LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
DnaJ domain/Domain of unknown function (DUF3395) - putative
Species:
Leishmania infantum
UniProt:
A4I223_LEIIN
TriTrypDb:
LINF_260014300
Length:
843

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4I223
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I223

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0007005 mitochondrion organization 5 1
GO:0007006 mitochondrial membrane organization 5 1
GO:0007007 inner mitochondrial membrane organization 6 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0042407 cristae formation 7 1
GO:0061024 membrane organization 4 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 17 21 PF00656 0.602
CLV_C14_Caspase3-7 22 26 PF00656 0.456
CLV_C14_Caspase3-7 85 89 PF00656 0.335
CLV_NRD_NRD_1 122 124 PF00675 0.474
CLV_NRD_NRD_1 453 455 PF00675 0.443
CLV_NRD_NRD_1 53 55 PF00675 0.314
CLV_NRD_NRD_1 683 685 PF00675 0.404
CLV_NRD_NRD_1 740 742 PF00675 0.363
CLV_NRD_NRD_1 817 819 PF00675 0.308
CLV_PCSK_KEX2_1 122 124 PF00082 0.470
CLV_PCSK_KEX2_1 53 55 PF00082 0.314
CLV_PCSK_KEX2_1 731 733 PF00082 0.388
CLV_PCSK_KEX2_1 739 741 PF00082 0.319
CLV_PCSK_KEX2_1 819 821 PF00082 0.272
CLV_PCSK_PC1ET2_1 731 733 PF00082 0.313
CLV_PCSK_PC1ET2_1 819 821 PF00082 0.351
CLV_PCSK_PC7_1 735 741 PF00082 0.215
CLV_PCSK_SKI1_1 112 116 PF00082 0.455
CLV_PCSK_SKI1_1 222 226 PF00082 0.556
CLV_PCSK_SKI1_1 356 360 PF00082 0.395
CLV_PCSK_SKI1_1 509 513 PF00082 0.518
CLV_PCSK_SKI1_1 53 57 PF00082 0.291
CLV_PCSK_SKI1_1 728 732 PF00082 0.313
CLV_PCSK_SKI1_1 8 12 PF00082 0.443
DEG_Nend_UBRbox_2 1 3 PF02207 0.565
DEG_SPOP_SBC_1 186 190 PF00917 0.534
DOC_CKS1_1 242 247 PF01111 0.607
DOC_CKS1_1 803 808 PF01111 0.404
DOC_CYCLIN_yCln2_LP_2 620 626 PF00134 0.489
DOC_MAPK_DCC_7 598 608 PF00069 0.512
DOC_MAPK_FxFP_2 162 165 PF00069 0.531
DOC_MAPK_gen_1 508 514 PF00069 0.472
DOC_MAPK_gen_1 53 59 PF00069 0.292
DOC_MAPK_gen_1 553 561 PF00069 0.468
DOC_MAPK_gen_1 596 605 PF00069 0.511
DOC_MAPK_gen_1 663 671 PF00069 0.404
DOC_MAPK_gen_1 681 691 PF00069 0.404
DOC_MAPK_gen_1 818 825 PF00069 0.283
DOC_MAPK_HePTP_8 593 605 PF00069 0.381
DOC_MAPK_MEF2A_6 596 605 PF00069 0.436
DOC_MAPK_MEF2A_6 762 770 PF00069 0.335
DOC_PP1_RVXF_1 810 817 PF00149 0.337
DOC_PP2B_LxvP_1 367 370 PF13499 0.428
DOC_PP2B_LxvP_1 620 623 PF13499 0.418
DOC_PP2B_LxvP_1 785 788 PF13499 0.271
DOC_PP4_FxxP_1 162 165 PF00568 0.551
DOC_PP4_FxxP_1 608 611 PF00568 0.426
DOC_PP4_FxxP_1 798 801 PF00568 0.271
DOC_USP7_MATH_1 165 169 PF00917 0.658
DOC_USP7_MATH_1 186 190 PF00917 0.670
DOC_USP7_MATH_1 209 213 PF00917 0.717
DOC_USP7_MATH_1 228 232 PF00917 0.736
DOC_USP7_MATH_1 251 255 PF00917 0.661
DOC_USP7_MATH_1 32 36 PF00917 0.508
DOC_USP7_MATH_1 538 542 PF00917 0.552
DOC_USP7_MATH_1 611 615 PF00917 0.509
DOC_USP7_MATH_1 670 674 PF00917 0.378
DOC_USP7_MATH_1 744 748 PF00917 0.333
DOC_USP7_MATH_1 756 760 PF00917 0.250
DOC_USP7_UBL2_3 681 685 PF12436 0.292
DOC_WW_Pin1_4 241 246 PF00397 0.740
DOC_WW_Pin1_4 253 258 PF00397 0.783
DOC_WW_Pin1_4 41 46 PF00397 0.404
DOC_WW_Pin1_4 532 537 PF00397 0.484
DOC_WW_Pin1_4 567 572 PF00397 0.529
DOC_WW_Pin1_4 607 612 PF00397 0.414
DOC_WW_Pin1_4 707 712 PF00397 0.316
DOC_WW_Pin1_4 713 718 PF00397 0.405
DOC_WW_Pin1_4 802 807 PF00397 0.404
LIG_14-3-3_CanoR_1 361 365 PF00244 0.455
LIG_14-3-3_CanoR_1 371 377 PF00244 0.454
LIG_14-3-3_CanoR_1 383 391 PF00244 0.456
LIG_14-3-3_CanoR_1 454 462 PF00244 0.436
LIG_14-3-3_CanoR_1 477 481 PF00244 0.537
LIG_14-3-3_CanoR_1 527 533 PF00244 0.406
LIG_14-3-3_CanoR_1 598 604 PF00244 0.457
LIG_14-3-3_CanoR_1 644 652 PF00244 0.386
LIG_14-3-3_CanoR_1 757 762 PF00244 0.375
LIG_Actin_WH2_2 126 143 PF00022 0.427
LIG_APCC_ABBA_1 823 828 PF00400 0.404
LIG_BIR_III_2 764 768 PF00653 0.378
LIG_BIR_III_4 103 107 PF00653 0.428
LIG_BRCT_BRCA1_1 356 360 PF00533 0.474
LIG_BRCT_BRCA1_1 372 376 PF00533 0.477
LIG_BRCT_BRCA1_1 580 584 PF00533 0.599
LIG_EH1_1 626 634 PF00400 0.521
LIG_FHA_1 156 162 PF00498 0.601
LIG_FHA_1 386 392 PF00498 0.650
LIG_FHA_1 457 463 PF00498 0.497
LIG_FHA_1 482 488 PF00498 0.595
LIG_FHA_1 540 546 PF00498 0.445
LIG_FHA_1 560 566 PF00498 0.306
LIG_FHA_1 803 809 PF00498 0.483
LIG_FHA_2 28 34 PF00498 0.539
LIG_FHA_2 282 288 PF00498 0.594
LIG_FHA_2 391 397 PF00498 0.496
LIG_FHA_2 46 52 PF00498 0.404
LIG_HCF-1_HBM_1 472 475 PF13415 0.391
LIG_LIR_Apic_2 163 167 PF02991 0.562
LIG_LIR_Apic_2 546 551 PF02991 0.461
LIG_LIR_Gen_1 35 45 PF02991 0.326
LIG_LIR_Gen_1 362 372 PF02991 0.440
LIG_LIR_Gen_1 478 487 PF02991 0.473
LIG_LIR_Gen_1 492 502 PF02991 0.449
LIG_LIR_Gen_1 581 592 PF02991 0.457
LIG_LIR_Gen_1 699 709 PF02991 0.404
LIG_LIR_Gen_1 81 91 PF02991 0.270
LIG_LIR_Nem_3 35 41 PF02991 0.291
LIG_LIR_Nem_3 362 367 PF02991 0.514
LIG_LIR_Nem_3 478 483 PF02991 0.508
LIG_LIR_Nem_3 492 497 PF02991 0.435
LIG_LIR_Nem_3 581 587 PF02991 0.470
LIG_LIR_Nem_3 631 637 PF02991 0.494
LIG_LIR_Nem_3 699 705 PF02991 0.404
LIG_LIR_Nem_3 81 86 PF02991 0.274
LIG_LIR_Nem_3 88 93 PF02991 0.275
LIG_MAD2 265 273 PF02301 0.536
LIG_PCNA_yPIPBox_3 342 354 PF02747 0.495
LIG_PCNA_yPIPBox_3 661 675 PF02747 0.404
LIG_Pex14_2 360 364 PF04695 0.394
LIG_Pex14_2 476 480 PF04695 0.356
LIG_PTB_Apo_2 689 696 PF02174 0.271
LIG_PTB_Apo_2 77 84 PF02174 0.267
LIG_PTB_Phospho_1 689 695 PF10480 0.271
LIG_REV1ctd_RIR_1 574 584 PF16727 0.539
LIG_SH2_CRK 38 42 PF00017 0.289
LIG_SH2_PTP2 90 93 PF00017 0.384
LIG_SH2_SRC 549 552 PF00017 0.388
LIG_SH2_STAP1 405 409 PF00017 0.410
LIG_SH2_STAT3 646 649 PF00017 0.406
LIG_SH2_STAT5 129 132 PF00017 0.432
LIG_SH2_STAT5 475 478 PF00017 0.493
LIG_SH2_STAT5 501 504 PF00017 0.447
