LeishMANIAdb
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Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Thioredoxin domain-containing protein
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania infantum
UniProt:
A4I1Z9_LEIIN
TriTrypDb:
Length:
114

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4I1Z9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Z9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 20 22 PF00675 0.421
CLV_NRD_NRD_1 63 65 PF00675 0.454
CLV_PCSK_FUR_1 60 64 PF00082 0.432
CLV_PCSK_KEX2_1 20 22 PF00082 0.640
CLV_PCSK_KEX2_1 62 64 PF00082 0.449
CLV_PCSK_PC7_1 58 64 PF00082 0.419
DEG_Nend_UBRbox_3 1 3 PF02207 0.524
DOC_MAPK_gen_1 100 110 PF00069 0.496
DOC_MAPK_MEF2A_6 103 112 PF00069 0.484
DOC_MAPK_MEF2A_6 23 32 PF00069 0.403
DOC_PP4_MxPP_1 32 35 PF00568 0.385
LIG_14-3-3_CanoR_1 62 68 PF00244 0.476
LIG_Integrin_RGD_1 75 77 PF01839 0.533
LIG_LIR_Nem_3 25 30 PF02991 0.631
LIG_LYPXL_yS_3 27 30 PF13949 0.402
LIG_SH3_3 7 13 PF00018 0.410
MOD_GlcNHglycan 24 27 PF01048 0.458
MOD_GSK3_1 22 29 PF00069 0.629
MOD_PKA_1 62 68 PF00069 0.476
MOD_PKA_2 62 68 PF00069 0.476
MOD_PKB_1 60 68 PF00069 0.460
MOD_Plk_4 26 32 PF00069 0.612
MOD_Plk_4 63 69 PF00069 0.572
TRG_ENDOCYTIC_2 27 30 PF00928 0.402
TRG_ER_diArg_1 20 22 PF00400 0.421
TRG_ER_diArg_1 61 64 PF00400 0.446
TRG_ER_diArg_1 68 71 PF00400 0.483
TRG_ER_diArg_1 72 75 PF00400 0.472
TRG_ER_diArg_1 81 84 PF00400 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IDR3 Leishmania donovani 100% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS