LeishMANIAdb
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Protein disulfide-isomerase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein disulfide-isomerase
Gene product:
protein disulfide isomerase - putative
Species:
Leishmania infantum
UniProt:
A4I1Z8_LEIIN
TriTrypDb:
LINF_260011600
Length:
377

Annotations

LeishMANIAdb annotations

Appears to be a family of secreted proteins, probably ER-localized, like its homologs in other Eukaryotes.. Seems to carry a putative KDEL-like signal on its C-terminus.. Localization: Secreted (by homology)

Annotations by Jardim et al.

Redox homeostasis, Thioredoxin Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 9, no: 2
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0005794 Golgi apparatus 5 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4I1Z8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I1Z8

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0003756 protein disulfide isomerase activity 3 10
GO:0003824 catalytic activity 1 11
GO:0016853 isomerase activity 2 11
GO:0016860 intramolecular oxidoreductase activity 3 10
GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 4 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 357 361 PF00656 0.328
CLV_MEL_PAP_1 101 107 PF00089 0.516
CLV_NRD_NRD_1 220 222 PF00675 0.560
CLV_NRD_NRD_1 3 5 PF00675 0.313
CLV_NRD_NRD_1 358 360 PF00675 0.516
CLV_PCSK_FUR_1 345 349 PF00082 0.517
CLV_PCSK_KEX2_1 103 105 PF00082 0.517
CLV_PCSK_KEX2_1 3 5 PF00082 0.310
CLV_PCSK_KEX2_1 347 349 PF00082 0.512
CLV_PCSK_KEX2_1 358 360 PF00082 0.437
CLV_PCSK_PC1ET2_1 103 105 PF00082 0.517
CLV_PCSK_PC1ET2_1 347 349 PF00082 0.536
CLV_PCSK_SKI1_1 174 178 PF00082 0.476
CLV_PCSK_SKI1_1 189 193 PF00082 0.450
CLV_PCSK_SKI1_1 197 201 PF00082 0.487
CLV_PCSK_SKI1_1 222 226 PF00082 0.575
CLV_PCSK_SKI1_1 292 296 PF00082 0.522
CLV_PCSK_SKI1_1 50 54 PF00082 0.554
CLV_PCSK_SKI1_1 85 89 PF00082 0.518
DEG_Nend_UBRbox_3 1 3 PF02207 0.634
DEG_SPOP_SBC_1 293 297 PF00917 0.290
DOC_CYCLIN_yClb5_NLxxxL_5 253 259 PF00134 0.317
DOC_MAPK_gen_1 3 11 PF00069 0.510
DOC_MAPK_gen_1 358 366 PF00069 0.248
DOC_MAPK_gen_1 48 56 PF00069 0.373
DOC_MAPK_MEF2A_6 3 11 PF00069 0.505
DOC_MAPK_MEF2A_6 359 368 PF00069 0.328
DOC_PP2B_LxvP_1 148 151 PF13499 0.340
DOC_PP4_FxxP_1 180 183 PF00568 0.268
DOC_PP4_FxxP_1 56 59 PF00568 0.258
DOC_SPAK_OSR1_1 104 108 PF12202 0.262
DOC_USP7_MATH_1 117 121 PF00917 0.216
DOC_USP7_MATH_1 294 298 PF00917 0.318
DOC_USP7_MATH_1 310 314 PF00917 0.345
DOC_USP7_UBL2_3 170 174 PF12436 0.345
LIG_14-3-3_CanoR_1 221 229 PF00244 0.317
LIG_14-3-3_CanoR_1 3 8 PF00244 0.494
LIG_14-3-3_CanoR_1 345 351 PF00244 0.373
LIG_Actin_WH2_2 132 149 PF00022 0.364
LIG_FHA_2 129 135 PF00498 0.345
LIG_FHA_2 161 167 PF00498 0.366
LIG_FHA_2 312 318 PF00498 0.340
LIG_Integrin_isoDGR_2 251 253 PF01839 0.517
LIG_LIR_Apic_2 234 239 PF02991 0.373
LIG_LIR_Apic_2 55 59 PF02991 0.252
LIG_LIR_Gen_1 163 172 PF02991 0.268
LIG_LIR_Gen_1 256 266 PF02991 0.347
LIG_LIR_Gen_1 40 46 PF02991 0.354
LIG_LIR_Gen_1 70 78 PF02991 0.293
LIG_LIR_Nem_3 108 113 PF02991 0.311
LIG_LIR_Nem_3 133 138 PF02991 0.284
LIG_LIR_Nem_3 163 168 PF02991 0.268
LIG_LIR_Nem_3 230 235 PF02991 0.222
LIG_LIR_Nem_3 256 261 PF02991 0.347
LIG_LIR_Nem_3 277 283 PF02991 0.393
LIG_LIR_Nem_3 40 45 PF02991 0.334
LIG_LIR_Nem_3 70 74 PF02991 0.279
LIG_Pex14_2 180 184 PF04695 0.266
LIG_Pex14_2 56 60 PF04695 0.251
LIG_RPA_C_Fungi 207 219 PF08784 0.390
LIG_SH2_CRK 195 199 PF00017 0.429
LIG_SH2_CRK 280 284 PF00017 0.292
LIG_SH2_CRK 71 75 PF00017 0.356
LIG_SH2_SRC 338 341 PF00017 0.351
LIG_SH2_STAT5 115 118 PF00017 0.363
LIG_SH2_STAT5 138 141 PF00017 0.437
LIG_SH2_STAT5 236 239 PF00017 0.427
LIG_SH2_STAT5 324 327 PF00017 0.405
LIG_SH2_STAT5 338 341 PF00017 0.288
LIG_SH3_3 148 154 PF00018 0.565
LIG_SH3_3 166 172 PF00018 0.276
LIG_SUMO_SIM_anti_2 86 91 PF11976 0.441
LIG_UBA3_1 368 377 PF00899 0.436
LIG_UBA3_1 87 92 PF00899 0.425
LIG_WRC_WIRS_1 258 263 PF05994 0.429
MOD_CK1_1 21 27 PF00069 0.568
MOD_CK1_1 297 303 PF00069 0.453
MOD_CK1_1 313 319 PF00069 0.355
MOD_CK2_1 293 299 PF00069 0.369
MOD_CK2_1 311 317 PF00069 0.340
MOD_Cter_Amidation 101 104 PF01082 0.390
MOD_GlcNHglycan 117 120 PF01048 0.319
MOD_GlcNHglycan 140 143 PF01048 0.473
MOD_GlcNHglycan 229 232 PF01048 0.402
MOD_GlcNHglycan 296 299 PF01048 0.398
MOD_GlcNHglycan 342 345 PF01048 0.405
MOD_GSK3_1 105 112 PF00069 0.359
MOD_GSK3_1 227 234 PF00069 0.315
MOD_GSK3_1 293 300 PF00069 0.391
MOD_GSK3_1 311 318 PF00069 0.137
MOD_NEK2_1 105 110 PF00069 0.365
MOD_NEK2_1 146 151 PF00069 0.532
MOD_NEK2_1 160 165 PF00069 0.288
MOD_NEK2_1 18 23 PF00069 0.422
MOD_NEK2_1 346 351 PF00069 0.413
MOD_PK_1 3 9 PF00069 0.467
MOD_PKA_1 3 9 PF00069 0.432
MOD_PKA_2 146 152 PF00069 0.549
MOD_PKA_2 3 9 PF00069 0.342
MOD_Plk_1 274 280 PF00069 0.415
MOD_Plk_4 109 115 PF00069 0.331
MOD_Plk_4 231 237 PF00069 0.355
MOD_Plk_4 257 263 PF00069 0.361
MOD_Plk_4 3 9 PF00069 0.367
TRG_ENDOCYTIC_2 195 198 PF00928 0.355
TRG_ENDOCYTIC_2 280 283 PF00928 0.433
TRG_ENDOCYTIC_2 71 74 PF00928 0.377
TRG_ER_diArg_1 3 5 PF00400 0.383
TRG_Pf-PMV_PEXEL_1 253 257 PF00026 0.332

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVU7 Leptomonas seymouri 50% 100%
A0A0S4IKM8 Bodo saltans 23% 98%
A0A0S4JJE1 Bodo saltans 47% 100%
A0A1X0NSF7 Trypanosomatidae 48% 99%
A0A3S7WZP2 Leishmania donovani 100% 100%
A0A422N2J8 Trypanosoma rangeli 49% 100%
A4HES1 Leishmania braziliensis 53% 100%
C9ZS16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AY45 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
O13704 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
O13811 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 100%
O22263 Arabidopsis thaliana 43% 100%
P38660 Mesocricetus auratus 33% 86%
P38661 Medicago sativa 42% 100%
Q00216 Aspergillus niger 42% 100%
Q11067 Caenorhabditis elegans 30% 86%
Q15084 Homo sapiens 34% 86%
Q4Q9C8 Leishmania major 94% 100%
Q5I0H9 Rattus norvegicus 33% 73%
Q5R6T1 Pongo abelii 34% 86%
Q63081 Rattus norvegicus 33% 86%
Q75M08 Oryza sativa subsp. japonica 43% 100%
Q86IA3 Dictyostelium discoideum 35% 100%
Q92249 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 41% 100%
Q922R8 Mus musculus 33% 86%
Q942L2 Oryza sativa subsp. japonica 40% 100%
Q9MAU6 Arabidopsis thaliana 30% 84%
Q9V438 Drosophila melanogaster 37% 87%
Q9VYV3 Drosophila melanogaster 27% 91%
V5DR98 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS