Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I244_LEIIN

TriTrypDb:

LINF_260016500

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I244

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I244

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.647
CLV_C14_Caspase3-7	193	197	PF00656	0.614
CLV_C14_Caspase3-7	700	704	PF00656	0.628
CLV_C14_Caspase3-7	712	716	PF00656	0.445
CLV_C14_Caspase3-7	730	734	PF00656	0.487
CLV_NRD_NRD_1	269	271	PF00675	0.718
CLV_NRD_NRD_1	310	312	PF00675	0.701
CLV_NRD_NRD_1	397	399	PF00675	0.390
CLV_NRD_NRD_1	4	6	PF00675	0.697
CLV_NRD_NRD_1	444	446	PF00675	0.565
CLV_NRD_NRD_1	503	505	PF00675	0.601
CLV_NRD_NRD_1	584	586	PF00675	0.747
CLV_NRD_NRD_1	587	589	PF00675	0.670
CLV_NRD_NRD_1	774	776	PF00675	0.701
CLV_PCSK_FUR_1	584	588	PF00082	0.723
CLV_PCSK_KEX2_1	268	270	PF00082	0.719
CLV_PCSK_KEX2_1	3	5	PF00082	0.699
CLV_PCSK_KEX2_1	310	312	PF00082	0.701
CLV_PCSK_KEX2_1	444	446	PF00082	0.565
CLV_PCSK_KEX2_1	503	505	PF00082	0.601
CLV_PCSK_KEX2_1	584	586	PF00082	0.747
CLV_PCSK_KEX2_1	587	589	PF00082	0.670
CLV_PCSK_KEX2_1	774	776	PF00082	0.701
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.726
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.806
CLV_PCSK_SKI1_1	103	107	PF00082	0.509
CLV_PCSK_SKI1_1	200	204	PF00082	0.599
CLV_PCSK_SKI1_1	310	314	PF00082	0.634
CLV_PCSK_SKI1_1	343	347	PF00082	0.595
CLV_PCSK_SKI1_1	504	508	PF00082	0.596
CLV_PCSK_SKI1_1	544	548	PF00082	0.604
CLV_PCSK_SKI1_1	775	779	PF00082	0.601
CLV_Separin_Metazoa	331	335	PF03568	0.499
DEG_APCC_DBOX_1	102	110	PF00400	0.496
DEG_APCC_DBOX_1	397	405	PF00400	0.469
DEG_SCF_FBW7_1	628	635	PF00400	0.709
DEG_SPOP_SBC_1	536	540	PF00917	0.656
DEG_SPOP_SBC_1	627	631	PF00917	0.692
DOC_CYCLIN_RxL_1	107	115	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	763	769	PF00134	0.524
DOC_PP1_RVXF_1	652	658	PF00149	0.549
DOC_PP1_RVXF_1	733	740	PF00149	0.459
DOC_PP4_FxxP_1	225	228	PF00568	0.591
DOC_PP4_MxPP_1	323	326	PF00568	0.691
DOC_SPAK_OSR1_1	224	228	PF12202	0.594
DOC_USP7_MATH_1	132	136	PF00917	0.628
DOC_USP7_MATH_1	15	19	PF00917	0.606
DOC_USP7_MATH_1	353	357	PF00917	0.551
DOC_USP7_MATH_1	408	412	PF00917	0.715
DOC_USP7_MATH_1	451	455	PF00917	0.614
DOC_USP7_MATH_1	536	540	PF00917	0.755
DOC_USP7_MATH_1	621	625	PF00917	0.777
DOC_USP7_MATH_1	632	636	PF00917	0.661
DOC_USP7_MATH_1	644	648	PF00917	0.660
DOC_USP7_MATH_1	653	657	PF00917	0.370
DOC_USP7_MATH_1	768	772	PF00917	0.527
DOC_WW_Pin1_4	229	234	PF00397	0.572
DOC_WW_Pin1_4	238	243	PF00397	0.665
DOC_WW_Pin1_4	459	464	PF00397	0.588
DOC_WW_Pin1_4	628	633	PF00397	0.711
LIG_14-3-3_CanoR_1	398	408	PF00244	0.590
LIG_14-3-3_CanoR_1	486	491	PF00244	0.511
LIG_14-3-3_CanoR_1	49	55	PF00244	0.689
LIG_14-3-3_CanoR_1	504	510	PF00244	0.333
LIG_14-3-3_CanoR_1	567	573	PF00244	0.661
LIG_14-3-3_CanoR_1	585	591	PF00244	0.755
LIG_14-3-3_CanoR_1	654	663	PF00244	0.541
LIG_14-3-3_CanoR_1	728	732	PF00244	0.565
LIG_14-3-3_CanoR_1	752	758	PF00244	0.475
LIG_14-3-3_CanoR_1	774	778	PF00244	0.705
LIG_Actin_WH2_2	470	488	PF00022	0.689
LIG_BIR_III_4	715	719	PF00653	0.645
LIG_deltaCOP1_diTrp_1	680	690	PF00928	0.494
LIG_FHA_1	197	203	PF00498	0.418
LIG_FHA_1	244	250	PF00498	0.797
LIG_FHA_1	486	492	PF00498	0.561
LIG_FHA_1	650	656	PF00498	0.546
LIG_FHA_2	342	348	PF00498	0.429
LIG_FHA_2	506	512	PF00498	0.572
LIG_FHA_2	558	564	PF00498	0.573
LIG_FHA_2	569	575	PF00498	0.619
LIG_FHA_2	587	593	PF00498	0.684
LIG_FHA_2	629	635	PF00498	0.707
LIG_FHA_2	675	681	PF00498	0.685
LIG_FHA_2	728	734	PF00498	0.502
LIG_Integrin_RGD_1	673	675	PF01839	0.671
LIG_LIR_Gen_1	42	51	PF02991	0.585
LIG_LIR_Gen_1	656	663	PF02991	0.496
LIG_LIR_Gen_1	747	758	PF02991	0.466
LIG_LIR_Nem_3	361	366	PF02991	0.468
LIG_LIR_Nem_3	42	47	PF02991	0.582
LIG_LIR_Nem_3	429	434	PF02991	0.551
LIG_LIR_Nem_3	6	11	PF02991	0.576
LIG_LIR_Nem_3	656	660	PF02991	0.502
LIG_LIR_Nem_3	747	753	PF02991	0.468
LIG_NRBOX	210	216	PF00104	0.542
LIG_PDZ_Class_1	779	784	PF00595	0.626
LIG_Pex14_1	113	117	PF04695	0.483
LIG_SH2_CRK	363	367	PF00017	0.461
LIG_SH2_CRK	44	48	PF00017	0.584
LIG_SH2_CRK	750	754	PF00017	0.438
LIG_SH2_NCK_1	44	48	PF00017	0.584
LIG_SH2_SRC	418	421	PF00017	0.593
LIG_SH2_STAP1	510	514	PF00017	0.486
LIG_SH2_STAP1	750	754	PF00017	0.460
LIG_SH2_STAT5	746	749	PF00017	0.577
LIG_SH3_3	322	328	PF00018	0.578
LIG_SH3_3	345	351	PF00018	0.509
LIG_SUMO_SIM_par_1	334	340	PF11976	0.480
LIG_SUMO_SIM_par_1	344	349	PF11976	0.494
LIG_SUMO_SIM_par_1	557	563	PF11976	0.604
LIG_TRAF2_1	328	331	PF00917	0.604
LIG_TRAF2_1	560	563	PF00917	0.649
LIG_TRAF2_1	678	681	PF00917	0.581
LIG_UBA3_1	558	565	PF00899	0.636
LIG_WW_2	325	328	PF00397	0.564
MOD_CDK_SPK_2	229	234	PF00069	0.463
MOD_CK1_1	256	262	PF00069	0.715
MOD_CK1_1	275	281	PF00069	0.489
MOD_CK1_1	377	383	PF00069	0.466
MOD_CK1_1	454	460	PF00069	0.588
MOD_CK1_1	52	58	PF00069	0.701
MOD_CK1_1	647	653	PF00069	0.595
MOD_CK2_1	173	179	PF00069	0.538
MOD_CK2_1	461	467	PF00069	0.536
MOD_CK2_1	557	563	PF00069	0.600
MOD_CK2_1	586	592	PF00069	0.712
MOD_CK2_1	674	680	PF00069	0.605
MOD_GlcNHglycan	114	117	PF01048	0.478
MOD_GlcNHglycan	13	16	PF01048	0.677
MOD_GlcNHglycan	134	137	PF01048	0.423
MOD_GlcNHglycan	253	256	PF01048	0.728
MOD_GlcNHglycan	292	295	PF01048	0.700
MOD_GlcNHglycan	355	358	PF01048	0.608
MOD_GlcNHglycan	401	404	PF01048	0.597
MOD_GlcNHglycan	410	413	PF01048	0.638
MOD_GlcNHglycan	435	438	PF01048	0.619
MOD_GlcNHglycan	439	442	PF01048	0.525
MOD_GlcNHglycan	453	456	PF01048	0.655
MOD_GlcNHglycan	5	8	PF01048	0.588
MOD_GlcNHglycan	55	58	PF01048	0.684
MOD_GlcNHglycan	607	610	PF01048	0.750
MOD_GlcNHglycan	623	626	PF01048	0.715
MOD_GlcNHglycan	63	66	PF01048	0.531
MOD_GlcNHglycan	645	649	PF01048	0.725
MOD_GlcNHglycan	664	667	PF01048	0.412
MOD_GlcNHglycan	770	773	PF01048	0.545
MOD_GlcNHglycan	79	82	PF01048	0.502
MOD_GSK3_1	11	18	PF00069	0.651
MOD_GSK3_1	173	180	PF00069	0.460
MOD_GSK3_1	229	236	PF00069	0.596
MOD_GSK3_1	259	266	PF00069	0.667
MOD_GSK3_1	272	279	PF00069	0.520
MOD_GSK3_1	35	42	PF00069	0.633
MOD_GSK3_1	365	372	PF00069	0.487
MOD_GSK3_1	376	383	PF00069	0.430
MOD_GSK3_1	433	440	PF00069	0.444
MOD_GSK3_1	451	458	PF00069	0.633
MOD_GSK3_1	49	56	PF00069	0.649
MOD_GSK3_1	568	575	PF00069	0.783
MOD_GSK3_1	628	635	PF00069	0.718
MOD_GSK3_1	649	656	PF00069	0.625
MOD_GSK3_1	73	80	PF00069	0.537
MOD_GSK3_1	82	89	PF00069	0.540
MOD_N-GLC_1	251	256	PF02516	0.618
MOD_N-GLC_1	289	294	PF02516	0.676
MOD_N-GLC_1	605	610	PF02516	0.796
MOD_NEK2_1	11	16	PF00069	0.752
MOD_NEK2_1	112	117	PF00069	0.521
MOD_NEK2_1	173	178	PF00069	0.440
MOD_NEK2_1	24	29	PF00069	0.565
MOD_NEK2_1	346	351	PF00069	0.523
MOD_NEK2_1	376	381	PF00069	0.419
MOD_NEK2_1	505	510	PF00069	0.532
MOD_NEK2_1	572	577	PF00069	0.672
MOD_NEK2_1	88	93	PF00069	0.712
MOD_NEK2_2	305	310	PF00069	0.657
MOD_PIKK_1	17	23	PF00454	0.660
MOD_PIKK_1	269	275	PF00454	0.712
MOD_PIKK_1	578	584	PF00454	0.818
MOD_PK_1	486	492	PF00069	0.595
MOD_PKA_1	269	275	PF00069	0.712
MOD_PKA_1	3	9	PF00069	0.650
MOD_PKA_1	444	450	PF00069	0.628
MOD_PKA_1	586	592	PF00069	0.776
MOD_PKA_2	24	30	PF00069	0.684
MOD_PKA_2	269	275	PF00069	0.690
MOD_PKA_2	3	9	PF00069	0.691
MOD_PKA_2	444	450	PF00069	0.628
MOD_PKA_2	485	491	PF00069	0.571
MOD_PKA_2	586	592	PF00069	0.747
MOD_PKA_2	653	659	PF00069	0.580
MOD_PKA_2	727	733	PF00069	0.511
MOD_PKA_2	773	779	PF00069	0.703
MOD_PKB_1	484	492	PF00069	0.564
MOD_Plk_1	275	281	PF00069	0.683
MOD_Plk_2-3	245	251	PF00069	0.643
MOD_Plk_4	365	371	PF00069	0.487
MOD_Plk_4	486	492	PF00069	0.567
MOD_Plk_4	505	511	PF00069	0.499
MOD_Plk_4	727	733	PF00069	0.511
MOD_Plk_4	753	759	PF00069	0.486
MOD_ProDKin_1	229	235	PF00069	0.578
MOD_ProDKin_1	238	244	PF00069	0.666
MOD_ProDKin_1	459	465	PF00069	0.592
MOD_ProDKin_1	628	634	PF00069	0.714
MOD_SUMO_rev_2	562	566	PF00179	0.550
TRG_DiLeu_BaEn_1	210	215	PF01217	0.440
TRG_DiLeu_BaEn_3	157	163	PF01217	0.495
TRG_DiLeu_BaEn_4	154	160	PF01217	0.541
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.581
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.457
TRG_ENDOCYTIC_2	363	366	PF00928	0.461
TRG_ENDOCYTIC_2	44	47	PF00928	0.586
TRG_ENDOCYTIC_2	750	753	PF00928	0.465
TRG_ER_diArg_1	2	5	PF00400	0.690
TRG_ER_diArg_1	309	311	PF00400	0.705
TRG_ER_diArg_1	443	445	PF00400	0.599
TRG_ER_diArg_1	484	487	PF00400	0.607
TRG_ER_diArg_1	503	505	PF00400	0.499
TRG_ER_diArg_1	583	585	PF00400	0.741
TRG_ER_diArg_1	599	602	PF00400	0.627
TRG_ER_diArg_1	773	775	PF00400	0.562
TRG_NES_CRM1_1	206	220	PF08389	0.432
TRG_NLS_MonoCore_2	584	589	PF00514	0.811
TRG_NLS_MonoExtN_4	583	590	PF00514	0.801
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC42	Leptomonas seymouri	39%	96%
A0A3Q8IDS0	Leishmania donovani	99%	100%
A4HEX0	Leishmania braziliensis	67%	100%
E9AY94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q979	Leishmania major	86%	98%