Appears to be a family of secreted proteins, probably ER-localized, like its homologs in other Eukaryotes.. Seems to carry a putative KDEL-like signal on its C-terminus.. Localization: Secreted (by homology)
Redox homeostasis, Thioredoxin Uncharacterized
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | yes | yes: 4 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | yes | yes: 16 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 9, no: 2 |
NetGPI | no | yes: 0, no: 11 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | 5 | 12 |
GO:0043226 | organelle | 2 | 12 |
GO:0043227 | membrane-bounded organelle | 3 | 12 |
GO:0043229 | intracellular organelle | 3 | 12 |
GO:0043231 | intracellular membrane-bounded organelle | 4 | 12 |
GO:0110165 | cellular anatomical entity | 1 | 12 |
GO:0005794 | Golgi apparatus | 5 | 1 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pescher et al. (upgregulation) | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: A4I1Z8
Term | Name | Level | Count |
---|---|---|---|
GO:0006457 | protein folding | 2 | 1 |
GO:0009987 | cellular process | 1 | 1 |
Term | Name | Level | Count |
---|---|---|---|
GO:0003756 | protein disulfide isomerase activity | 3 | 10 |
GO:0003824 | catalytic activity | 1 | 11 |
GO:0016853 | isomerase activity | 2 | 11 |
GO:0016860 | intramolecular oxidoreductase activity | 3 | 10 |
GO:0016864 | intramolecular oxidoreductase activity, transposing S-S bonds | 4 | 10 |
GO:0140096 | catalytic activity, acting on a protein | 2 | 10 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 357 | 361 | PF00656 | 0.328 |
CLV_MEL_PAP_1 | 101 | 107 | PF00089 | 0.516 |
CLV_NRD_NRD_1 | 220 | 222 | PF00675 | 0.560 |
CLV_NRD_NRD_1 | 3 | 5 | PF00675 | 0.313 |
CLV_NRD_NRD_1 | 358 | 360 | PF00675 | 0.516 |
CLV_PCSK_FUR_1 | 345 | 349 | PF00082 | 0.517 |
CLV_PCSK_KEX2_1 | 103 | 105 | PF00082 | 0.517 |
CLV_PCSK_KEX2_1 | 3 | 5 | PF00082 | 0.310 |
CLV_PCSK_KEX2_1 | 347 | 349 | PF00082 | 0.512 |
CLV_PCSK_KEX2_1 | 358 | 360 | PF00082 | 0.437 |
CLV_PCSK_PC1ET2_1 | 103 | 105 | PF00082 | 0.517 |
CLV_PCSK_PC1ET2_1 | 347 | 349 | PF00082 | 0.536 |
CLV_PCSK_SKI1_1 | 174 | 178 | PF00082 | 0.476 |
CLV_PCSK_SKI1_1 | 189 | 193 | PF00082 | 0.450 |
CLV_PCSK_SKI1_1 | 197 | 201 | PF00082 | 0.487 |
CLV_PCSK_SKI1_1 | 222 | 226 | PF00082 | 0.575 |
CLV_PCSK_SKI1_1 | 292 | 296 | PF00082 | 0.522 |
CLV_PCSK_SKI1_1 | 50 | 54 | PF00082 | 0.554 |
CLV_PCSK_SKI1_1 | 85 | 89 | PF00082 | 0.518 |
DEG_Nend_UBRbox_3 | 1 | 3 | PF02207 | 0.634 |
DEG_SPOP_SBC_1 | 293 | 297 | PF00917 | 0.290 |
DOC_CYCLIN_yClb5_NLxxxL_5 | 253 | 259 | PF00134 | 0.317 |
DOC_MAPK_gen_1 | 3 | 11 | PF00069 | 0.510 |
DOC_MAPK_gen_1 | 358 | 366 | PF00069 | 0.248 |
