LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Meiotic cell cortex C-terminal pleckstrin homology - putative
Species:
Leishmania infantum
UniProt:
A4I224_LEIIN
TriTrypDb:
LINF_260014400
Length:
613

Annotations

Annotations by Jardim et al.

Intracellular signaling, Pleckstrin homology (PH) domain

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 6
GO:0005938 cell cortex 3 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4I224
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I224

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 6
GO:0032065 maintenance of protein location in cell cortex 4 6
GO:0032507 maintenance of protein location in cell 3 6
GO:0045185 maintenance of protein location 3 6
GO:0051179 localization 1 6
GO:0051235 maintenance of location 2 6
GO:0051651 maintenance of location in cell 2 6
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0005543 phospholipid binding 3 6
GO:0008289 lipid binding 2 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 197 199 PF00675 0.863
CLV_NRD_NRD_1 331 333 PF00675 0.652
CLV_NRD_NRD_1 353 355 PF00675 0.735
CLV_NRD_NRD_1 376 378 PF00675 0.639
CLV_NRD_NRD_1 50 52 PF00675 0.800
CLV_NRD_NRD_1 7 9 PF00675 0.762
CLV_PCSK_KEX2_1 197 199 PF00082 0.863
CLV_PCSK_KEX2_1 298 300 PF00082 0.774
CLV_PCSK_KEX2_1 331 333 PF00082 0.652
CLV_PCSK_KEX2_1 353 355 PF00082 0.735
CLV_PCSK_KEX2_1 376 378 PF00082 0.639
CLV_PCSK_KEX2_1 49 51 PF00082 0.799
CLV_PCSK_KEX2_1 6 8 PF00082 0.758
CLV_PCSK_KEX2_1 71 73 PF00082 0.763
CLV_PCSK_PC1ET2_1 298 300 PF00082 0.735
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.763
CLV_PCSK_PC7_1 372 378 PF00082 0.661
DEG_SCF_FBW7_1 73 78 PF00400 0.743
DEG_SCF_TRCP1_1 11 16 PF00400 0.745
DEG_SCF_TRCP1_1 27 33 PF00400 0.572
DEG_SPOP_SBC_1 275 279 PF00917 0.744
DEG_SPOP_SBC_1 282 286 PF00917 0.669
DEG_SPOP_SBC_1 608 612 PF00917 0.798
DEG_SPOP_SBC_1 83 87 PF00917 0.719
DOC_CKS1_1 522 527 PF01111 0.429
DOC_CKS1_1 76 81 PF01111 0.777
DOC_CYCLIN_yCln2_LP_2 510 516 PF00134 0.452
DOC_MAPK_MEF2A_6 436 443 PF00069 0.600
DOC_PP2B_LxvP_1 177 180 PF13499 0.809
DOC_PP2B_LxvP_1 390 393 PF13499 0.578
DOC_PP2B_LxvP_1 510 513 PF13499 0.413
DOC_PP2B_LxvP_1 549 552 PF13499 0.544
DOC_USP7_MATH_1 129 133 PF00917 0.848
DOC_USP7_MATH_1 134 138 PF00917 0.763
DOC_USP7_MATH_1 149 153 PF00917 0.589
DOC_USP7_MATH_1 180 184 PF00917 0.852
DOC_USP7_MATH_1 228 232 PF00917 0.786
DOC_USP7_MATH_1 247 251 PF00917 0.765
DOC_USP7_MATH_1 25 29 PF00917 0.766
DOC_USP7_MATH_1 275 279 PF00917 0.712
DOC_USP7_MATH_1 282 286 PF00917 0.719
DOC_USP7_MATH_1 428 432 PF00917 0.714
DOC_USP7_MATH_1 565 569 PF00917 0.782
DOC_USP7_MATH_1 608 612 PF00917 0.625
DOC_USP7_MATH_1 79 83 PF00917 0.797
DOC_USP7_UBL2_3 77 81 PF12436 0.773
DOC_WW_Pin1_4 107 112 PF00397 0.786
DOC_WW_Pin1_4 139 144 PF00397 0.776
DOC_WW_Pin1_4 158 163 PF00397 0.573
DOC_WW_Pin1_4 166 171 PF00397 0.657
DOC_WW_Pin1_4 205 210 PF00397 0.859
DOC_WW_Pin1_4 252 257 PF00397 0.729
DOC_WW_Pin1_4 269 274 PF00397 0.560
DOC_WW_Pin1_4 278 283 PF00397 0.688
DOC_WW_Pin1_4 303 308 PF00397 0.702
DOC_WW_Pin1_4 501 506 PF00397 0.530
DOC_WW_Pin1_4 521 526 PF00397 0.199
DOC_WW_Pin1_4 582 587 PF00397 0.674
DOC_WW_Pin1_4 64 69 PF00397 0.774
DOC_WW_Pin1_4 71 76 PF00397 0.676
LIG_14-3-3_CanoR_1 158 162 PF00244 0.768
LIG_14-3-3_CanoR_1 186 195 PF00244 0.773
LIG_14-3-3_CanoR_1 276 282 PF00244 0.833
LIG_14-3-3_CanoR_1 283 292 PF00244 0.769
LIG_14-3-3_CanoR_1 315 321 PF00244 0.831
LIG_14-3-3_CanoR_1 326 334 PF00244 0.643
LIG_14-3-3_CanoR_1 413 421 PF00244 0.681
LIG_14-3-3_CanoR_1 527 532 PF00244 0.528
LIG_14-3-3_CanoR_1 564 570 PF00244 0.787
LIG_BIR_II_1 1 5 PF00653 0.753
LIG_deltaCOP1_diTrp_1 454 459 PF00928 0.530
LIG_EH_1 372 376 PF12763 0.741
LIG_EVH1_2 391 395 PF00568 0.766
LIG_FHA_1 31 37 PF00498 0.639
LIG_FHA_1 553 559 PF00498 0.640
LIG_FHA_1 86 92 PF00498 0.834
LIG_FHA_2 206 212 PF00498 0.778
LIG_FHA_2 232 238 PF00498 0.748
LIG_FHA_2 430 436 PF00498 0.702
LIG_LIR_Apic_2 16 20 PF02991 0.734
LIG_LIR_Apic_2 554 559 PF02991 0.676
LIG_LIR_Gen_1 379 387 PF02991 0.712
LIG_LIR_Gen_1 540 551 PF02991 0.530
LIG_LIR_Nem_3 11 17 PF02991 0.660
LIG_LIR_Nem_3 379 383 PF02991 0.706
LIG_LIR_Nem_3 540 546 PF02991 0.530
LIG_LIR_Nem_3 582 587 PF02991 0.764
LIG_Pex14_1 580 584 PF04695 0.769
LIG_PTB_Apo_2 383 390 PF02174 0.714
LIG_PTB_Phospho_1 383 389 PF10480 0.712
LIG_REV1ctd_RIR_1 514 523 PF16727 0.530
LIG_SH2_CRK 17 21 PF00017 0.674
LIG_SH2_CRK 543 547 PF00017 0.455
LIG_SH2_CRK 556 560 PF00017 0.530
LIG_SH2_CRK 584 588 PF00017 0.758
LIG_SH2_NCK_1 600 604 PF00017 0.728
LIG_SH2_PTP2 469 472 PF00017 0.530
LIG_SH2_SRC 389 392 PF00017 0.648
LIG_SH2_SRC 604 607 PF00017 0.804
LIG_SH2_SRC 9 12 PF00017 0.755
LIG_SH2_STAT3 363 366 PF00017 0.807
LIG_SH2_STAT5 363 366 PF00017 0.807
LIG_SH2_STAT5 369 372 PF00017 0.688
LIG_SH2_STAT5 389 392 PF00017 0.396
LIG_SH2_STAT5 469 472 PF00017 0.530
LIG_SH2_STAT5 9 12 PF00017 0.755
LIG_SH3_3 137 143 PF00018 0.776
LIG_SH3_3 188 194 PF00018 0.834
LIG_SH3_3 217 223 PF00018 0.652
LIG_SH3_3 289 295 PF00018 0.755
LIG_SH3_3 318 324 PF00018 0.776
LIG_SH3_3 331 337 PF00018 0.665
LIG_SH3_3 52 58 PF00018 0.774
LIG_SH3_3 73 79 PF00018 0.744
LIG_TRAF2_1 432 435 PF00917 0.701
LIG_TYR_ITIM 541 546 PF00017 0.530
LIG_UBA3_1 479 487 PF00899 0.316
LIG_WW_3 218 222 PF00397 0.686
MOD_CDC14_SPxK_1 255 258 PF00782 0.768
MOD_CDK_SPK_2 278 283 PF00069 0.784
MOD_CDK_SPxK_1 252 258 PF00069 0.767
MOD_CDK_SPxK_1 521 527 PF00069 0.429
MOD_CDK_SPxK_1 71 77 PF00069 0.764
MOD_CDK_SPxxK_3 269 276 PF00069 0.658
MOD_CDK_SPxxK_3 308 315 PF00069 0.770
MOD_CDK_SPxxK_3 64 71 PF00069 0.763
MOD_CK1_1 100 106 PF00069 0.615
MOD_CK1_1 130 136 PF00069 0.707
MOD_CK1_1 139 145 PF00069 0.630
MOD_CK1_1 169 175 PF00069 0.674
MOD_CK1_1 184 190 PF00069 0.655
MOD_CK1_1 203 209 PF00069 0.709
MOD_CK1_1 231 237 PF00069 0.808
MOD_CK1_1 250 256 PF00069 0.763
MOD_CK1_1 278 284 PF00069 0.690
MOD_CK1_1 311 317 PF00069 0.766
MOD_CK1_1 412 418 PF00069 0.627
MOD_CK1_1 482 488 PF00069 0.370
MOD_CK1_1 498 504 PF00069 0.320
MOD_CK1_1 530 536 PF00069 0.495
MOD_CK1_1 582 588 PF00069 0.748
MOD_CK1_1 63 69 PF00069 0.785
MOD_CK1_1 82 88 PF00069 0.520
MOD_CK2_1 205 211 PF00069 0.716
MOD_CK2_1 428 434 PF00069 0.715
MOD_CK2_1 87 93 PF00069 0.718
MOD_GlcNHglycan 100 103 PF01048 0.644
MOD_GlcNHglycan 11 14 PF01048 0.807
MOD_GlcNHglycan 129 132 PF01048 0.849
MOD_GlcNHglycan 136 139 PF01048 0.733
MOD_GlcNHglycan 185 189 PF01048 0.705
MOD_GlcNHglycan 202 205 PF01048 0.677
MOD_GlcNHglycan 27 30 PF01048 0.568
MOD_GlcNHglycan 443 446 PF01048 0.346
MOD_GlcNHglycan 487 490 PF01048 0.515
MOD_GlcNHglycan 62 65 PF01048 0.772
MOD_GlcNHglycan 81 84 PF01048 0.529
MOD_GSK3_1 103 110 PF00069 0.617
MOD_GSK3_1 129 136 PF00069 0.705
MOD_GSK3_1 180 187 PF00069 0.776
MOD_GSK3_1 200 207 PF00069 0.603
MOD_GSK3_1 228 235 PF00069 0.677
MOD_GSK3_1 237 244 PF00069 0.636
MOD_GSK3_1 274 281 PF00069 0.790
MOD_GSK3_1 282 289 PF00069 0.711
MOD_GSK3_1 310 317 PF00069 0.741
MOD_GSK3_1 475 482 PF00069 0.420
MOD_GSK3_1 485 492 PF00069 0.316
MOD_GSK3_1 495 502 PF00069 0.401
MOD_GSK3_1 530 537 PF00069 0.328
MOD_GSK3_1 547 554 PF00069 0.402
MOD_GSK3_1 575 582 PF00069 0.692
MOD_GSK3_1 591 598 PF00069 0.509
MOD_GSK3_1 60 67 PF00069 0.789
MOD_GSK3_1 71 78 PF00069 0.635
MOD_GSK3_1 79 86 PF00069 0.548
MOD_GSK3_1 87 94 PF00069 0.637
MOD_GSK3_1 9 16 PF00069 0.770
MOD_N-GLC_1 120 125 PF02516 0.787
MOD_N-GLC_1 552 557 PF02516 0.621
MOD_N-GLC_1 592 597 PF02516 0.761
MOD_N-GLC_1 98 103 PF02516 0.788
MOD_NEK2_1 127 132 PF00069 0.753
MOD_NEK2_1 409 414 PF00069 0.636
MOD_NEK2_1 479 484 PF00069 0.394
MOD_NEK2_1 60 65 PF00069 0.792
MOD_NEK2_1 91 96 PF00069 0.770
MOD_NEK2_2 247 252 PF00069 0.765
MOD_PIKK_1 115 121 PF00454 0.759
MOD_PIKK_1 169 175 PF00454 0.710
MOD_PIKK_1 367 373 PF00454 0.773
MOD_PIKK_1 412 418 PF00454 0.662
MOD_PKA_2 103 109 PF00069 0.762
MOD_PKA_2 127 133 PF00069 0.705
MOD_PKA_2 149 155 PF00069 0.697
MOD_PKA_2 157 163 PF00069 0.715
MOD_PKA_2 181 187 PF00069 0.739
MOD_PKA_2 275 281 PF00069 0.687
MOD_PKA_2 282 288 PF00069 0.712
MOD_PKA_2 30 36 PF00069 0.613
MOD_PKA_2 314 320 PF00069 0.832
MOD_PKA_2 325 331 PF00069 0.636
MOD_PKA_2 412 418 PF00069 0.724
MOD_PKA_2 475 481 PF00069 0.491
MOD_PKA_2 563 569 PF00069 0.785
MOD_Plk_1 552 558 PF00069 0.552
MOD_Plk_4 136 142 PF00069 0.778
MOD_Plk_4 172 178 PF00069 0.660
MOD_Plk_4 228 234 PF00069 0.785
MOD_Plk_4 316 322 PF00069 0.743
MOD_Plk_4 475 481 PF00069 0.530
MOD_Plk_4 87 93 PF00069 0.730
MOD_ProDKin_1 107 113 PF00069 0.801
MOD_ProDKin_1 139 145 PF00069 0.776
MOD_ProDKin_1 158 164 PF00069 0.572
MOD_ProDKin_1 166 172 PF00069 0.656
MOD_ProDKin_1 205 211 PF00069 0.859
MOD_ProDKin_1 252 258 PF00069 0.730
MOD_ProDKin_1 269 275 PF00069 0.559
MOD_ProDKin_1 278 284 PF00069 0.687
MOD_ProDKin_1 303 309 PF00069 0.698
MOD_ProDKin_1 501 507 PF00069 0.530
MOD_ProDKin_1 521 527 PF00069 0.199
MOD_ProDKin_1 582 588 PF00069 0.670
MOD_ProDKin_1 64 70 PF00069 0.772
MOD_ProDKin_1 71 77 PF00069 0.679
MOD_SUMO_rev_2 488 498 PF00179 0.530
TRG_DiLeu_BaEn_1 438 443 PF01217 0.619
TRG_DiLeu_BaLyEn_6 420 425 PF01217 0.494
TRG_ENDOCYTIC_2 469 472 PF00928 0.530
TRG_ENDOCYTIC_2 543 546 PF00928 0.455
TRG_ENDOCYTIC_2 584 587 PF00928 0.763
TRG_ER_diArg_1 331 333 PF00400 0.754
TRG_ER_diArg_1 352 354 PF00400 0.733
TRG_ER_diArg_1 375 377 PF00400 0.659
TRG_ER_diArg_1 48 51 PF00400 0.797
TRG_ER_diArg_1 5 8 PF00400 0.750

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IP29 Leishmania donovani 99% 100%
A4HEV0 Leishmania braziliensis 58% 92%
E9AY73 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q999 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS