KH_dom_type_1 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I215_LEIIN

TriTrypDb:

LINF_260013400

Length:

321

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I215

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I215

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.348
CLV_NRD_NRD_1	108	110	PF00675	0.352
CLV_NRD_NRD_1	195	197	PF00675	0.432
CLV_NRD_NRD_1	286	288	PF00675	0.451
CLV_NRD_NRD_1	318	320	PF00675	0.391
CLV_NRD_NRD_1	5	7	PF00675	0.590
CLV_PCSK_FUR_1	106	110	PF00082	0.349
CLV_PCSK_KEX2_1	108	110	PF00082	0.336
CLV_PCSK_KEX2_1	318	320	PF00082	0.481
CLV_PCSK_KEX2_1	5	7	PF00082	0.590
CLV_PCSK_SKI1_1	265	269	PF00082	0.453
CLV_PCSK_SKI1_1	79	83	PF00082	0.520
DEG_APCC_DBOX_1	69	77	PF00400	0.554
DOC_MAPK_gen_1	196	203	PF00069	0.343
DOC_MAPK_gen_1	70	78	PF00069	0.358
DOC_MAPK_MEF2A_6	196	205	PF00069	0.339
DOC_PP2B_LxvP_1	24	27	PF13499	0.526
DOC_PP2B_LxvP_1	252	255	PF13499	0.411
DOC_PP4_FxxP_1	208	211	PF00568	0.362
DOC_USP7_MATH_1	13	17	PF00917	0.490
DOC_USP7_MATH_1	257	261	PF00917	0.560
DOC_USP7_MATH_1	27	31	PF00917	0.508
DOC_USP7_MATH_1	289	293	PF00917	0.452
DOC_USP7_UBL2_3	79	83	PF12436	0.381
DOC_WW_Pin1_4	128	133	PF00397	0.690
DOC_WW_Pin1_4	250	255	PF00397	0.423
DOC_WW_Pin1_4	71	76	PF00397	0.409
LIG_deltaCOP1_diTrp_1	110	115	PF00928	0.403
LIG_EH1_1	43	51	PF00400	0.353
LIG_FHA_1	165	171	PF00498	0.552
LIG_FHA_1	237	243	PF00498	0.432
LIG_FHA_1	274	280	PF00498	0.500
LIG_FHA_1	308	314	PF00498	0.557
LIG_FHA_1	46	52	PF00498	0.482
LIG_FHA_2	202	208	PF00498	0.380
LIG_FHA_2	56	62	PF00498	0.360
LIG_FHA_2	63	69	PF00498	0.428
LIG_Integrin_RGD_1	98	100	PF01839	0.440
LIG_LIR_Apic_2	207	211	PF02991	0.371
LIG_LIR_Gen_1	101	112	PF02991	0.362
LIG_LIR_Nem_3	101	107	PF02991	0.352
LIG_PCNA_yPIPBox_3	36	50	PF02747	0.384
LIG_SH2_CRK	104	108	PF00017	0.331
LIG_SH2_STAT3	40	43	PF00017	0.370
LIG_SH2_STAT5	104	107	PF00017	0.335
LIG_SH2_STAT5	163	166	PF00017	0.596
LIG_SH2_STAT5	295	298	PF00017	0.495
LIG_SH2_STAT5	40	43	PF00017	0.367
LIG_SH3_3	154	160	PF00018	0.686
LIG_SH3_3	264	270	PF00018	0.493
LIG_SUMO_SIM_par_1	47	54	PF11976	0.374
LIG_TYR_ITIM	102	107	PF00017	0.356
MOD_CK1_1	16	22	PF00069	0.529
MOD_CK1_1	253	259	PF00069	0.469
MOD_CK2_1	16	22	PF00069	0.547
MOD_CK2_1	268	274	PF00069	0.533
MOD_CK2_1	55	61	PF00069	0.351
MOD_CK2_1	62	68	PF00069	0.422
MOD_Cter_Amidation	316	319	PF01082	0.377
MOD_GlcNHglycan	151	154	PF01048	0.741
MOD_GlcNHglycan	259	262	PF01048	0.559
MOD_GlcNHglycan	291	294	PF01048	0.432
MOD_GSK3_1	246	253	PF00069	0.402
MOD_GSK3_1	257	264	PF00069	0.355
MOD_GSK3_1	291	298	PF00069	0.443
MOD_GSK3_1	9	16	PF00069	0.501
MOD_N-GLC_1	257	262	PF02516	0.638
MOD_N-GLC_1	27	32	PF02516	0.623
MOD_NEK2_2	275	280	PF00069	0.408
MOD_Plk_1	246	252	PF00069	0.409
MOD_Plk_4	16	22	PF00069	0.538
MOD_Plk_4	237	243	PF00069	0.410
MOD_Plk_4	291	297	PF00069	0.447
MOD_Plk_4	45	51	PF00069	0.404
MOD_ProDKin_1	128	134	PF00069	0.689
MOD_ProDKin_1	250	256	PF00069	0.435
MOD_ProDKin_1	71	77	PF00069	0.401
TRG_DiLeu_BaEn_4	68	74	PF01217	0.476
TRG_ENDOCYTIC_2	104	107	PF00928	0.335
TRG_ER_diArg_1	106	109	PF00400	0.340
TRG_ER_diArg_1	318	320	PF00400	0.519
TRG_ER_diArg_1	4	6	PF00400	0.595
TRG_ER_diArg_1	70	73	PF00400	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0T3	Leptomonas seymouri	68%	76%
A0A0S4JP39	Bodo saltans	40%	87%
A0A1X0NTU5	Trypanosomatidae	44%	80%
A0A3R7RM36	Trypanosoma rangeli	49%	86%
A0A3S7WZT0	Leishmania donovani	100%	100%
A4HEU0	Leishmania braziliensis	88%	100%
C9ZRZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	89%
E9AY63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9A9	Leishmania major	95%	100%
V5B9C8	Trypanosoma cruzi	53%	85%