Protein disulfide-isomerase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein disulfide isomerase - putative

Species:

Leishmania infantum

UniProt:

A4I1Z8_LEIIN

TriTrypDb:

LINF_260011600

Length:

377

Annotations

LeishMANIAdb annotations

Appears to be a family of secreted proteins, probably ER-localized, like its homologs in other Eukaryotes.. Seems to carry a putative KDEL-like signal on its C-terminus.. Localization: Secreted (by homology)

Annotations by Jardim et al.

Redox homeostasis, Thioredoxin Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	12
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4I1Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Z8

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	10
GO:0003824	catalytic activity	1	11
GO:0016853	isomerase activity	2	11
GO:0016860	intramolecular oxidoreductase activity	3	10
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.328
CLV_MEL_PAP_1	101	107	PF00089	0.516
CLV_NRD_NRD_1	220	222	PF00675	0.560
CLV_NRD_NRD_1	3	5	PF00675	0.313
CLV_NRD_NRD_1	358	360	PF00675	0.516
CLV_PCSK_FUR_1	345	349	PF00082	0.517
CLV_PCSK_KEX2_1	103	105	PF00082	0.517
CLV_PCSK_KEX2_1	3	5	PF00082	0.310
CLV_PCSK_KEX2_1	347	349	PF00082	0.512
CLV_PCSK_KEX2_1	358	360	PF00082	0.437

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVU7	Leptomonas seymouri	50%	100%
A0A0S4IKM8	Bodo saltans	23%	98%
A0A0S4JJE1	Bodo saltans	47%	100%
A0A1X0NSF7	Trypanosomatidae	48%	99%
A0A3S7WZP2	Leishmania donovani	100%	100%
A0A422N2J8	Trypanosoma rangeli	49%	100%
A4HES1	Leishmania braziliensis	53%	100%
C9ZS16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AY45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O13704	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%

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