Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pentapeptide repeats (9 copies) - putative

Species:

Leishmania infantum

UniProt:

A4I202_LEIIN

TriTrypDb:

LINF_260012000

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I202

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I202

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.743
CLV_C14_Caspase3-7	35	39	PF00656	0.608
CLV_C14_Caspase3-7	444	448	PF00656	0.542
CLV_C14_Caspase3-7	459	463	PF00656	0.484
CLV_NRD_NRD_1	11	13	PF00675	0.618
CLV_NRD_NRD_1	272	274	PF00675	0.487
CLV_NRD_NRD_1	316	318	PF00675	0.698
CLV_NRD_NRD_1	398	400	PF00675	0.545
CLV_NRD_NRD_1	460	462	PF00675	0.578
CLV_NRD_NRD_1	49	51	PF00675	0.734
CLV_NRD_NRD_1	89	91	PF00675	0.763
CLV_PCSK_FUR_1	224	228	PF00082	0.607
CLV_PCSK_KEX2_1	11	13	PF00082	0.576
CLV_PCSK_KEX2_1	223	225	PF00082	0.655
CLV_PCSK_KEX2_1	226	228	PF00082	0.674
CLV_PCSK_KEX2_1	316	318	PF00082	0.738
CLV_PCSK_KEX2_1	398	400	PF00082	0.545
CLV_PCSK_KEX2_1	460	462	PF00082	0.588
CLV_PCSK_KEX2_1	49	51	PF00082	0.734
CLV_PCSK_KEX2_1	89	91	PF00082	0.763
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.655
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.674
CLV_PCSK_SKI1_1	273	277	PF00082	0.530
CLV_PCSK_SKI1_1	344	348	PF00082	0.522
CLV_PCSK_SKI1_1	384	388	PF00082	0.545
CLV_PCSK_SKI1_1	488	492	PF00082	0.515
DEG_APCC_DBOX_1	272	280	PF00400	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DEG_SPOP_SBC_1	327	331	PF00917	0.650
DOC_CYCLIN_RxL_1	355	366	PF00134	0.345
DOC_MAPK_gen_1	11	19	PF00069	0.576
DOC_MAPK_gen_1	223	233	PF00069	0.754
DOC_MAPK_gen_1	273	281	PF00069	0.576
DOC_MAPK_gen_1	460	468	PF00069	0.499
DOC_MAPK_MEF2A_6	224	233	PF00069	0.808
DOC_MAPK_MEF2A_6	460	468	PF00069	0.604
DOC_PP1_RVXF_1	272	279	PF00149	0.573
DOC_PP2B_LxvP_1	336	339	PF13499	0.573
DOC_USP7_MATH_1	142	146	PF00917	0.531
DOC_USP7_MATH_1	180	184	PF00917	0.767
DOC_USP7_MATH_1	200	204	PF00917	0.759
DOC_USP7_MATH_1	238	242	PF00917	0.733
DOC_USP7_MATH_1	248	252	PF00917	0.704
DOC_USP7_MATH_1	312	316	PF00917	0.828
DOC_USP7_MATH_1	327	331	PF00917	0.520
DOC_USP7_MATH_1	438	442	PF00917	0.704
DOC_USP7_MATH_1	83	87	PF00917	0.765
DOC_WW_Pin1_4	110	115	PF00397	0.812
DOC_WW_Pin1_4	124	129	PF00397	0.632
DOC_WW_Pin1_4	17	22	PF00397	0.620
DOC_WW_Pin1_4	172	177	PF00397	0.746
DOC_WW_Pin1_4	234	239	PF00397	0.668
DOC_WW_Pin1_4	285	290	PF00397	0.714
DOC_WW_Pin1_4	318	323	PF00397	0.656
LIG_14-3-3_CanoR_1	23	31	PF00244	0.655
LIG_14-3-3_CanoR_1	32	37	PF00244	0.670
LIG_14-3-3_CanoR_1	358	363	PF00244	0.345
LIG_14-3-3_CanoR_1	371	377	PF00244	0.345
LIG_14-3-3_CanoR_1	413	422	PF00244	0.577
LIG_14-3-3_CanoR_1	56	60	PF00244	0.759
LIG_14-3-3_CanoR_1	94	102	PF00244	0.763
LIG_Actin_WH2_2	10	25	PF00022	0.576
LIG_APCC_ABBAyCdc20_2	226	232	PF00400	0.613
LIG_BIR_III_4	199	203	PF00653	0.565
LIG_BRCT_BRCA1_1	464	468	PF00533	0.554
LIG_FHA_1	226	232	PF00498	0.803
LIG_FHA_1	286	292	PF00498	0.572
LIG_FHA_1	401	407	PF00498	0.415
LIG_FHA_2	33	39	PF00498	0.730
LIG_FHA_2	374	380	PF00498	0.345
LIG_FHA_2	442	448	PF00498	0.692
LIG_FHA_2	93	99	PF00498	0.710
LIG_LIR_Gen_1	366	375	PF02991	0.345
LIG_LIR_Gen_1	5	13	PF02991	0.555
LIG_LIR_Nem_3	182	187	PF02991	0.802
LIG_LIR_Nem_3	198	204	PF02991	0.624
LIG_LIR_Nem_3	366	370	PF02991	0.345
LIG_LIR_Nem_3	5	10	PF02991	0.572
LIG_SH2_CRK	184	188	PF00017	0.616
LIG_SH2_CRK	33	37	PF00017	0.675
LIG_SH2_NCK_1	33	37	PF00017	0.600
LIG_SH2_STAP1	148	152	PF00017	0.561
LIG_SH3_3	170	176	PF00018	0.655
LIG_SUMO_SIM_par_1	138	145	PF11976	0.514
LIG_WRC_WIRS_1	261	266	PF05994	0.645
MOD_CDK_SPxK_1	110	116	PF00069	0.741
MOD_CDK_SPxK_1	17	23	PF00069	0.554
MOD_CK1_1	110	116	PF00069	0.705
MOD_CK1_1	241	247	PF00069	0.760
MOD_CK1_1	252	258	PF00069	0.653
MOD_CK1_1	283	289	PF00069	0.584
MOD_CK1_1	323	329	PF00069	0.712
MOD_CK1_1	373	379	PF00069	0.345
MOD_CK1_1	415	421	PF00069	0.600
MOD_CK1_1	441	447	PF00069	0.614
MOD_CK1_1	55	61	PF00069	0.683
MOD_CK2_1	124	130	PF00069	0.759
MOD_CK2_1	38	44	PF00069	0.826
MOD_CK2_1	92	98	PF00069	0.712
MOD_Cter_Amidation	87	90	PF01082	0.755
MOD_GlcNHglycan	144	147	PF01048	0.540
MOD_GlcNHglycan	243	246	PF01048	0.781
MOD_GlcNHglycan	285	288	PF01048	0.580
MOD_GlcNHglycan	291	294	PF01048	0.678
MOD_GlcNHglycan	322	325	PF01048	0.687
MOD_GlcNHglycan	330	333	PF01048	0.446
MOD_GlcNHglycan	496	499	PF01048	0.564
MOD_GlcNHglycan	86	89	PF01048	0.625
MOD_GSK3_1	103	110	PF00069	0.741
MOD_GSK3_1	22	29	PF00069	0.660
MOD_GSK3_1	234	241	PF00069	0.669
MOD_GSK3_1	248	255	PF00069	0.711
MOD_GSK3_1	256	263	PF00069	0.679
MOD_GSK3_1	285	292	PF00069	0.658
MOD_GSK3_1	293	300	PF00069	0.652
MOD_GSK3_1	323	330	PF00069	0.676
MOD_GSK3_1	412	419	PF00069	0.614
MOD_GSK3_1	490	497	PF00069	0.566
MOD_GSK3_1	90	97	PF00069	0.745
MOD_LATS_1	356	362	PF00433	0.345
MOD_N-GLC_1	283	288	PF02516	0.564
MOD_N-GLC_1	400	405	PF02516	0.615
MOD_NEK2_1	115	120	PF00069	0.721
MOD_NEK2_1	141	146	PF00069	0.514
MOD_NEK2_1	209	214	PF00069	0.516
MOD_NEK2_1	22	27	PF00069	0.539
MOD_NEK2_1	3	8	PF00069	0.552
MOD_NEK2_1	382	387	PF00069	0.415
MOD_NEK2_1	416	421	PF00069	0.457
MOD_NEK2_1	478	483	PF00069	0.482
MOD_PIKK_1	297	303	PF00454	0.799
MOD_PIKK_1	478	484	PF00454	0.527
MOD_PKA_2	107	113	PF00069	0.734
MOD_PKA_2	115	121	PF00069	0.688
MOD_PKA_2	22	28	PF00069	0.581
MOD_PKA_2	3	9	PF00069	0.552
MOD_PKA_2	31	37	PF00069	0.659
MOD_PKA_2	370	376	PF00069	0.345
MOD_PKA_2	412	418	PF00069	0.591
MOD_PKA_2	441	447	PF00069	0.598
MOD_PKA_2	55	61	PF00069	0.769
MOD_Plk_1	103	109	PF00069	0.696
MOD_Plk_1	365	371	PF00069	0.345
MOD_Plk_4	256	262	PF00069	0.543
MOD_Plk_4	358	364	PF00069	0.379
MOD_Plk_4	391	397	PF00069	0.361
MOD_ProDKin_1	110	116	PF00069	0.812
MOD_ProDKin_1	124	130	PF00069	0.627
MOD_ProDKin_1	17	23	PF00069	0.622
MOD_ProDKin_1	172	178	PF00069	0.745
MOD_ProDKin_1	234	240	PF00069	0.666
MOD_ProDKin_1	285	291	PF00069	0.721
MOD_ProDKin_1	318	324	PF00069	0.652
MOD_SUMO_rev_2	268	276	PF00179	0.496
TRG_ENDOCYTIC_2	184	187	PF00928	0.795
TRG_ENDOCYTIC_2	201	204	PF00928	0.629
TRG_ENDOCYTIC_2	33	36	PF00928	0.723
TRG_ER_diArg_1	10	12	PF00400	0.567
TRG_ER_diArg_1	397	399	PF00400	0.345
TRG_ER_diArg_1	48	50	PF00400	0.703
TRG_ER_diArg_1	503	506	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M8	Leptomonas seymouri	41%	100%
A0A3Q8IC33	Leishmania donovani	100%	100%
A4HES5	Leishmania braziliensis	65%	100%
E9AY49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4Q9C4	Leishmania major	86%	100%