LeishMANIAdb
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Heat shock 70 protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Heat shock 70 protein-like protein
Gene product:
heat shock 70 protein-like protein
Species:
Leishmania infantum
UniProt:
A4I219_LEIIN
TriTrypDb:
LINF_260013900 *
Length:
742

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Heat shock 70 -like (Fragment)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0043226 organelle 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 1

Expansion

Sequence features

A4I219
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I219

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0006458 'de novo' protein folding 3 1
GO:0006950 response to stress 2 1
GO:0006986 response to unfolded protein 4 1
GO:0009987 cellular process 1 1
GO:0010033 response to organic substance 3 1
GO:0033554 cellular response to stress 3 1
GO:0034620 cellular response to unfolded protein 5 1
GO:0035966 response to topologically incorrect protein 3 1
GO:0035967 cellular response to topologically incorrect protein 4 1
GO:0042026 protein refolding 3 1
GO:0042221 response to chemical 2 1
GO:0050896 response to stimulus 1 1
GO:0051084 'de novo' post-translational protein folding 4 1
GO:0051085 chaperone cofactor-dependent protein refolding 4 1
GO:0051716 cellular response to stimulus 2 1
GO:0061077 chaperone-mediated protein folding 3 1
GO:0070887 cellular response to chemical stimulus 3 1
GO:0071310 cellular response to organic substance 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0044183 protein folding chaperone 1 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:0140657 ATP-dependent activity 1 10
GO:0140662 ATP-dependent protein folding chaperone 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10
GO:0003824 catalytic activity 1 1
GO:0005515 protein binding 2 1
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0016887 ATP hydrolysis activity 7 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1
GO:0031072 heat shock protein binding 3 1
GO:0051082 unfolded protein binding 3 1
GO:0051787 misfolded protein binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 280 284 PF00656 0.518
CLV_C14_Caspase3-7 688 692 PF00656 0.571
CLV_NRD_NRD_1 113 115 PF00675 0.381
CLV_NRD_NRD_1 569 571 PF00675 0.521
CLV_NRD_NRD_1 619 621 PF00675 0.503
CLV_NRD_NRD_1 635 637 PF00675 0.486
CLV_NRD_NRD_1 642 644 PF00675 0.546
CLV_NRD_NRD_1 66 68 PF00675 0.564
CLV_NRD_NRD_1 7 9 PF00675 0.709
CLV_PCSK_FUR_1 276 280 PF00082 0.416
CLV_PCSK_FUR_1 85 89 PF00082 0.637
CLV_PCSK_KEX2_1 113 115 PF00082 0.402
CLV_PCSK_KEX2_1 162 164 PF00082 0.317
CLV_PCSK_KEX2_1 278 280 PF00082 0.496
CLV_PCSK_KEX2_1 333 335 PF00082 0.481
CLV_PCSK_KEX2_1 569 571 PF00082 0.521
CLV_PCSK_KEX2_1 619 621 PF00082 0.503
CLV_PCSK_KEX2_1 635 637 PF00082 0.486
CLV_PCSK_KEX2_1 65 67 PF00082 0.564
CLV_PCSK_KEX2_1 650 652 PF00082 0.477
CLV_PCSK_KEX2_1 7 9 PF00082 0.709
CLV_PCSK_KEX2_1 87 89 PF00082 0.649
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.317
CLV_PCSK_PC1ET2_1 278 280 PF00082 0.569
CLV_PCSK_PC1ET2_1 333 335 PF00082 0.481
CLV_PCSK_PC1ET2_1 650 652 PF00082 0.503
CLV_PCSK_PC1ET2_1 87 89 PF00082 0.649
CLV_PCSK_PC7_1 3 9 PF00082 0.665
CLV_PCSK_SKI1_1 213 217 PF00082 0.317
CLV_PCSK_SKI1_1 243 247 PF00082 0.317
CLV_PCSK_SKI1_1 3 7 PF00082 0.701
CLV_PCSK_SKI1_1 359 363 PF00082 0.381
CLV_PCSK_SKI1_1 506 510 PF00082 0.317
CLV_PCSK_SKI1_1 573 577 PF00082 0.624
CLV_PCSK_SKI1_1 619 623 PF00082 0.487
CLV_PCSK_SKI1_1 635 639 PF00082 0.500
CLV_PCSK_SKI1_1 678 682 PF00082 0.509
CLV_Separin_Metazoa 675 679 PF03568 0.471
DEG_SPOP_SBC_1 304 308 PF00917 0.710
DEG_SPOP_SBC_1 319 323 PF00917 0.627
DOC_CKS1_1 237 242 PF01111 0.317
DOC_CYCLIN_RxL_1 333 342 PF00134 0.318
DOC_CYCLIN_RxL_1 410 420 PF00134 0.317
DOC_CYCLIN_RxL_1 501 511 PF00134 0.417
DOC_CYCLIN_RxL_1 569 581 PF00134 0.661
DOC_CYCLIN_RxL_1 616 627 PF00134 0.534
DOC_CYCLIN_yCln2_LP_2 464 470 PF00134 0.347
DOC_MAPK_gen_1 333 341 PF00069 0.367
DOC_MAPK_gen_1 445 452 PF00069 0.342
DOC_MAPK_gen_1 569 577 PF00069 0.656
DOC_MAPK_MEF2A_6 190 197 PF00069 0.317
DOC_PP1_RVXF_1 335 342 PF00149 0.317
DOC_PP1_RVXF_1 421 427 PF00149 0.317
DOC_USP7_MATH_1 121 125 PF00917 0.306
DOC_USP7_MATH_1 150 154 PF00917 0.417
DOC_USP7_MATH_1 230 234 PF00917 0.417
DOC_USP7_MATH_1 303 307 PF00917 0.704
DOC_USP7_MATH_1 317 321 PF00917 0.642
DOC_USP7_MATH_1 35 39 PF00917 0.717
DOC_WW_Pin1_4 117 122 PF00397 0.317
DOC_WW_Pin1_4 236 241 PF00397 0.317
DOC_WW_Pin1_4 288 293 PF00397 0.668
DOC_WW_Pin1_4 321 326 PF00397 0.684
LIG_14-3-3_CanoR_1 151 158 PF00244 0.317
LIG_14-3-3_CanoR_1 200 205 PF00244 0.294
LIG_14-3-3_CanoR_1 213 223 PF00244 0.294
LIG_14-3-3_CanoR_1 334 340 PF00244 0.374
LIG_14-3-3_CanoR_1 48 54 PF00244 0.619
LIG_14-3-3_CanoR_1 7 15 PF00244 0.691
LIG_APCC_ABBA_1 139 144 PF00400 0.317
LIG_BIR_III_4 328 332 PF00653 0.542
LIG_BRCT_BRCA1_1 337 341 PF00533 0.317
LIG_BRCT_BRCA1_1 382 386 PF00533 0.298
LIG_BRCT_BRCA1_1 549 553 PF00533 0.517
LIG_BRCT_BRCA1_2 382 388 PF00533 0.417
LIG_Clathr_ClatBox_1 610 614 PF01394 0.495
LIG_EH1_1 201 209 PF00400 0.317
LIG_EH1_1 254 262 PF00400 0.410
LIG_FHA_1 180 186 PF00498 0.317
LIG_FHA_1 199 205 PF00498 0.317
LIG_FHA_1 463 469 PF00498 0.342
LIG_FHA_1 549 555 PF00498 0.500
LIG_FHA_1 577 583 PF00498 0.626
LIG_FHA_1 693 699 PF00498 0.592
LIG_FHA_1 8 14 PF00498 0.760
LIG_FHA_2 184 190 PF00498 0.317
LIG_FHA_2 270 276 PF00498 0.385
LIG_FHA_2 365 371 PF00498 0.317
LIG_FHA_2 455 461 PF00498 0.317
LIG_FHA_2 721 727 PF00498 0.697
LIG_FHA_2 731 737 PF00498 0.720
LIG_GBD_Chelix_1 204 212 PF00786 0.342
LIG_GBD_Chelix_1 567 575 PF00786 0.579
LIG_GBD_Chelix_1 679 687 PF00786 0.538
LIG_LIR_Apic_2 122 128 PF02991 0.317
LIG_LIR_Apic_2 391 397 PF02991 0.317
LIG_LIR_Gen_1 201 210 PF02991 0.342
LIG_LIR_Gen_1 377 386 PF02991 0.363
LIG_LIR_Gen_1 459 468 PF02991 0.317
LIG_LIR_Nem_3 201 205 PF02991 0.342
LIG_LIR_Nem_3 377 381 PF02991 0.363
LIG_LIR_Nem_3 430 436 PF02991 0.375
LIG_LIR_Nem_3 459 464 PF02991 0.317
LIG_LIR_Nem_3 543 547 PF02991 0.551
LIG_LIR_Nem_3 75 80 PF02991 0.601
LIG_LRP6_Inhibitor_1 582 594 PF00058 0.547
LIG_MAD2 516 524 PF02301 0.458
LIG_PCNA_TLS_4 506 513 PF02747 0.458
LIG_Pex14_2 386 390 PF04695 0.317
LIG_PTB_Apo_2 329 336 PF02174 0.507
LIG_PTB_Phospho_1 329 335 PF10480 0.519
LIG_SH2_CRK 202 206 PF00017 0.342
LIG_SH2_GRB2like 55 58 PF00017 0.654
LIG_SH2_NCK_1 436 440 PF00017 0.317
LIG_SH2_NCK_1 485 489 PF00017 0.381
LIG_SH2_PTP2 461 464 PF00017 0.287
LIG_SH2_SRC 107 110 PF00017 0.410
LIG_SH2_SRC 55 58 PF00017 0.696
LIG_SH2_STAP1 527 531 PF00017 0.317
LIG_SH2_STAP1 606 610 PF00017 0.479
LIG_SH2_STAT5 107 110 PF00017 0.317
LIG_SH2_STAT5 202 205 PF00017 0.317
LIG_SH2_STAT5 214 217 PF00017 0.317
LIG_SH2_STAT5 237 240 PF00017 0.404
LIG_SH2_STAT5 271 274 PF00017 0.402
LIG_SH2_STAT5 335 338 PF00017 0.476
LIG_SH2_STAT5 461 464 PF00017 0.298
LIG_SH2_STAT5 512 515 PF00017 0.317
LIG_SH2_STAT5 574 577 PF00017 0.486
LIG_SH2_STAT5 78 81 PF00017 0.637
LIG_SH3_2 46 51 PF14604 0.624
LIG_SH3_3 21 27 PF00018 0.700
LIG_SH3_3 229 235 PF00018 0.317
LIG_SH3_3 43 49 PF00018 0.636
LIG_SUMO_SIM_anti_2 256 263 PF11976 0.317
LIG_SUMO_SIM_anti_2 491 497 PF11976 0.317
LIG_SUMO_SIM_par_1 182 189 PF11976 0.317
LIG_SUMO_SIM_par_1 256 263 PF11976 0.317
LIG_TRAF2_1 397 400 PF00917 0.417
LIG_TRAF2_1 457 460 PF00917 0.317
LIG_TRAF2_1 599 602 PF00917 0.496
LIG_TYR_ITIM 269 274 PF00017 0.402
LIG_UBA3_1 652 660 PF00899 0.546
MOD_CDK_SPxxK_3 236 243 PF00069 0.317
MOD_CK1_1 177 183 PF00069 0.458
MOD_CK1_1 306 312 PF00069 0.555
MOD_CK1_1 320 326 PF00069 0.578
MOD_CK1_1 429 435 PF00069 0.417
MOD_CK2_1 183 189 PF00069 0.317
MOD_CK2_1 214 220 PF00069 0.381
MOD_CK2_1 269 275 PF00069 0.341
MOD_CK2_1 320 326 PF00069 0.684
MOD_CK2_1 454 460 PF00069 0.317
MOD_CK2_1 540 546 PF00069 0.467
MOD_CK2_1 557 563 PF00069 0.483
MOD_CK2_1 596 602 PF00069 0.527
MOD_CK2_1 720 726 PF00069 0.683
MOD_Cter_Amidation 160 163 PF01082 0.316
MOD_Cter_Amidation 513 516 PF01082 0.417
MOD_GlcNHglycan 152 155 PF01048 0.317
MOD_GlcNHglycan 159 162 PF01048 0.317
MOD_GlcNHglycan 262 267 PF01048 0.317
MOD_GlcNHglycan 294 297 PF01048 0.669
MOD_GlcNHglycan 301 304 PF01048 0.692
MOD_GlcNHglycan 308 311 PF01048 0.691
MOD_GlcNHglycan 42 45 PF01048 0.610
MOD_GlcNHglycan 554 557 PF01048 0.560
MOD_GlcNHglycan 720 723 PF01048 0.641
MOD_GlcNHglycan 89 92 PF01048 0.586
MOD_GSK3_1 117 124 PF00069 0.317
MOD_GSK3_1 150 157 PF00069 0.317
MOD_GSK3_1 179 186 PF00069 0.317
MOD_GSK3_1 288 295 PF00069 0.629
MOD_GSK3_1 299 306 PF00069 0.679
MOD_GSK3_1 317 324 PF00069 0.647
MOD_GSK3_1 35 42 PF00069 0.707
MOD_GSK3_1 548 555 PF00069 0.499
MOD_GSK3_1 699 706 PF00069 0.543
MOD_GSK3_1 709 716 PF00069 0.557
MOD_GSK3_1 720 727 PF00069 0.571
MOD_GSK3_1 731 738 PF00069 0.649
MOD_N-GLC_1 177 182 PF02516 0.381
MOD_N-GLC_1 35 40 PF02516 0.763
MOD_N-GLC_1 730 735 PF02516 0.721
MOD_N-GLC_2 102 104 PF02516 0.317
MOD_NEK2_1 179 184 PF00069 0.317
MOD_NEK2_1 198 203 PF00069 0.317
MOD_NEK2_1 269 274 PF00069 0.317
MOD_NEK2_1 364 369 PF00069 0.317
MOD_NEK2_1 452 457 PF00069 0.317
MOD_NEK2_1 480 485 PF00069 0.287
MOD_NEK2_1 540 545 PF00069 0.404
MOD_NEK2_1 547 552 PF00069 0.477
MOD_NEK2_1 577 582 PF00069 0.582
MOD_NEK2_1 6 11 PF00069 0.683
MOD_NEK2_1 613 618 PF00069 0.605
MOD_NEK2_1 709 714 PF00069 0.627
MOD_NEK2_1 98 103 PF00069 0.317
MOD_PIKK_1 380 386 PF00454 0.317
MOD_PKA_1 635 641 PF00069 0.499
MOD_PKA_1 7 13 PF00069 0.677
MOD_PKA_1 87 93 PF00069 0.575
MOD_PKA_2 150 156 PF00069 0.317
MOD_PKA_2 6 12 PF00069 0.686
MOD_PKA_2 635 641 PF00069 0.499
MOD_PKA_2 87 93 PF00069 0.528
MOD_Plk_1 35 41 PF00069 0.685
MOD_Plk_1 452 458 PF00069 0.317
MOD_Plk_4 121 127 PF00069 0.317
MOD_Plk_4 200 206 PF00069 0.342
MOD_Plk_4 269 275 PF00069 0.317
MOD_Plk_4 377 383 PF00069 0.374
MOD_Plk_4 429 435 PF00069 0.417
MOD_ProDKin_1 117 123 PF00069 0.317
MOD_ProDKin_1 236 242 PF00069 0.317
MOD_ProDKin_1 288 294 PF00069 0.674
MOD_ProDKin_1 321 327 PF00069 0.679
MOD_SUMO_for_1 215 218 PF00179 0.317
MOD_SUMO_for_1 277 280 PF00179 0.550
MOD_SUMO_for_1 59 62 PF00179 0.672
TRG_DiLeu_BaEn_2 217 223 PF01217 0.342
TRG_DiLeu_BaEn_4 459 465 PF01217 0.347
TRG_DiLeu_BaLyEn_6 160 165 PF01217 0.317
TRG_DiLeu_BaLyEn_6 617 622 PF01217 0.497
TRG_ENDOCYTIC_2 202 205 PF00928 0.342
TRG_ENDOCYTIC_2 271 274 PF00928 0.402
TRG_ENDOCYTIC_2 358 361 PF00928 0.381
TRG_ENDOCYTIC_2 461 464 PF00928 0.298
TRG_ENDOCYTIC_2 574 577 PF00928 0.486
TRG_ENDOCYTIC_2 77 80 PF00928 0.623
TRG_ER_diArg_1 113 115 PF00400 0.381
TRG_ER_diArg_1 468 471 PF00400 0.299
TRG_ER_diArg_1 568 570 PF00400 0.524
TRG_ER_diArg_1 591 594 PF00400 0.558
TRG_ER_diArg_1 6 8 PF00400 0.714
TRG_ER_diArg_1 619 621 PF00400 0.503
TRG_ER_diArg_1 634 636 PF00400 0.489
TRG_ER_diArg_1 65 67 PF00400 0.562
TRG_ER_diArg_1 74 77 PF00400 0.550
TRG_Pf-PMV_PEXEL_1 213 218 PF00026 0.317
TRG_Pf-PMV_PEXEL_1 221 225 PF00026 0.317
TRG_Pf-PMV_PEXEL_1 337 342 PF00026 0.317
TRG_Pf-PMV_PEXEL_1 413 418 PF00026 0.317
TRG_Pf-PMV_PEXEL_1 506 510 PF00026 0.375
TRG_Pf-PMV_PEXEL_1 608 612 PF00026 0.489
TRG_Pf-PMV_PEXEL_1 619 624 PF00026 0.484
TRG_Pf-PMV_PEXEL_1 67 71 PF00026 0.629
TRG_Pf-PMV_PEXEL_1 681 685 PF00026 0.485

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEK8 Leptomonas seymouri 81% 80%
A0A1X0NSC2 Trypanosomatidae 70% 84%
A0A3Q8IB80 Leishmania donovani 29% 100%
A0A3Q8ICR2 Leishmania donovani 100% 79%
A0A3Q8IQX0 Leishmania donovani 29% 100%
A0A3S7WZX1 Leishmania donovani 26% 100%
A0A3S7X203 Leishmania donovani 26% 100%
A4HEU5 Leishmania braziliensis 89% 100%
A4HEX9 Leishmania braziliensis 25% 100%
A4HGY1 Leishmania braziliensis 28% 100%
A4HGY5 Leishmania braziliensis 26% 100%
A4I253 Leishmania infantum 26% 100%
A4I412 Leishmania infantum 29% 100%
A4I417 Leishmania infantum 26% 100%
A4X148 Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) 27% 100%
A8LWM4 Salinispora arenicola (strain CNS-205) 27% 100%
B8D758 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7) 28% 100%
B8D8V4 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A) 28% 100%
C9ZRY8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 85%
E9AHH0 Leishmania infantum 29% 100%
E9AHH1 Leishmania infantum 29% 100%
E9AY68 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9AYA3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B099 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B0A4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
O32464 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 28% 100%
O65719 Arabidopsis thaliana 28% 100%
P09189 Petunia hybrida 28% 100%
P22953 Arabidopsis thaliana 27% 100%
P27322 Solanum lycopersicum 28% 100%
Q4Q7Y0 Leishmania major 25% 100%
Q4Q7Y4 Leishmania major 28% 100%
Q4Q970 Leishmania major 27% 100%
Q4Q9A4 Leishmania major 96% 100%
Q6G1F9 Bartonella quintana (strain Toulouse) 29% 100%
Q6G554 Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) 29% 100%
Q7U6R7 Parasynechococcus marenigrum (strain WH8102) 29% 100%
Q8K9Y8 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 28% 100%
Q9LHA8 Arabidopsis thaliana 28% 100%
V5BUG8 Trypanosoma cruzi 69% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS