LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Ion transport protein/Polycystin cation channel - putative
Species:
Leishmania infantum
UniProt:
A4I228_LEIIN
TriTrypDb:
LINF_260014800
Length:
590

Annotations

Annotations by Jardim et al.

Transporters, Polycystin cation channel, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 9
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4I228
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I228

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 9
GO:0005216 monoatomic ion channel activity 4 9
GO:0005261 monoatomic cation channel activity 5 9
GO:0008324 monoatomic cation transmembrane transporter activity 4 9
GO:0015075 monoatomic ion transmembrane transporter activity 3 9
GO:0015267 channel activity 4 9
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 9
GO:0022803 passive transmembrane transporter activity 3 9
GO:0022857 transmembrane transporter activity 2 9
GO:0022890 inorganic cation transmembrane transporter activity 4 9
GO:0005217 intracellular ligand-gated monoatomic ion channel activity 6 1
GO:0005262 calcium channel activity 6 1
GO:0015085 calcium ion transmembrane transporter activity 6 1
GO:0015276 ligand-gated monoatomic ion channel activity 5 1
GO:0015278 calcium-release channel activity 7 1
GO:0022834 ligand-gated channel activity 6 1
GO:0022836 gated channel activity 5 1
GO:0046873 metal ion transmembrane transporter activity 5 1
GO:0072345 NAADP-sensitive calcium-release channel activity 8 1
GO:0099094 ligand-gated monoatomic cation channel activity 6 1
GO:0099604 ligand-gated calcium channel activity 7 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 30 34 PF00656 0.318
CLV_C14_Caspase3-7 92 96 PF00656 0.341
CLV_MEL_PAP_1 164 170 PF00089 0.606
CLV_NRD_NRD_1 192 194 PF00675 0.599
CLV_NRD_NRD_1 232 234 PF00675 0.638
CLV_NRD_NRD_1 524 526 PF00675 0.521
CLV_NRD_NRD_1 55 57 PF00675 0.562
CLV_NRD_NRD_1 560 562 PF00675 0.518
CLV_PCSK_FUR_1 190 194 PF00082 0.589
CLV_PCSK_KEX2_1 192 194 PF00082 0.616
CLV_PCSK_KEX2_1 232 234 PF00082 0.603
CLV_PCSK_KEX2_1 329 331 PF00082 0.574
CLV_PCSK_KEX2_1 524 526 PF00082 0.575
CLV_PCSK_KEX2_1 55 57 PF00082 0.598
CLV_PCSK_KEX2_1 560 562 PF00082 0.518
CLV_PCSK_KEX2_1 579 581 PF00082 0.293
CLV_PCSK_PC1ET2_1 329 331 PF00082 0.574
CLV_PCSK_PC1ET2_1 579 581 PF00082 0.421
CLV_PCSK_SKI1_1 177 181 PF00082 0.526
CLV_PCSK_SKI1_1 182 186 PF00082 0.484
CLV_PCSK_SKI1_1 198 202 PF00082 0.600
CLV_PCSK_SKI1_1 570 574 PF00082 0.474
CLV_PCSK_SKI1_1 579 583 PF00082 0.352
CLV_PCSK_SKI1_1 82 86 PF00082 0.583
CLV_Separin_Metazoa 571 575 PF03568 0.664
DEG_APCC_DBOX_1 176 184 PF00400 0.346
DEG_SPOP_SBC_1 499 503 PF00917 0.639
DOC_ANK_TNKS_1 166 173 PF00023 0.391
DOC_CYCLIN_RxL_1 79 89 PF00134 0.395
DOC_MAPK_MEF2A_6 177 185 PF00069 0.357
DOC_MAPK_MEF2A_6 218 227 PF00069 0.358
DOC_MAPK_MEF2A_6 354 361 PF00069 0.305
DOC_PP1_RVXF_1 180 186 PF00149 0.271
DOC_USP7_MATH_1 477 481 PF00917 0.556
DOC_USP7_MATH_1 500 504 PF00917 0.697
DOC_USP7_MATH_1 553 557 PF00917 0.766
DOC_USP7_MATH_1 78 82 PF00917 0.373
DOC_USP7_MATH_2 528 534 PF00917 0.622
DOC_WW_Pin1_4 129 134 PF00397 0.415
DOC_WW_Pin1_4 149 154 PF00397 0.335
DOC_WW_Pin1_4 199 204 PF00397 0.397
DOC_WW_Pin1_4 289 294 PF00397 0.675
DOC_WW_Pin1_4 435 440 PF00397 0.339
DOC_WW_Pin1_4 549 554 PF00397 0.710
DOC_WW_Pin1_4 565 570 PF00397 0.720
LIG_14-3-3_CanoR_1 167 175 PF00244 0.342
LIG_14-3-3_CanoR_1 182 188 PF00244 0.286
LIG_14-3-3_CanoR_1 198 203 PF00244 0.430
LIG_14-3-3_CanoR_1 226 231 PF00244 0.436
LIG_14-3-3_CanoR_1 330 336 PF00244 0.278
LIG_14-3-3_CanoR_1 35 39 PF00244 0.340
LIG_14-3-3_CanoR_1 531 537 PF00244 0.807
LIG_14-3-3_CterR_2 587 590 PF00244 0.677
LIG_Actin_WH2_2 168 184 PF00022 0.371
LIG_BRCT_BRCA1_1 39 43 PF00533 0.358
LIG_deltaCOP1_diTrp_1 302 307 PF00928 0.540
LIG_EH1_1 352 360 PF00400 0.389
LIG_EVH1_2 101 105 PF00568 0.367
LIG_FHA_1 101 107 PF00498 0.350
LIG_FHA_1 123 129 PF00498 0.360
LIG_FHA_1 138 144 PF00498 0.373
LIG_FHA_1 203 209 PF00498 0.374
LIG_FHA_1 220 226 PF00498 0.345
LIG_FHA_1 295 301 PF00498 0.572
LIG_FHA_1 312 318 PF00498 0.324
LIG_FHA_1 319 325 PF00498 0.354
LIG_FHA_1 339 345 PF00498 0.162
LIG_FHA_2 57 63 PF00498 0.325
LIG_LIR_Gen_1 117 126 PF02991 0.351
LIG_LIR_Gen_1 318 326 PF02991 0.378
LIG_LIR_Gen_1 430 439 PF02991 0.248
LIG_LIR_Gen_1 453 462 PF02991 0.272
LIG_LIR_Nem_3 103 108 PF02991 0.343
LIG_LIR_Nem_3 117 121 PF02991 0.301
LIG_LIR_Nem_3 302 308 PF02991 0.532
LIG_LIR_Nem_3 318 322 PF02991 0.377
LIG_LIR_Nem_3 351 356 PF02991 0.365
LIG_LIR_Nem_3 453 457 PF02991 0.272
LIG_NRBOX 12 18 PF00104 0.331
LIG_Pex14_1 506 510 PF04695 0.679
LIG_Pex14_2 446 450 PF04695 0.272
LIG_Pex14_2 454 458 PF04695 0.278
LIG_RPA_C_Fungi 187 199 PF08784 0.455
LIG_SH2_CRK 118 122 PF00017 0.503
LIG_SH2_CRK 23 27 PF00017 0.364
LIG_SH2_CRK 275 279 PF00017 0.569
LIG_SH2_CRK 75 79 PF00017 0.336
LIG_SH2_GRB2like 88 91 PF00017 0.491
LIG_SH2_NCK_1 36 40 PF00017 0.412
LIG_SH2_NCK_1 75 79 PF00017 0.395
LIG_SH2_PTP2 366 369 PF00017 0.296
LIG_SH2_STAP1 126 130 PF00017 0.532
LIG_SH2_STAP1 474 478 PF00017 0.398
LIG_SH2_STAP1 481 485 PF00017 0.425
LIG_SH2_STAT5 310 313 PF00017 0.389
LIG_SH2_STAT5 36 39 PF00017 0.479
LIG_SH2_STAT5 366 369 PF00017 0.291
LIG_SH2_STAT5 408 411 PF00017 0.272
LIG_SH2_STAT5 41 44 PF00017 0.451
LIG_SH2_STAT5 52 55 PF00017 0.459
LIG_SH2_STAT5 88 91 PF00017 0.439
LIG_SH3_3 130 136 PF00018 0.406
LIG_SH3_3 563 569 PF00018 0.708
LIG_SUMO_SIM_anti_2 11 17 PF11976 0.237
LIG_SUMO_SIM_anti_2 176 182 PF11976 0.406
LIG_SUMO_SIM_anti_2 321 326 PF11976 0.390
LIG_SUMO_SIM_anti_2 337 344 PF11976 0.245
LIG_SUMO_SIM_par_1 247 253 PF11976 0.327
LIG_TRAF2_1 279 282 PF00917 0.602
LIG_TRAF2_1 335 338 PF00917 0.389
LIG_WRC_WIRS_1 316 321 PF05994 0.331
LIG_WRC_WIRS_1 350 355 PF05994 0.389
LIG_WRC_WIRS_1 429 434 PF05994 0.272
LIG_WRC_WIRS_1 451 456 PF05994 0.272
MOD_CDK_SPK_2 565 570 PF00069 0.746
MOD_CK1_1 147 153 PF00069 0.580
MOD_CK1_1 228 234 PF00069 0.429
MOD_CK1_1 318 324 PF00069 0.341
MOD_CK1_1 411 417 PF00069 0.314
MOD_CK1_1 480 486 PF00069 0.521
MOD_CK1_1 535 541 PF00069 0.756
MOD_CK1_1 544 550 PF00069 0.698
MOD_CK1_1 93 99 PF00069 0.518
MOD_CK2_1 332 338 PF00069 0.406
MOD_CK2_1 511 517 PF00069 0.613
MOD_CK2_1 544 550 PF00069 0.641
MOD_CK2_1 56 62 PF00069 0.460
MOD_CK2_1 565 571 PF00069 0.733
MOD_CK2_1 580 586 PF00069 0.431
MOD_GlcNHglycan 168 171 PF01048 0.452
MOD_GlcNHglycan 404 407 PF01048 0.434
MOD_GlcNHglycan 413 416 PF01048 0.331
MOD_GlcNHglycan 512 516 PF01048 0.571
MOD_GlcNHglycan 534 537 PF01048 0.635
MOD_GSK3_1 122 129 PF00069 0.496
MOD_GSK3_1 145 152 PF00069 0.585
MOD_GSK3_1 198 205 PF00069 0.502
MOD_GSK3_1 221 228 PF00069 0.404
MOD_GSK3_1 311 318 PF00069 0.266
MOD_GSK3_1 411 418 PF00069 0.332
MOD_GSK3_1 42 49 PF00069 0.539
MOD_GSK3_1 461 468 PF00069 0.428
MOD_GSK3_1 477 484 PF00069 0.457
MOD_GSK3_1 532 539 PF00069 0.686
MOD_GSK3_1 549 556 PF00069 0.719
MOD_GSK3_1 86 93 PF00069 0.506
MOD_LATS_1 328 334 PF00433 0.340
MOD_LATS_1 54 60 PF00433 0.381
MOD_N-GLC_1 138 143 PF02516 0.480
MOD_N-GLC_1 144 149 PF02516 0.460
MOD_N-GLC_1 8 13 PF02516 0.237
MOD_N-GLC_1 89 94 PF02516 0.523
MOD_NEK2_1 137 142 PF00069 0.582
MOD_NEK2_1 183 188 PF00069 0.361
MOD_NEK2_1 3 8 PF00069 0.313
MOD_NEK2_1 311 316 PF00069 0.239
MOD_NEK2_1 349 354 PF00069 0.314
MOD_NEK2_1 372 377 PF00069 0.484
MOD_NEK2_1 419 424 PF00069 0.293
MOD_NEK2_1 428 433 PF00069 0.246
MOD_NEK2_1 450 455 PF00069 0.321
MOD_NEK2_1 86 91 PF00069 0.438
MOD_PIKK_1 472 478 PF00454 0.389
MOD_PK_1 226 232 PF00069 0.500
MOD_PKA_1 329 335 PF00069 0.439
MOD_PKA_2 166 172 PF00069 0.435
MOD_PKA_2 225 231 PF00069 0.506
MOD_PKA_2 329 335 PF00069 0.503
MOD_PKA_2 34 40 PF00069 0.488
MOD_PKA_2 530 536 PF00069 0.750
MOD_PKA_2 93 99 PF00069 0.492
MOD_Plk_1 138 144 PF00069 0.549
MOD_Plk_1 8 14 PF00069 0.237
MOD_Plk_4 100 106 PF00069 0.546
MOD_Plk_4 3 9 PF00069 0.334
MOD_Plk_4 338 344 PF00069 0.293
MOD_Plk_4 37 43 PF00069 0.474
MOD_Plk_4 415 421 PF00069 0.311
MOD_Plk_4 428 434 PF00069 0.306
MOD_Plk_4 450 456 PF00069 0.290
MOD_Plk_4 465 471 PF00069 0.287
MOD_Plk_4 48 54 PF00069 0.617
MOD_ProDKin_1 129 135 PF00069 0.520
MOD_ProDKin_1 149 155 PF00069 0.410
MOD_ProDKin_1 199 205 PF00069 0.491
MOD_ProDKin_1 289 295 PF00069 0.607
MOD_ProDKin_1 435 441 PF00069 0.415
MOD_ProDKin_1 549 555 PF00069 0.657
MOD_ProDKin_1 565 571 PF00069 0.666
MOD_SUMO_rev_2 571 581 PF00179 0.670
TRG_DiLeu_BaEn_1 338 343 PF01217 0.389
TRG_DiLeu_LyEn_5 236 241 PF01217 0.476
TRG_ENDOCYTIC_2 118 121 PF00928 0.520
TRG_ENDOCYTIC_2 23 26 PF00928 0.365
TRG_ENDOCYTIC_2 275 278 PF00928 0.707
TRG_ENDOCYTIC_2 366 369 PF00928 0.296
TRG_ENDOCYTIC_2 510 513 PF00928 0.670
TRG_ENDOCYTIC_2 74 77 PF00928 0.299
TRG_ER_diArg_1 190 193 PF00400 0.463
TRG_ER_diArg_1 256 259 PF00400 0.363
TRG_ER_diArg_1 26 29 PF00400 0.337
TRG_ER_diArg_1 524 527 PF00400 0.657
TRG_ER_diArg_1 55 57 PF00400 0.443
TRG_Pf-PMV_PEXEL_1 233 237 PF00026 0.430
TRG_PTS1 587 590 PF00515 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKU9 Leptomonas seymouri 59% 97%
A0A1X0NSA4 Trypanosomatidae 41% 100%
A0A3R7KKX3 Trypanosoma rangeli 37% 100%
A0A3S7WZS8 Leishmania donovani 98% 100%
C9ZRX7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AY77 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q995 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS