LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Qc-SNARE protein - putative
Species:
Leishmania infantum
UniProt:
A4I201_LEIIN
TriTrypDb:
LINF_260011900
Length:
250

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, Qc-SNARE , putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0012505 endomembrane system 2 1
GO:0016020 membrane 2 7
GO:0031201 SNARE complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0098796 membrane protein complex 2 1
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4I201
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I201

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 8
GO:0006886 intracellular protein transport 4 1
GO:0006906 vesicle fusion 6 1
GO:0006996 organelle organization 4 1
GO:0008104 protein localization 4 3
GO:0009987 cellular process 1 3
GO:0015031 protein transport 4 3
GO:0016043 cellular component organization 3 1
GO:0016050 vesicle organization 5 1
GO:0022406 membrane docking 2 1
GO:0033036 macromolecule localization 2 3
GO:0045184 establishment of protein localization 3 3
GO:0046907 intracellular transport 3 1
GO:0048278 vesicle docking 4 1
GO:0048284 organelle fusion 5 1
GO:0051179 localization 1 8
GO:0051234 establishment of localization 2 8
GO:0051640 organelle localization 2 1
GO:0051641 cellular localization 2 3
GO:0051649 establishment of localization in cell 3 1
GO:0061024 membrane organization 4 1
GO:0061025 membrane fusion 5 1
GO:0070727 cellular macromolecule localization 3 3
GO:0071702 organic substance transport 4 3
GO:0071705 nitrogen compound transport 4 3
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090174 organelle membrane fusion 6 1
GO:0140056 organelle localization by membrane tethering 3 1
GO:0016192 vesicle-mediated transport 4 7
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 1
GO:0005484 SNAP receptor activity 3 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0030674 protein-macromolecule adaptor activity 2 1
GO:0060090 molecular adaptor activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 138 142 PF00656 0.622
CLV_NRD_NRD_1 128 130 PF00675 0.369
CLV_NRD_NRD_1 215 217 PF00675 0.312
CLV_PCSK_KEX2_1 130 132 PF00082 0.362
CLV_PCSK_PC1ET2_1 130 132 PF00082 0.424
CLV_PCSK_SKI1_1 202 206 PF00082 0.328
CLV_PCSK_SKI1_1 80 84 PF00082 0.357
DEG_Nend_UBRbox_3 1 3 PF02207 0.725
DOC_MAPK_gen_1 178 186 PF00069 0.568
DOC_MAPK_gen_1 228 236 PF00069 0.456
DOC_MAPK_MEF2A_6 152 161 PF00069 0.534
DOC_MAPK_MEF2A_6 228 236 PF00069 0.456
DOC_USP7_MATH_1 21 25 PF00917 0.748
DOC_USP7_MATH_1 4 8 PF00917 0.745
LIG_14-3-3_CanoR_1 171 179 PF00244 0.619
LIG_Actin_RPEL_3 221 240 PF02755 0.536
LIG_AP2alpha_2 28 30 PF02296 0.570
LIG_EH1_1 237 245 PF00400 0.421
LIG_FHA_2 23 29 PF00498 0.714
LIG_FHA_2 83 89 PF00498 0.553
LIG_FHA_2 94 100 PF00498 0.542
LIG_GBD_Chelix_1 241 249 PF00786 0.376
LIG_TRAF2_1 96 99 PF00917 0.570
MOD_CK2_1 21 27 PF00069 0.708
MOD_CK2_1 82 88 PF00069 0.546
MOD_CK2_1 93 99 PF00069 0.542
MOD_GlcNHglycan 173 176 PF01048 0.419
MOD_GSK3_1 13 20 PF00069 0.719
MOD_GSK3_1 51 58 PF00069 0.622
MOD_GSK3_1 89 96 PF00069 0.655
MOD_NEK2_1 221 226 PF00069 0.470
MOD_NEK2_1 51 56 PF00069 0.648
MOD_PIKK_1 189 195 PF00454 0.581
MOD_PIKK_1 4 10 PF00454 0.700
MOD_PKA_1 216 222 PF00069 0.523
MOD_PKA_2 170 176 PF00069 0.596
MOD_PKA_2 51 57 PF00069 0.677
MOD_Plk_1 165 171 PF00069 0.591
MOD_Plk_2-3 165 171 PF00069 0.591
MOD_Plk_4 157 163 PF00069 0.665
MOD_Plk_4 55 61 PF00069 0.567
TRG_DiLeu_BaEn_2 145 151 PF01217 0.594
TRG_ER_diArg_1 129 132 PF00400 0.587
TRG_NES_CRM1_1 198 212 PF08389 0.536

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4C8 Leptomonas seymouri 27% 100%
A0A0N1IK90 Leptomonas seymouri 77% 97%
A0A0S4JJL1 Bodo saltans 42% 100%
A0A1X0NSP4 Trypanosomatidae 54% 100%
A0A3Q8IBW4 Leishmania donovani 31% 100%
A0A3Q8IDN9 Leishmania donovani 100% 100%
A0A3R7KG01 Trypanosoma rangeli 59% 100%
A4HES4 Leishmania braziliensis 84% 100%
A4HZL4 Leishmania infantum 30% 100%
E9AY48 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
O43752 Homo sapiens 29% 98%
O60499 Homo sapiens 26% 100%
Q4Q9C5 Leishmania major 95% 100%
Q5R6Q2 Pongo abelii 29% 98%
Q63635 Rattus norvegicus 32% 98%
Q946Y7 Arabidopsis thaliana 28% 100%
Q9JKK1 Mus musculus 31% 98%
V5BUP0 Trypanosoma cruzi 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS