LeishMANIAdb
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60S ribosomal export protein NMD3

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
60S ribosomal export protein NMD3
Gene product:
NMD3 family - putative
Species:
Leishmania infantum
UniProt:
A4I226_LEIIN
TriTrypDb:
LINF_260014600
Length:
563

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005737 cytoplasm 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I226
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I226

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0000054 ribosomal subunit export from nucleus 3 1
GO:0000055 ribosomal large subunit export from nucleus 4 1
GO:0006913 nucleocytoplasmic transport 5 1
GO:0031503 protein-containing complex localization 2 1
GO:0033750 ribosome localization 3 1
GO:0046907 intracellular transport 3 1
GO:0051168 nuclear export 6 1
GO:0051169 nuclear transport 4 1
GO:0051640 organelle localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0051656 establishment of organelle localization 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0043021 ribonucleoprotein complex binding 3 12
GO:0043023 ribosomal large subunit binding 4 12
GO:0044877 protein-containing complex binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 232 236 PF00656 0.398
CLV_C14_Caspase3-7 500 504 PF00656 0.482
CLV_C14_Caspase3-7 546 550 PF00656 0.704
CLV_NRD_NRD_1 11 13 PF00675 0.564
CLV_NRD_NRD_1 233 235 PF00675 0.198
CLV_NRD_NRD_1 412 414 PF00675 0.322
CLV_NRD_NRD_1 422 424 PF00675 0.364
CLV_NRD_NRD_1 425 427 PF00675 0.365
CLV_NRD_NRD_1 450 452 PF00675 0.591
CLV_NRD_NRD_1 477 479 PF00675 0.403
CLV_NRD_NRD_1 494 496 PF00675 0.434
CLV_NRD_NRD_1 556 558 PF00675 0.545
CLV_PCSK_FUR_1 423 427 PF00082 0.383
CLV_PCSK_KEX2_1 120 122 PF00082 0.198
CLV_PCSK_KEX2_1 192 194 PF00082 0.275
CLV_PCSK_KEX2_1 233 235 PF00082 0.198
CLV_PCSK_KEX2_1 422 424 PF00082 0.367
CLV_PCSK_KEX2_1 425 427 PF00082 0.363
CLV_PCSK_KEX2_1 450 452 PF00082 0.578
CLV_PCSK_KEX2_1 494 496 PF00082 0.554
CLV_PCSK_KEX2_1 87 89 PF00082 0.198
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.198
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.275
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.198
CLV_PCSK_SKI1_1 120 124 PF00082 0.198
CLV_PCSK_SKI1_1 130 134 PF00082 0.198
CLV_PCSK_SKI1_1 158 162 PF00082 0.198
CLV_PCSK_SKI1_1 180 184 PF00082 0.198
CLV_PCSK_SKI1_1 413 417 PF00082 0.476
CLV_PCSK_SKI1_1 79 83 PF00082 0.209
CLV_PCSK_SKI1_1 87 91 PF00082 0.209
DEG_APCC_DBOX_1 263 271 PF00400 0.280
DEG_Nend_UBRbox_2 1 3 PF02207 0.556
DEG_ODPH_VHL_1 259 270 PF01847 0.311
DOC_CYCLIN_yClb1_LxF_4 219 225 PF00134 0.409
DOC_MAPK_gen_1 120 128 PF00069 0.398
DOC_MAPK_gen_1 179 185 PF00069 0.398
DOC_MAPK_gen_1 233 239 PF00069 0.398
DOC_MAPK_gen_1 425 435 PF00069 0.352
DOC_MAPK_MEF2A_6 120 128 PF00069 0.398
DOC_MAPK_MEF2A_6 79 86 PF00069 0.394
DOC_MAPK_NFAT4_5 121 129 PF00069 0.484
DOC_MAPK_RevD_3 481 495 PF00069 0.496
DOC_PP2B_LxvP_1 65 68 PF13499 0.409
DOC_PP4_FxxP_1 298 301 PF00568 0.336
DOC_USP7_MATH_1 213 217 PF00917 0.423
DOC_USP7_MATH_1 318 322 PF00917 0.418
DOC_USP7_MATH_1 538 542 PF00917 0.510
DOC_USP7_UBL2_3 175 179 PF12436 0.398
LIG_14-3-3_CanoR_1 125 129 PF00244 0.484
LIG_14-3-3_CanoR_1 451 460 PF00244 0.504
LIG_Actin_WH2_2 289 307 PF00022 0.317
LIG_APCC_ABBA_1 269 274 PF00400 0.453
LIG_APCC_ABBAyCdc20_2 180 186 PF00400 0.398
LIG_BRCT_BRCA1_1 294 298 PF00533 0.345
LIG_FAT_LD_1 520 528 PF03623 0.446
LIG_FHA_1 226 232 PF00498 0.480
LIG_FHA_1 252 258 PF00498 0.398
LIG_FHA_1 308 314 PF00498 0.440
LIG_FHA_1 343 349 PF00498 0.354
LIG_FHA_1 350 356 PF00498 0.261
LIG_FHA_1 44 50 PF00498 0.398
LIG_FHA_1 81 87 PF00498 0.398
LIG_FHA_2 230 236 PF00498 0.398
LIG_FHA_2 322 328 PF00498 0.424
LIG_FHA_2 498 504 PF00498 0.573
LIG_LIR_Apic_2 295 301 PF02991 0.330
LIG_LIR_Gen_1 131 141 PF02991 0.448
LIG_LIR_Gen_1 181 190 PF02991 0.398
LIG_LIR_Gen_1 196 205 PF02991 0.398
LIG_LIR_Gen_1 52 59 PF02991 0.398
LIG_LIR_Nem_3 131 136 PF02991 0.448
LIG_LIR_Nem_3 181 185 PF02991 0.397
LIG_LIR_Nem_3 196 201 PF02991 0.398
LIG_LIR_Nem_3 330 334 PF02991 0.325
LIG_LIR_Nem_3 52 56 PF02991 0.398
LIG_LRP6_Inhibitor_1 194 200 PF00058 0.284
LIG_PCNA_yPIPBox_3 12 26 PF02747 0.492
LIG_Pex14_1 315 319 PF04695 0.338
LIG_PTB_Apo_2 340 347 PF02174 0.346
LIG_PTB_Phospho_1 340 346 PF10480 0.367
LIG_REV1ctd_RIR_1 209 219 PF16727 0.409
LIG_RPA_C_Fungi 490 502 PF08784 0.607
LIG_SH2_PTP2 53 56 PF00017 0.250
LIG_SH2_STAT3 184 187 PF00017 0.285
LIG_SH2_STAT5 146 149 PF00017 0.266
LIG_SH2_STAT5 184 187 PF00017 0.285
LIG_SH2_STAT5 276 279 PF00017 0.361
LIG_SH2_STAT5 332 335 PF00017 0.298
LIG_SH2_STAT5 384 387 PF00017 0.319
LIG_SH2_STAT5 53 56 PF00017 0.244
LIG_SH2_STAT5 64 67 PF00017 0.223
LIG_SH3_3 371 377 PF00018 0.415
LIG_SH3_5 271 275 PF00018 0.478
LIG_SUMO_SIM_anti_2 265 271 PF11976 0.277
LIG_SUMO_SIM_anti_2 408 413 PF11976 0.326
LIG_TRAF2_1 519 522 PF00917 0.487
LIG_TRAF2_2 403 408 PF00917 0.434
LIG_UBA3_1 267 273 PF00899 0.453
LIG_UBA3_1 81 87 PF00899 0.250
LIG_WW_1 67 70 PF00397 0.250
MOD_CK1_1 241 247 PF00069 0.316
MOD_CK1_1 29 35 PF00069 0.283
MOD_CK1_1 321 327 PF00069 0.391
MOD_CK1_1 455 461 PF00069 0.500
MOD_CK1_1 95 101 PF00069 0.361
MOD_CK2_1 321 327 PF00069 0.363
MOD_CK2_1 435 441 PF00069 0.470
MOD_CK2_1 545 551 PF00069 0.670
MOD_GlcNHglycan 445 448 PF01048 0.507
MOD_GlcNHglycan 454 457 PF01048 0.628
MOD_GlcNHglycan 94 97 PF01048 0.371
MOD_GSK3_1 112 119 PF00069 0.256
MOD_GSK3_1 225 232 PF00069 0.323
MOD_GSK3_1 241 248 PF00069 0.162
MOD_GSK3_1 318 325 PF00069 0.333
MOD_GSK3_1 349 356 PF00069 0.303
MOD_GSK3_1 91 98 PF00069 0.359
MOD_N-GLC_1 225 230 PF02516 0.366
MOD_N-GLC_1 245 250 PF02516 0.124
MOD_N-GLC_1 29 34 PF02516 0.397
MOD_N-GLC_1 342 347 PF02516 0.418
MOD_N-GLC_1 92 97 PF02516 0.371
MOD_N-GLC_2 33 35 PF02516 0.250
MOD_NEK2_1 124 129 PF00069 0.335
MOD_NEK2_1 225 230 PF00069 0.366
MOD_NEK2_1 92 97 PF00069 0.371
MOD_PIKK_1 415 421 PF00454 0.471
MOD_PIKK_1 435 441 PF00454 0.217
MOD_PKA_1 494 500 PF00069 0.575
MOD_PKA_2 124 130 PF00069 0.371
MOD_PKA_2 494 500 PF00069 0.518
MOD_Plk_1 245 251 PF00069 0.266
MOD_Plk_1 440 446 PF00069 0.501
MOD_Plk_1 538 544 PF00069 0.688
MOD_Plk_4 178 184 PF00069 0.266
MOD_Plk_4 292 298 PF00069 0.294
MOD_Plk_4 538 544 PF00069 0.625
MOD_SUMO_rev_2 6 15 PF00179 0.608
TRG_DiLeu_BaEn_1 265 270 PF01217 0.289
TRG_DiLeu_BaEn_1 77 82 PF01217 0.250
TRG_ENDOCYTIC_2 484 487 PF00928 0.422
TRG_ENDOCYTIC_2 53 56 PF00928 0.250
TRG_ER_diArg_1 422 425 PF00400 0.392
TRG_NLS_Bipartite_1 179 195 PF00514 0.371
TRG_NLS_MonoExtC_3 190 196 PF00514 0.371
TRG_NLS_MonoExtC_3 556 561 PF00514 0.559
TRG_NLS_MonoExtN_4 117 124 PF00514 0.250
TRG_NLS_MonoExtN_4 557 562 PF00514 0.503
TRG_Pf-PMV_PEXEL_1 192 196 PF00026 0.371
TRG_Pf-PMV_PEXEL_1 326 330 PF00026 0.376
TRG_Pf-PMV_PEXEL_1 389 394 PF00026 0.451

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P651 Leptomonas seymouri 87% 100%
A0A0S4IPD8 Bodo saltans 57% 100%
A0A1X0NSC0 Trypanosomatidae 63% 100%
A0A3S5IRS4 Trypanosoma rangeli 67% 100%
A0A3S7WZS7 Leishmania donovani 99% 100%
A4HEV2 Leishmania braziliensis 91% 100%
C9ZRY2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9AY75 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
G0S488 Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 36% 100%
P38861 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 100%
Q08DS5 Bos taurus 37% 100%
Q09817 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 100%
Q4Q997 Leishmania major 97% 100%
Q55BF2 Dictyostelium discoideum 42% 100%
Q5BLF0 Danio rerio 36% 100%
Q5RC82 Pongo abelii 37% 100%
Q6GNS3 Xenopus laevis 36% 100%
Q6P2Z6 Xenopus tropicalis 36% 100%
Q96D46 Homo sapiens 37% 100%
Q99L48 Mus musculus 37% 100%
V5BUG5 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS