LeishMANIAdb
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Nicalin

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nicalin
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4I233_LEIIN
TriTrypDb:
LINF_260015400
Length:
549

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 10, no: 0
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0031090 organelle membrane 3 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I233
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I233

Function

Biological processes
Term Name Level Count
GO:0009966 regulation of signal transduction 4 11
GO:0010646 regulation of cell communication 4 11
GO:0023051 regulation of signaling 3 11
GO:0048583 regulation of response to stimulus 3 11
GO:0050789 regulation of biological process 2 11
GO:0050794 regulation of cellular process 3 11
GO:0065007 biological regulation 1 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 394 398 PF00656 0.376
CLV_NRD_NRD_1 168 170 PF00675 0.543
CLV_NRD_NRD_1 240 242 PF00675 0.481
CLV_NRD_NRD_1 389 391 PF00675 0.582
CLV_PCSK_KEX2_1 168 170 PF00082 0.543
CLV_PCSK_KEX2_1 240 242 PF00082 0.481
CLV_PCSK_KEX2_1 320 322 PF00082 0.601
CLV_PCSK_KEX2_1 389 391 PF00082 0.582
CLV_PCSK_KEX2_1 403 405 PF00082 0.448
CLV_PCSK_PC1ET2_1 320 322 PF00082 0.601
CLV_PCSK_PC1ET2_1 403 405 PF00082 0.539
CLV_PCSK_SKI1_1 154 158 PF00082 0.586
CLV_PCSK_SKI1_1 159 163 PF00082 0.552
CLV_PCSK_SKI1_1 240 244 PF00082 0.551
CLV_PCSK_SKI1_1 289 293 PF00082 0.514
CLV_PCSK_SKI1_1 33 37 PF00082 0.512
CLV_PCSK_SKI1_1 366 370 PF00082 0.471
CLV_PCSK_SKI1_1 478 482 PF00082 0.574
CLV_PCSK_SKI1_1 52 56 PF00082 0.516
CLV_PCSK_SKI1_1 99 103 PF00082 0.562
CLV_Separin_Metazoa 59 63 PF03568 0.334
DEG_Nend_Nbox_1 1 3 PF02207 0.531
DEG_SCF_FBW7_1 493 499 PF00400 0.383
DEG_SPOP_SBC_1 271 275 PF00917 0.354
DOC_ANK_TNKS_1 38 45 PF00023 0.328
DOC_CKS1_1 493 498 PF01111 0.385
DOC_CYCLIN_yCln2_LP_2 297 300 PF00134 0.344
DOC_MAPK_gen_1 99 108 PF00069 0.310
DOC_MAPK_MEF2A_6 22 31 PF00069 0.332
DOC_MAPK_MEF2A_6 3 11 PF00069 0.519
DOC_MAPK_MEF2A_6 336 344 PF00069 0.293
DOC_MAPK_MEF2A_6 99 108 PF00069 0.351
DOC_MAPK_RevD_3 308 321 PF00069 0.332
DOC_PP1_RVXF_1 31 38 PF00149 0.316
DOC_PP2B_LxvP_1 297 300 PF13499 0.310
DOC_PP2B_LxvP_1 92 95 PF13499 0.319
DOC_USP7_MATH_1 152 156 PF00917 0.346
DOC_USP7_MATH_1 362 366 PF00917 0.325
DOC_USP7_MATH_1 418 422 PF00917 0.435
DOC_USP7_MATH_1 443 447 PF00917 0.293
DOC_USP7_MATH_1 480 484 PF00917 0.299
DOC_USP7_MATH_1 65 69 PF00917 0.421
DOC_WW_Pin1_4 217 222 PF00397 0.354
DOC_WW_Pin1_4 242 247 PF00397 0.412
DOC_WW_Pin1_4 446 451 PF00397 0.279
DOC_WW_Pin1_4 492 497 PF00397 0.390
LIG_14-3-3_CanoR_1 146 151 PF00244 0.378
LIG_14-3-3_CanoR_1 154 162 PF00244 0.355
LIG_14-3-3_CanoR_1 240 246 PF00244 0.372
LIG_14-3-3_CanoR_1 33 38 PF00244 0.303
LIG_14-3-3_CanoR_1 366 373 PF00244 0.365
LIG_14-3-3_CanoR_1 390 400 PF00244 0.407
LIG_14-3-3_CanoR_1 478 487 PF00244 0.326
LIG_14-3-3_CterR_2 545 549 PF00244 0.597
LIG_APCC_ABBA_1 501 506 PF00400 0.301
LIG_APCC_ABBA_1 544 549 PF00400 0.594
LIG_BRCT_BRCA1_1 119 123 PF00533 0.349
LIG_BRCT_BRCA1_1 514 518 PF00533 0.298
LIG_EH1_1 255 263 PF00400 0.293
LIG_eIF4E_1 256 262 PF01652 0.286
LIG_FHA_1 12 18 PF00498 0.561
LIG_FHA_1 155 161 PF00498 0.369
LIG_FHA_1 165 171 PF00498 0.378
LIG_FHA_1 257 263 PF00498 0.285
LIG_FHA_1 272 278 PF00498 0.280
LIG_FHA_1 373 379 PF00498 0.325
LIG_FHA_1 493 499 PF00498 0.329
LIG_FHA_1 505 511 PF00498 0.304
LIG_FHA_1 539 545 PF00498 0.534
LIG_FHA_1 73 79 PF00498 0.255
LIG_FHA_2 111 117 PF00498 0.283
LIG_FHA_2 279 285 PF00498 0.396
LIG_FHA_2 392 398 PF00498 0.368
LIG_FHA_2 487 493 PF00498 0.380
LIG_GBD_Chelix_1 234 242 PF00786 0.507
LIG_GBD_Chelix_1 290 298 PF00786 0.433
LIG_LIR_Gen_1 211 222 PF02991 0.264
LIG_LIR_Gen_1 309 319 PF02991 0.287
LIG_LIR_Gen_1 489 498 PF02991 0.382
LIG_LIR_Nem_3 211 217 PF02991 0.256
LIG_LIR_Nem_3 237 242 PF02991 0.261
LIG_LIR_Nem_3 286 291 PF02991 0.278
LIG_LIR_Nem_3 309 314 PF02991 0.282
LIG_LIR_Nem_3 349 354 PF02991 0.323
LIG_LIR_Nem_3 382 388 PF02991 0.358
LIG_LIR_Nem_3 489 493 PF02991 0.372
LIG_LIR_Nem_3 499 504 PF02991 0.311
LIG_LIR_Nem_3 68 74 PF02991 0.348
LIG_MLH1_MIPbox_1 119 123 PF16413 0.361
LIG_NRBOX 143 149 PF00104 0.380
LIG_NRBOX 526 532 PF00104 0.400
LIG_PCNA_PIPBox_1 207 216 PF02747 0.356
LIG_SH2_PTP2 535 538 PF00017 0.422
LIG_SH2_SRC 311 314 PF00017 0.345
LIG_SH2_SRC 535 538 PF00017 0.553
LIG_SH2_STAP1 256 260 PF00017 0.252
LIG_SH2_STAP1 354 358 PF00017 0.290
LIG_SH2_STAP1 461 465 PF00017 0.267
LIG_SH2_STAP1 504 508 PF00017 0.259
LIG_SH2_STAP1 74 78 PF00017 0.311
LIG_SH2_STAT3 247 250 PF00017 0.436
LIG_SH2_STAT5 133 136 PF00017 0.265
LIG_SH2_STAT5 188 191 PF00017 0.346
LIG_SH2_STAT5 311 314 PF00017 0.345
LIG_SH2_STAT5 435 438 PF00017 0.344
LIG_SH2_STAT5 516 519 PF00017 0.414
LIG_SH2_STAT5 535 538 PF00017 0.282
LIG_SH2_STAT5 63 66 PF00017 0.386
LIG_SH2_STAT5 74 77 PF00017 0.262
LIG_SH3_3 186 192 PF00018 0.368
LIG_SUMO_SIM_anti_2 257 262 PF11976 0.204
LIG_SUMO_SIM_par_1 104 114 PF11976 0.350
LIG_SUMO_SIM_par_1 257 266 PF11976 0.281
LIG_SUMO_SIM_par_1 8 14 PF11976 0.524
LIG_TRAF2_1 248 251 PF00917 0.464
LIG_TRAF2_1 489 492 PF00917 0.383
LIG_TRAF2_1 503 506 PF00917 0.313
LIG_UBA3_1 337 343 PF00899 0.322
LIG_WRC_WIRS_1 118 123 PF05994 0.334
LIG_WW_3 298 302 PF00397 0.337
MOD_CDK_SPxxK_3 217 224 PF00069 0.386
MOD_CDK_SPxxK_3 242 249 PF00069 0.417
MOD_CK1_1 220 226 PF00069 0.338
MOD_CK1_1 275 281 PF00069 0.390
MOD_CK1_1 346 352 PF00069 0.367
MOD_CK1_1 446 452 PF00069 0.284
MOD_CK1_1 483 489 PF00069 0.313
MOD_CK2_1 110 116 PF00069 0.287
MOD_CK2_1 152 158 PF00069 0.341
MOD_CK2_1 278 284 PF00069 0.352
MOD_CK2_1 486 492 PF00069 0.324
MOD_GlcNHglycan 154 157 PF01048 0.561
MOD_GlcNHglycan 180 183 PF01048 0.534
MOD_GlcNHglycan 200 203 PF01048 0.454
MOD_GlcNHglycan 225 228 PF01048 0.506
MOD_GlcNHglycan 229 232 PF01048 0.476
MOD_GlcNHglycan 345 348 PF01048 0.565
MOD_GlcNHglycan 420 423 PF01048 0.616
MOD_GlcNHglycan 482 485 PF01048 0.586
MOD_GlcNHglycan 67 70 PF01048 0.560
MOD_GSK3_1 117 124 PF00069 0.307
MOD_GSK3_1 138 145 PF00069 0.346
MOD_GSK3_1 160 167 PF00069 0.356
MOD_GSK3_1 174 181 PF00069 0.299
MOD_GSK3_1 194 201 PF00069 0.257
MOD_GSK3_1 213 220 PF00069 0.331
MOD_GSK3_1 222 229 PF00069 0.288
MOD_GSK3_1 271 278 PF00069 0.357
MOD_GSK3_1 362 369 PF00069 0.292
MOD_GSK3_1 479 486 PF00069 0.291
MOD_GSK3_1 492 499 PF00069 0.308
MOD_GSK3_1 61 68 PF00069 0.315
MOD_GSK3_1 78 85 PF00069 0.377
MOD_N-GLC_1 136 141 PF02516 0.499
MOD_N-GLC_1 175 180 PF02516 0.512
MOD_NEK2_1 1 6 PF00069 0.538
MOD_NEK2_1 10 15 PF00069 0.466
MOD_NEK2_1 121 126 PF00069 0.322
MOD_NEK2_1 261 266 PF00069 0.268
MOD_NEK2_1 338 343 PF00069 0.354
MOD_NEK2_1 371 376 PF00069 0.355
MOD_NEK2_1 48 53 PF00069 0.311
MOD_NEK2_1 512 517 PF00069 0.295
MOD_NEK2_2 496 501 PF00069 0.353
MOD_PIKK_1 275 281 PF00454 0.354
MOD_PIKK_1 443 449 PF00454 0.309
MOD_PK_1 146 152 PF00069 0.389
MOD_PK_1 249 255 PF00069 0.387
MOD_PKA_1 168 174 PF00069 0.306
MOD_PKA_1 240 246 PF00069 0.372
MOD_PKA_2 168 174 PF00069 0.381
MOD_PKA_2 223 229 PF00069 0.400
MOD_PKA_2 240 246 PF00069 0.215
MOD_PKA_2 300 306 PF00069 0.373
MOD_PKA_2 61 67 PF00069 0.272
MOD_Plk_1 142 148 PF00069 0.311
MOD_Plk_1 174 180 PF00069 0.319
MOD_Plk_1 256 262 PF00069 0.355
MOD_Plk_1 504 510 PF00069 0.351
MOD_Plk_4 117 123 PF00069 0.364
MOD_Plk_4 256 262 PF00069 0.286
MOD_Plk_4 272 278 PF00069 0.309
MOD_Plk_4 424 430 PF00069 0.363
MOD_Plk_4 431 437 PF00069 0.287
MOD_Plk_4 512 518 PF00069 0.313
MOD_Plk_4 72 78 PF00069 0.254
MOD_ProDKin_1 217 223 PF00069 0.356
MOD_ProDKin_1 242 248 PF00069 0.415
MOD_ProDKin_1 446 452 PF00069 0.279
MOD_ProDKin_1 492 498 PF00069 0.386
TRG_DiLeu_BaEn_1 143 148 PF01217 0.376
TRG_DiLeu_BaEn_1 257 262 PF01217 0.204
TRG_DiLeu_LyEn_5 143 148 PF01217 0.376
TRG_ENDOCYTIC_2 311 314 PF00928 0.296
TRG_ENDOCYTIC_2 490 493 PF00928 0.346
TRG_ENDOCYTIC_2 535 538 PF00928 0.483
TRG_ER_diArg_1 168 170 PF00400 0.378
TRG_ER_diArg_1 239 241 PF00400 0.278
TRG_ER_diArg_1 388 390 PF00400 0.378
TRG_NES_CRM1_1 284 296 PF08389 0.308
TRG_NES_CRM1_1 309 322 PF08389 0.335
TRG_Pf-PMV_PEXEL_1 168 172 PF00026 0.560
TRG_Pf-PMV_PEXEL_1 283 287 PF00026 0.541
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.588

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P650 Leptomonas seymouri 61% 100%
A0A1X0NSR2 Trypanosomatidae 33% 86%
A0A3R7MV36 Trypanosoma rangeli 34% 91%
A0A3S7WZU9 Leishmania donovani 100% 100%
A4HEW0 Leishmania braziliensis 79% 100%
C9ZRX2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 92%
E9AY83 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q990 Leishmania major 95% 100%
V5BPU6 Trypanosoma cruzi 34% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS