FYR C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I217_LEIIN

TriTrypDb:

LINF_260013600

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0031010	ISWI-type complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1

Expansion

Sequence features

A4I217

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I217

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.792
CLV_C14_Caspase3-7	483	487	PF00656	0.650
CLV_C14_Caspase3-7	728	732	PF00656	0.677
CLV_C14_Caspase3-7	767	771	PF00656	0.724
CLV_C14_Caspase3-7	88	92	PF00656	0.534
CLV_C14_Caspase3-7	97	101	PF00656	0.468
CLV_NRD_NRD_1	108	110	PF00675	0.613
CLV_NRD_NRD_1	217	219	PF00675	0.690
CLV_NRD_NRD_1	244	246	PF00675	0.739
CLV_NRD_NRD_1	250	252	PF00675	0.752
CLV_NRD_NRD_1	290	292	PF00675	0.720
CLV_NRD_NRD_1	293	295	PF00675	0.705
CLV_NRD_NRD_1	327	329	PF00675	0.723
CLV_NRD_NRD_1	414	416	PF00675	0.734
CLV_NRD_NRD_1	419	421	PF00675	0.745
CLV_NRD_NRD_1	463	465	PF00675	0.795
CLV_NRD_NRD_1	467	469	PF00675	0.613
CLV_NRD_NRD_1	500	502	PF00675	0.714
CLV_NRD_NRD_1	612	614	PF00675	0.714
CLV_NRD_NRD_1	735	737	PF00675	0.745
CLV_PCSK_FUR_1	291	295	PF00082	0.731
CLV_PCSK_FUR_1	467	471	PF00082	0.737
CLV_PCSK_FUR_1	498	502	PF00082	0.697
CLV_PCSK_KEX2_1	217	219	PF00082	0.690
CLV_PCSK_KEX2_1	243	245	PF00082	0.755
CLV_PCSK_KEX2_1	250	252	PF00082	0.717
CLV_PCSK_KEX2_1	288	290	PF00082	0.737
CLV_PCSK_KEX2_1	293	295	PF00082	0.706
CLV_PCSK_KEX2_1	325	327	PF00082	0.667
CLV_PCSK_KEX2_1	418	420	PF00082	0.745
CLV_PCSK_KEX2_1	467	469	PF00082	0.680
CLV_PCSK_KEX2_1	500	502	PF00082	0.714
CLV_PCSK_KEX2_1	602	604	PF00082	0.690
CLV_PCSK_KEX2_1	611	613	PF00082	0.702
CLV_PCSK_KEX2_1	704	706	PF00082	0.565
CLV_PCSK_KEX2_1	740	742	PF00082	0.712
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.755
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.737
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.667
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.734
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.690
CLV_PCSK_PC1ET2_1	704	706	PF00082	0.565
CLV_PCSK_PC1ET2_1	740	742	PF00082	0.754
CLV_PCSK_PC7_1	240	246	PF00082	0.755
CLV_PCSK_PC7_1	289	295	PF00082	0.735
CLV_PCSK_PC7_1	415	421	PF00082	0.741
CLV_PCSK_PC7_1	736	742	PF00082	0.754
CLV_PCSK_SKI1_1	102	106	PF00082	0.563
CLV_PCSK_SKI1_1	109	113	PF00082	0.476
CLV_PCSK_SKI1_1	244	248	PF00082	0.690
CLV_PCSK_SKI1_1	35	39	PF00082	0.484
CLV_PCSK_SKI1_1	717	721	PF00082	0.598
CLV_PCSK_SKI1_1	77	81	PF00082	0.599
DEG_APCC_DBOX_1	716	724	PF00400	0.581
DEG_COP1_1	486	494	PF00400	0.598
DEG_Nend_Nbox_1	1	3	PF02207	0.488
DEG_SCF_FBW7_1	223	228	PF00400	0.733
DEG_SPOP_SBC_1	11	15	PF00917	0.660
DEG_SPOP_SBC_1	190	194	PF00917	0.645
DEG_SPOP_SBC_1	37	41	PF00917	0.594
DOC_CYCLIN_yCln2_LP_2	557	563	PF00134	0.744
DOC_MAPK_DCC_7	341	350	PF00069	0.568
DOC_MAPK_gen_1	400	410	PF00069	0.726
DOC_MAPK_RevD_3	589	603	PF00069	0.640
DOC_PP2B_LxvP_1	126	129	PF13499	0.540
DOC_PP2B_LxvP_1	156	159	PF13499	0.564
DOC_PP2B_LxvP_1	373	376	PF13499	0.656
DOC_PP2B_LxvP_1	557	560	PF13499	0.661
DOC_PP4_FxxP_1	21	24	PF00568	0.660
DOC_SPAK_OSR1_1	708	712	PF12202	0.598
DOC_USP7_MATH_1	129	133	PF00917	0.540
DOC_USP7_MATH_1	168	172	PF00917	0.524
DOC_USP7_MATH_1	225	229	PF00917	0.758
DOC_USP7_MATH_1	239	243	PF00917	0.704
DOC_USP7_MATH_1	246	250	PF00917	0.745
DOC_USP7_MATH_1	260	264	PF00917	0.676
DOC_USP7_MATH_1	265	269	PF00917	0.598
DOC_USP7_MATH_1	320	324	PF00917	0.717
DOC_USP7_MATH_1	485	489	PF00917	0.772
DOC_USP7_MATH_1	512	516	PF00917	0.786
DOC_USP7_MATH_1	525	529	PF00917	0.575
DOC_USP7_MATH_1	730	734	PF00917	0.630
DOC_USP7_MATH_1	805	809	PF00917	0.679
DOC_USP7_MATH_2	232	238	PF00917	0.827
DOC_USP7_UBL2_3	226	230	PF12436	0.752
DOC_USP7_UBL2_3	465	469	PF12436	0.724
DOC_WW_Pin1_4	219	224	PF00397	0.671
DOC_WW_Pin1_4	256	261	PF00397	0.696
DOC_WW_Pin1_4	301	306	PF00397	0.818
DOC_WW_Pin1_4	359	364	PF00397	0.560
DOC_WW_Pin1_4	531	536	PF00397	0.681
DOC_WW_Pin1_4	671	676	PF00397	0.714
DOC_WW_Pin1_4	778	783	PF00397	0.767
LIG_14-3-3_CanoR_1	191	196	PF00244	0.664
LIG_14-3-3_CanoR_1	244	254	PF00244	0.803
LIG_14-3-3_CanoR_1	35	44	PF00244	0.567
LIG_14-3-3_CanoR_1	558	564	PF00244	0.637
LIG_14-3-3_CanoR_1	736	742	PF00244	0.611
LIG_Actin_WH2_2	134	151	PF00022	0.514
LIG_APCC_ABBAyCdc20_2	23	29	PF00400	0.493
LIG_BRCT_BRCA1_1	515	519	PF00533	0.683
LIG_DCNL_PONY_1	1	4	PF03556	0.580
LIG_FHA_1	176	182	PF00498	0.623
LIG_FHA_1	191	197	PF00498	0.689
LIG_FHA_1	262	268	PF00498	0.729
LIG_FHA_1	338	344	PF00498	0.596
LIG_FHA_1	347	353	PF00498	0.529
LIG_FHA_1	521	527	PF00498	0.721
LIG_FHA_1	71	77	PF00498	0.391
LIG_FHA_1	82	88	PF00498	0.598
LIG_FHA_2	442	448	PF00498	0.673
LIG_FHA_2	560	566	PF00498	0.719
LIG_FHA_2	716	722	PF00498	0.704
LIG_FHA_2	762	768	PF00498	0.664
LIG_FHA_2	86	92	PF00498	0.470
LIG_FHA_2	95	101	PF00498	0.447
LIG_FXI_DFP_1	116	120	PF00024	0.510
LIG_LIR_Apic_2	52	58	PF02991	0.686
LIG_LIR_Apic_2	549	555	PF02991	0.660
LIG_LIR_Gen_1	716	726	PF02991	0.560
LIG_LIR_Nem_3	383	389	PF02991	0.479
LIG_LIR_Nem_3	553	557	PF02991	0.773
LIG_LIR_Nem_3	716	722	PF02991	0.570
LIG_LRP6_Inhibitor_1	136	142	PF00058	0.517
LIG_LYPXL_yS_3	554	557	PF13949	0.669
LIG_MYND_1	371	375	PF01753	0.652
LIG_MYND_1	555	559	PF01753	0.668
LIG_Pex14_1	577	581	PF04695	0.604
LIG_SH2_CRK	55	59	PF00017	0.711
LIG_SH2_CRK	552	556	PF00017	0.687
LIG_SH2_STAT5	31	34	PF00017	0.404
LIG_SH2_STAT5	552	555	PF00017	0.615
LIG_SH2_STAT5	71	74	PF00017	0.576
LIG_SH2_STAT5	713	716	PF00017	0.689
LIG_SH2_STAT5	98	101	PF00017	0.539
LIG_SH3_3	22	28	PF00018	0.616
LIG_SH3_3	349	355	PF00018	0.706
LIG_SH3_3	368	374	PF00018	0.437
LIG_SH3_3	405	411	PF00018	0.728
LIG_SH3_3	529	535	PF00018	0.775
LIG_SH3_3	537	543	PF00018	0.693
LIG_SH3_3	553	559	PF00018	0.645
LIG_SH3_3	582	588	PF00018	0.559
LIG_SH3_3	669	675	PF00018	0.717
LIG_SH3_3	680	686	PF00018	0.671
LIG_SH3_4	465	472	PF00018	0.793
LIG_Sin3_3	487	494	PF02671	0.596
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.604
LIG_SUMO_SIM_anti_2	718	724	PF11976	0.583
LIG_SUMO_SIM_par_1	268	275	PF11976	0.621
LIG_SUMO_SIM_par_1	346	351	PF11976	0.693
LIG_SUMO_SIM_par_1	559	565	PF11976	0.728
LIG_SUMO_SIM_par_1	690	695	PF11976	0.604
LIG_TRAF2_1	546	549	PF00917	0.709
MOD_CDK_SPK_2	221	226	PF00069	0.746
MOD_CDK_SPxxK_3	219	226	PF00069	0.827
MOD_CK1_1	103	109	PF00069	0.503
MOD_CK1_1	179	185	PF00069	0.521
MOD_CK1_1	194	200	PF00069	0.800
MOD_CK1_1	331	337	PF00069	0.749
MOD_CK1_1	359	365	PF00069	0.575
MOD_CK1_1	515	521	PF00069	0.773
MOD_CK1_1	59	65	PF00069	0.669
MOD_CK1_1	666	672	PF00069	0.683
MOD_CK1_1	674	680	PF00069	0.664
MOD_CK1_1	715	721	PF00069	0.599
MOD_CK1_1	778	784	PF00069	0.828
MOD_CK2_1	441	447	PF00069	0.673
MOD_CK2_1	515	521	PF00069	0.724
MOD_CK2_1	559	565	PF00069	0.728
MOD_CK2_1	778	784	PF00069	0.787
MOD_Cter_Amidation	702	705	PF01082	0.557
MOD_Cter_Amidation	734	737	PF01082	0.832
MOD_GlcNHglycan	102	105	PF01048	0.534
MOD_GlcNHglycan	171	174	PF01048	0.623
MOD_GlcNHglycan	227	230	PF01048	0.719
MOD_GlcNHglycan	267	270	PF01048	0.754
MOD_GlcNHglycan	358	361	PF01048	0.626
MOD_GlcNHglycan	448	454	PF01048	0.786
MOD_GlcNHglycan	480	483	PF01048	0.738
MOD_GlcNHglycan	486	490	PF01048	0.729
MOD_GlcNHglycan	58	61	PF01048	0.647
MOD_GlcNHglycan	665	668	PF01048	0.730
MOD_GlcNHglycan	669	672	PF01048	0.758
MOD_GlcNHglycan	727	730	PF01048	0.625
MOD_GlcNHglycan	776	780	PF01048	0.829
MOD_GSK3_1	175	182	PF00069	0.503
MOD_GSK3_1	190	197	PF00069	0.680
MOD_GSK3_1	198	205	PF00069	0.668
MOD_GSK3_1	2	9	PF00069	0.501
MOD_GSK3_1	208	215	PF00069	0.669
MOD_GSK3_1	217	224	PF00069	0.658
MOD_GSK3_1	234	241	PF00069	0.749
MOD_GSK3_1	246	253	PF00069	0.706
MOD_GSK3_1	256	263	PF00069	0.644
MOD_GSK3_1	272	279	PF00069	0.543
MOD_GSK3_1	327	334	PF00069	0.744
MOD_GSK3_1	376	383	PF00069	0.591
MOD_GSK3_1	439	446	PF00069	0.692
MOD_GSK3_1	663	670	PF00069	0.702
MOD_GSK3_1	671	678	PF00069	0.670
MOD_GSK3_1	692	699	PF00069	0.555
MOD_GSK3_1	711	718	PF00069	0.472
MOD_GSK3_1	801	808	PF00069	0.682
MOD_GSK3_1	81	88	PF00069	0.487
MOD_GSK3_1	94	101	PF00069	0.545
MOD_N-GLC_1	2	7	PF02516	0.576
MOD_N-GLC_1	724	729	PF02516	0.642
MOD_NEK2_1	176	181	PF00069	0.554
MOD_NEK2_1	195	200	PF00069	0.711
MOD_NEK2_1	2	7	PF00069	0.483
MOD_NEK2_1	364	369	PF00069	0.698
MOD_NEK2_1	38	43	PF00069	0.636
MOD_NEK2_1	573	578	PF00069	0.590
MOD_NEK2_1	692	697	PF00069	0.565
MOD_NEK2_1	72	77	PF00069	0.375
MOD_NEK2_1	85	90	PF00069	0.422
MOD_NEK2_2	320	325	PF00069	0.584
MOD_PIKK_1	198	204	PF00454	0.813
MOD_PIKK_1	206	212	PF00454	0.707
MOD_PIKK_1	38	44	PF00454	0.644
MOD_PIKK_1	692	698	PF00454	0.611
MOD_PK_1	250	256	PF00069	0.716
MOD_PKA_1	217	223	PF00069	0.690
MOD_PKA_1	244	250	PF00069	0.728
MOD_PKA_1	289	295	PF00069	0.735
MOD_PKA_1	326	332	PF00069	0.700
MOD_PKA_1	419	425	PF00069	0.836
MOD_PKA_1	704	710	PF00069	0.572
MOD_PKA_1	736	742	PF00069	0.611
MOD_PKA_2	190	196	PF00069	0.658
MOD_PKA_2	217	223	PF00069	0.650
MOD_PKA_2	239	245	PF00069	0.760
MOD_PKA_2	250	256	PF00069	0.693
MOD_PKA_2	289	295	PF00069	0.735
MOD_PKA_2	326	332	PF00069	0.700
MOD_PKA_2	419	425	PF00069	0.836
MOD_PKA_2	502	508	PF00069	0.715
MOD_PKA_2	660	666	PF00069	0.671
MOD_PKA_2	704	710	PF00069	0.572
MOD_PKA_2	735	741	PF00069	0.608
MOD_PKB_1	326	334	PF00069	0.826
MOD_Plk_1	2	8	PF00069	0.576
MOD_Plk_1	436	442	PF00069	0.695
MOD_Plk_1	485	491	PF00069	0.705
MOD_Plk_1	692	698	PF00069	0.611
MOD_Plk_1	715	721	PF00069	0.599
MOD_Plk_1	94	100	PF00069	0.572
MOD_Plk_2-3	29	35	PF00069	0.589
MOD_Plk_4	191	197	PF00069	0.753
MOD_Plk_4	267	273	PF00069	0.645
MOD_Plk_4	348	354	PF00069	0.653
MOD_Plk_4	6	12	PF00069	0.563
MOD_Plk_4	786	792	PF00069	0.687
MOD_ProDKin_1	219	225	PF00069	0.669
MOD_ProDKin_1	256	262	PF00069	0.697
MOD_ProDKin_1	301	307	PF00069	0.816
MOD_ProDKin_1	359	365	PF00069	0.551
MOD_ProDKin_1	531	537	PF00069	0.685
MOD_ProDKin_1	671	677	PF00069	0.713
MOD_ProDKin_1	778	784	PF00069	0.766
MOD_SUMO_rev_2	474	480	PF00179	0.749
MOD_SUMO_rev_2	627	632	PF00179	0.808
MOD_SUMO_rev_2	95	104	PF00179	0.578
TRG_ENDOCYTIC_2	554	557	PF00928	0.669
TRG_ER_diArg_1	289	291	PF00400	0.742
TRG_ER_diArg_1	293	295	PF00400	0.685
TRG_ER_diArg_1	326	328	PF00400	0.668
TRG_ER_diArg_1	417	420	PF00400	0.743
TRG_ER_diArg_1	466	468	PF00400	0.787
TRG_ER_diArg_1	470	473	PF00400	0.538
TRG_ER_diArg_1	498	501	PF00400	0.695
TRG_ER_diArg_1	611	613	PF00400	0.702
TRG_NLS_MonoCore_2	324	329	PF00514	0.720
TRG_NLS_MonoCore_2	414	419	PF00514	0.699
TRG_NLS_MonoCore_2	463	468	PF00514	0.707
TRG_NLS_MonoExtC_3	414	419	PF00514	0.715
TRG_NLS_MonoExtC_3	463	468	PF00514	0.696
TRG_NLS_MonoExtN_4	240	247	PF00514	0.716
TRG_NLS_MonoExtN_4	465	472	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.737
TRG_Pf-PMV_PEXEL_1	708	712	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK0	Leptomonas seymouri	42%	100%
A0A3Q8IC42	Leishmania donovani	99%	100%
A4HEU2	Leishmania braziliensis	67%	96%
E9AY65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	97%
Q4Q9A7	Leishmania major	89%	100%