk_1	658	664	PF00069	0.615
MOD_Plk_4	208	214	PF00069	0.706
MOD_Plk_4	514	520	PF00069	0.510
MOD_Plk_4	544	550	PF00069	0.452
MOD_Plk_4	647	653	PF00069	0.575
MOD_ProDKin_1	136	142	PF00069	0.685
MOD_ProDKin_1	326	332	PF00069	0.591
MOD_ProDKin_1	38	44	PF00069	0.611
MOD_ProDKin_1	8	14	PF00069	0.632
MOD_ProDKin_1	92	98	PF00069	0.649
MOD_SUMO_rev_2	2	12	PF00179	0.590
TRG_DiLeu_BaEn_1	78	83	PF01217	0.500
TRG_ENDOCYTIC_2	227	230	PF00928	0.507
TRG_ENDOCYTIC_2	545	548	PF00928	0.502
TRG_ENDOCYTIC_2	664	667	PF00928	0.641
TRG_ER_diArg_1	143	145	PF00400	0.627
TRG_ER_diArg_1	431	433	PF00400	0.645
TRG_ER_diArg_1	595	597	PF00400	0.707
TRG_NLS_Bipartite_1	130	146	PF00514	0.618
TRG_NLS_MonoExtN_4	140	146	PF00514	0.688
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I055	Leptomonas seymouri	50%	98%
A0A3Q8IH11	Leishmania donovani	100%	100%
A4HEX3	Leishmania braziliensis	76%	100%
C9ZRV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AY97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q976	Leishmania major	92%	100%