Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4I214_LEIIN

TriTrypDb:

LINF_260013300

Length:

945

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 277, 299
Promastigote/Amastigote: 301

Expansion

Sequence features

A4I214

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I214

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.696
CLV_C14_Caspase3-7	349	353	PF00656	0.616
CLV_NRD_NRD_1	110	112	PF00675	0.752
CLV_NRD_NRD_1	274	276	PF00675	0.716
CLV_NRD_NRD_1	589	591	PF00675	0.613
CLV_NRD_NRD_1	63	65	PF00675	0.575
CLV_NRD_NRD_1	730	732	PF00675	0.628
CLV_NRD_NRD_1	855	857	PF00675	0.595
CLV_PCSK_KEX2_1	110	112	PF00082	0.752
CLV_PCSK_KEX2_1	380	382	PF00082	0.695
CLV_PCSK_KEX2_1	439	441	PF00082	0.584
CLV_PCSK_KEX2_1	589	591	PF00082	0.613
CLV_PCSK_KEX2_1	61	63	PF00082	0.623
CLV_PCSK_KEX2_1	730	732	PF00082	0.578
CLV_PCSK_KEX2_1	855	857	PF00082	0.595
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.695
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.685
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.623
CLV_PCSK_PC7_1	58	64	PF00082	0.614
CLV_PCSK_SKI1_1	308	312	PF00082	0.748
CLV_PCSK_SKI1_1	453	457	PF00082	0.497
CLV_PCSK_SKI1_1	490	494	PF00082	0.627
CLV_PCSK_SKI1_1	53	57	PF00082	0.593
CLV_PCSK_SKI1_1	745	749	PF00082	0.496
CLV_PCSK_SKI1_1	77	81	PF00082	0.626
CLV_PCSK_SKI1_1	822	826	PF00082	0.540
CLV_PCSK_SKI1_1	827	831	PF00082	0.546
CLV_PCSK_SKI1_1	849	853	PF00082	0.684
CLV_PCSK_SKI1_1	867	871	PF00082	0.515
CLV_PCSK_SKI1_1	87	91	PF00082	0.626
DEG_APCC_DBOX_1	768	776	PF00400	0.546
DEG_SPOP_SBC_1	12	16	PF00917	0.703
DEG_SPOP_SBC_1	254	258	PF00917	0.814
DEG_SPOP_SBC_1	532	536	PF00917	0.568
DOC_ANK_TNKS_1	796	803	PF00023	0.620
DOC_CKS1_1	485	490	PF01111	0.632
DOC_CKS1_1	701	706	PF01111	0.744
DOC_CYCLIN_RxL_1	50	60	PF00134	0.608
DOC_CYCLIN_yCln2_LP_2	327	333	PF00134	0.811
DOC_CYCLIN_yCln2_LP_2	641	644	PF00134	0.575
DOC_MAPK_DCC_7	650	660	PF00069	0.692
DOC_MAPK_gen_1	273	280	PF00069	0.640
DOC_MAPK_gen_1	450	458	PF00069	0.538
DOC_MAPK_gen_1	61	69	PF00069	0.581
DOC_MAPK_gen_1	97	106	PF00069	0.596
DOC_MAPK_HePTP_8	94	106	PF00069	0.588
DOC_MAPK_MEF2A_6	462	470	PF00069	0.560
DOC_MAPK_MEF2A_6	97	106	PF00069	0.596
DOC_PP1_RVXF_1	51	58	PF00149	0.606
DOC_PP1_RVXF_1	537	543	PF00149	0.507
DOC_PP1_RVXF_1	884	890	PF00149	0.590
DOC_PP2B_LxvP_1	641	644	PF13499	0.604
DOC_USP7_MATH_1	12	16	PF00917	0.667
DOC_USP7_MATH_1	155	159	PF00917	0.696
DOC_USP7_MATH_1	225	229	PF00917	0.756
DOC_USP7_MATH_1	254	258	PF00917	0.814
DOC_USP7_MATH_1	332	336	PF00917	0.729
DOC_USP7_MATH_1	368	372	PF00917	0.737
DOC_USP7_MATH_1	516	520	PF00917	0.607
DOC_USP7_MATH_1	532	536	PF00917	0.568
DOC_USP7_MATH_1	599	603	PF00917	0.755
DOC_USP7_MATH_1	697	701	PF00917	0.778
DOC_USP7_MATH_1	903	907	PF00917	0.599
DOC_USP7_UBL2_3	698	702	PF12436	0.751
DOC_USP7_UBL2_3	882	886	PF12436	0.671
DOC_USP7_UBL2_3	93	97	PF12436	0.579
DOC_WW_Pin1_4	15	20	PF00397	0.692
DOC_WW_Pin1_4	191	196	PF00397	0.727
DOC_WW_Pin1_4	205	210	PF00397	0.615
DOC_WW_Pin1_4	217	222	PF00397	0.678
DOC_WW_Pin1_4	314	319	PF00397	0.758
DOC_WW_Pin1_4	326	331	PF00397	0.615
DOC_WW_Pin1_4	430	435	PF00397	0.657
DOC_WW_Pin1_4	484	489	PF00397	0.630
DOC_WW_Pin1_4	613	618	PF00397	0.739
DOC_WW_Pin1_4	700	705	PF00397	0.741
DOC_WW_Pin1_4	870	875	PF00397	0.599
LIG_14-3-3_CanoR_1	440	445	PF00244	0.554
LIG_14-3-3_CanoR_1	453	459	PF00244	0.563
LIG_14-3-3_CanoR_1	500	509	PF00244	0.615
LIG_14-3-3_CanoR_1	714	719	PF00244	0.664
LIG_14-3-3_CanoR_1	77	82	PF00244	0.626
LIG_14-3-3_CanoR_1	902	908	PF00244	0.598
LIG_BRCT_BRCA1_1	527	531	PF00533	0.652
LIG_CaM_IQ_9	69	84	PF13499	0.710
LIG_Clathr_ClatBox_1	455	459	PF01394	0.552
LIG_Clathr_ClatBox_1	566	570	PF01394	0.505
LIG_EH1_1	246	254	PF00400	0.795
LIG_EVH1_1	642	646	PF00568	0.572
LIG_FHA_1	21	27	PF00498	0.724
LIG_FHA_1	535	541	PF00498	0.506
LIG_FHA_1	610	616	PF00498	0.662
LIG_FHA_1	669	675	PF00498	0.681
LIG_FHA_1	74	80	PF00498	0.616
LIG_FHA_1	793	799	PF00498	0.578
LIG_FHA_1	801	807	PF00498	0.622
LIG_FHA_1	808	814	PF00498	0.551
LIG_FHA_1	882	888	PF00498	0.573
LIG_FHA_1	913	919	PF00498	0.659
LIG_FHA_2	137	143	PF00498	0.752
LIG_FHA_2	229	235	PF00498	0.788
LIG_FHA_2	356	362	PF00498	0.691
LIG_FHA_2	368	374	PF00498	0.638
LIG_FHA_2	491	497	PF00498	0.618
LIG_FHA_2	679	685	PF00498	0.747
LIG_FHA_2	701	707	PF00498	0.741
LIG_FHA_2	871	877	PF00498	0.677
LIG_FHA_2	925	931	PF00498	0.599
LIG_GBD_Chelix_1	743	751	PF00786	0.518
LIG_HCF-1_HBM_1	755	758	PF13415	0.588
LIG_LIR_Apic_2	484	488	PF02991	0.635
LIG_LIR_Apic_2	699	704	PF02991	0.748
LIG_LIR_Gen_1	575	583	PF02991	0.584
LIG_LIR_Gen_1	764	775	PF02991	0.562
LIG_LIR_Nem_3	39	44	PF02991	0.655
LIG_LIR_Nem_3	451	455	PF02991	0.533
LIG_LIR_Nem_3	493	497	PF02991	0.614
LIG_LIR_Nem_3	562	567	PF02991	0.597
LIG_LIR_Nem_3	575	581	PF02991	0.495
LIG_LIR_Nem_3	723	729	PF02991	0.566
LIG_LIR_Nem_3	830	834	PF02991	0.555
LIG_MYND_1	640	644	PF01753	0.671
LIG_PCNA_yPIPBox_3	90	102	PF02747	0.588
LIG_PDZ_Class_3	940	945	PF00595	0.808
LIG_Pex14_2	448	452	PF04695	0.518
LIG_Pex14_2	722	726	PF04695	0.558
LIG_Pex14_2	814	818	PF04695	0.542
LIG_REV1ctd_RIR_1	887	897	PF16727	0.597
LIG_SH2_CRK	219	223	PF00017	0.746
LIG_SH2_CRK	476	480	PF00017	0.633
LIG_SH2_CRK	485	489	PF00017	0.632
LIG_SH2_CRK	65	69	PF00017	0.563
LIG_SH2_CRK	701	705	PF00017	0.709
LIG_SH2_CRK	831	835	PF00017	0.561
LIG_SH2_SRC	758	761	PF00017	0.714
LIG_SH2_STAP1	426	430	PF00017	0.692
LIG_SH2_STAT5	219	222	PF00017	0.737
LIG_SH2_STAT5	403	406	PF00017	0.699
LIG_SH2_STAT5	447	450	PF00017	0.529
LIG_SH2_STAT5	476	479	PF00017	0.629
LIG_SH2_STAT5	509	512	PF00017	0.613
LIG_SH2_STAT5	65	68	PF00017	0.554
LIG_SH2_STAT5	758	761	PF00017	0.612
LIG_SH3_3	291	297	PF00018	0.688
LIG_SH3_3	359	365	PF00018	0.818
LIG_SH3_3	637	643	PF00018	0.677
LIG_SH3_3	715	721	PF00018	0.643
LIG_SH3_3	736	742	PF00018	0.579
LIG_SH3_3	877	883	PF00018	0.544
LIG_SH3_4	882	889	PF00018	0.679
LIG_SUMO_SIM_par_1	329	336	PF11976	0.730
LIG_SUMO_SIM_par_1	454	460	PF11976	0.584
LIG_SUMO_SIM_par_1	565	570	PF11976	0.513
LIG_TRAF2_1	133	136	PF00917	0.811
LIG_TRAF2_1	141	144	PF00917	0.689
LIG_TRAF2_1	693	696	PF00917	0.813
LIG_TRAF2_1	906	909	PF00917	0.583
MOD_CDK_SPxK_1	484	490	PF00069	0.631
MOD_CK1_1	15	21	PF00069	0.664
MOD_CK1_1	228	234	PF00069	0.797
MOD_CK1_1	256	262	PF00069	0.823
MOD_CK1_1	484	490	PF00069	0.631
MOD_CK1_1	534	540	PF00069	0.515
MOD_CK1_1	579	585	PF00069	0.582
MOD_CK1_1	686	692	PF00069	0.724
MOD_CK1_1	700	706	PF00069	0.733
MOD_CK1_1	885	891	PF00069	0.597
MOD_CK1_1	892	898	PF00069	0.591
MOD_CK2_1	138	144	PF00069	0.742
MOD_CK2_1	228	234	PF00069	0.797
MOD_CK2_1	256	262	PF00069	0.815
MOD_CK2_1	282	288	PF00069	0.718
MOD_CK2_1	367	373	PF00069	0.730
MOD_CK2_1	490	496	PF00069	0.623
MOD_CK2_1	579	585	PF00069	0.558
MOD_CK2_1	669	675	PF00069	0.624
MOD_CK2_1	678	684	PF00069	0.627
MOD_CK2_1	749	755	PF00069	0.543
MOD_CK2_1	870	876	PF00069	0.590
MOD_CK2_1	902	908	PF00069	0.602
MOD_CK2_1	924	930	PF00069	0.699
MOD_GlcNHglycan	152	156	PF01048	0.682
MOD_GlcNHglycan	161	164	PF01048	0.691
MOD_GlcNHglycan	213	216	PF01048	0.693
MOD_GlcNHglycan	284	287	PF01048	0.496
MOD_GlcNHglycan	370	373	PF01048	0.726
MOD_GlcNHglycan	525	528	PF01048	0.659
MOD_GlcNHglycan	605	608	PF01048	0.633
MOD_GlcNHglycan	617	620	PF01048	0.549
MOD_GlcNHglycan	630	633	PF01048	0.644
MOD_GlcNHglycan	683	688	PF01048	0.692
MOD_GlcNHglycan	8	11	PF01048	0.705
MOD_GlcNHglycan	934	937	PF01048	0.682
MOD_GSK3_1	11	18	PF00069	0.685
MOD_GSK3_1	151	158	PF00069	0.799
MOD_GSK3_1	253	260	PF00069	0.734
MOD_GSK3_1	337	344	PF00069	0.825
MOD_GSK3_1	426	433	PF00069	0.683
MOD_GSK3_1	460	467	PF00069	0.558
MOD_GSK3_1	572	579	PF00069	0.584
MOD_GSK3_1	599	606	PF00069	0.673
MOD_GSK3_1	609	616	PF00069	0.639
MOD_GSK3_1	630	637	PF00069	0.700
MOD_GSK3_1	696	703	PF00069	0.757
MOD_GSK3_1	73	80	PF00069	0.620
MOD_GSK3_1	881	888	PF00069	0.566
MOD_GSK3_1	889	896	PF00069	0.604
MOD_GSK3_1	912	919	PF00069	0.663
MOD_N-GLC_1	102	107	PF02516	0.616
MOD_N-GLC_1	238	243	PF02516	0.756
MOD_N-GLC_1	464	469	PF02516	0.549
MOD_N-GLC_1	48	53	PF02516	0.638
MOD_N-GLC_1	576	581	PF02516	0.559
MOD_N-GLC_1	669	674	PF02516	0.719
MOD_N-GLC_1	714	719	PF02516	0.664
MOD_N-GLC_1	73	78	PF02516	0.723
MOD_N-GLC_1	808	813	PF02516	0.550
MOD_N-GLC_1	903	908	PF02516	0.549
MOD_N-GLC_2	774	776	PF02516	0.522
MOD_NEK2_1	20	25	PF00069	0.707
MOD_NEK2_1	226	231	PF00069	0.814
MOD_NEK2_1	255	260	PF00069	0.740
MOD_NEK2_1	425	430	PF00069	0.797
MOD_NEK2_1	576	581	PF00069	0.559
MOD_NEK2_1	583	588	PF00069	0.592
MOD_NEK2_1	668	673	PF00069	0.759
MOD_NEK2_1	72	77	PF00069	0.493
MOD_NEK2_1	770	775	PF00069	0.533
MOD_NEK2_1	847	852	PF00069	0.672
MOD_NEK2_1	889	894	PF00069	0.607
MOD_PIKK_1	226	232	PF00454	0.812
MOD_PIKK_1	460	466	PF00454	0.597
MOD_PKA_1	110	116	PF00069	0.740
MOD_PKA_2	110	116	PF00069	0.740
MOD_PKA_2	274	280	PF00069	0.634
MOD_PKA_2	340	346	PF00069	0.655
MOD_PKA_2	546	552	PF00069	0.558
MOD_PKA_2	892	898	PF00069	0.591
MOD_PKA_2	932	938	PF00069	0.674
MOD_PKB_1	891	899	PF00069	0.594
MOD_Plk_1	102	108	PF00069	0.620
MOD_Plk_1	426	432	PF00069	0.689
MOD_Plk_1	464	470	PF00069	0.546
MOD_Plk_1	576	582	PF00069	0.555
MOD_Plk_1	583	589	PF00069	0.595
MOD_Plk_1	669	675	PF00069	0.775
MOD_Plk_1	714	720	PF00069	0.656
MOD_Plk_1	749	755	PF00069	0.543
MOD_Plk_1	808	814	PF00069	0.551
MOD_Plk_1	903	909	PF00069	0.598
MOD_Plk_2-3	136	142	PF00069	0.805
MOD_Plk_2-3	298	304	PF00069	0.821
MOD_Plk_2-3	749	755	PF00069	0.543
MOD_Plk_4	420	426	PF00069	0.724
MOD_Plk_4	583	589	PF00069	0.593
MOD_Plk_4	669	675	PF00069	0.681
MOD_Plk_4	786	792	PF00069	0.540
MOD_Plk_4	809	815	PF00069	0.548
MOD_Plk_4	885	891	PF00069	0.550
MOD_Plk_4	916	922	PF00069	0.561
MOD_ProDKin_1	15	21	PF00069	0.684
MOD_ProDKin_1	191	197	PF00069	0.725
MOD_ProDKin_1	205	211	PF00069	0.615
MOD_ProDKin_1	217	223	PF00069	0.679
MOD_ProDKin_1	314	320	PF00069	0.757
MOD_ProDKin_1	326	332	PF00069	0.613
MOD_ProDKin_1	430	436	PF00069	0.647
MOD_ProDKin_1	484	490	PF00069	0.631
MOD_ProDKin_1	613	619	PF00069	0.741
MOD_ProDKin_1	700	706	PF00069	0.738
MOD_ProDKin_1	870	876	PF00069	0.590
MOD_SUMO_for_1	798	801	PF00179	0.626
MOD_SUMO_rev_2	300	310	PF00179	0.734
MOD_SUMO_rev_2	672	679	PF00179	0.678
MOD_SUMO_rev_2	695	700	PF00179	0.813
TRG_DiLeu_BaEn_1	451	456	PF01217	0.527
TRG_DiLeu_BaEn_1	755	760	PF01217	0.695
TRG_DiLeu_BaEn_1	801	806	PF01217	0.632
TRG_DiLeu_BaEn_2	915	921	PF01217	0.559
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.530
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.583
TRG_ENDOCYTIC_2	219	222	PF00928	0.620
TRG_ENDOCYTIC_2	476	479	PF00928	0.629
TRG_ENDOCYTIC_2	65	68	PF00928	0.554
TRG_ENDOCYTIC_2	767	770	PF00928	0.565
TRG_ENDOCYTIC_2	831	834	PF00928	0.557
TRG_ER_diArg_1	109	111	PF00400	0.757
TRG_ER_diArg_1	588	590	PF00400	0.611
TRG_ER_diArg_1	62	64	PF00400	0.588
TRG_ER_diArg_1	729	731	PF00400	0.605
TRG_ER_diArg_1	890	893	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	565	570	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	822	826	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I256	Leptomonas seymouri	63%	95%
A0A3S7WZV1	Leishmania donovani	100%	100%
A4HET9	Leishmania braziliensis	82%	99%
E9AY62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9B0	Leishmania major	94%	100%