LIG_SH2_STAT5 549 552 PF00017 0.496
LIG_SH2_STAT5 646 649 PF00017 0.335
LIG_SH2_STAT5 804 807 PF00017 0.349
LIG_SH2_STAT5 90 93 PF00017 0.314
LIG_SH3_3 239 245 PF00018 0.753
LIG_SH3_3 294 300 PF00018 0.507
LIG_SH3_3 516 522 PF00018 0.622
LIG_SH3_3 568 574 PF00018 0.553
LIG_SH3_3 694 700 PF00018 0.271
LIG_SH3_3 705 711 PF00018 0.271
LIG_SH3_3 800 806 PF00018 0.365
LIG_SH3_3 829 835 PF00018 0.271
LIG_SH3_CIN85_PxpxPR_1 334 339 PF14604 0.591
LIG_Sin3_3 561 568 PF02671 0.406
LIG_SUMO_SIM_anti_2 672 678 PF11976 0.404
LIG_SUMO_SIM_par_1 129 134 PF11976 0.493
LIG_SUMO_SIM_par_1 766 771 PF11976 0.295
LIG_TRAF2_1 300 303 PF00917 0.534
LIG_TRAF2_1 680 683 PF00917 0.404
LIG_UBA3_1 605 612 PF00899 0.439
LIG_WRPW_2 634 637 PF00400 0.447
LIG_WW_1 522 525 PF00397 0.562
MOD_CDK_SPK_2 41 46 PF00069 0.335
MOD_CDK_SPK_2 607 612 PF00069 0.430
MOD_CK1_1 147 153 PF00069 0.446
MOD_CK1_1 155 161 PF00069 0.451
MOD_CK1_1 173 179 PF00069 0.750
MOD_CK1_1 227 233 PF00069 0.624
MOD_CK1_1 321 327 PF00069 0.652
MOD_CK1_1 390 396 PF00069 0.508
MOD_CK1_1 760 766 PF00069 0.396
MOD_CK1_1 783 789 PF00069 0.349
MOD_CK2_1 175 181 PF00069 0.684
MOD_CK2_1 194 200 PF00069 0.800
MOD_CK2_1 210 216 PF00069 0.587
MOD_CK2_1 281 287 PF00069 0.528
MOD_CK2_1 390 396 PF00069 0.471
MOD_CK2_1 466 472 PF00069 0.408
MOD_Cter_Amidation 506 509 PF01082 0.418
MOD_GlcNHglycan 146 149 PF01048 0.536
MOD_GlcNHglycan 177 180 PF01048 0.773
MOD_GlcNHglycan 20 24 PF01048 0.723
MOD_GlcNHglycan 226 229 PF01048 0.693
MOD_GlcNHglycan 253 256 PF01048 0.776
MOD_GlcNHglycan 274 277 PF01048 0.702
MOD_GlcNHglycan 319 323 PF01048 0.642
MOD_GlcNHglycan 325 328 PF01048 0.691
MOD_GlcNHglycan 33 37 PF01048 0.459
MOD_GlcNHglycan 441 444 PF01048 0.596
MOD_GlcNHglycan 456 459 PF01048 0.373
MOD_GlcNHglycan 580 583 PF01048 0.667
MOD_GlcNHglycan 620 623 PF01048 0.439
MOD_GlcNHglycan 717 720 PF01048 0.430
MOD_GlcNHglycan 782 785 PF01048 0.404
MOD_GSK3_1 146 153 PF00069 0.499
MOD_GSK3_1 170 177 PF00069 0.644
MOD_GSK3_1 19 26 PF00069 0.694
MOD_GSK3_1 218 225 PF00069 0.723
MOD_GSK3_1 236 243 PF00069 0.653
MOD_GSK3_1 28 35 PF00069 0.659
MOD_GSK3_1 321 328 PF00069 0.634
MOD_GSK3_1 356 363 PF00069 0.453
MOD_GSK3_1 375 382 PF00069 0.324
MOD_GSK3_1 385 392 PF00069 0.453
MOD_GSK3_1 401 408 PF00069 0.322
MOD_GSK3_1 41 48 PF00069 0.247
MOD_GSK3_1 450 457 PF00069 0.387
MOD_GSK3_1 528 535 PF00069 0.392
MOD_GSK3_1 607 614 PF00069 0.496
MOD_GSK3_1 618 625 PF00069 0.472
MOD_GSK3_1 67 74 PF00069 0.440
MOD_GSK3_1 740 747 PF00069 0.454
MOD_GSK3_1 756 763 PF00069 0.150
MOD_GSK3_1 766 773 PF00069 0.418
MOD_N-GLC_1 259 264 PF02516 0.729
MOD_N-GLC_1 532 537 PF02516 0.474
MOD_N-GLC_1 713 718 PF02516 0.292
MOD_NEK2_1 139 144 PF00069 0.482
MOD_NEK2_1 146 151 PF00069 0.507
MOD_NEK2_1 224 229 PF00069 0.620
MOD_NEK2_1 325 330 PF00069 0.705
MOD_NEK2_1 360 365 PF00069 0.359
MOD_NEK2_1 372 377 PF00069 0.376
MOD_NEK2_1 384 389 PF00069 0.476
MOD_NEK2_1 439 444 PF00069 0.454
MOD_NEK2_1 448 453 PF00069 0.362
MOD_NEK2_1 466 471 PF00069 0.285
MOD_NEK2_1 476 481 PF00069 0.362
MOD_NEK2_1 500 505 PF00069 0.405
MOD_NEK2_1 528 533 PF00069 0.402
MOD_NEK2_1 559 564 PF00069 0.383
MOD_NEK2_1 57 62 PF00069 0.336
MOD_NEK2_1 618 623 PF00069 0.416
MOD_NEK2_2 405 410 PF00069 0.456
MOD_NEK2_2 428 433 PF00069 0.582
MOD_PIKK_1 147 153 PF00454 0.564
MOD_PIKK_1 45 51 PF00454 0.362
MOD_PIKK_1 551 557 PF00454 0.440
MOD_PIKK_1 57 63 PF00454 0.275
MOD_PIKK_1 67 73 PF00454 0.314
MOD_PIKK_1 720 726 PF00454 0.404
MOD_PKA_1 454 460 PF00069 0.421
MOD_PKA_1 740 746 PF00069 0.257
MOD_PKA_2 193 199 PF00069 0.607
MOD_PKA_2 360 366 PF00069 0.456
MOD_PKA_2 370 376 PF00069 0.462
MOD_PKA_2 476 482 PF00069 0.445
MOD_PKA_2 599 605 PF00069 0.498
MOD_PKA_2 740 746 PF00069 0.492
MOD_PKA_2 756 762 PF00069 0.236
MOD_PKA_2 780 786 PF00069 0.289
MOD_Plk_1 3 9 PF00069 0.449
MOD_Plk_1 405 411 PF00069 0.522
MOD_Plk_1 448 454 PF00069 0.365
MOD_Plk_1 770 776 PF00069 0.271
MOD_Plk_2-3 401 407 PF00069 0.458
MOD_Plk_4 434 440 PF00069 0.443
MOD_Plk_4 490 496 PF00069 0.455
MOD_Plk_4 588 594 PF00069 0.377
MOD_Plk_4 622 628 PF00069 0.496
MOD_Plk_4 670 676 PF00069 0.281
MOD_Plk_4 791 797 PF00069 0.404
MOD_ProDKin_1 241 247 PF00069 0.739
MOD_ProDKin_1 253 259 PF00069 0.782
MOD_ProDKin_1 41 47 PF00069 0.404
MOD_ProDKin_1 532 538 PF00069 0.490
MOD_ProDKin_1 567 573 PF00069 0.532
MOD_ProDKin_1 607 613 PF00069 0.416
MOD_ProDKin_1 707 713 PF00069 0.316
MOD_ProDKin_1 802 808 PF00069 0.404
MOD_SUMO_for_1 680 683 PF00179 0.292
MOD_SUMO_rev_2 195 203 PF00179 0.777
MOD_SUMO_rev_2 515 522 PF00179 0.557
TRG_DiLeu_BaEn_1 672 677 PF01217 0.404
TRG_ENDOCYTIC_2 38 41 PF00928 0.291
TRG_ENDOCYTIC_2 494 497 PF00928 0.410
TRG_ENDOCYTIC_2 525 528 PF00928 0.521
TRG_ENDOCYTIC_2 695 698 PF00928 0.271
TRG_ENDOCYTIC_2 90 93 PF00928 0.271
TRG_ER_diArg_1 121 123 PF00400 0.516
TRG_ER_diArg_1 308 311 PF00400 0.578
TRG_ER_diArg_1 52 54 PF00400 0.314
TRG_ER_diArg_1 598 601 PF00400 0.600
TRG_ER_diArg_1 663 666 PF00400 0.420
TRG_ER_diArg_1 738 741 PF00400 0.394
TRG_ER_diArg_1 817 820 PF00400 0.295
TRG_NES_CRM1_1 461 472 PF08389 0.428
TRG_NLS_MonoCore_2 817 822 PF00514 0.404
TRG_NLS_MonoExtN_4 818 823 PF00514 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P653 Leptomonas seymouri 61% 92%
A0A1X0NU14 Trypanosomatidae 32% 100%
A0A3S7WZV8 Leishmania donovani 100% 100%
A0A422MXE6 Trypanosoma rangeli 35% 100%
A4HEU9 Leishmania braziliensis 78% 99%
C9ZRY4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9AY72 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q9A0 Leishmania major 94% 100%
V5B9C2 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS