Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I236_LEIIN

TriTrypDb:

LINF_260015700

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I236

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I236

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.658
CLV_MEL_PAP_1	250	256	PF00089	0.593
CLV_NRD_NRD_1	26	28	PF00675	0.741
CLV_NRD_NRD_1	309	311	PF00675	0.563
CLV_NRD_NRD_1	44	46	PF00675	0.541
CLV_NRD_NRD_1	507	509	PF00675	0.590
CLV_NRD_NRD_1	522	524	PF00675	0.515
CLV_NRD_NRD_1	539	541	PF00675	0.506
CLV_NRD_NRD_1	544	546	PF00675	0.627
CLV_PCSK_KEX2_1	26	28	PF00082	0.744
CLV_PCSK_KEX2_1	309	311	PF00082	0.570
CLV_PCSK_KEX2_1	43	45	PF00082	0.627
CLV_PCSK_KEX2_1	507	509	PF00082	0.590
CLV_PCSK_KEX2_1	539	541	PF00082	0.506
CLV_PCSK_KEX2_1	544	546	PF00082	0.627
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.682
CLV_PCSK_PC7_1	40	46	PF00082	0.652
CLV_PCSK_PC7_1	540	546	PF00082	0.584
CLV_PCSK_SKI1_1	120	124	PF00082	0.644
CLV_PCSK_SKI1_1	202	206	PF00082	0.702
CLV_PCSK_SKI1_1	496	500	PF00082	0.701
DEG_APCC_DBOX_1	154	162	PF00400	0.775
DOC_CYCLIN_RxL_1	117	127	PF00134	0.671
DOC_MAPK_MEF2A_6	353	361	PF00069	0.552
DOC_PP1_RVXF_1	222	229	PF00149	0.515
DOC_PP4_FxxP_1	162	165	PF00568	0.664
DOC_USP7_MATH_1	109	113	PF00917	0.754
DOC_USP7_MATH_1	137	141	PF00917	0.735
DOC_USP7_MATH_1	165	169	PF00917	0.716
DOC_USP7_MATH_1	216	220	PF00917	0.780
DOC_USP7_MATH_1	257	261	PF00917	0.619
DOC_USP7_MATH_1	299	303	PF00917	0.634
DOC_USP7_MATH_1	373	377	PF00917	0.599
DOC_USP7_MATH_1	420	424	PF00917	0.723
DOC_USP7_MATH_1	473	477	PF00917	0.714
DOC_USP7_UBL2_3	43	47	PF12436	0.616
DOC_WW_Pin1_4	163	168	PF00397	0.683
DOC_WW_Pin1_4	183	188	PF00397	0.610
DOC_WW_Pin1_4	217	222	PF00397	0.655
DOC_WW_Pin1_4	29	34	PF00397	0.686
DOC_WW_Pin1_4	60	65	PF00397	0.737
DOC_WW_Pin1_4	86	91	PF00397	0.734
LIG_14-3-3_CanoR_1	147	157	PF00244	0.679
LIG_14-3-3_CanoR_1	239	247	PF00244	0.486
LIG_14-3-3_CanoR_1	26	30	PF00244	0.648
LIG_14-3-3_CanoR_1	309	317	PF00244	0.458
LIG_14-3-3_CanoR_1	38	46	PF00244	0.605
LIG_14-3-3_CanoR_1	388	395	PF00244	0.564
LIG_14-3-3_CanoR_1	421	430	PF00244	0.696
LIG_14-3-3_CanoR_1	477	485	PF00244	0.760
LIG_14-3-3_CanoR_1	496	502	PF00244	0.760
LIG_14-3-3_CanoR_1	544	552	PF00244	0.696
LIG_BIR_III_2	425	429	PF00653	0.719
LIG_BRCT_BRCA1_1	139	143	PF00533	0.730
LIG_BRCT_BRCA1_1	185	189	PF00533	0.585
LIG_BRCT_BRCA1_1	250	254	PF00533	0.687
LIG_BRCT_BRCA1_1	259	263	PF00533	0.564
LIG_BRCT_BRCA1_1	303	307	PF00533	0.642
LIG_BRCT_BRCA1_1	311	315	PF00533	0.427
LIG_BRCT_BRCA1_1	348	352	PF00533	0.378
LIG_deltaCOP1_diTrp_1	243	247	PF00928	0.581
LIG_deltaCOP1_diTrp_1	280	289	PF00928	0.592
LIG_eIF4E_1	553	559	PF01652	0.576
LIG_FHA_1	133	139	PF00498	0.680
LIG_FHA_1	388	394	PF00498	0.679
LIG_FHA_1	395	401	PF00498	0.525
LIG_FHA_1	497	503	PF00498	0.678
LIG_FHA_2	203	209	PF00498	0.717
LIG_FHA_2	285	291	PF00498	0.592
LIG_FHA_2	400	406	PF00498	0.584
LIG_FHA_2	409	415	PF00498	0.474
LIG_GBD_Chelix_1	529	537	PF00786	0.532
LIG_LIR_Apic_2	160	165	PF02991	0.661
LIG_LIR_Gen_1	225	236	PF02991	0.513
LIG_LIR_Gen_1	242	252	PF02991	0.524
LIG_LIR_Gen_1	451	461	PF02991	0.627
LIG_LIR_Nem_3	17	22	PF02991	0.669
LIG_LIR_Nem_3	186	192	PF02991	0.582
LIG_LIR_Nem_3	225	231	PF02991	0.660
LIG_LIR_Nem_3	242	247	PF02991	0.495
LIG_LIR_Nem_3	349	355	PF02991	0.347
LIG_LIR_Nem_3	451	457	PF02991	0.611
LIG_MYND_1	2	6	PF01753	0.563
LIG_Pex14_1	7	11	PF04695	0.593
LIG_SH2_CRK	133	137	PF00017	0.651
LIG_SH2_CRK	19	23	PF00017	0.710
LIG_SH2_NCK_1	133	137	PF00017	0.651
LIG_SH2_NCK_1	401	405	PF00017	0.584
LIG_SH2_STAP1	347	351	PF00017	0.404
LIG_SH2_STAT3	234	237	PF00017	0.713
LIG_SH2_STAT3	347	350	PF00017	0.631
LIG_SH2_STAT5	125	128	PF00017	0.649
LIG_SH2_STAT5	319	322	PF00017	0.489
LIG_SH2_STAT5	401	404	PF00017	0.438
LIG_SH2_STAT5	532	535	PF00017	0.560
LIG_SH3_2	3	8	PF14604	0.626
LIG_SH3_3	103	109	PF00018	0.613
LIG_SH3_3	189	195	PF00018	0.620
LIG_SH3_3	209	215	PF00018	0.581
LIG_SH3_3	549	555	PF00018	0.754
LIG_SH3_3	59	65	PF00018	0.782
LIG_SH3_3	87	93	PF00018	0.789
LIG_TRAF2_1	114	117	PF00917	0.772
LIG_TRAF2_1	288	291	PF00917	0.505
LIG_WW_3	107	111	PF00397	0.700
MOD_CDC14_SPxK_1	63	66	PF00782	0.738
MOD_CDK_SPxK_1	60	66	PF00069	0.745
MOD_CDK_SPxxK_3	217	224	PF00069	0.614
MOD_CDK_SPxxK_3	29	36	PF00069	0.630
MOD_CK1_1	112	118	PF00069	0.776
MOD_CK1_1	170	176	PF00069	0.744
MOD_CK1_1	203	209	PF00069	0.734
MOD_CK1_1	217	223	PF00069	0.613
MOD_CK1_1	255	261	PF00069	0.663
MOD_CK1_1	32	38	PF00069	0.726
MOD_CK1_1	476	482	PF00069	0.608
MOD_CK1_1	82	88	PF00069	0.764
MOD_CK1_1	89	95	PF00069	0.674
MOD_CK2_1	111	117	PF00069	0.745
MOD_CK2_1	163	169	PF00069	0.717
MOD_CK2_1	202	208	PF00069	0.699
MOD_CK2_1	229	235	PF00069	0.664
MOD_CK2_1	284	290	PF00069	0.586
MOD_CK2_1	399	405	PF00069	0.541
MOD_CK2_1	519	525	PF00069	0.562
MOD_Cter_Amidation	542	545	PF01082	0.667
MOD_GlcNHglycan	139	142	PF01048	0.725
MOD_GlcNHglycan	16	19	PF01048	0.689
MOD_GlcNHglycan	169	172	PF01048	0.786
MOD_GlcNHglycan	176	179	PF01048	0.695
MOD_GlcNHglycan	216	219	PF01048	0.586
MOD_GlcNHglycan	22	25	PF01048	0.652
MOD_GlcNHglycan	250	253	PF01048	0.696
MOD_GlcNHglycan	255	258	PF01048	0.612
MOD_GlcNHglycan	296	299	PF01048	0.655
MOD_GlcNHglycan	301	304	PF01048	0.698
MOD_GlcNHglycan	311	314	PF01048	0.328
MOD_GlcNHglycan	479	482	PF01048	0.717
MOD_GlcNHglycan	541	544	PF01048	0.499
MOD_GlcNHglycan	67	70	PF01048	0.798
MOD_GSK3_1	108	115	PF00069	0.696
MOD_GSK3_1	163	170	PF00069	0.711
MOD_GSK3_1	216	223	PF00069	0.740
MOD_GSK3_1	248	255	PF00069	0.662
MOD_GSK3_1	25	32	PF00069	0.667
MOD_GSK3_1	301	308	PF00069	0.580
MOD_GSK3_1	369	376	PF00069	0.580
MOD_GSK3_1	387	394	PF00069	0.475
MOD_GSK3_1	399	406	PF00069	0.411
MOD_GSK3_1	473	480	PF00069	0.637
MOD_GSK3_1	539	546	PF00069	0.678
MOD_GSK3_1	79	86	PF00069	0.711
MOD_LATS_1	494	500	PF00433	0.704
MOD_LATS_1	77	83	PF00433	0.699
MOD_NEK2_1	132	137	PF00069	0.753
MOD_NEK2_1	174	179	PF00069	0.782
MOD_NEK2_1	25	30	PF00069	0.692
MOD_NEK2_1	369	374	PF00069	0.637
MOD_NEK2_1	403	408	PF00069	0.552
MOD_NEK2_1	450	455	PF00069	0.442
MOD_NEK2_1	84	89	PF00069	0.677
MOD_NEK2_2	157	162	PF00069	0.676
MOD_PIKK_1	148	154	PF00454	0.625
MOD_PIKK_1	319	325	PF00454	0.461
MOD_PIKK_1	346	352	PF00454	0.422
MOD_PIKK_1	79	85	PF00454	0.787
MOD_PKA_1	309	315	PF00069	0.534
MOD_PKA_1	539	545	PF00069	0.607
MOD_PKA_2	109	115	PF00069	0.724
MOD_PKA_2	146	152	PF00069	0.748
MOD_PKA_2	25	31	PF00069	0.651
MOD_PKA_2	252	258	PF00069	0.697
MOD_PKA_2	309	315	PF00069	0.534
MOD_PKA_2	387	393	PF00069	0.597
MOD_PKA_2	420	426	PF00069	0.744
MOD_PKA_2	476	482	PF00069	0.623
MOD_PKA_2	519	525	PF00069	0.570
MOD_PKA_2	539	545	PF00069	0.607
MOD_PKB_1	36	44	PF00069	0.611
MOD_Plk_1	224	230	PF00069	0.512
MOD_Plk_1	465	471	PF00069	0.769
MOD_Plk_4	157	163	PF00069	0.679
MOD_Plk_4	450	456	PF00069	0.501
MOD_Plk_4	497	503	PF00069	0.679
MOD_Plk_4	554	560	PF00069	0.629
MOD_ProDKin_1	163	169	PF00069	0.685
MOD_ProDKin_1	183	189	PF00069	0.612
MOD_ProDKin_1	217	223	PF00069	0.651
MOD_ProDKin_1	29	35	PF00069	0.687
MOD_ProDKin_1	60	66	PF00069	0.738
MOD_ProDKin_1	86	92	PF00069	0.732
TRG_DiLeu_BaEn_2	184	190	PF01217	0.582
TRG_DiLeu_BaEn_2	443	449	PF01217	0.553
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.695
TRG_ENDOCYTIC_2	133	136	PF00928	0.652
TRG_ENDOCYTIC_2	19	22	PF00928	0.713
TRG_ER_diArg_1	25	27	PF00400	0.749
TRG_ER_diArg_1	36	39	PF00400	0.621
TRG_ER_diArg_1	44	46	PF00400	0.527
TRG_ER_diArg_1	539	541	PF00400	0.544
TRG_NLS_Bipartite_1	26	47	PF00514	0.637
TRG_NLS_MonoExtC_3	42	47	PF00514	0.636
TRG_NLS_MonoExtN_4	40	47	PF00514	0.657
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.754

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P648	Leptomonas seymouri	33%	100%
A0A3S7WZS1	Leishmania donovani	99%	100%
A4HEW3	Leishmania braziliensis	66%	100%
E9AY86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q987	Leishmania major	89%	100%