LeishMANIAdb
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PseudoU_synth_2 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PseudoU_synth_2 domain-containing protein
Gene product:
RNA pseudouridylate synthase - putative
Species:
Leishmania infantum
UniProt:
A4I245_LEIIN
TriTrypDb:
LINF_260016600 *
Length:
757

Annotations

Annotations by Jardim et al.

RNA Processing, Pseudouridine synthase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I245
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I245

Function

Biological processes
Term Name Level Count
GO:0001522 pseudouridine synthesis 6 7
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009451 RNA modification 5 7
GO:0009987 cellular process 1 7
GO:0016070 RNA metabolic process 5 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0046483 heterocycle metabolic process 3 7
GO:0071704 organic substance metabolic process 2 7
GO:0090304 nucleic acid metabolic process 4 7
GO:1901360 organic cyclic compound metabolic process 3 7
GO:0000154 rRNA modification 6 1
GO:0000455 enzyme-directed rRNA pseudouridine synthesis 8 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0016072 rRNA metabolic process 7 1
GO:0031118 rRNA pseudouridine synthesis 7 1
GO:0034470 ncRNA processing 7 1
GO:0034660 ncRNA metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0003824 catalytic activity 1 7
GO:0005488 binding 1 7
GO:0009982 pseudouridine synthase activity 4 7
GO:0016853 isomerase activity 2 7
GO:0016866 intramolecular transferase activity 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 222 226 PF00656 0.702
CLV_NRD_NRD_1 171 173 PF00675 0.308
CLV_NRD_NRD_1 178 180 PF00675 0.424
CLV_NRD_NRD_1 195 197 PF00675 0.459
CLV_NRD_NRD_1 554 556 PF00675 0.767
CLV_NRD_NRD_1 736 738 PF00675 0.425
CLV_PCSK_KEX2_1 171 173 PF00082 0.292
CLV_PCSK_KEX2_1 194 196 PF00082 0.614
CLV_PCSK_KEX2_1 52 54 PF00082 0.292
CLV_PCSK_KEX2_1 554 556 PF00082 0.703
CLV_PCSK_KEX2_1 576 578 PF00082 0.618
CLV_PCSK_KEX2_1 736 738 PF00082 0.425
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.376
CLV_PCSK_PC1ET2_1 576 578 PF00082 0.618
CLV_PCSK_SKI1_1 179 183 PF00082 0.545
CLV_PCSK_SKI1_1 559 563 PF00082 0.693
CLV_PCSK_SKI1_1 573 577 PF00082 0.526
CLV_PCSK_SKI1_1 671 675 PF00082 0.543
CLV_Separin_Metazoa 191 195 PF03568 0.588
DEG_APCC_DBOX_1 432 440 PF00400 0.453
DEG_Nend_UBRbox_4 1 3 PF02207 0.472
DEG_ODPH_VHL_1 49 60 PF01847 0.576
DEG_SCF_FBW7_2 211 216 PF00400 0.761
DEG_SPOP_SBC_1 459 463 PF00917 0.605
DEG_SPOP_SBC_1 711 715 PF00917 0.578
DOC_ANK_TNKS_1 736 743 PF00023 0.424
DOC_CDC14_PxL_1 389 397 PF14671 0.534
DOC_CKS1_1 287 292 PF01111 0.713
DOC_CKS1_1 421 426 PF01111 0.439
DOC_CYCLIN_yCln2_LP_2 304 310 PF00134 0.701
DOC_MAPK_gen_1 152 162 PF00069 0.492
DOC_MAPK_gen_1 510 518 PF00069 0.556
DOC_MAPK_gen_1 52 60 PF00069 0.576
DOC_PP2B_LxvP_1 302 305 PF13499 0.675
DOC_PP4_FxxP_1 390 393 PF00568 0.614
DOC_PP4_FxxP_1 747 750 PF00568 0.428
DOC_USP7_MATH_1 125 129 PF00917 0.485
DOC_USP7_MATH_1 199 203 PF00917 0.697
DOC_USP7_MATH_1 221 225 PF00917 0.626
DOC_USP7_MATH_1 325 329 PF00917 0.524
DOC_USP7_MATH_1 374 378 PF00917 0.628
DOC_USP7_MATH_1 407 411 PF00917 0.648
DOC_USP7_MATH_1 450 454 PF00917 0.522
DOC_USP7_MATH_1 459 463 PF00917 0.651
DOC_USP7_MATH_1 550 554 PF00917 0.793
DOC_USP7_MATH_1 580 584 PF00917 0.633
DOC_USP7_MATH_1 605 609 PF00917 0.665
DOC_USP7_MATH_1 623 627 PF00917 0.547
DOC_USP7_MATH_1 700 704 PF00917 0.696
DOC_USP7_MATH_1 709 713 PF00917 0.654
DOC_WW_Pin1_4 209 214 PF00397 0.759
DOC_WW_Pin1_4 217 222 PF00397 0.660
DOC_WW_Pin1_4 236 241 PF00397 0.648
DOC_WW_Pin1_4 286 291 PF00397 0.753
DOC_WW_Pin1_4 294 299 PF00397 0.698
DOC_WW_Pin1_4 375 380 PF00397 0.655
DOC_WW_Pin1_4 420 425 PF00397 0.439
DOC_WW_Pin1_4 485 490 PF00397 0.625
DOC_WW_Pin1_4 548 553 PF00397 0.748
DOC_WW_Pin1_4 685 690 PF00397 0.696
DOC_WW_Pin1_4 702 707 PF00397 0.505
DOC_WW_Pin1_4 72 77 PF00397 0.545
LIG_14-3-3_CanoR_1 249 257 PF00244 0.459
LIG_14-3-3_CanoR_1 329 337 PF00244 0.556
LIG_14-3-3_CanoR_1 433 443 PF00244 0.437
LIG_14-3-3_CanoR_1 529 535 PF00244 0.523
LIG_14-3-3_CanoR_1 559 564 PF00244 0.692
LIG_14-3-3_CanoR_1 94 100 PF00244 0.515
LIG_APCC_ABBAyCdc20_2 513 519 PF00400 0.573
LIG_BIR_III_4 564 568 PF00653 0.668
LIG_FHA_1 155 161 PF00498 0.492
LIG_FHA_1 187 193 PF00498 0.496
LIG_FHA_1 252 258 PF00498 0.438
LIG_FHA_1 364 370 PF00498 0.558
LIG_FHA_1 40 46 PF00498 0.492
LIG_FHA_1 424 430 PF00498 0.530
LIG_FHA_1 570 576 PF00498 0.555
LIG_FHA_1 607 613 PF00498 0.671
LIG_FHA_1 656 662 PF00498 0.593
LIG_FHA_1 69 75 PF00498 0.492
LIG_LIR_Gen_1 514 523 PF02991 0.567
LIG_LIR_Nem_3 514 518 PF02991 0.578
LIG_LIR_Nem_3 81 86 PF02991 0.491
LIG_NRBOX 384 390 PF00104 0.636
LIG_NRBOX 40 46 PF00104 0.576
LIG_NRP_CendR_1 756 757 PF00754 0.627
LIG_PTAP_UEV_1 88 93 PF05743 0.451
LIG_SH2_CRK 17 21 PF00017 0.335
LIG_SH2_CRK 38 42 PF00017 0.492
LIG_SH2_CRK 86 90 PF00017 0.476
LIG_SH2_GRB2like 37 40 PF00017 0.576
LIG_SH2_NCK_1 640 644 PF00017 0.569
LIG_SH2_NCK_1 86 90 PF00017 0.530
LIG_SH2_SRC 86 89 PF00017 0.576
LIG_SH2_STAP1 83 87 PF00017 0.576
LIG_SH2_STAT3 255 258 PF00017 0.426
LIG_SH2_STAT5 123 126 PF00017 0.530
LIG_SH2_STAT5 261 264 PF00017 0.429
LIG_SH2_STAT5 326 329 PF00017 0.603
LIG_SH2_STAT5 425 428 PF00017 0.475
LIG_SH2_STAT5 47 50 PF00017 0.541
LIG_SH2_STAT5 530 533 PF00017 0.644
LIG_SH3_1 86 92 PF00018 0.530
LIG_SH3_2 89 94 PF14604 0.530
LIG_SH3_3 143 149 PF00018 0.576
LIG_SH3_3 19 25 PF00018 0.576
LIG_SH3_3 230 236 PF00018 0.729
LIG_SH3_3 237 243 PF00018 0.581
LIG_SH3_3 287 293 PF00018 0.777
LIG_SH3_3 295 301 PF00018 0.762
LIG_SH3_3 364 370 PF00018 0.678
LIG_SH3_3 45 51 PF00018 0.492
LIG_SH3_3 465 471 PF00018 0.632
LIG_SH3_3 57 63 PF00018 0.492
LIG_SH3_3 613 619 PF00018 0.569
LIG_SH3_3 703 709 PF00018 0.647
LIG_SH3_3 86 92 PF00018 0.553
LIG_SH3_3 96 102 PF00018 0.502
LIG_Sin3_3 4 11 PF02671 0.447
LIG_SUMO_SIM_anti_2 157 164 PF11976 0.492
LIG_TRAF2_1 414 417 PF00917 0.526
LIG_TRAF2_1 537 540 PF00917 0.485
LIG_TRFH_1 47 51 PF08558 0.492
LIG_WW_3 94 98 PF00397 0.451
MOD_CDC14_SPxK_1 488 491 PF00782 0.598
MOD_CDC14_SPxK_1 551 554 PF00782 0.699
MOD_CDK_SPK_2 689 694 PF00069 0.573
MOD_CDK_SPxK_1 485 491 PF00069 0.600
MOD_CDK_SPxK_1 548 554 PF00069 0.687
MOD_CDK_SPxxK_3 548 555 PF00069 0.754
MOD_CDK_SPxxK_3 72 79 PF00069 0.530
MOD_CK1_1 116 122 PF00069 0.520
MOD_CK1_1 128 134 PF00069 0.437
MOD_CK1_1 276 282 PF00069 0.756
MOD_CK1_1 40 46 PF00069 0.530
MOD_CK1_1 410 416 PF00069 0.529
MOD_CK1_1 67 73 PF00069 0.484
MOD_CK1_1 684 690 PF00069 0.730
MOD_CK1_1 712 718 PF00069 0.578
MOD_CK2_1 128 134 PF00069 0.455
MOD_CK2_1 250 256 PF00069 0.600
MOD_CK2_1 40 46 PF00069 0.530
MOD_CK2_1 410 416 PF00069 0.636
MOD_CK2_1 710 716 PF00069 0.660
MOD_CK2_1 72 78 PF00069 0.492
MOD_GlcNHglycan 116 119 PF01048 0.321
MOD_GlcNHglycan 129 133 PF01048 0.249
MOD_GlcNHglycan 157 160 PF01048 0.292
MOD_GlcNHglycan 268 271 PF01048 0.592
MOD_GlcNHglycan 275 278 PF01048 0.644
MOD_GlcNHglycan 332 335 PF01048 0.569
MOD_GlcNHglycan 352 355 PF01048 0.713
MOD_GlcNHglycan 396 399 PF01048 0.699
MOD_GlcNHglycan 412 415 PF01048 0.549
MOD_GlcNHglycan 452 455 PF01048 0.714
MOD_GlcNHglycan 479 482 PF01048 0.616
MOD_GlcNHglycan 499 503 PF01048 0.585
MOD_GlcNHglycan 658 661 PF01048 0.460
MOD_GlcNHglycan 719 722 PF01048 0.702
MOD_GlcNHglycan 89 92 PF01048 0.237
MOD_GSK3_1 110 117 PF00069 0.562
MOD_GSK3_1 124 131 PF00069 0.427
MOD_GSK3_1 217 224 PF00069 0.701
MOD_GSK3_1 23 30 PF00069 0.492
MOD_GSK3_1 235 242 PF00069 0.656
MOD_GSK3_1 325 332 PF00069 0.543
MOD_GSK3_1 406 413 PF00069 0.736
MOD_GSK3_1 475 482 PF00069 0.762
MOD_GSK3_1 64 71 PF00069 0.490
MOD_GSK3_1 681 688 PF00069 0.735
MOD_GSK3_1 698 705 PF00069 0.528
MOD_N-GLC_1 199 204 PF02516 0.571
MOD_N-GLC_1 725 730 PF02516 0.665
MOD_NEK2_1 330 335 PF00069 0.550
MOD_NEK2_1 434 439 PF00069 0.581
MOD_NEK2_1 606 611 PF00069 0.671
MOD_NEK2_1 64 69 PF00069 0.484
MOD_NEK2_1 698 703 PF00069 0.662
MOD_NEK2_2 530 535 PF00069 0.576
MOD_PIKK_1 461 467 PF00454 0.669
MOD_PK_1 172 178 PF00069 0.530
MOD_PKA_2 506 512 PF00069 0.696
MOD_PKB_1 264 272 PF00069 0.657
MOD_Plk_4 172 178 PF00069 0.481
MOD_Plk_4 40 46 PF00069 0.530
MOD_Plk_4 64 70 PF00069 0.484
MOD_ProDKin_1 209 215 PF00069 0.756
MOD_ProDKin_1 217 223 PF00069 0.660
MOD_ProDKin_1 236 242 PF00069 0.640
MOD_ProDKin_1 286 292 PF00069 0.753
MOD_ProDKin_1 294 300 PF00069 0.698
MOD_ProDKin_1 375 381 PF00069 0.649
MOD_ProDKin_1 420 426 PF00069 0.440
MOD_ProDKin_1 485 491 PF00069 0.625
MOD_ProDKin_1 548 554 PF00069 0.751
MOD_ProDKin_1 685 691 PF00069 0.694
MOD_ProDKin_1 702 708 PF00069 0.508
MOD_ProDKin_1 72 78 PF00069 0.545
MOD_SUMO_rev_2 594 604 PF00179 0.598
TRG_DiLeu_BaEn_4 416 422 PF01217 0.577
TRG_DiLeu_BaLyEn_6 60 65 PF01217 0.492
TRG_ENDOCYTIC_2 17 20 PF00928 0.355
TRG_ENDOCYTIC_2 38 41 PF00928 0.492
TRG_ER_diArg_1 171 173 PF00400 0.508
TRG_ER_diArg_1 193 196 PF00400 0.607
TRG_ER_diArg_1 264 267 PF00400 0.591
TRG_ER_diArg_1 343 346 PF00400 0.622
TRG_ER_diArg_1 471 474 PF00400 0.598
TRG_ER_diArg_1 736 738 PF00400 0.495
TRG_ER_diArg_1 755 757 PF00400 0.575
TRG_NLS_MonoExtN_4 573 580 PF00514 0.674
TRG_Pf-PMV_PEXEL_1 736 741 PF00026 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHN9 Leptomonas seymouri 39% 94%
A0A3Q8IC63 Leishmania donovani 100% 78%
A4HEX1 Leishmania braziliensis 68% 100%
E9AY95 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q978 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS