Putative sphingosine kinase A, B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sphingosine kinase A - B - putative

Species:

Leishmania infantum

UniProt:

A4I203_LEIIN

TriTrypDb:

LINF_260012100

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4I203

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I203

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006670	sphingosine metabolic process	6	1
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	4
GO:0016310	phosphorylation	5	4
GO:0019751	polyol metabolic process	4	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0034311	diol metabolic process	5	1
GO:0034312	diol biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0046173	polyol biosynthetic process	5	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:0046512	sphingosine biosynthetic process	5	1
GO:0046519	sphingoid metabolic process	5	1
GO:0046520	sphingoid biosynthetic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0001727	lipid kinase activity	5	5
GO:0003824	catalytic activity	1	10
GO:0008481	sphinganine kinase activity	5	5
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017050	D-erythro-sphingosine kinase activity	5	10
GO:0003951	NAD+ kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.582
CLV_C14_Caspase3-7	49	53	PF00656	0.568
CLV_C14_Caspase3-7	595	599	PF00656	0.345
CLV_C14_Caspase3-7	908	912	PF00656	0.357
CLV_NRD_NRD_1	384	386	PF00675	0.448
CLV_NRD_NRD_1	424	426	PF00675	0.349
CLV_NRD_NRD_1	590	592	PF00675	0.534
CLV_PCSK_KEX2_1	384	386	PF00082	0.448
CLV_PCSK_KEX2_1	424	426	PF00082	0.348
CLV_PCSK_KEX2_1	497	499	PF00082	0.702
CLV_PCSK_KEX2_1	589	591	PF00082	0.473
CLV_PCSK_KEX2_1	707	709	PF00082	0.402
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.679
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.402
CLV_PCSK_SKI1_1	189	193	PF00082	0.483
CLV_PCSK_SKI1_1	223	227	PF00082	0.544
CLV_PCSK_SKI1_1	368	372	PF00082	0.360
CLV_PCSK_SKI1_1	426	430	PF00082	0.437
CLV_PCSK_SKI1_1	434	438	PF00082	0.455
CLV_PCSK_SKI1_1	622	626	PF00082	0.492
CLV_PCSK_SKI1_1	630	634	PF00082	0.517
CLV_PCSK_SKI1_1	665	669	PF00082	0.380
CLV_PCSK_SKI1_1	704	708	PF00082	0.522
CLV_PCSK_SKI1_1	710	714	PF00082	0.443
DEG_APCC_DBOX_1	423	431	PF00400	0.476
DEG_APCC_KENBOX_2	307	311	PF00400	0.505
DEG_SCF_FBW7_1	271	278	PF00400	0.628
DEG_SCF_FBW7_1	776	783	PF00400	0.648
DEG_SCF_TRCP1_1	110	115	PF00400	0.622
DEG_SPOP_SBC_1	120	124	PF00917	0.646
DEG_SPOP_SBC_1	62	66	PF00917	0.658
DEG_SPOP_SBC_1	73	77	PF00917	0.599
DOC_CYCLIN_yCln2_LP_2	30	33	PF00134	0.626
DOC_CYCLIN_yCln2_LP_2	842	848	PF00134	0.408
DOC_MAPK_DCC_7	813	822	PF00069	0.389
DOC_MAPK_gen_1	187	196	PF00069	0.512
DOC_MAPK_gen_1	341	349	PF00069	0.377
DOC_MAPK_gen_1	365	373	PF00069	0.351
DOC_MAPK_gen_1	618	627	PF00069	0.586
DOC_MAPK_gen_1	813	822	PF00069	0.433
DOC_MAPK_gen_1	867	876	PF00069	0.300
DOC_MAPK_gen_1	895	903	PF00069	0.395
DOC_MAPK_gen_1	921	931	PF00069	0.408
DOC_MAPK_HePTP_8	810	822	PF00069	0.389
DOC_MAPK_MEF2A_6	187	196	PF00069	0.520
DOC_MAPK_MEF2A_6	365	373	PF00069	0.377
DOC_MAPK_MEF2A_6	665	673	PF00069	0.448
DOC_MAPK_MEF2A_6	813	822	PF00069	0.440
DOC_MAPK_MEF2A_6	895	903	PF00069	0.463
DOC_PP1_RVXF_1	221	227	PF00149	0.579
DOC_PP1_RVXF_1	312	319	PF00149	0.455
DOC_PP1_RVXF_1	663	669	PF00149	0.401
DOC_PP2B_LxvP_1	192	195	PF13499	0.470
DOC_PP2B_LxvP_1	30	33	PF13499	0.626
DOC_PP2B_LxvP_1	625	628	PF13499	0.525
DOC_PP2B_LxvP_1	842	845	PF13499	0.408
DOC_SPAK_OSR1_1	693	697	PF12202	0.427
DOC_USP7_MATH_1	118	122	PF00917	0.680
DOC_USP7_MATH_1	275	279	PF00917	0.696
DOC_USP7_MATH_1	292	296	PF00917	0.617
DOC_USP7_MATH_1	399	403	PF00917	0.346
DOC_USP7_MATH_1	438	442	PF00917	0.658
DOC_USP7_MATH_1	450	454	PF00917	0.750
DOC_USP7_MATH_1	506	510	PF00917	0.538
DOC_USP7_MATH_1	540	544	PF00917	0.417
DOC_USP7_MATH_1	667	671	PF00917	0.331
DOC_USP7_MATH_1	717	721	PF00917	0.499
DOC_USP7_MATH_1	780	784	PF00917	0.763
DOC_USP7_MATH_1	847	851	PF00917	0.337
DOC_USP7_MATH_1	91	95	PF00917	0.659
DOC_USP7_MATH_1	916	920	PF00917	0.408
DOC_USP7_UBL2_3	724	728	PF12436	0.505
DOC_WW_Pin1_4	121	126	PF00397	0.711
DOC_WW_Pin1_4	269	274	PF00397	0.643
DOC_WW_Pin1_4	33	38	PF00397	0.643
DOC_WW_Pin1_4	446	451	PF00397	0.681
DOC_WW_Pin1_4	481	486	PF00397	0.668
DOC_WW_Pin1_4	504	509	PF00397	0.655
DOC_WW_Pin1_4	576	581	PF00397	0.484
DOC_WW_Pin1_4	6	11	PF00397	0.629
DOC_WW_Pin1_4	636	641	PF00397	0.524
DOC_WW_Pin1_4	76	81	PF00397	0.667
DOC_WW_Pin1_4	776	781	PF00397	0.714
LIG_14-3-3_CanoR_1	164	169	PF00244	0.539
LIG_14-3-3_CanoR_1	257	265	PF00244	0.565
LIG_14-3-3_CanoR_1	375	379	PF00244	0.358
LIG_14-3-3_CanoR_1	431	437	PF00244	0.520
LIG_14-3-3_CanoR_1	589	597	PF00244	0.544
LIG_14-3-3_CanoR_1	630	638	PF00244	0.548
LIG_APCC_ABBA_1	474	479	PF00400	0.542
LIG_APCC_ABBA_1	796	801	PF00400	0.517
LIG_BIR_III_4	54	58	PF00653	0.653
LIG_BRCT_BRCA1_1	173	177	PF00533	0.459
LIG_BRCT_BRCA1_1	669	673	PF00533	0.340
LIG_eIF4E_1	799	805	PF01652	0.506
LIG_FHA_1	186	192	PF00498	0.599
LIG_FHA_1	219	225	PF00498	0.643
LIG_FHA_1	231	237	PF00498	0.508
LIG_FHA_1	25	31	PF00498	0.660
LIG_FHA_1	262	268	PF00498	0.733
LIG_FHA_1	288	294	PF00498	0.512
LIG_FHA_1	443	449	PF00498	0.725
LIG_FHA_1	637	643	PF00498	0.546
LIG_FHA_2	202	208	PF00498	0.431
LIG_FHA_2	511	517	PF00498	0.519
LIG_FHA_2	577	583	PF00498	0.526
LIG_FHA_2	631	637	PF00498	0.580
LIG_FHA_2	73	79	PF00498	0.721
LIG_FHA_2	743	749	PF00498	0.426
LIG_Integrin_isoDGR_2	229	231	PF01839	0.681
LIG_Integrin_RGD_1	823	825	PF01839	0.430
LIG_LIR_Gen_1	486	495	PF02991	0.743
LIG_LIR_Gen_1	527	537	PF02991	0.404
LIG_LIR_Gen_1	855	863	PF02991	0.380
LIG_LIR_Nem_3	486	491	PF02991	0.729
LIG_LIR_Nem_3	527	532	PF02991	0.414
LIG_LIR_Nem_3	603	607	PF02991	0.489
LIG_LIR_Nem_3	855	861	PF02991	0.380
LIG_LIR_Nem_3	889	893	PF02991	0.408
LIG_PCNA_yPIPBox_3	152	164	PF02747	0.353
LIG_PCNA_yPIPBox_3	328	341	PF02747	0.386
LIG_PTB_Apo_2	688	695	PF02174	0.387
LIG_SH2_CRK	700	704	PF00017	0.453
LIG_SH2_SRC	87	90	PF00017	0.559
LIG_SH2_STAP1	299	303	PF00017	0.303
LIG_SH2_STAT3	302	305	PF00017	0.521
LIG_SH2_STAT3	799	802	PF00017	0.444
LIG_SH2_STAT5	170	173	PF00017	0.516
LIG_SH2_STAT5	302	305	PF00017	0.414
LIG_SH2_STAT5	392	395	PF00017	0.369
LIG_SH2_STAT5	715	718	PF00017	0.402
LIG_SH2_STAT5	756	759	PF00017	0.474
LIG_SH2_STAT5	799	802	PF00017	0.522
LIG_SH2_STAT5	858	861	PF00017	0.408
LIG_SH2_STAT5	893	896	PF00017	0.300
LIG_SH3_3	479	485	PF00018	0.624
LIG_SUMO_SIM_anti_2	550	555	PF11976	0.394
LIG_SUMO_SIM_anti_2	572	577	PF11976	0.444
LIG_SUMO_SIM_par_1	552	558	PF11976	0.494
LIG_TYR_ITIM	856	861	PF00017	0.388
LIG_UBA3_1	346	353	PF00899	0.353
LIG_UBA3_1	702	710	PF00899	0.467
LIG_UBA3_1	712	721	PF00899	0.335
LIG_WRC_WIRS_1	1	6	PF05994	0.561
LIG_WW_3	627	631	PF00397	0.552
MOD_CDK_SPxxK_3	636	643	PF00069	0.503
MOD_CDK_SPxxK_3	76	83	PF00069	0.586
MOD_CK1_1	11	17	PF00069	0.560
MOD_CK1_1	111	117	PF00069	0.612
MOD_CK1_1	121	127	PF00069	0.701
MOD_CK1_1	3	9	PF00069	0.653
MOD_CK1_1	312	318	PF00069	0.460
MOD_CK1_1	351	357	PF00069	0.293
MOD_CK1_1	374	380	PF00069	0.411
MOD_CK1_1	446	452	PF00069	0.653
MOD_CK1_1	481	487	PF00069	0.729
MOD_CK1_1	61	67	PF00069	0.780
MOD_CK1_1	654	660	PF00069	0.547
MOD_CK1_1	76	82	PF00069	0.686
MOD_CK1_1	765	771	PF00069	0.659
MOD_CK1_1	98	104	PF00069	0.716
MOD_CK2_1	201	207	PF00069	0.415
MOD_CK2_1	510	516	PF00069	0.522
MOD_CK2_1	552	558	PF00069	0.433
MOD_CK2_1	576	582	PF00069	0.489
MOD_CK2_1	72	78	PF00069	0.719
MOD_CK2_1	742	748	PF00069	0.563
MOD_CK2_1	788	794	PF00069	0.532
MOD_CK2_1	907	913	PF00069	0.318
MOD_GlcNHglycan	110	113	PF01048	0.622
MOD_GlcNHglycan	13	16	PF01048	0.740
MOD_GlcNHglycan	173	176	PF01048	0.473
MOD_GlcNHglycan	22	25	PF01048	0.552
MOD_GlcNHglycan	241	244	PF01048	0.714
MOD_GlcNHglycan	320	323	PF01048	0.595
MOD_GlcNHglycan	350	353	PF01048	0.321
MOD_GlcNHglycan	445	448	PF01048	0.779
MOD_GlcNHglycan	452	455	PF01048	0.653
MOD_GlcNHglycan	467	470	PF01048	0.728
MOD_GlcNHglycan	508	511	PF01048	0.635
MOD_GlcNHglycan	542	545	PF01048	0.412
MOD_GlcNHglycan	592	595	PF01048	0.404
MOD_GlcNHglycan	70	73	PF01048	0.610
MOD_GlcNHglycan	790	793	PF01048	0.557
MOD_GlcNHglycan	881	884	PF01048	0.366
MOD_GlcNHglycan	97	100	PF01048	0.738
MOD_GSK3_1	106	113	PF00069	0.697
MOD_GSK3_1	116	123	PF00069	0.603
MOD_GSK3_1	13	20	PF00069	0.719
MOD_GSK3_1	177	184	PF00069	0.493
MOD_GSK3_1	2	9	PF00069	0.713
MOD_GSK3_1	22	29	PF00069	0.580
MOD_GSK3_1	253	260	PF00069	0.529
MOD_GSK3_1	269	276	PF00069	0.644
MOD_GSK3_1	288	295	PF00069	0.556
MOD_GSK3_1	434	441	PF00069	0.552
MOD_GSK3_1	442	449	PF00069	0.586
MOD_GSK3_1	506	513	PF00069	0.620
MOD_GSK3_1	57	64	PF00069	0.644
MOD_GSK3_1	68	75	PF00069	0.566
MOD_GSK3_1	742	749	PF00069	0.452
MOD_GSK3_1	776	783	PF00069	0.735
MOD_GSK3_1	91	98	PF00069	0.572
MOD_GSK3_1	916	923	PF00069	0.375
MOD_LATS_1	255	261	PF00433	0.512
MOD_LATS_1	588	594	PF00433	0.341
MOD_N-GLC_1	20	25	PF02516	0.532
MOD_N-GLC_1	247	252	PF02516	0.502
MOD_N-GLC_1	450	455	PF02516	0.611
MOD_N-GLC_1	576	581	PF02516	0.472
MOD_N-GLC_1	6	11	PF02516	0.633
MOD_N-GLC_1	771	776	PF02516	0.732
MOD_N-GLC_1	780	785	PF02516	0.737
MOD_N-GLC_1	95	100	PF02516	0.777
MOD_NEK2_1	177	182	PF00069	0.539
MOD_NEK2_1	236	241	PF00069	0.696
MOD_NEK2_1	253	258	PF00069	0.600
MOD_NEK2_1	318	323	PF00069	0.522
MOD_NEK2_1	371	376	PF00069	0.318
MOD_NEK2_1	39	44	PF00069	0.651
MOD_NEK2_1	535	540	PF00069	0.369
MOD_NEK2_1	592	597	PF00069	0.581
MOD_NEK2_1	63	68	PF00069	0.558
MOD_NEK2_1	669	674	PF00069	0.341
MOD_NEK2_1	746	751	PF00069	0.589
MOD_NEK2_1	925	930	PF00069	0.408
MOD_NEK2_2	261	266	PF00069	0.513
MOD_NEK2_2	462	467	PF00069	0.557
MOD_NEK2_2	682	687	PF00069	0.491
MOD_NEK2_2	742	747	PF00069	0.520
MOD_NEK2_2	818	823	PF00069	0.476
MOD_NEK2_2	916	921	PF00069	0.408
MOD_OFUCOSY	744	750	PF10250	0.491
MOD_PIKK_1	129	135	PF00454	0.576
MOD_PIKK_1	602	608	PF00454	0.598
MOD_PKA_1	590	596	PF00069	0.468
MOD_PKA_2	17	23	PF00069	0.661
MOD_PKA_2	177	183	PF00069	0.463
MOD_PKA_2	230	236	PF00069	0.673
MOD_PKA_2	374	380	PF00069	0.364
MOD_PKA_2	590	596	PF00069	0.483
MOD_PKA_2	68	74	PF00069	0.579
MOD_PKA_2	746	752	PF00069	0.569
MOD_PKA_2	920	926	PF00069	0.408
MOD_Plk_1	218	224	PF00069	0.546
MOD_Plk_1	247	253	PF00069	0.526
MOD_Plk_1	25	31	PF00069	0.566
MOD_Plk_1	478	484	PF00069	0.774
MOD_Plk_1	602	608	PF00069	0.406
MOD_Plk_2-3	552	558	PF00069	0.453
MOD_Plk_4	247	253	PF00069	0.538
MOD_Plk_4	26	32	PF00069	0.658
MOD_Plk_4	330	336	PF00069	0.422
MOD_Plk_4	401	407	PF00069	0.408
MOD_Plk_4	559	565	PF00069	0.364
MOD_Plk_4	58	64	PF00069	0.543
MOD_ProDKin_1	121	127	PF00069	0.712
MOD_ProDKin_1	269	275	PF00069	0.645
MOD_ProDKin_1	33	39	PF00069	0.644
MOD_ProDKin_1	446	452	PF00069	0.681
MOD_ProDKin_1	481	487	PF00069	0.664
MOD_ProDKin_1	504	510	PF00069	0.641
MOD_ProDKin_1	576	582	PF00069	0.489
MOD_ProDKin_1	6	12	PF00069	0.625
MOD_ProDKin_1	636	642	PF00069	0.512
MOD_ProDKin_1	76	82	PF00069	0.668
MOD_ProDKin_1	776	782	PF00069	0.713
MOD_SUMO_for_1	812	815	PF00179	0.404
MOD_SUMO_rev_2	603	613	PF00179	0.431
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.526
TRG_ENDOCYTIC_2	700	703	PF00928	0.371
TRG_ENDOCYTIC_2	709	712	PF00928	0.350
TRG_ENDOCYTIC_2	858	861	PF00928	0.383
TRG_ER_diArg_1	589	591	PF00400	0.614
TRG_ER_diArg_1	618	621	PF00400	0.569
TRG_NLS_MonoExtN_4	704	711	PF00514	0.379
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	714	719	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P530	Leptomonas seymouri	54%	96%
A0A1X0NSV1	Trypanosomatidae	31%	100%
A0A3Q8IGX7	Leishmania donovani	100%	100%
A0A422NN92	Trypanosoma rangeli	33%	100%
A4HES6	Leishmania braziliensis	74%	100%
C9ZS12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AY50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
Q4Q9C3	Leishmania major	88%	100%