AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I222_LEIIN

TriTrypDb:

LINF_260014200

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I222

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I222

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0032200	telomere organization	6	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003678	DNA helicase activity	3	1
GO:0003824	catalytic activity	1	1
GO:0004386	helicase activity	2	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017076	purine nucleotide binding	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.635
CLV_MEL_PAP_1	101	107	PF00089	0.559
CLV_NRD_NRD_1	165	167	PF00675	0.426
CLV_NRD_NRD_1	229	231	PF00675	0.515
CLV_NRD_NRD_1	27	29	PF00675	0.543
CLV_NRD_NRD_1	486	488	PF00675	0.465
CLV_NRD_NRD_1	509	511	PF00675	0.516
CLV_PCSK_KEX2_1	165	167	PF00082	0.429
CLV_PCSK_KEX2_1	229	231	PF00082	0.533
CLV_PCSK_KEX2_1	27	29	PF00082	0.543
CLV_PCSK_KEX2_1	384	386	PF00082	0.502
CLV_PCSK_KEX2_1	488	490	PF00082	0.495
CLV_PCSK_KEX2_1	509	511	PF00082	0.516
CLV_PCSK_KEX2_1	667	669	PF00082	0.491
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.502
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.495
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.484
CLV_PCSK_SKI1_1	229	233	PF00082	0.454
CLV_PCSK_SKI1_1	362	366	PF00082	0.711
CLV_PCSK_SKI1_1	381	385	PF00082	0.406
CLV_PCSK_SKI1_1	78	82	PF00082	0.397
DEG_MDM2_SWIB_1	581	589	PF02201	0.329
DEG_Nend_Nbox_1	1	3	PF02207	0.658
DEG_SPOP_SBC_1	397	401	PF00917	0.543
DOC_CKS1_1	171	176	PF01111	0.570
DOC_CYCLIN_RxL_1	654	662	PF00134	0.419
DOC_MAPK_gen_1	226	236	PF00069	0.393
DOC_MAPK_gen_1	487	495	PF00069	0.566
DOC_MAPK_gen_1	611	620	PF00069	0.463
DOC_MAPK_gen_1	74	81	PF00069	0.414
DOC_MAPK_MEF2A_6	611	620	PF00069	0.407
DOC_MAPK_MEF2A_6	655	663	PF00069	0.405
DOC_PP1_RVXF_1	622	629	PF00149	0.424
DOC_PP1_RVXF_1	76	82	PF00149	0.404
DOC_PP2B_LxvP_1	240	243	PF13499	0.523
DOC_USP7_MATH_1	577	581	PF00917	0.459
DOC_USP7_MATH_1	80	84	PF00917	0.367
DOC_USP7_UBL2_3	246	250	PF12436	0.407
DOC_USP7_UBL2_3	555	559	PF12436	0.478
DOC_WW_Pin1_4	170	175	PF00397	0.382
DOC_WW_Pin1_4	308	313	PF00397	0.556
LIG_14-3-3_CanoR_1	229	237	PF00244	0.439
LIG_14-3-3_CanoR_1	260	265	PF00244	0.703
LIG_14-3-3_CanoR_1	525	532	PF00244	0.427
LIG_14-3-3_CanoR_1	533	541	PF00244	0.455
LIG_14-3-3_CanoR_1	635	642	PF00244	0.421
LIG_APCC_ABBA_1	607	612	PF00400	0.419
LIG_BRCT_BRCA1_1	171	175	PF00533	0.506
LIG_BRCT_BRCA1_1	258	262	PF00533	0.587
LIG_BRCT_BRCA1_1	354	358	PF00533	0.659
LIG_BRCT_BRCA1_1	447	451	PF00533	0.471
LIG_BRCT_BRCA1_1	6	10	PF00533	0.666
LIG_Clathr_ClatBox_1	157	161	PF01394	0.449
LIG_Clathr_ClatBox_1	201	205	PF01394	0.424
LIG_deltaCOP1_diTrp_1	205	211	PF00928	0.332
LIG_deltaCOP1_diTrp_1	566	575	PF00928	0.497
LIG_deltaCOP1_diTrp_1	627	631	PF00928	0.376
