RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit - putative

Species:

Leishmania infantum

UniProt:

A4I243_LEIIN

TriTrypDb:

LINF_260016400

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I243

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I243

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	192	194	PF00675	0.330
CLV_NRD_NRD_1	225	227	PF00675	0.327
CLV_NRD_NRD_1	286	288	PF00675	0.428
CLV_NRD_NRD_1	297	299	PF00675	0.406
CLV_NRD_NRD_1	306	308	PF00675	0.379
CLV_NRD_NRD_1	363	365	PF00675	0.361
CLV_NRD_NRD_1	61	63	PF00675	0.623
CLV_NRD_NRD_1	7	9	PF00675	0.544
CLV_PCSK_KEX2_1	192	194	PF00082	0.330
CLV_PCSK_KEX2_1	225	227	PF00082	0.327
CLV_PCSK_KEX2_1	286	288	PF00082	0.429
CLV_PCSK_KEX2_1	297	299	PF00082	0.364
CLV_PCSK_KEX2_1	306	308	PF00082	0.364
CLV_PCSK_KEX2_1	492	494	PF00082	0.450
CLV_PCSK_KEX2_1	61	63	PF00082	0.598
CLV_PCSK_KEX2_1	7	9	PF00082	0.544
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.450
CLV_PCSK_SKI1_1	163	167	PF00082	0.515
CLV_PCSK_SKI1_1	217	221	PF00082	0.344
CLV_PCSK_SKI1_1	260	264	PF00082	0.361
CLV_PCSK_SKI1_1	281	285	PF00082	0.354
CLV_PCSK_SKI1_1	298	302	PF00082	0.287
CLV_PCSK_SKI1_1	411	415	PF00082	0.623
CLV_PCSK_SKI1_1	495	499	PF00082	0.394
CLV_Separin_Metazoa	222	226	PF03568	0.342
DEG_APCC_DBOX_1	297	305	PF00400	0.325
DEG_APCC_DBOX_1	419	427	PF00400	0.384
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DEG_SCF_FBW7_1	21	27	PF00400	0.560
DEG_SCF_FBW7_1	30	37	PF00400	0.525
DOC_CKS1_1	21	26	PF01111	0.503
DOC_CYCLIN_RxL_1	257	268	PF00134	0.479
DOC_MAPK_gen_1	364	371	PF00069	0.370
DOC_MAPK_HePTP_8	467	479	PF00069	0.407
DOC_MAPK_MEF2A_6	364	373	PF00069	0.349
DOC_MAPK_MEF2A_6	470	479	PF00069	0.503
DOC_PP2B_LxvP_1	109	112	PF13499	0.533
DOC_PP4_FxxP_1	315	318	PF00568	0.343
DOC_PP4_MxPP_1	332	335	PF00568	0.437
DOC_USP7_MATH_1	24	28	PF00917	0.642
DOC_USP7_MATH_1	336	340	PF00917	0.470
DOC_USP7_MATH_1	34	38	PF00917	0.700
DOC_USP7_MATH_1	460	464	PF00917	0.374
DOC_USP7_MATH_1	50	54	PF00917	0.489
DOC_USP7_UBL2_3	525	529	PF12436	0.503
DOC_WW_Pin1_4	176	181	PF00397	0.429
DOC_WW_Pin1_4	20	25	PF00397	0.682
DOC_WW_Pin1_4	30	35	PF00397	0.711
DOC_WW_Pin1_4	330	335	PF00397	0.388
DOC_WW_Pin1_4	349	354	PF00397	0.349
DOC_WW_Pin1_4	65	70	PF00397	0.676
DOC_WW_Pin1_4	96	101	PF00397	0.563
LIG_14-3-3_CanoR_1	17	22	PF00244	0.688
LIG_14-3-3_CanoR_1	192	196	PF00244	0.328
LIG_14-3-3_CanoR_1	217	222	PF00244	0.339
LIG_14-3-3_CanoR_1	298	308	PF00244	0.461
LIG_14-3-3_CanoR_1	364	369	PF00244	0.381
LIG_14-3-3_CanoR_1	380	387	PF00244	0.341
LIG_14-3-3_CanoR_1	495	500	PF00244	0.547
LIG_14-3-3_CanoR_1	61	71	PF00244	0.624
LIG_Actin_RPEL_3	219	238	PF02755	0.340
LIG_Clathr_ClatBox_1	368	372	PF01394	0.433
LIG_DLG_GKlike_1	364	371	PF00625	0.351
LIG_FHA_1	111	117	PF00498	0.450
LIG_FHA_1	165	171	PF00498	0.398
LIG_FHA_1	218	224	PF00498	0.369
LIG_FHA_1	240	246	PF00498	0.333
LIG_FHA_1	291	297	PF00498	0.387
LIG_FHA_1	303	309	PF00498	0.328
LIG_FHA_1	34	40	PF00498	0.737
LIG_FHA_1	343	349	PF00498	0.388
LIG_FHA_1	41	47	PF00498	0.695
LIG_FHA_1	439	445	PF00498	0.403
LIG_FHA_1	467	473	PF00498	0.469
LIG_FHA_2	143	149	PF00498	0.622
LIG_FHA_2	164	170	PF00498	0.511
LIG_FHA_2	326	332	PF00498	0.337
LIG_FHA_2	350	356	PF00498	0.357
LIG_FHA_2	381	387	PF00498	0.483
LIG_FHA_2	79	85	PF00498	0.697
LIG_LIR_Apic_2	205	209	PF02991	0.436
LIG_LIR_Apic_2	314	318	PF02991	0.351
LIG_LIR_Gen_1	22	30	PF02991	0.591
LIG_LIR_Gen_1	401	408	PF02991	0.433
LIG_LIR_Nem_3	22	28	PF02991	0.587
LIG_LIR_Nem_3	401	406	PF02991	0.412
LIG_LIR_Nem_3	436	442	PF02991	0.274
LIG_LIR_Nem_3	68	73	PF02991	0.586
LIG_LYPXL_yS_3	70	73	PF13949	0.592
LIG_NRBOX	504	510	PF00104	0.342
LIG_NRBOX	519	525	PF00104	0.336
LIG_SH2_CRK	212	216	PF00017	0.458
LIG_SH2_CRK	25	29	PF00017	0.604
LIG_SH2_CRK	403	407	PF00017	0.390
LIG_SH2_CRK	57	61	PF00017	0.692
LIG_SH2_NCK_1	267	271	PF00017	0.376
LIG_SH2_NCK_1	403	407	PF00017	0.410
LIG_SH2_STAP1	197	201	PF00017	0.313
LIG_SH2_STAP1	212	216	PF00017	0.315
LIG_SH2_STAP1	25	29	PF00017	0.604
LIG_SH2_STAT5	212	215	PF00017	0.384
LIG_SH2_STAT5	239	242	PF00017	0.324
LIG_SH2_STAT5	327	330	PF00017	0.328
LIG_SH2_STAT5	458	461	PF00017	0.348
LIG_SH3_3	228	234	PF00018	0.463
LIG_SH3_3	80	86	PF00018	0.761
LIG_SUMO_SIM_anti_2	166	174	PF11976	0.503
LIG_SUMO_SIM_anti_2	220	225	PF11976	0.363
LIG_SUMO_SIM_par_1	217	222	PF11976	0.355
LIG_SUMO_SIM_par_1	394	401	PF11976	0.412
LIG_TRAF2_1	352	355	PF00917	0.503
LIG_TYR_ITSM	21	28	PF00017	0.589
LIG_TYR_ITSM	399	406	PF00017	0.439
MOD_CK1_1	20	26	PF00069	0.682
MOD_CK1_1	302	308	PF00069	0.323
MOD_CK1_1	349	355	PF00069	0.515
MOD_CK1_1	37	43	PF00069	0.600
MOD_CK1_1	398	404	PF00069	0.490
MOD_CK1_1	463	469	PF00069	0.381
MOD_CK1_1	65	71	PF00069	0.638
MOD_CK1_1	99	105	PF00069	0.619
MOD_CK2_1	163	169	PF00069	0.504
MOD_CK2_1	349	355	PF00069	0.372
MOD_CK2_1	380	386	PF00069	0.489
MOD_CK2_1	78	84	PF00069	0.728
MOD_Cter_Amidation	490	493	PF01082	0.461
MOD_GlcNHglycan	101	104	PF01048	0.591
MOD_GlcNHglycan	301	304	PF01048	0.448
MOD_GlcNHglycan	393	396	PF01048	0.459
MOD_GlcNHglycan	408	411	PF01048	0.635
MOD_GlcNHglycan	65	68	PF01048	0.656
MOD_GlcNHglycan	74	77	PF01048	0.679
MOD_GSK3_1	107	114	PF00069	0.512
MOD_GSK3_1	121	128	PF00069	0.366
MOD_GSK3_1	16	23	PF00069	0.649
MOD_GSK3_1	239	246	PF00069	0.342
MOD_GSK3_1	30	37	PF00069	0.547
MOD_GSK3_1	342	349	PF00069	0.519
MOD_GSK3_1	38	45	PF00069	0.553
MOD_GSK3_1	391	398	PF00069	0.472
MOD_GSK3_1	90	97	PF00069	0.690
MOD_LATS_1	15	21	PF00433	0.712
MOD_NEK2_1	1	6	PF00069	0.676
MOD_NEK2_1	191	196	PF00069	0.326
MOD_NEK2_1	238	243	PF00069	0.304
MOD_NEK2_1	258	263	PF00069	0.270
MOD_NEK2_1	282	287	PF00069	0.374
MOD_NEK2_1	38	43	PF00069	0.661
MOD_NEK2_1	391	396	PF00069	0.454
MOD_NEK2_2	197	202	PF00069	0.335
MOD_NEK2_2	395	400	PF00069	0.316
MOD_PIKK_1	357	363	PF00454	0.385
MOD_PKA_1	225	231	PF00069	0.488
MOD_PKA_1	364	370	PF00069	0.401
MOD_PKA_2	16	22	PF00069	0.610
MOD_PKA_2	191	197	PF00069	0.325
MOD_PKA_2	225	231	PF00069	0.488
MOD_PKA_2	342	348	PF00069	0.388
MOD_PKA_2	404	410	PF00069	0.561
MOD_PKB_1	493	501	PF00069	0.398
MOD_Plk_1	258	264	PF00069	0.410
MOD_Plk_1	435	441	PF00069	0.487
MOD_Plk_1	78	84	PF00069	0.671
MOD_Plk_4	211	217	PF00069	0.446
MOD_Plk_4	24	30	PF00069	0.700
MOD_Plk_4	258	264	PF00069	0.410
MOD_Plk_4	316	322	PF00069	0.332
MOD_Plk_4	34	40	PF00069	0.616
MOD_Plk_4	463	469	PF00069	0.387
MOD_Plk_4	519	525	PF00069	0.479
MOD_Plk_4	78	84	PF00069	0.663
MOD_Plk_4	90	96	PF00069	0.670
MOD_ProDKin_1	176	182	PF00069	0.425
MOD_ProDKin_1	20	26	PF00069	0.684
MOD_ProDKin_1	30	36	PF00069	0.711
MOD_ProDKin_1	330	336	PF00069	0.391
MOD_ProDKin_1	349	355	PF00069	0.345
MOD_ProDKin_1	65	71	PF00069	0.678
MOD_ProDKin_1	96	102	PF00069	0.567
MOD_SUMO_rev_2	156	165	PF00179	0.367
TRG_DiLeu_BaEn_1	169	174	PF01217	0.374
TRG_DiLeu_BaEn_1	259	264	PF01217	0.500
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.494
TRG_ENDOCYTIC_2	212	215	PF00928	0.412
TRG_ENDOCYTIC_2	25	28	PF00928	0.739
TRG_ENDOCYTIC_2	267	270	PF00928	0.378
TRG_ENDOCYTIC_2	403	406	PF00928	0.382
TRG_ENDOCYTIC_2	70	73	PF00928	0.777
TRG_ER_diArg_1	191	193	PF00400	0.332
TRG_ER_diArg_1	224	226	PF00400	0.337
TRG_ER_diArg_1	296	298	PF00400	0.379
TRG_ER_diArg_1	306	308	PF00400	0.378
TRG_ER_diArg_1	493	496	PF00400	0.435
TRG_ER_diArg_1	6	8	PF00400	0.613
TRG_ER_diArg_1	60	62	PF00400	0.619
TRG_NES_CRM1_1	361	375	PF08389	0.405
TRG_NLS_MonoExtC_3	491	496	PF00514	0.456
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGU4	Leptomonas seymouri	79%	94%
A0A0S4JSB1	Bodo saltans	54%	100%
A0A1X0NS86	Trypanosomatidae	67%	100%
A0A3Q8IDM7	Leishmania donovani	100%	100%
A0A422N6M4	Trypanosoma rangeli	64%	100%
A4HEW9	Leishmania braziliensis	90%	100%
C9ZRW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9AY93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
Q4Q980	Leishmania major	96%	100%
V5B995	Trypanosoma cruzi	65%	100%