DOC_MAPK_gen_1 | 48 | 56 | PF00069 | 0.373 |
DOC_MAPK_MEF2A_6 | 3 | 11 | PF00069 | 0.505 |
DOC_MAPK_MEF2A_6 | 359 | 368 | PF00069 | 0.328 |
DOC_PP2B_LxvP_1 | 148 | 151 | PF13499 | 0.340 |
DOC_PP4_FxxP_1 | 180 | 183 | PF00568 | 0.268 |
DOC_PP4_FxxP_1 | 56 | 59 | PF00568 | 0.258 |
DOC_SPAK_OSR1_1 | 104 | 108 | PF12202 | 0.262 |
DOC_USP7_MATH_1 | 117 | 121 | PF00917 | 0.216 |
DOC_USP7_MATH_1 | 294 | 298 | PF00917 | 0.318 |
DOC_USP7_MATH_1 | 310 | 314 | PF00917 | 0.345 |
DOC_USP7_UBL2_3 | 170 | 174 | PF12436 | 0.345 |
LIG_14-3-3_CanoR_1 | 221 | 229 | PF00244 | 0.317 |
LIG_14-3-3_CanoR_1 | 3 | 8 | PF00244 | 0.494 |
LIG_14-3-3_CanoR_1 | 345 | 351 | PF00244 | 0.373 |
LIG_Actin_WH2_2 | 132 | 149 | PF00022 | 0.364 |
LIG_FHA_2 | 129 | 135 | PF00498 | 0.345 |
LIG_FHA_2 | 161 | 167 | PF00498 | 0.366 |
LIG_FHA_2 | 312 | 318 | PF00498 | 0.340 |
LIG_Integrin_isoDGR_2 | 251 | 253 | PF01839 | 0.517 |
LIG_LIR_Apic_2 | 234 | 239 | PF02991 | 0.373 |
LIG_LIR_Apic_2 | 55 | 59 | PF02991 | 0.252 |
LIG_LIR_Gen_1 | 163 | 172 | PF02991 | 0.268 |
LIG_LIR_Gen_1 | 256 | 266 | PF02991 | 0.347 |
LIG_LIR_Gen_1 | 40 | 46 | PF02991 | 0.354 |
LIG_LIR_Gen_1 | 70 | 78 | PF02991 | 0.293 |
LIG_LIR_Nem_3 | 108 | 113 | PF02991 | 0.311 |
LIG_LIR_Nem_3 | 133 | 138 | PF02991 | 0.284 |
LIG_LIR_Nem_3 | 163 | 168 | PF02991 | 0.268 |
LIG_LIR_Nem_3 | 230 | 235 | PF02991 | 0.222 |
LIG_LIR_Nem_3 | 256 | 261 | PF02991 | 0.347 |
LIG_LIR_Nem_3 | 277 | 283 | PF02991 | 0.393 |
LIG_LIR_Nem_3 | 40 | 45 | PF02991 | 0.334 |
LIG_LIR_Nem_3 | 70 | 74 | PF02991 | 0.279 |
LIG_Pex14_2 | 180 | 184 | PF04695 | 0.266 |
LIG_Pex14_2 | 56 | 60 | PF04695 | 0.251 |
LIG_RPA_C_Fungi | 207 | 219 | PF08784 | 0.390 |
LIG_SH2_CRK | 195 | 199 | PF00017 | 0.429 |
LIG_SH2_CRK | 280 | 284 | PF00017 | 0.292 |
LIG_SH2_CRK | 71 | 75 | PF00017 | 0.356 |
LIG_SH2_SRC | 338 | 341 | PF00017 | 0.351 |
LIG_SH2_STAT5 | 115 | 118 | PF00017 | 0.363 |
LIG_SH2_STAT5 | 138 | 141 | PF00017 | 0.437 |
LIG_SH2_STAT5 | 236 | 239 | PF00017 | 0.427 |
LIG_SH2_STAT5 | 324 | 327 | PF00017 | 0.405 |
LIG_SH2_STAT5 | 338 | 341 | PF00017 | 0.288 |
LIG_SH3_3 | 148 | 154 | PF00018 | 0.565 |
LIG_SH3_3 | 166 | 172 | PF00018 | 0.276 |
LIG_SUMO_SIM_anti_2 | 86 | 91 | PF11976 | 0.441 |
LIG_UBA3_1 | 368 | 377 | PF00899 | 0.436 |
LIG_UBA3_1 | 87 | 92 | PF00899 | 0.425 |
LIG_WRC_WIRS_1 | 258 | 263 | PF05994 | 0.429 |
MOD_CK1_1 | 21 | 27 | PF00069 | 0.568 |
MOD_CK1_1 | 297 | 303 | PF00069 | 0.453 |
MOD_CK1_1 | 313 | 319 | PF00069 | 0.355 |
MOD_CK2_1 | 293 | 299 | PF00069 | 0.369 |
MOD_CK2_1 | 311 | 317 | PF00069 | 0.340 |
MOD_Cter_Amidation | 101 | 104 | PF01082 | 0.390 |
MOD_GlcNHglycan | 117 | 120 | PF01048 | 0.319 |
MOD_GlcNHglycan | 140 | 143 | PF01048 | 0.473 |
MOD_GlcNHglycan | 229 | 232 | PF01048 | 0.402 |
MOD_GlcNHglycan | 296 | 299 | PF01048 | 0.398 |
MOD_GlcNHglycan | 342 | 345 | PF01048 | 0.405 |
MOD_GSK3_1 | 105 | 112 | PF00069 | 0.359 |
MOD_GSK3_1 | 227 | 234 | PF00069 | 0.315 |
MOD_GSK3_1 | 293 | 300 | PF00069 | 0.391 |
MOD_GSK3_1 | 311 | 318 | PF00069 | 0.137 |
MOD_NEK2_1 | 105 | 110 | PF00069 | 0.365 |
MOD_NEK2_1 | 146 | 151 | PF00069 | 0.532 |
MOD_NEK2_1 | 160 | 165 | PF00069 | 0.288 |
MOD_NEK2_1 | 18 | 23 | PF00069 | 0.422 |
MOD_NEK2_1 | 346 | 351 | PF00069 | 0.413 |
MOD_PK_1 | 3 | 9 | PF00069 | 0.467 |
MOD_PKA_1 | 3 | 9 | PF00069 | 0.432 |
MOD_PKA_2 | 146 | 152 | PF00069 | 0.549 |
MOD_PKA_2 | 3 | 9 | PF00069 | 0.342 |
MOD_Plk_1 | 274 | 280 | PF00069 | 0.415 |
MOD_Plk_4 | 109 | 115 | PF00069 | 0.331 |
MOD_Plk_4 | 231 | 237 | PF00069 | 0.355 |
MOD_Plk_4 | 257 | 263 | PF00069 | 0.361 |
MOD_Plk_4 | 3 | 9 | PF00069 | 0.367 |
TRG_ENDOCYTIC_2 | 195 | 198 | PF00928 | 0.355 |
TRG_ENDOCYTIC_2 | 280 | 283 | PF00928 | 0.433 |
TRG_ENDOCYTIC_2 | 71 | 74 | PF00928 | 0.377 |
TRG_ER_diArg_1 | 3 | 5 | PF00400 | 0.383 |
TRG_Pf-PMV_PEXEL_1 | 253 | 257 | PF00026 | 0.332 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N1HVU7 | Leptomonas seymouri | 50% | 100% |
A0A0S4IKM8 | Bodo saltans | 23% | 98% |
A0A0S4JJE1 | Bodo saltans | 47% | 100% |
A0A1X0NSF7 | Trypanosomatidae | 48% | 99% |
A0A3S7WZP2 | Leishmania donovani | 100% | 100% |
A0A422N2J8 | Trypanosoma rangeli | 49% | 100% |
A4HES1 | Leishmania braziliensis | 53% | 100% |
C9ZS16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 43% | 100% |
E9AY45 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 89% | 100% |
O13704 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 25% | 100% |
O13811 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 37% | 100% |
O22263 | Arabidopsis thaliana | 43% | 100% |
P38660 | Mesocricetus auratus | 33% | 86% |
P38661 | Medicago sativa | 42% | 100% |
Q00216 | Aspergillus niger | 42% | 100% |
Q11067 | Caenorhabditis elegans | 30% | 86% |
Q15084 | Homo sapiens | 34% | 86% |
Q4Q9C8 | Leishmania major | 94% | 100% |
Q5I0H9 | Rattus norvegicus | 33% | 73% |
Q5R6T1 | Pongo abelii | 34% | 86% |
Q63081 | Rattus norvegicus | 33% | 86% |
Q75M08 | Oryza sativa subsp. japonica | 43% | 100% |
Q86IA3 | Dictyostelium discoideum | 35% | 100% |
Q92249 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 41% | 100% |
Q922R8 | Mus musculus | 33% | 86% |
Q942L2 | Oryza sativa subsp. japonica | 40% | 100% |
Q9MAU6 | Arabidopsis thaliana | 30% | 84% |
Q9V438 | Drosophila melanogaster | 37% | 87% |
Q9VYV3 | Drosophila melanogaster | 27% | 91% |
V5DR98 | Trypanosoma cruzi | 45% | 100% |