LIG_EH1_1	390	398	PF00400	0.514
LIG_FHA_1	153	159	PF00498	0.481
LIG_FHA_1	455	461	PF00498	0.365
LIG_FHA_1	512	518	PF00498	0.443
LIG_FHA_1	57	63	PF00498	0.352
LIG_FHA_1	599	605	PF00498	0.484
LIG_FHA_1	654	660	PF00498	0.397
LIG_FHA_2	267	273	PF00498	0.684
LIG_FHA_2	275	281	PF00498	0.784
LIG_FHA_2	320	326	PF00498	0.648
LIG_FHA_2	561	567	PF00498	0.449
LIG_Integrin_isoDGR_2	507	509	PF01839	0.536
LIG_LIR_Apic_2	185	190	PF02991	0.382
LIG_LIR_Apic_2	427	432	PF02991	0.491
LIG_LIR_Gen_1	205	213	PF02991	0.351
LIG_LIR_Gen_1	526	532	PF02991	0.404
LIG_LIR_Gen_1	535	545	PF02991	0.437
LIG_LIR_Gen_1	7	17	PF02991	0.428
LIG_LIR_Nem_3	172	178	PF02991	0.350
LIG_LIR_Nem_3	185	189	PF02991	0.372
LIG_LIR_Nem_3	205	210	PF02991	0.340
LIG_LIR_Nem_3	25	29	PF02991	0.493
LIG_LIR_Nem_3	497	501	PF02991	0.642
LIG_LIR_Nem_3	526	530	PF02991	0.415
LIG_LIR_Nem_3	535	541	PF02991	0.409
LIG_LIR_Nem_3	648	654	PF02991	0.449
LIG_LIR_Nem_3	7	13	PF02991	0.514
LIG_LYPXL_S_1	471	475	PF13949	0.469
LIG_LYPXL_yS_3	472	475	PF13949	0.433
LIG_LYPXL_yS_3	498	501	PF13949	0.371
LIG_MLH1_MIPbox_1	6	10	PF16413	0.462
LIG_NRBOX	516	522	PF00104	0.507
LIG_PCNA_PIPBox_1	3	12	PF02747	0.523
LIG_PCNA_yPIPBox_3	3	15	PF02747	0.510
LIG_Pex14_1	207	211	PF04695	0.315
LIG_Pex14_2	22	26	PF04695	0.540
LIG_Pex14_2	581	585	PF04695	0.325
LIG_SH2_CRK	237	241	PF00017	0.522
LIG_SH2_CRK	380	384	PF00017	0.580
LIG_SH2_CRK	429	433	PF00017	0.464
LIG_SH2_CRK	553	557	PF00017	0.405
LIG_SH2_NCK_1	181	185	PF00017	0.434
LIG_SH2_STAT3	200	203	PF00017	0.359
LIG_SH2_STAT3	477	480	PF00017	0.435
LIG_SH2_STAT5	200	203	PF00017	0.399
LIG_SH2_STAT5	95	98	PF00017	0.491
LIG_SH3_1	168	174	PF00018	0.518
LIG_SH3_2	483	488	PF14604	0.437
LIG_SH3_3	168	174	PF00018	0.506
LIG_SH3_3	187	193	PF00018	0.316
LIG_SH3_3	206	212	PF00018	0.324
LIG_SH3_3	309	315	PF00018	0.594
LIG_SH3_3	326	332	PF00018	0.798
LIG_SH3_3	365	371	PF00018	0.573
LIG_SH3_3	455	461	PF00018	0.419
LIG_SH3_3	467	473	PF00018	0.414
LIG_SH3_3	480	486	PF00018	0.308
LIG_SH3_3	542	548	PF00018	0.469
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.322
LIG_SUMO_SIM_anti_2	340	352	PF11976	0.589
LIG_SUMO_SIM_anti_2	603	608	PF11976	0.411
LIG_SUMO_SIM_par_1	142	147	PF11976	0.346
LIG_SUMO_SIM_par_1	154	159	PF11976	0.372
LIG_SUMO_SIM_par_1	600	605	PF11976	0.496
LIG_TRAF2_1	111	114	PF00917	0.521
LIG_TYR_ITIM	378	383	PF00017	0.594
LIG_TYR_ITIM	496	501	PF00017	0.378
LIG_TYR_ITIM	551	556	PF00017	0.372
MOD_CK1_1	134	140	PF00069	0.336
MOD_CK1_1	263	269	PF00069	0.674
MOD_CK1_1	334	340	PF00069	0.647
MOD_CK1_1	341	347	PF00069	0.599
MOD_CK1_1	400	406	PF00069	0.582
MOD_CK1_1	528	534	PF00069	0.474
MOD_CK2_1	103	109	PF00069	0.605
MOD_CK2_1	249	255	PF00069	0.620
MOD_CK2_1	264	270	PF00069	0.530
MOD_CK2_1	274	280	PF00069	0.641
MOD_CK2_1	560	566	PF00069	0.387
MOD_CK2_1	577	583	PF00069	0.432
MOD_CMANNOS	628	631	PF00535	0.376
MOD_Cter_Amidation	507	510	PF01082	0.501
MOD_GlcNHglycan	333	336	PF01048	0.656
MOD_GlcNHglycan	343	346	PF01048	0.577
MOD_GlcNHglycan	400	403	PF01048	0.588
MOD_GlcNHglycan	556	559	PF01048	0.467
MOD_GlcNHglycan	82	85	PF01048	0.379
MOD_GSK3_1	126	133	PF00069	0.497
MOD_GSK3_1	152	159	PF00069	0.333
MOD_GSK3_1	256	263	PF00069	0.599
MOD_GSK3_1	331	338	PF00069	0.650
MOD_GSK3_1	354	361	PF00069	0.524
MOD_GSK3_1	396	403	PF00069	0.590
MOD_GSK3_1	528	535	PF00069	0.468
MOD_GSK3_1	672	679	PF00069	0.572
MOD_LATS_1	523	529	PF00433	0.500
MOD_N-GLC_1	533	538	PF02516	0.531
MOD_N-GLC_1	598	603	PF02516	0.418
MOD_NEK2_1	126	131	PF00069	0.413
MOD_NEK2_1	2	7	PF00069	0.567
MOD_NEK2_1	217	222	PF00069	0.532
MOD_NEK2_1	262	267	PF00069	0.699
MOD_NEK2_1	339	344	PF00069	0.689
MOD_NEK2_1	358	363	PF00069	0.580
MOD_NEK2_1	396	401	PF00069	0.445
MOD_NEK2_1	407	412	PF00069	0.448
MOD_NEK2_2	577	582	PF00069	0.457
MOD_NEK2_2	588	593	PF00069	0.392
MOD_PIKK_1	109	115	PF00454	0.494
MOD_PIKK_1	34	40	PF00454	0.386
MOD_PKA_1	229	235	PF00069	0.510
MOD_PKA_2	103	109	PF00069	0.574
MOD_PKA_2	229	235	PF00069	0.430
MOD_PKA_2	532	538	PF00069	0.496
MOD_PKA_2	634	640	PF00069	0.413
MOD_Plk_1	127	133	PF00069	0.417
MOD_Plk_1	528	534	PF00069	0.397
MOD_Plk_1	598	604	PF00069	0.502
MOD_Plk_2-3	249	255	PF00069	0.603
MOD_Plk_2-3	409	415	PF00069	0.568
MOD_Plk_2-3	454	460	PF00069	0.513
MOD_Plk_4	152	158	PF00069	0.350
MOD_Plk_4	212	218	PF00069	0.453
MOD_Plk_4	354	360	PF00069	0.628
MOD_Plk_4	577	583	PF00069	0.382
MOD_ProDKin_1	170	176	PF00069	0.374
MOD_ProDKin_1	308	314	PF00069	0.557
TRG_DiLeu_BaEn_2	386	392	PF01217	0.546
TRG_ENDOCYTIC_2	237	240	PF00928	0.440
TRG_ENDOCYTIC_2	380	383	PF00928	0.583
TRG_ENDOCYTIC_2	468	471	PF00928	0.416
TRG_ENDOCYTIC_2	472	475	PF00928	0.427
TRG_ENDOCYTIC_2	498	501	PF00928	0.371
TRG_ENDOCYTIC_2	553	556	PF00928	0.385
TRG_ER_diArg_1	165	168	PF00400	0.382
TRG_ER_diArg_1	228	230	PF00400	0.536
TRG_ER_diArg_1	26	28	PF00400	0.557
TRG_ER_diArg_1	461	464	PF00400	0.379
TRG_ER_diArg_1	486	489	PF00400	0.536
TRG_ER_diArg_1	509	511	PF00400	0.541
TRG_ER_diArg_1	654	657	PF00400	0.406
TRG_NES_CRM1_1	114	128	PF08389	0.531
TRG_NES_CRM1_1	244	255	PF08389	0.431
TRG_NES_CRM1_1	409	424	PF08389	0.435
TRG_NLS_MonoExtN_4	486	491	PF00514	0.475
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F1	Leptomonas seymouri	69%	99%
A0A0S4IRV6	Bodo saltans	42%	99%
A0A1X0NSL8	Trypanosomatidae	52%	94%
A0A3S7WZQ1	Leishmania donovani	100%	100%
A0A422MXA7	Trypanosoma rangeli	53%	95%
A4HEU8	Leishmania braziliensis	89%	100%
C9ZRY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AY71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q9A1	Leishmania major	97%	100%
Q57VU6	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	52%	99%
V5DR06	Trypanosoma cruzi	52%	95%