Glutathione peroxidase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

type II (glutathione peroxidase-like) tryparedoxin peroxidase

Species:

Leishmania infantum

UniProt:

A4I212_LEIIN

TriTrypDb:

LINF_260013100

Length:

174

Annotations

Annotations by Jardim et al.

Redox homeostasis, Glutathione peroxidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I212

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I212

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	25
GO:0006979	response to oxidative stress	3	25
GO:0050896	response to stimulus	1	25

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004601	peroxidase activity	2	25
GO:0004602	glutathione peroxidase activity	3	25
GO:0016209	antioxidant activity	1	25
GO:0016491	oxidoreductase activity	2	25
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	25
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	115	119	PF00082	0.484
CLV_PCSK_SKI1_1	153	157	PF00082	0.485
DEG_SPOP_SBC_1	168	172	PF00917	0.453
DOC_CYCLIN_RxL_1	50	58	PF00134	0.444
DOC_PP1_RVXF_1	51	58	PF00149	0.482
DOC_USP7_MATH_1	146	150	PF00917	0.430
DOC_USP7_UBL2_3	111	115	PF12436	0.559
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_FHA_1	118	124	PF00498	0.421
LIG_FHA_1	126	132	PF00498	0.336
LIG_FHA_2	145	151	PF00498	0.521
LIG_FHA_2	72	78	PF00498	0.369
LIG_LIR_Nem_3	46	52	PF02991	0.339
LIG_Pex14_2	86	90	PF04695	0.338
LIG_SH2_CRK	107	111	PF00017	0.469
LIG_SH2_NCK_1	29	33	PF00017	0.355
LIG_SH2_NCK_1	42	46	PF00017	0.332
LIG_SH2_STAP1	4	8	PF00017	0.361
LIG_SH2_STAT5	109	112	PF00017	0.378
LIG_TRAF2_1	68	71	PF00917	0.374
LIG_TRAF2_1	74	77	PF00917	0.329
MOD_CK2_1	144	150	PF00069	0.480
MOD_CK2_1	71	77	PF00069	0.351
MOD_GSK3_1	167	174	PF00069	0.694
MOD_N-GLC_1	125	130	PF02516	0.358
MOD_N-GLC_1	8	13	PF02516	0.467
MOD_NEK2_1	118	123	PF00069	0.445
MOD_NEK2_1	169	174	PF00069	0.621
MOD_NEK2_1	55	60	PF00069	0.444
MOD_NEK2_1	81	86	PF00069	0.361
MOD_Plk_1	125	131	PF00069	0.356
MOD_Plk_2-3	71	77	PF00069	0.449
MOD_Plk_4	118	124	PF00069	0.462
MOD_Plk_4	44	50	PF00069	0.298
MOD_SUMO_for_1	86	89	PF00179	0.402
MOD_SUMO_rev_2	149	156	PF00179	0.459
MOD_SUMO_rev_2	2	8	PF00179	0.435
MOD_SUMO_rev_2	71	81	PF00179	0.327
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.445
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.341
TRG_ENDOCYTIC_2	107	110	PF00928	0.338
TRG_ENDOCYTIC_2	52	55	PF00928	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD2	Leptomonas seymouri	30%	100%
A0A0S4IL06	Bodo saltans	72%	96%
A0A0S4IL19	Bodo saltans	72%	95%
A0A0S4IZF2	Bodo saltans	72%	96%
A0A0S4JV67	Bodo saltans	35%	100%
A0A1X0NS99	Trypanosomatidae	36%	100%
A0A1X0NSC3	Trypanosomatidae	69%	100%
A0A1X0NSD3	Trypanosomatidae	75%	99%
A0A1X0NSE0	Trypanosomatidae	71%	93%
A0A3Q8IDK7	Leishmania donovani	100%	100%
A0A3Q8IDS3	Leishmania donovani	96%	95%
A0A3Q8IKY0	Leishmania donovani	33%	100%
A0A422NMY9	Trypanosoma rangeli	73%	100%
A0A422NMZ4	Trypanosoma rangeli	73%	100%
A0A422NNB6	Trypanosoma rangeli	74%	91%
A0A422NZP6	Trypanosoma rangeli	33%	100%
A1KV41	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	40%	98%
A4HET6	Leishmania braziliensis	84%	100%
A4HET7	Leishmania braziliensis	83%	100%
A4HPG7	Leishmania braziliensis	32%	100%
A4I211	Leishmania infantum	98%	100%
A4ID89	Leishmania infantum	33%	100%
A6QLY2	Bos taurus	36%	94%
C9ZRZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
C9ZS00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	99%
D0AAG4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AT79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AY59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AY60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
G9JJU2	Procambarus clarkii	31%	100%
O02621	Caenorhabditis elegans	42%	100%
O04922	Arabidopsis thaliana	51%	100%
O08368	Pseudomonas wisconsinensis	30%	78%
O18994	Sus scrofa	34%	79%
O22850	Arabidopsis thaliana	49%	84%
O23814	Spinacia oleracea	54%	100%
O23968	Helianthus annuus	56%	97%
O23970	Helianthus annuus	49%	100%
O24031	Solanum lycopersicum	50%	100%
O24296	Pisum sativum	52%	74%
O32770	Lactococcus lactis subsp. cremoris (strain MG1363)	43%	100%
O46607	Canis lupus familiaris	32%	79%
O48646	Arabidopsis thaliana	54%	75%
O49069	Gossypium hirsutum	51%	100%
O59858	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
O62327	Caenorhabditis elegans	41%	100%
O70325	Mus musculus	40%	88%
O75715	Homo sapiens	36%	79%
P00435	Bos taurus	34%	85%
P04041	Rattus norvegicus	35%	87%
P06610	Escherichia coli (strain K12)	39%	95%
P07203	Homo sapiens	33%	86%
P0A0T4	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	40%	98%
P0A0T5	Neisseria meningitidis serogroup B (strain MC58)	40%	98%
P0C2T0	Neisseria meningitidis serogroup C	40%	98%
P11352	Mus musculus	35%	87%
P11909	Oryctolagus cuniculus	32%	87%
P18283	Homo sapiens	30%	92%
P21765	Mus musculus	33%	79%
P22352	Homo sapiens	33%	77%
P23764	Rattus norvegicus	32%	77%
P28714	Macaca fascicularis	36%	79%
P30708	Nicotiana sylvestris	51%	100%
P30710	Rattus norvegicus	32%	79%
P35666	Wuchereria bancrofti	33%	78%
P36014	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P36968	Sus scrofa	40%	88%
P36969	Homo sapiens	42%	88%
P36970	Rattus norvegicus	40%	88%
P37141	Bos taurus	32%	77%
P38143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P40581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	100%
P46412	Mus musculus	32%	77%
P52032	Arabidopsis thaliana	51%	74%
P52033	Dirofilaria immitis	35%	79%
P52035	Bacillus subtilis (strain 168)	44%	100%
P59796	Homo sapiens	33%	79%
P64290	Staphylococcus aureus (strain Mu50 / ATCC 700699)	45%	100%
P64291	Staphylococcus aureus (strain MW2)	45%	100%
P67877	Brugia malayi	33%	78%
P67878	Brugia pahangi	33%	78%
P73824	Synechocystis sp. (strain PCC 6803 / Kazusa)	41%	100%
P74250	Synechocystis sp. (strain PCC 6803 / Kazusa)	45%	100%
P83564	Chlamydomonas reinhardtii	42%	87%
P83645	Rattus norvegicus	31%	92%
P99097	Staphylococcus aureus (strain N315)	45%	100%
Q00277	Schistosoma mansoni	40%	100%
Q06652	Citrus sinensis	53%	100%
Q0EF98	Callithrix jacchus	30%	92%
Q0EF99	Callithrix jacchus	30%	87%
Q0EFA0	Pan troglodytes	32%	87%
Q2NL01	Bos taurus	32%	83%
Q32QL6	Callithrix jacchus	42%	88%
Q4AEG9	Sapajus apella	42%	88%
Q4AEH0	Macaca fuscata fuscata	42%	88%
Q4AEH1	Hylobates lar	42%	88%
Q4AEH2	Pongo pygmaeus	42%	88%
Q4AEH3	Sapajus apella	33%	77%
Q4AEH4	Macaca fuscata fuscata	33%	77%
Q4AEH5	Hylobates lar	33%	77%
Q4AEH7	Sapajus apella	30%	92%
Q4AEH8	Macaca fuscata fuscata	30%	92%
Q4AEH9	Hylobates lar	30%	92%
Q4AEI0	Pongo pygmaeus	30%	92%
Q4AEI1	Sapajus apella	30%	87%
Q4AEI2	Hylobates lar	33%	87%
Q4AEI3	Pongo pygmaeus	33%	87%
Q4Q1B8	Leishmania major	33%	100%
Q4Q9B2	Leishmania major	94%	100%
Q4Q9B3	Leishmania major	94%	100%
Q4Q9B4	Leishmania major	94%	100%
Q4RSM6	Tetraodon nigroviridis	26%	83%
Q59WD3	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	100%
Q5HGC7	Staphylococcus aureus (strain COL)	45%	100%
Q5HKZ3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	42%	100%
Q5RFG3	Pongo pygmaeus	33%	77%
Q5U583	Xenopus laevis	32%	83%
Q64625	Rattus norvegicus	33%	79%
Q6G9Q8	Staphylococcus aureus (strain MSSA476)	45%	100%
Q6GHD0	Staphylococcus aureus (strain MRSA252)	45%	100%
Q6IRC8	Xenopus laevis	31%	83%
Q7ZV14	Danio rerio	31%	83%
Q865R2	Macaca fuscata fuscata	33%	87%
Q8CSR9	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	44%	100%
Q8L910	Arabidopsis thaliana	48%	100%
Q8LBU2	Arabidopsis thaliana	46%	100%
Q8MJ14	Sus scrofa	31%	84%
Q8SSH7	Encephalitozoon cuniculi (strain GB-M1)	36%	98%
Q8TED1	Homo sapiens	31%	83%
Q91WR8	Mus musculus	31%	79%
Q95003	Caenorhabditis elegans	33%	78%
Q96SL4	Homo sapiens	36%	93%
Q98234	Molluscum contagiosum virus subtype 1	31%	79%
Q99LJ6	Mus musculus	38%	94%
Q9CFV1	Lactococcus lactis subsp. lactis (strain IL1403)	41%	100%
Q9D7B7	Mus musculus	33%	83%
Q9FXS3	Nicotiana tabacum	51%	100%
Q9JHC0	Mus musculus	31%	92%
Q9LEF0	Mesembryanthemum crystallinum	53%	100%
Q9LYB4	Arabidopsis thaliana	54%	100%
Q9N2J2	Bos taurus	41%	88%
Q9SZ54	Arabidopsis thaliana	54%	75%
Q9Z9N7	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	45%	100%
V5B9J0	Trypanosoma cruzi	72%	98%
V5BZH0	Trypanosoma cruzi	73%	98%